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11. 发明授权

US07374894B2 Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing a chloride intracellular channel 1 protein 有权
标题翻译：使用氯化物细胞内通道1蛋白鉴定调节IL-4受体介导的IgE合成的化合物的方法
公开(公告)号：US07374894B2
公开(公告)日：2008-05-20
申请号：US10197945
申请日：2002-07-16
申请人： Esteban Masuda , Todd M. Kinsella , Justin E. Warner , Taisei Kinoshita , Mark K. Bennett , David C. Anderson
发明人： Esteban Masuda , Todd M. Kinsella , Justin E. Warner , Taisei Kinoshita , Mark K. Bennett , David C. Anderson
IPC分类号： G01N33/53 , G01N33/00 , G01N33/566 , A61K45/00 , A61K38/00 , C07K17/00
CPC分类号： C07K7/08 , C07K14/47 , G01N33/6872 , G01N2333/5406
摘要： The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL 4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a chloride intracellular channel 1 (CLIC1) as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vivo and ex vivo contexts.
摘要翻译：本发明提供能够调节IL-4受体介导的IgE产生的化合物以及与其相关的IL 4诱导的过程，用于鉴定利用氯化物细胞内通道1（CLIC1）作为替代分析物的化合物的方法和试剂盒，使用各种体外，体内和体外上下文中的化合物。

12. 发明授权

US06342374B1 Human collagenase inhibitor, recombinant vector system for using same and recombinant-DNA method for the manufacture of same 失效
标题翻译：人胶原酶抑制剂，重组载体系统及其重组DNA方法的制备
公开(公告)号：US06342374B1
公开(公告)日：2002-01-29
申请号：US09452817
申请日：1999-12-01
申请人： David F. Carmichael , David C. Anderson , George P. Stricklin , Howard G. Welgus
发明人： David F. Carmichael , David C. Anderson , George P. Stricklin , Howard G. Welgus
IPC分类号： C12N1509
CPC分类号： C07K14/8146 , A61K38/00 , C07K14/24 , C07K14/245 , C07K2319/02 , C12N15/70
摘要： A portable DNA sequence is disclosed which is capable of directing intracellular production of metalloproteinanse inhibitors. Vectors containing this portable DNA sequence are also set forth, including the vector pUC9-F5/237P10 (ATCC Accession No. 53003). A recombinant-DNA method for the microbial production of a metalloproteinase inhibitor, which method incorporates at least one of the portable DNA sequences and the vectors disclosed herein.
摘要翻译：公开了能够引导细胞内产生金属蛋白酶抑制剂的便携式DNA序列。还载有含有该携带DNA序列的载体，包括载体pUC9-F5 / 237P10（ATCC登录号53003）。用于微生物产生金属蛋白酶抑制剂的重组DNA方法，该方法包含本文公开的至少一种便携式DNA序列和载体。

13. 发明授权

US5759517A Hemoglobins as drug delivery agents 失效
标题翻译：血红蛋白作为药物递送剂
公开(公告)号：US5759517A
公开(公告)日：1998-06-02
申请号：US457753
申请日：1995-06-01
申请人： David C. Anderson , Antony James Mathews
发明人： David C. Anderson , Antony James Mathews
IPC分类号： A61K38/00 , A61K47/42 , A61K47/48 , C07K1/10 , C07K14/805 , C12N15/81 , A61K51/00 , A61M36/14
CPC分类号： C12N15/81 , A61K47/48307 , A61K38/00 , C07K2319/00
摘要： A tracer, such as a radioisotope, is conjugated to a hemoglobin-like protein, such as normal hemoglobin, for use as an in vitro diagnostic imaging agent.
摘要翻译：诸如放射性同位素的示踪剂与血红蛋白样蛋白（例如正常血红蛋白）缀合，用作体外诊断显像剂。

14. 发明授权

US07604951B2 Method for identifying compounds that modulate RXR associated processes with IgE production 有权
标题翻译：用于鉴定用IgE生产调节RXR相关过程的化合物的方法
公开(公告)号：US07604951B2
公开(公告)日：2009-10-20
申请号：US11608782
申请日：2006-12-08
申请人： Todd M. Kinsella , Esteban Masuda , Mark K. Bennett , Justin E. Warner , David C. Anderson
发明人： Todd M. Kinsella , Esteban Masuda , Mark K. Bennett , Justin E. Warner , David C. Anderson
IPC分类号： G01N33/53
CPC分类号： G01N33/6869 , G01N33/566 , G01N33/6875 , G01N2333/70567
摘要： The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a retinoid X receptor as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.
摘要翻译：本发明提供能够调节IL-4受体介导的IgE产生的化合物以及与其相关的IL-4诱导的过程，用于鉴定利用类视黄醇X受体作为替代分析物的化合物的方法和试剂盒以及使用该化合物的方法在各种体外，体外和体外上下文中。

15. 发明授权

US07141434B2 Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing an adenosine kinase 有权
标题翻译：鉴定使用腺苷激酶调节IL-4受体介导的IgE合成的化合物的方法
公开(公告)号：US07141434B2
公开(公告)日：2006-11-28
申请号：US10197381
申请日：2002-07-16
申请人： Esteban Masuda , Todd M. Kinsella , Justin E. Warner , Taisei Kinoshita , Mark K. Bennett , David C. Anderson
发明人： Esteban Masuda , Todd M. Kinsella , Justin E. Warner , Taisei Kinoshita , Mark K. Bennett , David C. Anderson
IPC分类号： G01N33/566 , G01N33/567 , A61K45/00 , A61K38/00
CPC分类号： C12N9/1205 , A61K31/00 , A61K31/7076
摘要： The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize an adenosine kinase as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.
摘要翻译：本发明提供能够调节IL-4受体介导的IgE产生的化合物以及与其相关的IL-4诱导的过程，用于鉴定利用腺苷激酶作为替代分析物的化合物的方法和试剂盒以及使用该化合物的方法各种体外，体外和体外上下文。

16. 发明授权

US06397882B1 Pressure vacuum breaker cover assembly 失效
标题翻译：压力真空断路器盖组件
公开(公告)号：US06397882B1
公开(公告)日：2002-06-04
申请号：US09795035
申请日：2001-02-26
申请人： David C. Anderson
发明人： David C. Anderson
IPC分类号： E03C110
CPC分类号： E03C1/102 , Y10T137/7036 , Y10T137/7062
摘要： A pressure vacuum breaker cover assembly for protecting a vacuum breaker while simultaneously improving the appearance. The inventive device includes a pair of covers having a shell structure attachable to one another about a vacuum breaker. Each of the covers includes a lip that mates with the opposing cover lip, a plurality of apertures that allow the securing of the covers together with a conventional fastener, a lower cutout for receiving a lower pipe, and a side cutout for receiving an upper pipe from the vacuum breaker. The covers are preferably constructed of a STYROFOAM or polyfoam material for insulating and protecting the vacuum breaker and pipes. The exterior surface of the covers may be painted to match the exterior of the building structure.
摘要翻译：一种用于保护真空断路器同时改善外观的压力真空断路器盖组件。本发明的装置包括一对罩，其具有围绕真空破坏器彼此相连的外壳结构。每个盖包括与相对的盖唇缘配合的唇缘，允许通过常规紧固件固定盖的多个孔，用于接纳下管的下切口和用于接收上管的侧切口从真空断路器。盖子优选由用于绝缘和保护真空断路器和管道的STYROFOAM或聚苯乙烯材料构成。盖的外表面可以被涂漆以与建筑结构的外部相匹配。

17. 发明授权

US6041155A Universal dust cover 失效
标题翻译：通用防尘罩
公开(公告)号：US6041155A
公开(公告)日：2000-03-21
申请号：US988520
申请日：1997-12-10
申请人： David C. Anderson , Daniel Lee Stephenson
发明人： David C. Anderson , Daniel Lee Stephenson
IPC分类号： G02B6/38 , H01R13/52 , G02B6/00
CPC分类号： G02B6/3825 , G02B6/3849 , H01R13/5213
摘要： A connector adapter and dust cover therefor are pivotably connected by means of a pivot pin on the adapter and pivot arms on the dust cover whose distal ends engage the pivot pin. The pivot pin has a cam member located intermediate its ends, and the dust cover has a spring arm between the pivot arms whose distal end engages the cam member. In the closed position, the distal end of the spring arm engages the cam below its high point. In the fully open position, the distal end of the spring arm engages the cam beyond its high point. In both positions, the spring arm bears against the cam to resist dislodgment of the dust cover from either position.
摘要翻译：连接器适配器和防尘盖通过枢轴销在适配器上枢转地连接，并且枢转臂在防尘罩上，其远端接合枢轴销。枢轴销具有位于其端部中间的凸轮构件，并且防尘罩在其远端与凸轮构件接合的枢转臂之间具有弹簧臂。在关闭位置，弹簧臂的远端将凸轮与其高点相接合。在完全打开位置，弹簧臂的远端将凸轮与其高点接合。在两个位置上，弹簧臂抵靠凸轮，以抵抗防尘罩从任一位置的移动。

18. 发明授权

US5844088A Hemoglobin-like protein comprising genetically fused globin-like polypeptides 失效
公开(公告)号：US5844088A
公开(公告)日：1998-12-01
申请号：US444991
申请日：1995-05-19
申请人： Stephen J. Hoffman , Douglas L. Looker , Mary S. Rosendahl , Gary L. Stetler , Michael Wagenbach , David C. Anderson , Antony James Mathews , Kiyoshi Nagai
发明人： Stephen J. Hoffman , Douglas L. Looker , Mary S. Rosendahl , Gary L. Stetler , Michael Wagenbach , David C. Anderson , Antony James Mathews , Kiyoshi Nagai
IPC分类号： A61K38/16 , A61K38/00 , A61K47/48 , A61P7/08 , C07K20060101 , C07K1/113 , C07K14/805 , C12N15/00 , C12N15/09 , C12N15/12 , C12N15/81 , C12P21/02 , C12R1/19 , C12R1/91
CPC分类号： C07K14/805 , A61K47/48307 , C12N15/81 , A61K38/00 , C07K2319/00 , C07K2319/50 , C07K2319/92
摘要： The alpha subunits of hemoglobin, which in nature are formed as separate polypeptide chains which bind noncovalently to the beta subunits, are here provided in the form of the novel molecule di-alpha globin, a single polypeptide chain defined by connecting the two alpha subunits either directly via peptide bond or indirectly by a flexible amino acid or peptide linker. Di-alpha globin may be combined in vivo or in vitro with beta globin and heme to form hemoglobin. Di-alpha globin is expressed by recombinant DNA techniques. Di-beta globin may be similarly obtained. We further describe the production of tetrameric human hemoglobin and di-alpha/beta.sub.2 hemoglobin in the yeast Saccharomyces cerevisiae. The synthesis of the protein is directed by a synthetic promotor consisting of two functional parts, an upstream activator sequence (UAS) that confers inducible transcription by galactose from a consensus yeast transcriptional initiation site. The expression construct is designed such that translation is expected to initiate at the same position as the human wild-type genes for .alpha.- and .beta.-globin. Three different types of expression vectors have been used: (1) .alpha.-globin and .beta.-globin contained on two separate plasmids (pGS4688 and pGS4988) in a diploid yeast strain; (2) .alpha.-globin and .beta.-globin each contained on a single plasmid (pGS289 and pGS389) and expressed in either haploid or diploid strains; and (3) di-alpha-globin and beta globin contained on a single plasmid (pGS 3089)and expressed in haploid strains. Finally, we describe the co-expression of alpha and beta globin chains. The chains are folded together and combined intracellularly with heme to form active tetrameric hemoglobin. The hemoglobin may be recovered from the cells' soluble fraction. The invention thus obviates the need to express alpha and beta globin separately, solubilize, renature and purify them, and combine them in vitro with heme to obtain an artificial hemoglobin. By way of comparison, the separately expressed beta globin known in the art is deposited in inclusion bodies. Polycistronic co-expression of alpha and beta globins is particularly preferred.

19. 发明授权

US5252713A Polymeric carriers for non-covalent drug conjugation 失效
标题翻译：用于非共价药物共轭的聚合载体
公开(公告)号：US5252713A
公开(公告)日：1993-10-12
申请号：US248456
申请日：1988-09-23
申请人： Alton C. Morgan, Jr. , David C. Anderson
发明人： Alton C. Morgan, Jr. , David C. Anderson
IPC分类号： A61K38/00 , A61K47/48 , C07K14/36 , C07K14/465 , C07K14/47 , C07K14/72 , C07K14/76 , A61K37/02 , A61K39/44 , C07K3/08
CPC分类号： B82Y5/00 , A61K47/48238 , A61K47/48692 , A61K47/48746 , A61K47/48753 , C07K14/36 , C07K14/465 , C07K14/47 , C07K14/473 , C07K14/721 , C07K14/723 , C07K14/76 , A61K38/00
摘要： Polymeric carriers are polypeptides comprising at least one drug-binding domain that non-covalently binds a drug. A polymeric carrier may be attached to an antibody specific for desired target cells to form immunoconjugates that deliver a drug to the target cells in vivo. The carriers are derived from drug-binding proteins and produced through peptide synthesis or recombinant DNA technology.
摘要翻译：聚合载体是包含非共价结合药物的至少一个药物结合结构域的多肽。聚合物载体可以连接到对所需靶细胞特异性的抗体，以形成在体内将药物递送至靶细胞的免疫缀合物。载体衍生自药物结合蛋白并通过肽合成或重组DNA技术产生。

20. 发明授权

US5135736A Covalently-linked complexes and methods for enhanced cytotoxicity and imaging 失效
标题翻译：共连接的复合物和增强的细胞毒性和成像的方法
公开(公告)号：US5135736A
公开(公告)日：1992-08-04
申请号：US232337
申请日：1988-08-15
申请人： David C. Anderson , A. C. Morgan, Jr. , Paul G. Abrams
发明人： David C. Anderson , A. C. Morgan, Jr. , Paul G. Abrams
IPC分类号： G01N33/53 , A61K39/395 , A61K41/00 , A61K45/00 , A61K47/48 , A61K49/00 , A61K51/10 , C07K14/415 , C12N15/62 , G01N33/532
CPC分类号： C07K14/415 , A61K47/48238 , A61K51/1093 , A61K51/1096 , C12N15/62 , A61K2123/00 , C07K2319/00 , C07K2319/10 , C07K2319/55
摘要： Covalently-linked complexes (CLCs) for targeting a defined population of cells, comprising a targeting protein or peptide; a cytotoxic agent; and an enhancing moiety, wherein the enhancing moiety is capable of promoting CLC-membrane interaction are disclosed. Methods for using the claimed CLCs to obtain enhanced in vivo cytotoxicity and enhanced in vivo imaging are also described.

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