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11. 发明申请

US20060133952A1 Biosensor utilizing a resonator having a functionalized surface 有权
公开(公告)号：US20060133952A1
公开(公告)日：2006-06-22
申请号：US11317405
申请日：2005-12-22
申请人： Yuegang Zhang , Andrew Berlin , Qing Ma , Li-Peng Wang , Valluri Rao , Mineo Yamakawa
发明人： Yuegang Zhang , Andrew Berlin , Qing Ma , Li-Peng Wang , Valluri Rao , Mineo Yamakawa
IPC分类号： G01N33/48
CPC分类号： G01N33/54373 , B82Y15/00 , B82Y30/00 , G01N27/126 , G01N29/022 , G01N29/036 , G01N29/2437 , G01N29/348 , G01N33/0031 , G01N2291/02466 , G01N2291/0255 , G01N2291/0256 , G01N2291/0426 , Y10T436/11 , Y10T436/143333 , Y10T436/144444 , Y10T436/25375
摘要： Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator's frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator's frequency response.

12. 发明申请

US20050138996A1 Use of arrays of atomic force microscope/scanning tunneling microscope tips to scan nanocodes 有权
标题翻译：使用原子力显微镜阵列/扫描隧道显微镜尖端扫描纳代码
公开(公告)号：US20050138996A1
公开(公告)日：2005-06-30
申请号：US10748526
申请日：2003-12-29
申请人： Andrew Berlin , Narayanan Sundararajan , Mineo Yamakawa , Valluri Rao
发明人： Andrew Berlin , Narayanan Sundararajan , Mineo Yamakawa , Valluri Rao
IPC分类号： G01Q60/04 , G01Q70/12 , G01Q70/16 , G01Q70/18 , G01N13/10 , B82B1/00 , G01N13/12 , G01N13/16
CPC分类号： G01Q60/04 , G01Q70/06 , G01Q70/12 , G01Q70/18
摘要： A surface analysis device is disclosed for identifying molecules by simultaneously scanning nanocodes on a surface of a substrate. The device includes a scanning array that is capable of simultaneously scanning the nanocodes on the surface of the substrate and an analyzer that is coupled with the scanning array. The analyzer is capable of receiving simultaneously scanned information from the scanning array and identifying molecules associated with the nanocodes.
摘要翻译：公开了通过同时扫描基底表面上的纳代码来识别分子的表面分析装置。该器件包括能够同时扫描衬底表面上的纳代码的扫描阵列和与扫描阵列耦合的分析器。分析仪能够同时接收来自扫描阵列的扫描信息并识别与纳代码相关的分子。

13. 发明授权

US08173436B2 Biosensor utilizing a resonator having a functionalized surface 有权
标题翻译：使用具有官能化表面的谐振器的生物传感器
公开(公告)号：US08173436B2
公开(公告)日：2012-05-08
申请号：US12967964
申请日：2010-12-14
申请人： Yuegang Zhang , Andrew Berlin , Qing Ma , Li-Peng Wang , Valluri Rao , Mineo Yamakawa
发明人： Yuegang Zhang , Andrew Berlin , Qing Ma , Li-Peng Wang , Valluri Rao , Mineo Yamakawa
IPC分类号： G01N33/50
CPC分类号： G01N33/54373 , B82Y15/00 , B82Y30/00 , G01N27/126 , G01N29/022 , G01N29/036 , G01N29/2437 , G01N29/348 , G01N33/0031 , G01N2291/02466 , G01N2291/0255 , G01N2291/0256 , G01N2291/0426 , Y10T436/11 , Y10T436/143333 , Y10T436/144444 , Y10T436/25375
摘要： Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator's frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator's frequency response.
摘要翻译：使用包含具有功能化表面以与靶生物分子反应的共振器的生物传感器来检测样品中存在生物分子的系统和方法。在一个实施例中，器件包括压电谐振器，其具有被配置为与靶分子反应的官能化表面，从而改变谐振器的质量和/或电荷，从而改变谐振器的频率响应。将曝光后的谐振器频率响应与参考值进行比较，例如在暴露于采样之前的频率响应，存储的基准频率响应或控制谐振器的频率响应。

14. 发明申请

US20070224629A1 LASER EXPOSURE OF PHOTOSENSITIVE MASKS FOR DNA MICROARRAY FABRICATION 审中-公开
标题翻译：激光曝光用于DNA微量制备的光敏掩模
公开(公告)号：US20070224629A1
公开(公告)日：2007-09-27
申请号：US11757225
申请日：2007-06-01
申请人： Valluri Rao , Mineo Yamakawa , Andrew Berlin
发明人： Valluri Rao , Mineo Yamakawa , Andrew Berlin
IPC分类号： C12Q1/68 , C23C26/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00441 , B01J2219/00527 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00689 , B01J2219/00711 , B01J2219/00722
摘要： A method and apparatus for forming a polymer array on a substrate suitable for synthesizing polymer sequences. This includes forming an array, each location of the array having at least one strand end, forming photosensitive protection on the strand ends, and selectively scanning and modulating at least one energy beam to expose a pattern on the photosensitive protection. In some embodiments, the method further includes removing a protective group from selected strand ends based on the exposed pattern. The method then includes adding a predetermined one or more polymeric subunits to the deprotected strand ends. In some embodiments the photosensitive protection includes a layer of photoresist to cover the strand ends. Some embodiments use an ultra-violet laser.
摘要翻译：一种在适于合成聚合物序列的基材上形成聚合物阵列的方法和装置。这包括形成阵列，阵列的每个位置具有至少一个绞合端，在绞合端上形成感光保护，并且选择性地扫描和调制至少一个能量束以暴露感光保护上的图案。在一些实施方案中，该方法还包括基于暴露图案从选定的链末端去除保护基团。该方法然后包括将预定的一个或多个聚合物亚单位加入去保护的末端。在一些实施例中，感光保护包括一层光致抗蚀剂以覆盖绞合端。一些实施例使用紫外激光。

15. 发明申请

US20060133953A1 Biosensor utilizing a resonator having a functionalized surface 有权
公开(公告)号：US20060133953A1
公开(公告)日：2006-06-22
申请号：US11317518
申请日：2005-12-22
申请人： Yuegang Zhang , Andrew Berlin , Qing Ma , Li-Peng Wang , Valluri Rao , Mineo Yamakawa
发明人： Yuegang Zhang , Andrew Berlin , Qing Ma , Li-Peng Wang , Valluri Rao , Mineo Yamakawa
IPC分类号： G01N33/48
CPC分类号： G01N33/54373 , B82Y15/00 , B82Y30/00 , G01N27/126 , G01N29/022 , G01N29/036 , G01N29/2437 , G01N29/348 , G01N33/0031 , G01N2291/02466 , G01N2291/0255 , G01N2291/0256 , G01N2291/0426 , Y10T436/11 , Y10T436/143333 , Y10T436/144444 , Y10T436/25375
摘要： Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator's frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator's frequency response.

16. 发明申请

US20070054288A1 Programmable molecular barcodes 审中-公开
标题翻译：可编程分子条形码
公开(公告)号：US20070054288A1
公开(公告)日：2007-03-08
申请号：US11430612
申请日：2006-05-08
申请人： Xing Su , Tae-Woong Koo , Andrew Berlin , Lei Sun , Narayanan Sundararajan , Mineo Yamakawa
发明人： Xing Su , Tae-Woong Koo , Andrew Berlin , Lei Sun , Narayanan Sundararajan , Mineo Yamakawa
IPC分类号： C12Q1/68 , C12M1/34 , G06K7/10
CPC分类号： B82Y10/00 , B82Y5/00 , C12Q1/6816 , G06K19/06028 , C12Q2525/161 , C12Q2537/143 , C12Q2565/1025
摘要： The present disclosure concerns methods for producing and/or using molecular barcodes. In certain embodiments of the invention, the barcodes comprise polymer backbones that may contain one or more branch structures. Tags may be attached to the backbone and/or branch structures. The barcode may also comprise a probe that can bind to a target, such as proteins, nucleic acids and other biomolecules or aggregates. Different barcodes may be distinguished by the type and location of the tags. In other embodiments, barcodes may be produced by hybridization of one or more tagged oligonucleotides to a template, comprising a container section and a probe section. The tagged oligonucleotides may be designed as modular code sections, to form different barcodes specific for different targets. In alternative embodiments, barcodes may be prepared by polymerization of monomeric units. Bound barcodes may be detected by various imaging modalities, such as, surface plasmon resonance, fluorescent or Raman spectroscopy.
摘要翻译：本公开涉及用于生产和/或使用分子条形码的方法。在本发明的某些实施方案中，条形码包含可包含一个或多个分支结构的聚合物主链。标签可以附加到骨干和/或分支结构。条形码还可以包含可以与靶标结合的探针，例如蛋白质，核酸和其他生物分子或聚集体。可以通过标签的类型和位置区分不同的条形码。在其它实施方案中，条形码可以通过将一个或多个标记的寡核苷酸与包含容器部分和探针部分的模板杂交来产生。标记的寡核苷酸可以被设计为模块代码部分，以形成针对不同靶标的不同条形码。在替代实施例中，条形码可以通过单体单元的聚合来制备。可以通过各种成像方式，例如表面等离子体共振，荧光或拉曼光谱来检测结合条形码。

17. 发明申请

US20060009914A1 Detection and identification of nucleic acid, peptide, and protein modifications 审中-公开
标题翻译：检测和鉴定核酸，肽和蛋白质修饰
公开(公告)号：US20060009914A1
公开(公告)日：2006-01-12
申请号：US10919699
申请日：2004-08-16
申请人： Narayan Sundararajan , Lei Sun , Xing Su , Mineo Yamakawa , Zhang Jingwu , Selena Chan , Andrew Berlin , Tae-Woong Koo , Mark Roth , Phil Gafken
发明人： Narayan Sundararajan , Lei Sun , Xing Su , Mineo Yamakawa , Zhang Jingwu , Selena Chan , Andrew Berlin , Tae-Woong Koo , Mark Roth , Phil Gafken
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： G01N33/6842 , G01N33/6803 , G01N33/6818 , Y02A90/26
摘要： Embodiments of the present invention provide devices and methods for detecting, identifying, distinguishing, and quantifying modifications to nucleic acids, proteins, and peptides using SERS and Raman spectroscopy. Applications of embodiments of the present invention include proteome wide modification profiling and analyses with applications in disease diagnosis, prognosis and drug efficacy studies, enzymatic activity profiling and assays.
摘要翻译：本发明的实施方案提供用于使用SERS和拉曼光谱检测，鉴定，区分和定量对核酸，蛋白质和肽的修饰的装置和方法。本发明实施方案的应用包括在疾病诊断，预后和药物功效研究，酶活性分析和测定中的应用的蛋白质组广泛修饰分析和分析。

18. 发明申请

US20050244820A1 Detecting molecular binding by monitoring feedback controlled cantilever deflections 有权
标题翻译：通过监测反馈控制的悬臂偏转来检测分子结合
公开(公告)号：US20050244820A1
公开(公告)日：2005-11-03
申请号：US11111308
申请日：2005-04-20
申请人： Xing Su , Selena Chan , Tae-Woong Koo , Mineo Yamakawa , Andrew Berlin
发明人： Xing Su , Selena Chan , Tae-Woong Koo , Mineo Yamakawa , Andrew Berlin
IPC分类号： C12Q1/68 , G01N33/543 , C12Q1/70 , C12Q1/04
CPC分类号： C12Q1/6825 , B82Y5/00 , G01N33/54373 , G01N2800/52 , Y10S977/924 , C12Q2565/501
摘要： The present methods and apparatus concern the detection and/or identification of target analytes using probe molecules. In various embodiments of the invention, the probes or analytes are attached to one or more cantilevers. Binding of a probe to an analyte results in deflection of the cantilever, detected by a detection unit. A counterbalancing force may be applied to restore the cantilever to its original position. The counterbalancing force may be magnetic, electrical or radiative. The detection unit and the mechanism generating the counterbalancing force may be operably coupled to an information processing and control unit, such as a computer. The computer may regulate a feedback loop that maintains the cantilever in a fixed position by balancing the deflecting force and the counterbalancing force. The concentration of analytes in a sample may be determined from the magnitude of the counterbalancing force required to maintain the cantilever in a fixed position.
摘要翻译：本方法和装置涉及使用探针分子检测和/或鉴定目标分析物。在本发明的各种实施方案中，探针或分析物附着到一个或多个悬臂。将探针与分析物结合导致由检测单元检测到的悬臂的偏转。可以应用平衡力将悬臂恢复到其原始位置。平衡力可以是磁性的，电的或辐射的。生成平衡力的检测单元和机构可以可操作地耦合到诸如计算机的信息处理和控制单元。计算机可以通过平衡偏转力和平衡力来调节将悬臂维持在固定位置的反馈回路。样品中分析物的浓度可以从将悬臂维持在固定位置所需的平衡力的大小来确定。

19. 发明申请

US20050151126A1 Methods of producing carbon nanotubes using peptide or nucleic acid micropatterning 审中-公开
标题翻译：使用肽或核酸微图案生产碳纳米管的方法
公开(公告)号：US20050151126A1
公开(公告)日：2005-07-14
申请号：US10750141
申请日：2003-12-31
申请人： Mineo Yamakawa , Yeugang Zhang , Xing Su , Lei Sun , Andrew Berlin , Narayanan Sundararajan
发明人： Mineo Yamakawa , Yeugang Zhang , Xing Su , Lei Sun , Andrew Berlin , Narayanan Sundararajan
IPC分类号： C01B31/02 , D01F9/127 , H01L51/00 , H01L51/30 , D01F9/12 , H01L29/06
CPC分类号： B82Y40/00 , B82Y10/00 , B82Y30/00 , C01B32/162 , C01B2202/08 , C01B2202/36 , D01F9/127 , H01L51/0048 , H01L51/0052
摘要： The methods, apparatus and systems disclosed herein concern ordered arrays of carbon nanotubes. In particular embodiments of the invention, the nanotube arrays are formed by a method comprising attaching catalyst nanoparticles 140, 230 to polymer 120, 210 molecules, attaching the polymer 120, 210 molecules to a substrate, removing the polymer 120, 210 molecules and producing carbon nanotubes on the catalyst nanoparticles 140, 230. The polymer 120, 210 molecules can be attached to the substrate in ordered patterns, using self-assembly or molecular alignment techniques. The nanotube arrays can be attached to selected areas 110, 310 of the substrate. Within the selected areas 110, 310, the nanotubes are distributed non-randomly. Other embodiments disclosed herein concern apparatus that include ordered arrays of nanotubes attached to a substrate and systems that include ordered arrays of carbon nanotubes attached to a substrate, produced by the claimed methods. In certain embodiments, provided herein are methods for aligning a molecular wire, by ligating the molecular wire to a double stranded DNA molecule.
摘要翻译：本文公开的方法，装置和系统涉及碳纳米管的有序阵列。在本发明的具体实施方案中，纳米管阵列通过包括将催化剂纳米颗粒140,230连接到聚合物120,210分子，将聚合物120,210分子连接到基底上的方法形成，除去聚合物120,210分子并产生碳催化剂纳米颗粒140,230上的纳米管。聚合物120,210分子可以使用自组装或分子对准技术以有序图案附着到基底上。纳米管阵列可以附着到基板的选定区域110,310。在所选择的区域110,310内，纳米管是非随机分布的。本文公开的其它实施方案涉及包括连接到衬底的纳米管的有序阵列和包括通过所要求保护的方法产生的连接到衬底的碳纳米管的有序阵列的系统的装置。在某些实施方案中，本文提供了通过将分子线连接到双链DNA分子来对齐分子线的方法。

20. 发明申请

US20050147981A1 Methods and compositions for detecting nucleic acids using scanning probe microscopy and nanocodes 有权
标题翻译：使用扫描探针显微镜和纳代码检测核酸的方法和组合物
公开(公告)号：US20050147981A1
公开(公告)日：2005-07-07
申请号：US10750515
申请日：2003-12-31
申请人： Mineo Yamakawa , Andrew Berlin
发明人： Mineo Yamakawa , Andrew Berlin
IPC分类号： C12Q1/68 , G01Q60/10 , G01Q60/50 , C12M1/34
CPC分类号： C12Q1/6874 , B82Y5/00 , B82Y10/00 , C12Q2565/601 , C12Q2563/155 , C12Q2525/179
摘要： A method for determining a nucleotide sequence of a nucleic acid is provided that includes contacting the nucleic acid with a series of labeled oligonucleotides for binding to the nucleic acid, wherein each labeled oligonucleotide includes a known nucleotide sequence and a molecular nanocode. The nanocode of an isolated labeled oligonucleotides that binds to the nucleic acid is then detected using SPM. Nanocodes of the present invention in certain aspects include detectable features beyond the arrangement of tags that encode information about the barcoded object, which assist in detecting the tags that encode information about the barcoded object. The detectable features include structures of a nanocode or associated with a nanocode, referred to herein as detectable feature tags, for error checking/error-correction, encryption, and data reduction/compression.
摘要翻译：提供了用于确定核酸的核苷酸序列的方法，其包括使核酸与一系列用于结合核酸的标记的寡核苷酸接触，其中每个标记的寡核苷酸包括已知的核苷酸序列和分子纳代码。然后使用SPM检测与核酸结合的分离的标记寡核苷酸的纳代码。在某些方面，本发明的纳代码包括超过编码关于条形码对象的信息的标签布置的可检测特征，其有助于检测编码关于条形码对象的信息的标签。可检测特征包括用于错误校验/纠错，加密和数据缩减/压缩的纳代码或与纳代码相关联的结构，这里称为可检测特征标签。

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