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11. 发明授权

US08187220B2 Seal structures for wet/dry automatic injectors 有权
标题翻译：湿/干自动注射器的密封结构
公开(公告)号：US08187220B2
公开(公告)日：2012-05-29
申请号：US12784595
申请日：2010-05-21
申请人： Steven M. Griffiths , Robert L. Hill
发明人： Steven M. Griffiths , Robert L. Hill
IPC分类号： A61M37/00
CPC分类号： A61M5/31596 , A61M5/19 , A61M5/2033 , A61M5/2066 , A61M5/284 , A61M5/286 , A61M5/3145 , A61M5/31513 , A61M5/3202 , A61M5/3293 , A61M5/34 , A61M5/343 , A61M5/348 , A61M2005/206 , A61M2005/2073 , A61M2005/287 , A61M2005/3106 , A61M2005/3131 , A61M2005/3132 , A61M2202/064 , A61M2205/7536 , A61M2205/7545
摘要： An automatic medicament injector has a first compartment for a first medicament component and a second compartment for a second medicament component. The two compartments are separated by a seal structure that converts from a sealing condition to a mixing condition when the device is activated. The seal structure has a plug that opens a flow path through the seal structure to allow the second medicament component to mix with the first medicament component in the first compartment when the seal structure is in the mixing condition.
摘要翻译：自动药物注射器具有用于第一药物组分的第一隔室和用于第二药物组分的第二隔室。两个隔室由密封结构分开，当设备被激活时，该密封结构从密封条件转变为混合状态。密封结构具有塞子，该塞子打开通过密封结构的流动路径，以便当密封结构处于混合状态时允许第二药物组分与第一隔室中的第一药物组分混合。

12. 发明授权

US07608055B2 Flow-path inserts for wet/dry automatic injectors 有权
标题翻译：湿/干自动注射器的流路插入件
公开(公告)号：US07608055B2
公开(公告)日：2009-10-27
申请号：US11698964
申请日：2007-01-26
申请人： Steven M. Griffiths , Robert L. Hill
发明人： Steven M. Griffiths , Robert L. Hill
IPC分类号： A61M37/00 , A61M5/00
CPC分类号： A61M5/31596 , A61M5/19 , A61M5/2033 , A61M5/2066 , A61M5/284 , A61M5/286 , A61M5/3145 , A61M5/31513 , A61M5/3202 , A61M5/3293 , A61M5/34 , A61M5/343 , A61M5/348 , A61M2005/206 , A61M2005/2073 , A61M2005/287 , A61M2005/3106 , A61M2005/3131 , A61M2005/3132 , A61M2202/064 , A61M2205/7536 , A61M2205/7545
摘要： An automatic medicament injector having a compartment for a dry medicament component and a compartment for a wet medicament component. The two compartments are separated by a seal structure that converts from a sealing condition into a mixing condition when the device is activated. The seal structure includes a wiper that scrapes the interior walls in the dry component compartment to prevent the dry component from accumulating at the seal/glass interface. A tapered insert funnels the mixed medicament components to an attached needle assembly, but can be removed when the device is filled. A filter is provided between the medicament compartments and the needle assembly. A chamber between the filter and the needle allows for better flow through the filter. An actuation assembly drives the seal structure into the mixing condition and forces the mixed medicament through the needle and into the user.
摘要翻译：一种自动药物注射器，其具有用于干药物组分的隔室和用于湿药物组分的隔室。两个隔间由密封结构隔开，密封结构在装置被激活时从密封条件转换成混合状态。密封结构包括擦拭干燥部件隔室中的内壁以防止干燥部件在密封/玻璃界面处积聚的刮水器。锥形插入件将混合的药物组分漏出到附接的针组件，但是当装置被填充时可以将其移除。在药剂隔室和针组件之间设置过滤器。过滤器和针之间的腔室可以更好地流过过滤器。致动组件驱动密封结构进入混合状态，并迫使混合药物穿过针头进入使用者。

13. 发明授权

US06953445B2 Wet/dry automatic injector assembly 失效
标题翻译：湿/干自动注射器组件
公开(公告)号：US06953445B2
公开(公告)日：2005-10-11
申请号：US09971768
申请日：2001-10-09
申请人： John G. Wilmot , Robert L. Hill , John Whittier
发明人： John G. Wilmot , Robert L. Hill , John Whittier
IPC分类号： A61J1/05 , A61M5/20 , A61M5/28 , A61M5/31 , A61M5/32 , A61M5/34 , A61M37/00 , A61M5/00
CPC分类号： A61M5/343 , A61M5/2033 , A61M5/2066 , A61M5/286 , A61M5/3145 , A61M5/34 , A61M2005/206 , A61M2005/2073
摘要： The present invention is directed to an automatic injection device containing a pre-loaded charge of medicament for automatically self-administering the medicament upon actuation thereof. The automatic injection device includes a housing assembly having an interior chamber, an activation assembly and a needle assembly for dispensing a dissolved medicament to a user. A dry compartment for storing a predetermined dry charge of dry medicament is located within the interior chamber. A wet compartment for storing a predetermined amount of liquid injection solution is also located within the interior chamber. A separation assembly separates the dry compartment from the wet compartment. The separation assembly prevents transfer of the liquid injection solution from the wet compartment to the dry compartment prior to activation of the automatic injection device. One or more medicament support assemblies located within the dry compartment prevent the passage of undissolved medicament from the dry compartment.
摘要翻译：本发明涉及一种自动注射装置，其包含用于在致动药剂时自动给药的药物的预加载药物。自动注射装置包括壳体组件，其具有内部腔室，激活组件和用于将溶解的药物分配给使用者的针组件。用于存储预定的干药物的干燥室的干燥室位于内部室内。用于存储预定量的液体注射溶液的湿室也位于内部室内。分离组件将干燥室与湿室隔开。分离组件防止在启动自动注射装置之前将液体注射溶液从湿室转移到干燥室。位于干燥室内的一个或多个药物支持组件防止未溶解的药物从干燥室中通过。

14. 发明授权

US06210369B1 Automatic injector 失效
标题翻译：自动进样器
公开(公告)号：US06210369B1
公开(公告)日：2001-04-03
申请号：US09212570
申请日：1998-12-16
申请人： John G. Wilmot , Jeffrey L. Goldberg , Jon Page , Cliff Ketcham , Jeffrey P. Castleberry , Jason Morton , Dave Edsall , Robert R. Boyd , Robert L. Hill
发明人： John G. Wilmot , Jeffrey L. Goldberg , Jon Page , Cliff Ketcham , Jeffrey P. Castleberry , Jason Morton , Dave Edsall , Robert R. Boyd , Robert L. Hill
IPC分类号： A61M520
CPC分类号： A61M5/24 , A61M5/2033 , A61M5/3135 , A61M5/3202 , A61M5/3232 , A61M5/326 , A61M2005/206 , A61M2005/2073 , A61M2005/2407 , A61M2005/247 , A61M2005/2492 , A61M2005/3118
摘要： The present invention relates to an automatic injector having a drive assembly with an actuator extending from the rearward end portion of the housing and a removal resistant cover for preventing unintended operation of the actuator. The present invention also relates to a sealing arrangement wherein the needle is sealed within a sterilized needle chamber by at least three sealing members which cooperate to form the chamber. Also, the present invention relates to an injector in which the cartridge is mounted to a tubular cartridge mounting portion of the needle carrier with an annular sealing member disposed therebetween. The cartridge mounting portion has at least one generally axially extending groove which allows air to escape from the cartridge mounting portion as the cartridge is being moved forwardly to a medicament supplying position.
摘要翻译：本发明涉及一种具有驱动组件的自动喷射器，该驱动组件具有从壳体的后端部分延伸的致动器和用于防止致动器意外操作的防拆盖。本发明还涉及一种密封装置，其中针通过至少三个密封构件密封在灭菌的针室内，这些密封构件协作形成腔室。此外，本发明涉及一种注射器，其中药筒安装到针架的管状药筒安装部分，其间设置有环形密封件。盒安装部分具有至少一个大致轴向延伸的凹槽，当槽被向前移动到药物供应位置时，允许空气从盒安装部分逸出。

15. 发明授权

US4662922A Method and apparatus for the production of glass filaments 失效
标题翻译：用于生产玻璃丝的方法和设备
公开(公告)号：US4662922A
公开(公告)日：1987-05-05
申请号：US706061
申请日：1985-03-01
申请人： Robert L. Hill , Douglas J. Eberle
发明人： Robert L. Hill , Douglas J. Eberle
IPC分类号： C03B37/02 , C03B37/085
CPC分类号： C03B37/0206 , C03B37/0213 , C03B37/0216 , Y02P40/57
摘要： A continuous glass fiber forming system incorporates a high energy stream of fluid to establish and control induced air flow from around the feeder to (1) substantially simulate the induction of air into the filament forming region in the absence of filament attenuation like that induced during attenuation and/or (2) increase the amount of heat removal effected during attenuation of the filaments.
摘要翻译：连续的玻璃纤维形成系统结合了高能量的流体流，以建立和控制来自进料器周围的诱导空气流，（1）在不存在如衰减期间诱发的灯丝衰减的情况下，基本上模拟空气进入灯丝形成区域的空气和/或（2）增加在细丝衰减期间所进行的热去除量。

16. 发明授权

US08506526B2 Seal structures for wet/dry automatic injectors 有权
标题翻译：湿/干自动注射器的密封结构
公开(公告)号：US08506526B2
公开(公告)日：2013-08-13
申请号：US13468421
申请日：2012-05-10
申请人： Steven M. Griffiths , Robert L. Hill
发明人： Steven M. Griffiths , Robert L. Hill
IPC分类号： A61M37/00
CPC分类号： A61M5/31596 , A61M5/19 , A61M5/2033 , A61M5/2066 , A61M5/284 , A61M5/286 , A61M5/3145 , A61M5/31513 , A61M5/3202 , A61M5/3293 , A61M5/34 , A61M5/343 , A61M5/348 , A61M2005/206 , A61M2005/2073 , A61M2005/287 , A61M2005/3106 , A61M2005/3131 , A61M2005/3132 , A61M2202/064 , A61M2205/7536 , A61M2205/7545
摘要： An automatic injection device including a housing, a chamber with a first compartment and a second compartment, and a seal structure between the compartments. The seal structure is initially in a sealing condition that seals the first compartment from the second compartment, where the seal includes a plug and an outer sealing member. The plug is slidably movable within the outer sealing member to convert the seal structure from the sealing condition to a mixing condition by opening a path between the first compartment and the second compartment. The automatic injection device also includes a needle assembly and an activation assembly. Activation of the activation assembly causes (1) pressurization of the first compartment, (2) the seal structure to convert from the sealing condition to the mixing condition, and (3) the first and second medicament components to be mixed and forced through the needle assembly.
摘要翻译：一种自动注射装置，包括壳体，具有第一隔室的腔室和第二隔室，以及隔室之间的密封结构。密封结构最初处于将第一隔室与第二隔室密封的密封状态，其中密封件包括塞子和外密封件。塞子可在外部密封件内滑动移动，以通过打开第一隔室和第二隔室之间的路径将密封结构从密封状态转换成混合状态。自动注射装置还包括针组件和激活组件。激活组件的激活导致（1）第一隔室的加压，（2）密封结构从密封条件转化为混合状态，以及（3）要混合并强制通过针的第一和第二药物成分部件。

17. 发明申请

US20120220930A1 Seal Structures For Wet/Dry Automatic Injectors 有权
标题翻译：湿/干自动注射器的密封结构
公开(公告)号：US20120220930A1
公开(公告)日：2012-08-30
申请号：US13468421
申请日：2012-05-10
申请人： Steven M. GRIFFITHS , Robert L. Hill
发明人： Steven M. GRIFFITHS , Robert L. Hill
IPC分类号： A61M5/31
CPC分类号： A61M5/31596 , A61M5/19 , A61M5/2033 , A61M5/2066 , A61M5/284 , A61M5/286 , A61M5/3145 , A61M5/31513 , A61M5/3202 , A61M5/3293 , A61M5/34 , A61M5/343 , A61M5/348 , A61M2005/206 , A61M2005/2073 , A61M2005/287 , A61M2005/3106 , A61M2005/3131 , A61M2005/3132 , A61M2202/064 , A61M2205/7536 , A61M2205/7545
摘要： An automatic injection device including a housing, a chamber with a first compartment and a second compartment, and a seal structure between the compartments. The seal structure is initially in a sealing condition that seals the first compartment from the second compartment, where the seal includes a plug and an outer sealing member. The plug is slidably movable within the outer sealing member to convert the seal structure from the sealing condition to a mixing condition by opening a path between the first compartment and the second compartment. The automatic injection device also includes a needle assembly and an activation assembly. Activation of the activation assembly causes (1) pressurization of the first compartment, (2) the seal structure to convert from the sealing condition to the mixing condition, and (3) the first and second medicament components to be mixed and forced through the needle assembly.
摘要翻译：一种自动注射装置，包括壳体，具有第一隔室的腔室和第二隔室，以及隔室之间的密封结构。密封结构最初处于将第一隔室与第二隔室密封的密封状态，其中密封件包括塞子和外密封件。塞子可在外部密封件内滑动移动，以通过打开第一隔室和第二隔室之间的路径将密封结构从密封状态转换成混合状态。自动注射装置还包括针组件和激活组件。激活组件的激活导致（1）第一隔室的加压，（2）密封结构从密封条件转化为混合状态，以及（3）要混合并强制通过针的第一和第二药物成分部件。

18. 发明申请

US20100292643A1 Autoinjector With Needle Depth Adapter 审中-公开
标题翻译：自动注射器与针深度适配器
公开(公告)号：US20100292643A1
公开(公告)日：2010-11-18
申请号：US12844279
申请日：2010-07-27
申请人： John G. Wilmot , Robert L. Hill
发明人： John G. Wilmot , Robert L. Hill
IPC分类号： A61M5/46
CPC分类号： A61M5/24 , A61M5/2033 , A61M5/3202 , A61M5/46 , A61M2005/206 , A61M2005/2073 , A61M2005/3143 , A61M2005/3267
摘要： An autoinjector useful for, inter alia, providing an injection of liquid medicament is uniquely capable of providing injections, utilizes a needle depth adapter to provide injection depths with a combination of accuracy and precision not heretofore seen. In addition, the autoinjector with needle depth adapter can include a variety of size needle depth adapters to provide an autoinjector of varying, precise injection depths and which can be readily and easily manufactured. The autoinjector includes a housing, cartridge assembly, needle, needle depth adapter, and power providing assembly.
摘要翻译：用于特别是提供液体药物注射的自动注射器独特地能够提供注射，利用针深度适配器来提供没有以前看到的准确度和精度的组合的注射深度。此外，具有针深度适配器的自动注射器可以包括各种尺寸的针深度适配器，以提供具有变化的精确注射深度的自动注射器，并且其可容易且容易地制造。自动注射器包括壳体，筒组件，针，针深度适配器和动力提供组件。

19. 发明申请

US20100228190A1 SEAL STRUCTURES FOR WET/DRY AUTOMATIC INJECTORS 有权
标题翻译：湿/干自动注射器密封结构
公开(公告)号：US20100228190A1
公开(公告)日：2010-09-09
申请号：US12784595
申请日：2010-05-21
申请人： Steven M. Griffiths , Robert L. Hill
发明人： Steven M. Griffiths , Robert L. Hill
IPC分类号： A61M5/31
CPC分类号： A61M5/31596 , A61M5/19 , A61M5/2033 , A61M5/2066 , A61M5/284 , A61M5/286 , A61M5/3145 , A61M5/31513 , A61M5/3202 , A61M5/3293 , A61M5/34 , A61M5/343 , A61M5/348 , A61M2005/206 , A61M2005/2073 , A61M2005/287 , A61M2005/3106 , A61M2005/3131 , A61M2005/3132 , A61M2202/064 , A61M2205/7536 , A61M2205/7545
摘要： An automatic medicament injector has a first compartment for a first medicament component and a second compartment for a second medicament component. The two compartments are separated by a seal structure that converts from a sealing condition to a mixing condition when the device is activated. The seal structure has a plug that opens a flow path through the seal structure to allow the second medicament component to mix with the first medicament component in the first compartment when the seal structure is in the mixing condition.
摘要翻译：自动药物注射器具有用于第一药物组分的第一隔室和用于第二药物组分的第二隔室。两个隔室由密封结构分开，当设备被激活时，该密封结构从密封条件转变为混合状态。密封结构具有塞子，该塞子打开通过密封结构的流动路径，以便当密封结构处于混合状态时允许第二药物组分与第一隔室中的第一药物组分混合。

20. 发明授权

US07678073B2 Vortex feature for drug delivery system 有权
标题翻译：用于药物输送系统的涡旋特征
公开(公告)号：US07678073B2
公开(公告)日：2010-03-16
申请号：US11846601
申请日：2007-08-29
申请人： Steven M. Griffiths , Robert L. Hill , Matthew P. Robben
发明人： Steven M. Griffiths , Robert L. Hill , Matthew P. Robben
IPC分类号： A61M37/00
CPC分类号： A61M5/2066 , A61M5/2033 , A61M5/31596 , A61M2005/2013 , A61M2005/206 , A61M2005/2073
摘要： An automatic injector separately stores liquid and dry components in respective compartments. When the injector is activated, a fluid-directing member between the liquid and dry compartments causes the liquid component to form a vortex as the liquid flows into the dry compartment. This allows the two components to combine more thoroughly and quickly to form a liquid solution that is delivered to an injection site.
摘要翻译：自动注射器分别在相应的隔间中储存液体和干燥组分。当喷射器被激活时，在液体和干燥室之间的流体引导构件使液体组分在液体流入干燥室时形成涡流。这允许两个组分更彻底和快速地组合以形成被输送到注射部位的液体溶液。

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