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11. 发明授权

US08911987B2 System for rapid identification and/or characterization of a microbial agent in a sample 有权
标题翻译：用于在样品中快速鉴定和/或表征微生物剂的系统
公开(公告)号：US08911987B2
公开(公告)日：2014-12-16
申请号：US12800388
申请日：2010-05-14
申请人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Bradford G. Clay
发明人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Bradford G. Clay
IPC分类号： C12M1/00 , C12M3/00 , G01N35/00 , C12Q1/24 , G01N35/10
CPC分类号： C12Q1/24 , G01N35/0099 , G01N35/1079 , Y10S901/30
摘要： An automated instrument for identification and/or characterization of a microbial agent present in a sample. The instrument includes (a) a sample removal apparatus operative to remove a test sample from a specimen container and add the test sample to a disposable separation device; (b) a separation and concentration apparatus operative on the separation device to separate the microbial agent from other components which may be present in the test sample and concentrate the microbial agent within the separation device; and (c) a identification and/or characterization module interrogating the concentrated microbial agent to identify and/or characterize the microbial agent.
摘要翻译：用于鉴定和/或表征样品中存在的微生物剂的自动化仪器。仪器包括（a）样品去除装置，用于从试样容器中取出测试样品，并将测试样品加入到一次性分离装置中; （b）分离和浓缩装置，其在分离装置上操作以将微生物剂与可能存在于测试样品中的其它组分分离，并将微生物剂浓缩在分离装置内; 和（c）识别和/或表征模块，询问浓缩的微生物剂以鉴定和/或表征微生物剂。

12. 发明授权

US08652800B2 Method for separation, characterization and/or identification of microorganisms using spectroscopy 有权
标题翻译：使用光谱法分离，表征和/或鉴定微生物的方法
公开(公告)号：US08652800B2
公开(公告)日：2014-02-18
申请号：US12589952
申请日：2009-10-30
申请人： John Walsh , Jones M. Hyman , Thurman Thorpe , Bradford Clay , Christopher Ronsick
发明人： John Walsh , Jones M. Hyman , Thurman Thorpe , Bradford Clay , Christopher Ronsick
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04 , G01N21/35 , G01N21/3581 , G01N21/359 , G01N21/47 , G01N21/64 , G01N21/65 , G01N33/6848 , Y02A50/55
摘要： The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The invention further provides for spectroscopic interrogation of the separated microorganism sample to produce measurements of the microorganism and characterizing and/or identifying the microorganism in the sample using said spectroscopic measurements.
摘要翻译：本发明涉及一种用于分离，表征和/或鉴定测试样品中的微生物的方法。本发明的方法包括用于裂解可能存在于测试样品中的非微生物细胞的任选裂解步骤，随后是随后的分离步骤。该方法可用于从诸如含血培养基的复杂样品中分离，表征和/或鉴定微生物。本发明进一步提供分离的微生物样品的光谱询问以产生微生物的测量，并使用所述光谱测量来表征和/或鉴定样品中的微生物。

13. 发明授权

US08512975B2 Method for detection and characterization of a microorganism in a sample using time dependent spectroscopic measurements 有权
标题翻译：使用时间依赖光谱测量法检测和表征样品中微生物的方法
公开(公告)号：US08512975B2
公开(公告)日：2013-08-20
申请号：US12460607
申请日：2009-07-22
申请人： John D. Walsh , Jones M. Hyman , Bradford G. Clay , Thurman C. Thorpe
发明人： John D. Walsh , Jones M. Hyman , Bradford G. Clay , Thurman C. Thorpe
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04 , C12Q1/10 , G01N21/31 , G01N21/47 , G01N21/64 , G01N21/6486 , G01N2021/6419 , G01N2021/6421
摘要： The present invention provides a method for detecting, and characterizing a microorganism present in a blood culture medium whereby the method may be accomplished utilizing a time-dependent spectroscopic technique to obtain at least two measurements directly of a blood culture medium and correlating said measurements for the detection and characterization of a microorganism, that may be present in the blood culture.
摘要翻译：本发明提供了一种用于检测和表征存在于血液培养基中的微生物的方法，由此可以使用时间依赖性光谱技术来完成该方法，以直接获得血液培养基的至少两次测量，并将所述测量结果与可能存在于血液培养物中的微生物的检测和表征。

14. 发明申请

US20100291669A1 System for rapid identification and/or characterization of a microbial agent in a sample 有权
标题翻译：用于在样品中快速鉴定和/或表征微生物剂的系统
公开(公告)号：US20100291669A1
公开(公告)日：2010-11-18
申请号：US12800388
申请日：2010-05-14
申请人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Bradford G. Clay
发明人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Bradford G. Clay
IPC分类号： C12M1/34
CPC分类号： C12Q1/24 , G01N35/0099 , G01N35/1079 , Y10S901/30
摘要： An automated instrument for identification and/or characterization of a microbial agent present in a sample. The instrument includes (a) a sample removal apparatus operative to remove a test sample from a specimen container and add the test sample to a disposable separation device; (b) a separation and concentration apparatus operative on the separation device to separate the microbial agent from other components which may be present in the test sample and concentrate the microbial agent within the separation device; and (c) a identification and/or characterization module interrogating the concentrated microbial agent to identify and/or characterize the microbial agent.
摘要翻译：用于鉴定和/或表征样品中存在的微生物剂的自动化仪器。仪器包括（a）样品去除装置，用于从试样容器中取出测试样品，并将测试样品加入到一次性分离装置中; （b）分离和浓缩装置，其在分离装置上操作以将微生物剂与可能存在于测试样品中的其它组分分离，并将微生物剂浓缩在分离装置内; 和（c）识别和/或表征模块，询问浓缩的微生物剂以鉴定和/或表征微生物剂。

15. 发明申请

US20100288060A1 Device for sampling a specimen container 有权
标题翻译：用于取样样品容器的装置
公开(公告)号：US20100288060A1
公开(公告)日：2010-11-18
申请号：US12800392
申请日：2010-05-14
申请人： Christopher S. Ronsick , Mark S. Wilson , Ronnie J. Robinson , John D. Walsh , Jones M. Hyman
发明人： Christopher S. Ronsick , Mark S. Wilson , Ronnie J. Robinson , John D. Walsh , Jones M. Hyman
IPC分类号： G01N1/12
CPC分类号： C12Q1/24 , G01N35/0099 , G01N35/1079 , Y10S901/30
摘要： A sampling device for a specimen container having a closure sealing the interior of the specimen container from the environment includes a needle, a body coupled to the needle and defining a chamber in fluid communication with the needle, the body further comprising a port forming an opening in the body, the port in fluid communication with the chamber. A multitude of the sampling devices may be stored in a cassette. The sampling devices may include a second chamber for separation and concentration of a microbial agent present in a sample. In this configuration second chamber is connected to the first chamber via a valve or the like.
摘要翻译：用于样本容器的采样装置具有将样本容器的内部与环境密封的封闭件，其包括：针头，与所述针头相连并且限定与所述针流体连通的室，所述主体还包括形成开口在身体中，与腔室流体连通的端口。多个采样装置可以存储在盒中。采样装置可以包括用于分离和浓缩样品中存在的微生物剂的第二室。在该构造中，第二室通过阀等连接到第一室。

16. 发明授权

US07387883B2 Methods for detecting bacterial pathogens 有权
标题翻译：检测细菌病原体的方法
公开(公告)号：US07387883B2
公开(公告)日：2008-06-17
申请号：US11005668
申请日：2004-12-07
申请人： John D. Walsh , Jones M. Hyman
发明人： John D. Walsh , Jones M. Hyman
IPC分类号： C12Q1/14 , C14Q1/04
CPC分类号： G01N33/56938 , C12Q1/14
摘要： The present invention provides for methods for detecting Staphylococcus aureus in a sample. A preferred method includes the steps of: mixing a sample comprising a medium and microorganisms with a first solution in a vessel, the microorganisms suspected of comprising Staphylococcus aureus; separating the microorganisms from the medium and the bulk of the first solution and removing the medium and the bulk of the first solution from the vessel; adding a second solution to the vessel to resuspend the microorganisms; and detecting Staphylococcus aureus in the resulting suspension of step (c) by using an agglutination test.
摘要翻译：本发明提供了在样品中检测金黄色葡萄球菌的方法。优选的方法包括以下步骤：将包含培养基和微生物的样品与容器中的第一溶液混合，所述微生物怀疑包括金黄色葡萄球菌; 从培养基和大部分第一溶液中分离微生物并从容器中除去介质和第一溶液的体积; 向容器中加入第二溶液以重悬微生物; 并通过使用凝集试验在步骤（c）的所得悬浮液中检测金黄色葡萄球菌。

17. 发明授权

US06777226B2 Sensor device for detecting microorganisms, and method therefor 有权
标题翻译：用于检测微生物的传感器装置及其方法
公开(公告)号：US06777226B2
公开(公告)日：2004-08-17
申请号：US09741402
申请日：2000-12-18
申请人： Scott R. Jeffrey , Paul M. Matsumura , Martin J. Maresch , Jones M. Hyman , Thurman C. Thorpe
发明人： Scott R. Jeffrey , Paul M. Matsumura , Martin J. Maresch , Jones M. Hyman , Thurman C. Thorpe
IPC分类号： C12M134
CPC分类号： C12Q1/04 , C12M23/04 , C12M23/22 , C12M23/24 , C12M25/06 , C12M25/14 , C12Q1/045 , C12Q1/24
摘要： A device and method allow for detecting the presence of microorganisms in clinical and non-clinical specimens. The device, a sensor, provides an environment to culture microbial organism colonies from a fluid sample, and a means to facilitate microbial detection and quantification, either manually or with an instrument. The sensor has a microorganism immobilization matrix layer and a sensor layer. Detected microbial colonies are immediately available for further testing. The sensor provides an area for accepting a fluid sample, a mechanism to immobilize the fluid sample on an interior surface of the plate, nutrients to facilitate growth of microorganisms in the sample, and a sensor for allowing the detection and/or enumeration of microorganism colonies within the sample.
摘要翻译：一种装置和方法允许检测临床和非临床标本中微生物的存在。该装置，传感器，提供了从流体样品培养微生物菌落的环境，以及手动或用仪器促进微生物检测和定量的手段。传感器具有微生物固定基质层和传感器层。检测到的微生物菌落立即可用于进一步测试。传感器提供用于接受流体样品的区域，将流体样品固定在板的内表面上的机制，营养物质以促进样品中微生物的生长，以及用于允许微生物菌落的检测和/或计数的传感器在样品内。

18. 发明授权

US06251624B1 Apparatus and method for detecting, quantifying and characterizing microorganisms 有权
标题翻译：用于检测，定量和表征微生物的装置和方法
公开(公告)号：US06251624B1
公开(公告)日：2001-06-26
申请号：US09502678
申请日：2000-02-11
申请人： Paul M. Matsumura , Jones M. Hyman , Scott R. Jeffrey , Martin J. Maresch , Thurman C. Thorpe , William G. Barron
发明人： Paul M. Matsumura , Jones M. Hyman , Scott R. Jeffrey , Martin J. Maresch , Thurman C. Thorpe , William G. Barron
IPC分类号： C12Q104
CPC分类号： C12M41/46 , C12M41/36 , C12Q1/04 , C12Q1/18 , G01N21/253 , G01N2035/0425
摘要： A method and apparatus for performing microbial antibiotic susceptibility testing include disposable, multi-chambered susceptibility plates and an automated plate handler and image acquisition and processing instrument is described. The susceptibility plates are inoculated with a suitable microorganism such as bacteria, fungi, protozoa, algae or viruses and anti-microbial agent(s) are applied that the microorganism is exposed to at a variety of concentrations or a gradient of each anti-microbial agent. The plates are then placed in the instrument, which monitors and measures the growth or lack thereof of the microorganisms. This data is used to determine the susceptibility of the microorganism to the antibiotics. Such a system automates anti-microbial susceptibility testing using solid media and Carbo-Bauer standardized result reporting. The system provides a level of automation previously associated only with broth micro dilution testing, while retaining the advantages of the manual disk diffusion test.
摘要翻译：用于进行微生物抗生素敏感性试验的方法和装置包括一次性多室敏感性板和自动板处理器以及图像采集和处理仪器。敏感性板用合适的微生物如细菌，真菌，原生动物，藻类或病毒接种，并且应用抗微生物剂，微生物以各种浓度或每种抗微生物剂的梯度暴露。然后将板放置在仪器中，其监测和测量微生物的生长或缺乏。该数据用于确定微生物对抗生素的敏感性。这种系统使用固体培养基和Carbo-Bauer标准化结果报告自动化抗微生物敏感性测试。该系统提供以前仅与肉汤微量稀释测试相关的自动化水平，同时保留手动盘扩散测试的优点。

19. 发明授权

US10167494B2 Method for detection, characterization and/or identification of microorganisms in a sealed container 有权
公开(公告)号：US10167494B2
公开(公告)日：2019-01-01
申请号：US12589968
申请日：2009-10-30
申请人： John Walsh , Jones M. Hyman , Thurman Thorpe , Bradford Clay
发明人： John Walsh , Jones M. Hyman , Thurman Thorpe , Bradford Clay
IPC分类号： C12Q1/00 , C12Q1/04 , G01N21/65 , G01N33/68 , G01N21/35 , G01N21/3581 , G01N21/47 , G01N21/64 , G01N21/3577
摘要： The present invention provides a method and system for monitoring, detecting, and/or characterizing a biological particle that may be present in a sample. The method may be accomplished in a sealed container by utilizing a first step time-dependent spectroscopic technique to obtain at least two measurements of a growth composition comprising a sample and correlating said measurements for the detection and/or characterization of a biological particle that may be present in the sample. The method further provides for a subsequent step for the separation, characterizion and/or identification of the microorganisms in the sealed container.

20. 发明授权

US10059975B2 Methods for the isolation and identification of microorganisms 有权
公开(公告)号：US10059975B2
公开(公告)日：2018-08-28
申请号：US12589929
申请日：2009-10-30
申请人： John Walsh , Jones M. Hyman , Thurman Thorpe , Bradford Clay
发明人： John Walsh , Jones M. Hyman , Thurman Thorpe , Bradford Clay
IPC分类号： C12Q1/04 , G01N21/65 , G01N33/68 , G01N21/35 , G01N21/3581 , G01N21/47 , G01N21/64 , G01N21/359
CPC分类号： C12Q1/04 , G01N21/35 , G01N21/3581 , G01N21/359 , G01N21/47 , G01N21/64 , G01N21/65 , G01N33/6848
摘要： The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The invention further provides methods for separating, characterizing and/or identifying microorganisms in situ within a single system.

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