专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

US20090136548A1 MULTIPLE ANTIGENIC PEPTIDES IMMUNOGENIC AGAINST STREPTOCOCCUS PNEUMONIA 有权
标题翻译：多发性抗原肽免疫球蛋白抗菌肽
公开(公告)号：US20090136548A1
公开(公告)日：2009-05-28
申请号：US12360382
申请日：2009-01-27
申请人： Edwin W. Ades , Scott E. Johnson , Danny L. Jue , Jacquelyn S. Sampson , George M. Carlone
发明人： Edwin W. Ades , Scott E. Johnson , Danny L. Jue , Jacquelyn S. Sampson , George M. Carlone
IPC分类号： A61K39/09 , C07K7/06 , C07K7/08 , A61P37/04 , C07K14/315
CPC分类号： C07K7/08 , A61K38/00 , A61K39/00 , C07K14/3156 , Y10S530/806 , Y10S530/825
摘要： The invention provides a nucleic acid encoding the 37-kDa pneumococcal surface adhesion A protein (PsaA) from Streptococcus pneumoniae. The invention also provides purified polypeptides encoded by the nucleic acid encoding the 37-kDa protein from and the nucleic acids comprising unique fragment of at least 10 nucleotides of the 37-kDa protein. Additionally, multiple antigenic peptides that provide protection against S. pneumoniae challenge are provided. These multiple antigen peptides comprise the peptides that immunospecifically bind to the monoclonal antibodies. Also provided are vaccines comprising such immunogenic peptides, and methods of conferring protective immunity against Streptococcus pneumoniae infection by administering therapeutic composition comprising the immunogenic peptides of the invention. Also provided are methods of detecting the presence of Streptococcus pneumoniae in a sample using antibodies or antigens and methods of preventing and treating Streptococcus pneumoniae infection in a subject.
摘要翻译：本发明提供编码来自肺炎链球菌的37-kDa肺炎球菌表面粘附A蛋白（PsaA）的核酸。本发明还提供由编码37-kDa蛋白质的核酸编码的纯化多肽和包含37-kDa蛋白质至少10个核苷酸的独特片段的核酸。另外，提供了提供针对肺炎链球菌攻击的保护的多种抗原肽。这些多重抗原肽包含免疫特异性结合单克隆抗体的肽。还提供了包含这种免疫原性肽的疫苗，以及通过施用包含本发明的免疫原性肽的治疗组合物来赋予对肺炎链球菌感染的保护性免疫的方法。还提供了使用抗体或抗原检测样品中肺炎链球菌存在的方法以及在受试者中预防和治疗肺炎链球菌感染的方法。

12. 发明授权

US06903184B1 Multiple antigenic peptides immunogenic against Streptococcus pneumonia 有权
标题翻译：针对肺炎链球菌免疫原性的多种抗原肽
公开(公告)号：US06903184B1
公开(公告)日：2005-06-07
申请号：US09613092
申请日：2000-07-10
申请人： Edwin W. Ades , Scott E. Johnson , Danny L. Jue , Jacquelyn S. Sampson , George M. Carlone
发明人： Edwin W. Ades , Scott E. Johnson , Danny L. Jue , Jacquelyn S. Sampson , George M. Carlone
IPC分类号： A61K38/00 , A61K39/00 , C07K7/08 , C07K14/315 , C07K2/00 , A61K39/02 , A61K39/09 , C07K1/00 , C07K5/00
CPC分类号： C07K7/08 , A61K38/00 , A61K39/00 , C07K14/3156 , Y10S530/806 , Y10S530/825
摘要： The invention provides a nucleic acid encoding the 37-kDa pneumococcal surface adhesion A protein (PsaA) from Streptococcus pneumoniae. The invention also provides purified polypeptides encoded by the nucleic acid encoding the 37-kDa protein from and the nucleic acids comprising unique fragment of at least 10 nucleotides of the 37-kDa protein. Additionally, multiple antigenic peptides that provide protection against S. pneumoniae challenge are provided. These multiple antigen peptides comprise the peptides that immunospecifically bind to the monoclonal antibodies. Also provided are vaccines comprising such immunogenic peptides, and methods of conferring protective immunity against Streptococcus pneumoniae infection by administering therapeutic composition comprising the immunogenic peptides of the invention. Also provided are methods of detecting the presence of Streptococcus pneumoniae in a sample using antibodies or antigens and methods of preventing and treating Streptococcus pneumoniae infection in a subject.
摘要翻译：本发明提供编码来自肺炎链球菌的37-kDa肺炎球菌表面粘附A蛋白（PsaA）的核酸。本发明还提供由编码37-kDa蛋白质的核酸编码的纯化多肽和包含37-kDa蛋白质至少10个核苷酸的独特片段的核酸。另外，提供了提供针对肺炎链球菌攻击的保护的多种抗原肽。这些多重抗原肽包含免疫特异性结合单克隆抗体的肽。还提供了包含这种免疫原性肽的疫苗，以及通过施用包含本发明的免疫原性肽的治疗组合物来赋予对肺炎链球菌感染的保护性免疫的方法。还提供了使用抗体或抗原检测样品中肺炎链球菌存在的方法以及在受试者中预防和治疗肺炎链球菌感染的方法。

13. 发明授权

US08642048B2 Multiple antigenic peptides immunogenic against Streptococcus pneumonia 有权
标题翻译：针对肺炎链球菌免疫原性的多种抗原肽
公开(公告)号：US08642048B2
公开(公告)日：2014-02-04
申请号：US12360382
申请日：2009-01-27
申请人： Edwin W. Ades , Scott E. Johnson , Danny L. Jue , Jacquelyn S. Sampson , George M. Carlone
发明人： Edwin W. Ades , Scott E. Johnson , Danny L. Jue , Jacquelyn S. Sampson , George M. Carlone
IPC分类号： A61K39/00 , A61K39/02 , A61K39/09 , A61K38/00 , C07K2/00
CPC分类号： C07K7/08 , A61K38/00 , A61K39/00 , C07K14/3156 , Y10S530/806 , Y10S530/825
摘要： The invention provides a nucleic acid encoding the 37-kDa pneumococcal surface adhesion A protein (PsaA) from Streptococcus pneumoniae. The invention also provides purified polypeptides encoded by the nucleic acid encoding the 37-kDa protein from and the nucleic acids comprising unique fragment of at least 10 nucleotides of the 37-kDa protein. Additionally, multiple antigenic peptides that provide protection against S. pneumoniae challenge are provided. These multiple antigen peptides comprise the peptides that immunospecifically bind to the monoclonal antibodies. Also provided are vaccines comprising such immunogenic peptides, and methods of conferring protective immunity against Streptococcus pneumoniae infection by administering therapeutic composition comprising the immunogenic peptides of the invention. Also provided are methods of detecting the presence of Streptococcus pneumoniae in a sample using antibodies or antigens and methods of preventing and treating Streptococcus pneumoniae infection in a subject.
摘要翻译：本发明提供编码来自肺炎链球菌的37-kDa肺炎球菌表面粘附A蛋白（PsaA）的核酸。本发明还提供由编码37-kDa蛋白质的核酸编码的纯化多肽和包含37-kDa蛋白质至少10个核苷酸的独特片段的核酸。另外，提供了提供针对肺炎链球菌攻击的保护的多种抗原肽。这些多重抗原肽包含免疫特异性结合单克隆抗体的肽。还提供了包含这种免疫原性肽的疫苗，以及通过施用包含本发明的免疫原性肽的治疗组合物来赋予对肺炎链球菌感染的保护性免疫的方法。还提供了使用抗体或抗原检测样品中肺炎链球菌存在的方法以及在受试者中预防和治疗肺炎链球菌感染的方法。

14. 发明申请

US20100260802A1 RECOMBINANT LIPIDATED PsaA PROTEIN, METHODS OF PREPARATION AND USE 失效
标题翻译：重组脂肪酸PsaA蛋白，制备和使用方法
公开(公告)号：US20100260802A1
公开(公告)日：2010-10-14
申请号：US12619357
申请日：2009-11-16
申请人： Edwin W. Ades , George M. Carlone , Barun K. De , Jacquelyn S. Sampson , Robert C. Huebner
发明人： Edwin W. Ades , George M. Carlone , Barun K. De , Jacquelyn S. Sampson , Robert C. Huebner
IPC分类号： A61K39/09 , C07H21/04 , A61P31/04 , C07K14/315 , C12N15/63 , C12P21/00
CPC分类号： C07K14/3156 , A61K39/00 , C07K2319/00 , Y02A50/401
摘要： The present invention relates to recombinant lipidated PsaA proteins and recombinant constructs from which such lipidated PsaA proteins may be expressed. The invention relates further to lipidated PsaA proteins in which lipidation is effected by the use of a heterologous leader sequence derived from the ospA gene of Borrelia burgdorferi, which leader sequence is joined in translational reading frame with the psaA structural gene. The invention also provides methods of preparation of lipidated PsaA proteins and use of such proteins in immunological compositions. Also provided are vaccines comprising immunogenic lipidated PsaA proteins and methods of use of such vaccines in the prevention and treatment of S. pneumoniae infection.
摘要翻译：本发明涉及重组脂化的PsaA蛋白和重组构建体，其中可以表达这种脂质化的PsaA蛋白。本发明进一步涉及脂质化PsaA蛋白，其中通过使用源自博氏疏螺旋体的ospA基因的异源前导序列来实现脂化，该引导序列与psaA结构基因连接在翻译阅读框中。本发明还提供了脂质化PsaA蛋白的制备方法和这些蛋白质在免疫组合物中的应用。还提供了包含免疫原性脂化PsaA蛋白的疫苗以及这种疫苗在预防和治疗肺炎链球菌感染中的使用方法。

15. 发明授权

US06217884B1 Streptococcus pneumoniae 37-kDa surface adhesin a protein 失效
标题翻译：肺炎链球菌37-kDa表面粘附素a蛋白
公开(公告)号：US06217884B1
公开(公告)日：2001-04-17
申请号：US09221753
申请日：1998-12-28
申请人： Jacquelyn S. Sampson , Harold Russell , Jean A. Tharpe , Edwin W. Ades , George M. Carlone
发明人： Jacquelyn S. Sampson , Harold Russell , Jean A. Tharpe , Edwin W. Ades , George M. Carlone
IPC分类号： A61K3909
CPC分类号： C07K14/3156 , A61K39/00 , C07K16/1275
摘要： The invention provides a nucleic acid encoding the 37-kDa protein from Streptococcus pneumoniae. Also provided are isolated nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. The invention also provides purified polypeptides encoded by the nucleic acid encoding the 37-kDa protein from and the nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. Also provided are antibodies which selectively binds the polypeptides encoded by the nucleic acid encoding the 37-kDa protein and the nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. Also provided are vaccines comprising immunogenic polypeptides encoded by the nucleic acid encoding the 37-kDa protein and the nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. Further provided is a method of detecting the presence of Streptococcus pneumoniae in a sample comprising the steps of contacting a sample suspected of containing Streptococcus pneumoniae with nucleic acid primers capable of hybridizing to a nucleic acid comprising a portion of the nucleic acid encoding the 37-kDa protein, amplifying the nucleic acid and detecting the presence of an amplification product, the presence of the amplification product indicating the presence of Streptococcus pneumoniae in the sample. Further provided are methods of detecting the presence of Streptococcus pneumoniae in a sample using antibodies or antigens, methods of preventing and treating Streptococcus pneumoniae infection in a subject.
摘要翻译：本发明提供编码来自肺炎链球菌的37-kDa蛋白质的核酸。还提供了分离的核酸，其包含37-kDa蛋白质的至少10个核苷酸的独特片段。本发明还提供由编码37-kDa蛋白的核酸编码的纯化多肽，其核酸包含37-kDa蛋白质的至少10个核苷酸的独特片段。还提供了选择性结合由编码37-kDa蛋白的核酸编码的多肽的抗体和包含37-kDa蛋白质的至少10个核苷酸的独特片段的核酸。还提供了疫苗，其包含由编码37-kDa蛋白质的核酸编码的免疫原性多肽和包含37-kDa蛋白质至少10个核苷酸的独特片段的核酸。进一步提供一种检测样品中肺炎链球菌存在的方法，包括以下步骤：将疑似含有肺炎链球菌的样品与能够与编码37kDa的核酸的一部分核酸的核酸引物接触蛋白质，扩增核酸并检测扩增产物的存在，显示样品中存在显示肺炎链球菌存在的扩增产物。还提供了使用抗体或抗原检测样品中肺炎链球菌存在的方法，在受试者中预防和治疗肺炎链球菌感染的方法。

16. 发明授权

US08431134B2 Use of a pneumococcal P4 peptide for enhancing opsonophagocytosis in response to a pathogen 有权
标题翻译：使用肺炎球菌P4肽来增强针对病原体的调理吞噬作用
公开(公告)号：US08431134B2
公开(公告)日：2013-04-30
申请号：US13056522
申请日：2009-07-31
申请人： Edwin W. Ades , Gowrisankar Rajam , Sandra Steiner , George M. Carlone , Nikkoj Melnick , Jacquelyn S. Sampson , Joseph E. Martinez , Julie M. Skinner
发明人： Edwin W. Ades , Gowrisankar Rajam , Sandra Steiner , George M. Carlone , Nikkoj Melnick , Jacquelyn S. Sampson , Joseph E. Martinez , Julie M. Skinner
IPC分类号： A61K39/09 , A61K39/085 , C07K16/00
CPC分类号： A61K38/164 , A61K31/00 , A61K31/53 , A61K38/1725 , A61K39/395 , A61K39/40 , A61K39/42 , A61K45/06 , A61K2300/00
摘要： Methods for enhancing opsonophagocytosis of a pathogen of interest are disclosed. The disclosed methods include administering to a subject an isolated P4 peptide, which includes the amino acid sequence set forth as SEQ ID NO: 1 and optionally an isolated opsonic antibody or a fragment thereof that specifically binds to an antigen present on the surface of the pathogen of interest. In some examples isolated complement protein or a fragment thereof (for example, a C3a, C3b, iC3b, C3d, C4b, or C5a fragment of a complement protein) is also administered. Compositions containing isolated P4 peptide and one or more isolated opsonic antibodies or a fragment thereof that specifically binds to an antigen present of the surface of a pathogen of interest are also disclosed. In some examples, the compositions also include isolated complement protein or fragment thereof, such as one or more of C3a, C3b, iC3b, C3d, C4b, or C5a.
摘要翻译：公开了增加目的病原体的调理吞噬作用的方法。所公开的方法包括向受试者施用分离的P4肽，其包括SEQ ID NO：1所示的氨基酸序列和任选的特异性结合存在于病原体表面上的抗原的分离的调理蛋白抗体或其片段出于兴趣。在一些实施例中，还给予分离的补体蛋白或其片段（例如，补体蛋白的C3a，C3b，iC3b，C3d，C4b或C5a片段）。还公开了包含分离的P4肽和一种或多种分离的调理抗体或其特异性结合目的病原体表面存在的抗原的片段的组合物。在一些实例中，组合物还包括分离的补体蛋白或其片段，例如C3a，C3b，iC3b，C3d，C4b或C5a中的一种或多种。

17. 发明授权

US07635486B1 Recombinant lipidated PsaA protein, methods of preparation and use 失效
标题翻译：重组脂质化PsaA蛋白，制备和使用方法
公开(公告)号：US07635486B1
公开(公告)日：2009-12-22
申请号：US09600057
申请日：1999-01-14
申请人： Edwin W. Ades , George M. Carlone , Barun K. De , Jacquelyn S. Sampson , Robert C. Huebner
发明人： Edwin W. Ades , George M. Carlone , Barun K. De , Jacquelyn S. Sampson , Robert C. Huebner
IPC分类号： A61K39/02 , A61K45/00 , A61K39/09
CPC分类号： C07K14/3156 , A61K39/00 , C07K2319/00 , Y02A50/401
摘要： The present invention relates to recombinant lipidated PsaA proteins and recombinant constructs from which such lipidated PsaA proteins may be expressed. The invention relates further to lipidated PsaA proteins in which lipidation is effected by the use of a heterologous leader sequence derived from the ospA gene of Borrelia burgdorferi, which leader sequence is joined in translational reading frame with the psaA structural gene. The invention also provides methods of preparation of lipidated PsaA proteins and use of such proteins in immunological compositions. Also provided are vaccines comprising immunogenic lipidated PsaA proteins and methods of use of such vaccines in the prevention and treatment of S. pneumoniae infection.
摘要翻译：本发明涉及重组脂化的PsaA蛋白和重组构建体，其中可以表达这种脂质化的PsaA蛋白。本发明进一步涉及脂质化PsaA蛋白，其中通过使用源自博氏疏螺旋体的ospA基因的异源前导序列来实现脂化，该引导序列与psaA结构基因连接在翻译阅读框中。本发明还提供了脂质化PsaA蛋白的制备方法和这些蛋白质在免疫组合物中的应用。还提供了包含免疫原性脂化PsaA蛋白的疫苗以及这种疫苗在预防和治疗肺炎链球菌感染中的使用方法。

18. 发明申请

US20080305123A1 Functional Epitopes of Streptococcus Pneumoniae PsaA Antigen and Uses Thereof 有权
标题翻译：肺炎链球菌PsaA抗原的功能表位及其用途
公开(公告)号：US20080305123A1
公开(公告)日：2008-12-11
申请号：US11992719
申请日：2005-07-29
申请人： Edwin W. Ades , Jacquelyn S. Sampson , Sandra Steiner , George M. Carlone , Joseph J. Caba , GowriSankar Rajam
发明人： Edwin W. Ades , Jacquelyn S. Sampson , Sandra Steiner , George M. Carlone , Joseph J. Caba , GowriSankar Rajam
IPC分类号： A61K39/09 , C07K14/00 , C12N5/00 , A61P31/04 , C07K16/12 , G01N33/569
CPC分类号： C07K14/3156 , A61K39/00 , A61K2039/505 , Y10S530/825
摘要： Provided is a P4 peptide, which contains functional epitopes of the PsaA protein of Streptococcus pneumoniae, and related methods and compositions. A peptide that comprises the amino acid sequence defined in SEQ ID NO:1 (an example of the P4 peptide) is provided. Also provided is a peptide comprising the amino acid sequence defined as VPSLFVDSSVDDRPMKTVSQDTNIPIYAQIFTDS (SEQ ID NO:2). P4 peptide mimetics having a conformational structure identical or similar to the conformation of P4 (e.g., SEQ ID NO: 1 and SEQ ID NO:2) are provided. An antibody that specifically binds to the epitope defined by the disclosed peptides is provided. For example, the antibody can specifically bind to a peptide comprising the sequence set forth in SEQ ID NO: 1 and having the conformation defined by the peptide consisting of SEQ ID NO: 1. An antibody that specifically binds to a peptide comprising the sequence set forth in SEQ ID NO:2 and having the conformation defined by the peptide consisting of SEQ ID NO:2 is also provided. A P4-specific antibody is PsaA-specific since P4 defines an epitope specific for PsaA. A vaccine comprising the peptide of SEQ ID NO: 1 and a pharmaceutical carrier is provided. A vaccine comprising a peptide of SEQ ID NO:2 and a pharmaceutical carrier is also provided. Methods of using the peptides and antibodies of the invention are provided. Diagnostic kits comprising a P4 peptide is also provided.
摘要翻译：提供了含有肺炎链球菌PsaA蛋白的功能性表位的P4肽及其相关方法和组合物。提供了包含SEQ ID NO：1中定义的氨基酸序列（P4肽的实例）的肽。还提供了包含定义为VPSLFVDSSV DDRPMKTVSQDTNIPIYAQIFTDS（SEQ ID NO：2）的氨基酸序列的肽。提供了具有与P4的构象相同或相似的构象结构的P4肽模拟物（例如，SEQ ID NO：1和SEQ ID NO：2）。提供了特异性结合由公开的肽定义的表位的抗体。例如，抗体可以特异性结合包含SEQ ID NO：1所示序列并具有由SEQ ID NO：1组成的肽所定义的构象的肽。特异性结合包含序列集的肽的抗体还提供了具有由SEQ ID NO：2组成的肽定义的构象的SEQ ID NO：2中的SEQ ID NO：2。 P4特异性抗体是PsaA特异性的，因为P4定义了PsaA特异性表位。提供了包含SEQ ID NO：1的肽和药物载体的疫苗。还提供了包含SEQ ID NO：2的肽和药物载体的疫苗。提供使用本发明的肽和抗体的方法。还提供了包含P4肽的诊断试剂盒。

19. 发明授权

US5854416A Streptococcus pneumoniae 37-KDA surface adhesin a protein and nucleic acids coding therefor 失效
标题翻译：肺炎链球菌37-KDA表面粘附素a蛋白及其编码的核酸
公开(公告)号：US5854416A
公开(公告)日：1998-12-29
申请号：US715131
申请日：1996-09-17
申请人： Jacquelyn S. Sampson , Harold Russell , Jean A. Tharpe , Edwin W. Ades , George M. Carlone
发明人： Jacquelyn S. Sampson , Harold Russell , Jean A. Tharpe , Edwin W. Ades , George M. Carlone
IPC分类号： A61K39/00 , A61P31/04 , C07K14/315 , C07K16/12 , C12N1/21 , C07H21/04
CPC分类号： C07K14/3156 , C07K16/1275 , A61K39/00
摘要： The invention provides a nucleic acid encoding the 37-kDa protein from Streptococcus pneumoniae. Also provided are isolated nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. The invention also provides purified polypeptides encoded by the nucleic acid encoding the 37-kDa protein from and the nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. Also provided are antibodies which selectively binds the polypeptides encoded by the nucleic acid encoding the 37-kDa protein and the nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. Also provided are vaccines comprising immunogenic polypeptides encoded by the nucleic acid encoding the 37-kDa protein and the nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. Further provided is a method of detecting the presence of Streptococcus pneumoniae in a sample comprising the steps of contacting a sample suspected of containing Streptococcus pneumoniae with nucleic acid primers capable of hybridizing to a nucleic acid comprising a portion of the nucleic acid encoding the 37-kDa protein, amplifying the nucleic acid and detecting the presence of an amplification product, the presence of the amplification product indicating the presence of Streptococcus pneumoniae in the sample. Further provided are methods of detecting the presence of Streptococcus pneumoniae in a sample using antibodies or antigens, methods of preventing and treating Streptococcus pneumoniae infection in a subject.
摘要翻译：本发明提供编码来自肺炎链球菌的37-kDa蛋白质的核酸。还提供了分离的核酸，其包含37-kDa蛋白质的至少10个核苷酸的独特片段。本发明还提供由编码37-kDa蛋白的核酸编码的纯化多肽，其核酸包含37-kDa蛋白质的至少10个核苷酸的独特片段。还提供了选择性结合由编码37-kDa蛋白的核酸编码的多肽的抗体和包含37-kDa蛋白质的至少10个核苷酸的独特片段的核酸。还提供了疫苗，其包含由编码37-kDa蛋白质的核酸编码的免疫原性多肽和包含37-kDa蛋白质至少10个核苷酸的独特片段的核酸。进一步提供一种检测样品中肺炎链球菌存在的方法，包括以下步骤：将疑似含有肺炎链球菌的样品与能够与编码37kDa的核酸的一部分核酸的核酸引物接触蛋白质，扩增核酸并检测扩增产物的存在，显示样品中存在显示肺炎链球菌存在的扩增产物。还提供了使用抗体或抗原检测样品中肺炎链球菌存在的方法，在受试者中预防和治疗肺炎链球菌感染的方法。

20. 发明授权

US07476733B2 Development of a real-time PCR assay for detection of pneumococcal DNA and diagnosis of pneumococccal disease 有权
标题翻译：开发用于肺炎球菌DNA检测和肺炎球菌病诊断的实时PCR检测
公开(公告)号：US07476733B2
公开(公告)日：2009-01-13
申请号：US11089938
申请日：2005-03-25
申请人： Maria da Gloria Carvalho , Jacquelyn S. Sampson , Edwin W. Ades , George Carlone , Karen McCaustland
发明人： Maria da Gloria Carvalho , Jacquelyn S. Sampson , Edwin W. Ades , George Carlone , Karen McCaustland
IPC分类号： C07H21/04
CPC分类号： C12Q1/689
摘要： Disclosed are compositions and methods for detecting a specific sequence of the psaA gene using real-time PCR for diagnosis of Pneumococcal Disease.
摘要翻译：公开了使用实时PCR检测肺炎球菌病的psaA基因的特异性序列的组合物和方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式