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11. 发明授权

US06303151B1 Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment 有权
标题翻译：癌细胞抑制的癌细胞增殖抑制材料
公开(公告)号：US06303151B1
公开(公告)日：2001-10-16
申请号：US09437193
申请日：1999-11-09
申请人： Shirin Asina , Kanti Jain , Albert L. Rubin , Barry Smith , Kurt Stenzel
发明人： Shirin Asina , Kanti Jain , Albert L. Rubin , Barry Smith , Kurt Stenzel
IPC分类号： A61K3512
CPC分类号： C12N5/0693 , A61K35/13 , C12N11/04
摘要： A material for suppressing proliferation of cancer cells is produced by entrapping cancer cells in a selectively-permeable structure such as a bead, and culturing the entrapped cells in a culture medium. Entrapment restricts growth of the cancel cells during culturing and causes the cells to produce in the culture medium a material having a molecular weight of at least about 30 kd as measured by filtration that suppresses proliferation of cancer cells. The material is separated from the culture medium by filtering the medium through a filter that separates material having a molecular weight of at least about 30 kd from material having a molecular weight of less than 30 kd. The structure that entraps the cells may contain 10,000 to 500,000 cells. The material or the structure containing the entrapped cells that produce the material can be administered to a subject to suppress cancer cell proliferation.
摘要翻译：用于抑制癌细胞增殖的材料是通过将癌细胞包埋在选择性可渗透的结构如珠中产生的，并在培养基中培养包埋的细胞。包埋限制了培养过程中消除细胞的生长，并导致细胞在培养基中产生通过过滤测量的分子量至少为约30kd的材料，其抑制癌细胞的增殖。通过过滤器将培养基与培养基分离，该过滤器将具有至少约30kd分子量的材料与分子量小于30kd的材料分离。截留细胞的结构可能含有10,000至500,000个细胞。可以向受试者施用含有产生该物质的包埋细胞的材料或结构，以抑制癌细胞增殖。

12. 发明授权

US08741637B2 Method for isolating a chemotherapeutic agent resistant cancer cell with stem cell properties 有权
标题翻译：用于分离具有干细胞特性的抗化学药物抗癌细胞的方法
公开(公告)号：US08741637B2
公开(公告)日：2014-06-03
申请号：US13701705
申请日：2011-11-22
申请人： Lawrence Gazda , Barry Smith
发明人： Lawrence Gazda , Barry Smith
IPC分类号： C12N5/07 , C12N5/09 , C12N5/095 , C12N11/10
CPC分类号： A61K33/24 , A61K31/282 , A61K31/337 , A61K31/437 , A61K31/519 , A61K31/704 , C12N5/0695 , C12N2503/02 , C12N2533/76 , G01N33/54313 , G01N2333/4703
摘要： The invention relates to the use of encapsulates of cancer cells, in agarose coated, agarose containing beads, for isolating chemotherapeutic resistant cells which have at least one stem cell property, such as expression of OCT4. The cells thus isolated are also a feature of the invention, as is a method for screening for potential therapeutic agents.
摘要翻译：本发明涉及在琼脂糖包被的包含琼脂糖的珠粒中用于分离具有至少一种干细胞特性如OCT4表达的化疗抗性细胞的癌细胞的包封物的用途。如此分离的细胞也是本发明的特征，以及用于筛选潜在治疗剂的方法。

13. 发明申请

US20130244248A1 METHOD FOR ISOLATING A CHEMOTHERAPEUTIC AGENT RESISTANT CANCER CELL WITH STEM CELL PROPERTIES 有权
标题翻译：用于分离具有干细胞特性的化疗药物耐药性癌细胞的方法
公开(公告)号：US20130244248A1
公开(公告)日：2013-09-19
申请号：US13701705
申请日：2011-11-22
申请人： Lawrence Gazda , Barry Smith
发明人： Lawrence Gazda , Barry Smith
IPC分类号： C12N5/095
CPC分类号： A61K33/24 , A61K31/282 , A61K31/337 , A61K31/437 , A61K31/519 , A61K31/704 , C12N5/0695 , C12N2503/02 , C12N2533/76 , G01N33/54313 , G01N2333/4703
摘要： The invention relates to the use of encapsulates of cancer cells, in agarose coated, agarose containing beads, for isolating chemotherapeutic resistant cells which have at least one stem cell property, such as expression of OCT4. The cells thus isolated are also a feature of the invention, as is a method for screening for potential therapeutic
摘要翻译：本发明涉及在琼脂糖包被的包含琼脂糖的珠粒中用于分离具有至少一种干细胞特性如OCT4表达的化疗抗性细胞的癌细胞的包封物的用途。如此分离的细胞也是本发明的特征，以及用于筛选潜在治疗剂的方法

14. 发明授权

US08518394B2 Seakem gold agarose beads comprising islets and coated with agarose 有权
标题翻译： Seakem金琼脂糖珠包含胰岛并涂上琼脂糖
公开(公告)号：US08518394B2
公开(公告)日：2013-08-27
申请号：US11521977
申请日：2006-09-14
申请人： Lawrence Gazda , Barry Smith
发明人： Lawrence Gazda , Barry Smith
IPC分类号： C12N5/07 , C12N11/10 , A61K9/14 , A61F2/00
CPC分类号： C12N5/0677 , A61K2035/128 , C12N2533/76
摘要： The invention describes the manufacture and use of secretory cell containing bead structures that are coated with agarose. The beads, which are preferably 4 mm-12 mm in diameter, and which preferably contain islets, are made of a particular agarose, i.eagarose which has a sulfate content of less than 0.2 wt % but greater than zero, a pyruvate content of 0-0.1 wt %, and a Kjeldahl nitrogen content of 0-0.04 wt %. The gels found from the agarose exhibit a gel strength of at least 1200 g/cm2 (1.0 wt % concentration), substantial absence of DNA binding in 0.07 M or less tris acetate buffer, and an EEO at 1.0 wt % agarose concentration of 0.05 or less.
摘要翻译：本发明描述了用琼脂糖包被的包含分泌细胞的珠粒结构的制造和使用。优选直径为4mm-12mm，优选含有胰岛的珠由特定的琼脂糖，即具有小于0.2重量％但大于零的硫酸盐含量的琼脂糖制成，丙酮酸含量 0-0.1重量％，凯氏定氮含量为0-0.04重量％。从琼脂糖中发现的凝胶表现出至少1200g / cm 2（1.0重量％浓度）的凝胶强度，在0.07M或更少的三乙酸盐缓冲液中基本上不存在DNA结合，并且1.0重量％琼脂糖浓度的EEO为0.05或减。

15. 发明申请

US20110092992A1 METHOD AND APPARATUS FOR SURGICAL FASTENING 有权
标题翻译：手术治疗方法与装置
公开(公告)号：US20110092992A1
公开(公告)日：2011-04-21
申请号：US12977706
申请日：2010-12-23
申请人： Roger E. Darois , Gus Felix , Alan Bachman , Ray Adams , Joe Paul , Ed Chester , Adam Lehman , Barry Smith , Jeffrey A. Stein
发明人： Roger E. Darois , Gus Felix , Alan Bachman , Ray Adams , Joe Paul , Ed Chester , Adam Lehman , Barry Smith , Jeffrey A. Stein
IPC分类号： A61B17/03
CPC分类号： A61B17/068 , A61B17/064 , A61B17/861 , A61B17/864 , A61B17/8875 , A61B2017/0648 , A61L31/148 , B25B17/00 , B25B23/065
摘要： A surgical fastener system includes a plurality of fasteners having a throughbore with an internally threaded portion. The fasteners may engage with a threaded mandrel that passes through the throughbore of the fasteners. A rotator may rotate the fasteners relative to the mandrel to move at least one of the fasteners along the mandrel, e.g., along the mandrel's longitudinal axis. A distal end of the mandrel may be inserted into a material, such as a tissue, prosthetic or other, and a fastener may be deployed from the distal end of the mandrel while the distal end is positioned in the material. The throughbore of the fasteners may include a threaded portion and an unthreaded portion, may include an angled face or other feature to aid in fastener deployment and/or have curved depressions in the head portion.
摘要翻译：外科紧固件系统包括具有带内螺纹部分的通孔的多个紧固件。紧固件可以与穿过紧固件的通孔的螺纹心轴接合。旋转器可以相对于心轴旋转紧固件，以沿着心轴移动至少一个紧固件，例如沿心轴的纵向轴线。心轴的远端可以插入诸如组织，假体或其他材料中的材料中，并且紧固件可以从心轴的远端展开，而远端位于材料中。紧固件的通孔可以包括螺纹部分和无螺纹部分，可以包括成角度的面部或其他特征以帮助紧固件展开和/或在头部部分具有弯曲的凹陷。

16. 发明授权

US07862573B2 Method and apparatus for surgical fastening 有权
标题翻译：手术紧固方法和装置
公开(公告)号：US07862573B2
公开(公告)日：2011-01-04
申请号：US11408399
申请日：2006-04-21
申请人： Roger E. Darois , Gus Felix , Alan Bachman , Ray Adams , Joe Paul , Ed Chester , Adam Lehman , Barry Smith , Jeffrey Stein
发明人： Roger E. Darois , Gus Felix , Alan Bachman , Ray Adams , Joe Paul , Ed Chester , Adam Lehman , Barry Smith , Jeffrey Stein
IPC分类号： A61B17/08
CPC分类号： A61B17/068 , A61B17/064 , A61B17/861 , A61B17/864 , A61B17/8875 , A61B2017/0648 , A61L31/148 , B25B17/00 , B25B23/065
摘要： A surgical fastener system includes a plurality of fasteners having a throughbore with an internally threaded portion. The fasteners may engage with a threaded mandrel that passes through the throughbore of the fasteners. A rotator may rotate the fasteners relative to the mandrel to move at least one of the fasteners along the mandrel, e.g., along the mandrel's longitudinal axis. A distal end of the mandrel may be inserted into a material, such as a tissue, prosthetic or other, and a fastener may be deployed from the distal end of the mandrel while the distal end is positioned in the material. The throughbore of the fasteners may include a threaded portion and an unthreaded portion, may include an angled face or other feature to aid in fastener deployment and/or have curved depressions in the head portion.
摘要翻译：外科紧固件系统包括多个具有带内螺纹部分的通孔的紧固件。紧固件可以与穿过紧固件的通孔的螺纹心轴接合。旋转器可以相对于心轴旋转紧固件，以沿着心轴移动至少一个紧固件，例如沿心轴的纵向轴线。心轴的远端可以插入诸如组织，假体或其他材料中的材料中，并且紧固件可以从心轴的远端展开，而远端位于材料中。紧固件的通孔可以包括螺纹部分和无螺纹部分，可以包括成角度的面部或其他特征以帮助紧固件展开和/或在头部部分具有弯曲的凹陷。

17. 发明授权

US07838291B2 Entrapped stem cells and uses thereof 有权
标题翻译：包埋的干细胞及其用途
公开(公告)号：US07838291B2
公开(公告)日：2010-11-23
申请号：US11891526
申请日：2007-08-10
申请人： Bryan Conn , Barry Smith , Albert L. Rubin , Kurt Stenzel
发明人： Bryan Conn , Barry Smith , Albert L. Rubin , Kurt Stenzel
IPC分类号： C12N5/00 , C12N5/02
CPC分类号： C12N5/0693 , A01N1/0205 , A01N1/0231 , A61K35/13 , A61K35/545 , C12N5/0012 , C12N5/0606 , C12N2502/02 , C12N2533/76
摘要： The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal cells. It has also been found that entrapped cancer cells will produce material which inhibits the proliferation of stem cells. Further, it has been found that the entrapment of the stem cells inhibits their differentiation and thus the entrapment process can serve as a long-term storage device for maintaining the undifferentiated state of at least a portion of the entrapped cells.
摘要翻译：本发明特别涉及干细胞，胚胎干细胞。已经发现，当这些干细胞被捕获使得其增殖被抑制时，它们产生抑制其它非包埋细胞（包括干细胞，肿瘤和/或过度增殖，但是其他正常细胞）增殖的材料。也已经发现，截留的癌细胞将产生抑制干细胞增殖的物质。此外，已经发现，干细胞的捕获抑制其分化，因此捕获过程可以用作长期存储装置，用于保持至少一部分包埋细胞的未分化状态。

18. 发明申请

US20080020463A1 Entrapped stem cells and uses thereof 有权
标题翻译：包埋的干细胞及其用途
公开(公告)号：US20080020463A1
公开(公告)日：2008-01-24
申请号：US11891526
申请日：2007-08-10
申请人： Bryan Conn , Barry Smith , Albert Rubin , Kurt Stenzel
发明人： Bryan Conn , Barry Smith , Albert Rubin , Kurt Stenzel
IPC分类号： C12N5/02
CPC分类号： C12N5/0693 , A01N1/0205 , A01N1/0231 , A61K35/13 , A61K35/545 , C12N5/0012 , C12N5/0606 , C12N2502/02 , C12N2533/76
摘要： The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal cells. It has also been found that entrapped cancer cells will produce material which inhibits the proliferation of stem cells. Further, it has been found that the entrapment of the stem cells inhibits their differentiation and thus the entrapment process can serve as a long-term storage device for maintaining the undifferentiated state of at least a portion of the entrapped cells.
摘要翻译：本发明特别涉及干细胞，胚胎干细胞。已经发现，当这些干细胞被捕获使得其增殖被抑制时，它们产生抑制其它非包埋细胞（包括干细胞，肿瘤和/或过度增殖，但是其他正常细胞）增殖的材料。还发现被截留的癌细胞将产生抑制干细胞增殖的物质。此外，已经发现，干细胞的捕获抑制其分化，因此捕获过程可以用作长期存储装置，用于保持至少一部分包埋细胞的未分化状态。

19. 发明申请

US20070250064A1 Method and apparatus for surgical fastening 有权
标题翻译：手术紧固方法和装置
公开(公告)号：US20070250064A1
公开(公告)日：2007-10-25
申请号：US11408399
申请日：2006-04-21
申请人： Roger Darois , Gus Felix , Alan Bachman , Ray Adams , Joe Paul , Ed Chester , Adam Lehman , Barry Smith , Jeffrey Stein
发明人： Roger Darois , Gus Felix , Alan Bachman , Ray Adams , Joe Paul , Ed Chester , Adam Lehman , Barry Smith , Jeffrey Stein
IPC分类号： A61B17/58
CPC分类号： A61B17/068 , A61B17/064 , A61B17/861 , A61B17/864 , A61B17/8875 , A61B2017/0648 , A61L31/148 , B25B17/00 , B25B23/065
摘要： A surgical fastener system includes a plurality of fasteners having a throughbore with an internally threaded portion. The fasteners may engage with a threaded mandrel that passes through the throughbore of the fasteners. A rotator may rotate the fasteners relative to the mandrel to move at least one of the fasteners along the mandrel, e.g., along the mandrel's longitudinal axis. A distal end of the mandrel may be inserted into a material, such as a tissue, prosthetic or other, and a fastener may be deployed from the distal end of the mandrel while the distal end is positioned in the material. The throughbore of the fasteners may include a threaded portion and an unthreaded portion, may include an angled face or other feature to aid in fastener deployment and/or have curved depressions in the head portion.
摘要翻译：外科紧固件系统包括具有带内螺纹部分的通孔的多个紧固件。紧固件可以与穿过紧固件的通孔的螺纹心轴接合。旋转器可以相对于心轴旋转紧固件，以沿着心轴移动至少一个紧固件，例如沿心轴的纵向轴线。心轴的远端可以插入诸如组织，假体或其他材料中的材料中，并且紧固件可以从心轴的远端展开，而远端位于材料中。紧固件的通孔可以包括螺纹部分和无螺纹部分，可以包括成角度的面或其他特征，以帮助紧固件展开和/或在头部部分具有弯曲的凹陷。

20. 发明申请

US20070110773A1 Composition of restricted cancer cells which produce cancer cell proliferation suppressive materials, and uses thereof 审中-公开
公开(公告)号：US20070110773A1
公开(公告)日：2007-05-17
申请号：US11650753
申请日：2007-01-08
申请人： Shirin Asina , Kanti Jain , Albert Rubin , Barry Smith , Kurt Stenzel
发明人： Shirin Asina , Kanti Jain , Albert Rubin , Barry Smith , Kurt Stenzel
IPC分类号： A61K39/00
CPC分类号： A61K35/22 , A61K39/0011 , A61K2035/126 , A61K2035/128 , C12N5/0693 , C12N11/04
摘要： Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for making these compositions, and their use, are also described.

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