专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US06337342B1 Bis-aryl or heteroaryl indoles 失效
标题翻译：双芳基或杂芳基吲哚
公开(公告)号：US06337342B1
公开(公告)日：2002-01-08
申请号：US09230710
申请日：1999-01-29
申请人： Kostas Karabelas , Matti Lepisto , Peter Sjö
发明人： Kostas Karabelas , Matti Lepisto , Peter Sjö
IPC分类号： A61K314152
CPC分类号： C07D403/04 , C07D403/14 , C07D409/14 , C07D471/04
摘要： The present invention relates to compounds of formula (I): wherein: Ar is an optionally substituted aromatic or heteroaromatic group, R1 is H, C1-6alkyl, CF3, phenyl, benzyl, carboC1-6alkoxy, carbamoyl, or methyl(N—C1-6alkylcarbamoyl) R2 is H, C1-6alkyl, aminoC1-6alkyl, hydroxyC1-6alkyl, (mono- or di- C1-6alkyl)aminoC1-6alkyl, (aminoC1-3alkylphenyl)C1-3alkyl, amidinothio C1-6alkyl, R3 is H or C1-6alkoxy, R4 is H or together with R2, forms an annulated ring which may be substituted by hydroxyC1-3alkyl or amidinothio C1-3alkyl, or aminoC1-3alkyl; and pharmaceutically acceptable salts thereof; and the use of such compounds in medical therapies.
摘要翻译：本发明涉及式（I）的化合物：其中：Ar是任选取代的芳族或杂芳族基团，R 1是H，C 1-6烷基，CF 3，苯基，苄基，C 1 -C 6烷氧基，氨基甲酰基或甲基（N-C 1 （烷基氨基甲酰基）R 2是H，C 1-6烷基，氨基C 1-6烷基，羟基C 1-6烷基，（单 - 或二 - C 1-6烷基）氨基C 1-6烷基，（氨基C 1-3烷基苯基）C 1-3烷基，脒基硫代C 1-6烷基，R 3是H 或C 1-6烷氧基，R 4是H或与R 2一起形成可以被羟基C 1-3烷基或脒基C 1-3烷基或氨基C 1-3烷基取代的环状环;及其药学上可接受的盐;以及这些化合物在医学上的用途疗法。

12. 发明申请

US20060035938A1 2-Pyridone derivatives as inhibitors of neutrophile elastase 审中-公开
标题翻译： 2-吡啶酮衍生物作为嗜中性粒细胞弹性蛋白酶抑制剂
公开(公告)号：US20060035938A1
公开(公告)日：2006-02-16
申请号：US10534720
申请日：2003-11-11
申请人： Hakan Bladh , Tomas Klingstedt , Joakim Larsson , Karolina Lawitz , Matti Lepisto , Hans Lonn , Grigorios Nikitidis
发明人： Hakan Bladh , Tomas Klingstedt , Joakim Larsson , Karolina Lawitz , Matti Lepisto , Hans Lonn , Grigorios Nikitidis
IPC分类号： C07D211/72 , A61K31/4412
CPC分类号： C07D213/64 , C07D213/82 , C07D239/557 , C07D241/24 , C07D413/12
摘要： There are provided novel compounds of formula (I) wherein R1?, R4?. R5?, G1?, G2?, X, L, Y1?, Y2? and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors or neutrophil elastase.
摘要翻译：提供新的式（I）化合物，其中R 1？R 4？文件=“US20060035938A1-20060216-P00900.TIF”alt =“custom character”img-content =“character”img-id =“custom-character-00003”he =“2.46mm” 格式=“tif”/> 5 ?, G 1？G 2 ?, X，L，Y 1 ?, Y 2？和n如本说明书和光学异构体，外消旋体和互变异构体及其药学上可接受的盐所定义; 以及其制备方法，含有它们的组合物及其在治疗中的用途。化合物是抑制剂或嗜中性粒细胞弹性蛋白酶。

13. 发明授权

US4932140A Arrangement of pressure nozzles for the treatment of webs 失效
标题翻译：用于处理腹板的压力喷嘴的布置
公开(公告)号：US4932140A
公开(公告)日：1990-06-12
申请号：US358362
申请日：1989-05-03
申请人： Matti Lepisto
发明人： Matti Lepisto
IPC分类号： B65H20/14 , D21F5/18 , F26B13/20
CPC分类号： D21F5/188 , F26B13/104
摘要： An arrangement of pressure nozzles intended for the treatment of webs comprises a nozzle box. The nozzle box has a carrying face (16) placed facing the web, two nozzle slots (17,18) that blow towards each other being provided in connection with the carrying face, these nozzle slots being placed in the outer part of the space defined by the inner walls (14,15) and the outer walls (20,21) of the nozzle box. The arrangement of nozzles is asymmetric relative to the perpendicular center plane (A--A) of its pressurized carrying face (16). The arrangement of nozzles has a first nozzle slot (18), which is placed relative the carrying face (16) in such a way that the gas jet (v.sub.1) blown out of the nozzle slot follows and remains in contact with the curved carrying face (16) up to the area between the nozzle slots (17,18). The arrangement of nozzles includes a second nozzle slot (17), which is placed within the area of the edge of the curved guide face (14,R.sub.2) placed in its connection or, in the gas flow direction (v.sub.2), before the edge. The ratio of the width of the second nozzle slot (18) to the curve radius (R.sub.2) of its guide face (14) is chosen so, with the flow rates (v.sub.2) of the second nozzle generally occurring, that the gas flow is separated from the curved (R.sub.2) guide face of the second nozzle, before the carrying face area proper between the first and the second nozzle slot (17,18), or in the edge portion of this area.
摘要翻译： PCT No.PCT / FI88 / 00155 Sec。 371日期：1989年5月3日 102（e）日期1989年5月3日PCT提交1988年9月23日PCT公布。公开号WO89 / 02953 日本1989年4月6日。用于处理腹板的压力喷嘴的布置包括喷嘴箱。喷嘴箱具有面向腹板放置的承载面（16），与承载面相连接设置的彼此相对的两个喷嘴槽（17,18），这些喷嘴槽被放置在限定的空间的外部通过喷嘴箱的内壁（14,15）和外壁（20,21）。喷嘴的布置相对于其加压承载面（16）的垂直中心平面（A-A）是不对称的。喷嘴的布置具有第一喷嘴狭槽（18），其相对于承载面（16）放置，使得从喷嘴槽吹出的气体射流（v1）与弯曲的承载面保持接触（16）直到喷嘴槽（17,18）之间的区域。喷嘴的布置包括第二喷嘴槽（17），该第二喷嘴槽（17）被放置在弯曲导向面（14，R2）的边缘的区域内，或者沿气体流动方向（v2），在边缘。选择第二喷嘴狭槽（18）的宽度与其导向面（14）的曲线半径（R2）的比率，使得第二喷嘴的流速（v2）通常发生，气流为在第一和第二喷嘴槽（17,18）之间的承载面积区域中，或者在该区域的边缘部分中，与第二喷嘴的弯曲（R2）引导面分离。

14. 发明授权

US06548265B2 Treatment or prophylaxis of diseases caused by pilus-forming bacteria 失效
公开(公告)号：US06548265B2
公开(公告)日：2003-04-15
申请号：US09799576
申请日：2001-03-07
申请人： Scott Hultgren , Meta Kuehn , Zheng Xu , Derek Ogg , Mark Harris , Matti Lepisto , Charles Hal Jones , Jan Kihlberg
发明人： Scott Hultgren , Meta Kuehn , Zheng Xu , Derek Ogg , Mark Harris , Matti Lepisto , Charles Hal Jones , Jan Kihlberg
IPC分类号： G01N33569
CPC分类号： A61K31/7004 , A61K31/00 , A61K31/70 , C07H1/00 , G01N33/68 , G01N2333/195 , G01N2500/10 , G01N2500/20 , Y02A50/481 , Y10S435/849
摘要： Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.

15. 发明授权

US5570519A Method and device in contact-free treatment of a web 失效
标题翻译：网络无接触处理的方法和装置
公开(公告)号：US5570519A
公开(公告)日：1996-11-05
申请号：US386376
申请日：1995-02-10
申请人： Richard Solin , Matti Lepisto , Eelis Matilainen , Bertel Karlstedt
发明人： Richard Solin , Matti Lepisto , Eelis Matilainen , Bertel Karlstedt
IPC分类号： B65H23/022 , B65H20/14 , B65H23/24 , B65H23/32 , B65H23/34 , D21F5/18 , F26B13/20
CPC分类号： B65H20/14 , B65H23/24 , B65H23/34 , D21F5/187 , F26B13/104 , B65H2406/112
摘要： A method and device for contact-free treatment of a web in which the web is treated, for example supported, reversed, spread, carried, and/or dried, by blowings which provide a carrier-face zone. The carrier-face zone has a curved form regulatable in a direction transverse to the direction of progress of the web. The nozzle-carrier face unit of the device is bent to the curved form in the cross direction of the machine while a frame part of the device is kept in a stationary position. The device includes a regulation arrangement for bending the nozzle-carrier-face unit to a curve form in the direction transverse to the running direction of the web while the frame part of the device is supported in a stationary position.
摘要翻译：通过提供载体面区的吹塑，可以对其中纤维网进行处理，例如支撑，反向，铺展，承载和/或干燥的幅材的无接触处理方法和装置。载体面区域具有在横向于幅材进行方向的方向上可调节的弯曲形式。装置的喷嘴承载面单元在机器的横向方向上弯曲成弯曲形状，同时装置的框架部分保持在静止位置。该装置包括调节装置，该装置用于在装置的框架部分被支撑在静止位置的同时沿着横向于幅材的运行方向的方向将喷嘴 - 载体面单元弯曲成曲线形式。

16. 发明申请

US20090124607A1 Novel Bicyclic Sulfonamides for Use as Glucocorticoid Receptor Modulators in the Treatment of Inflammatory Diseases 审中-公开
标题翻译：用作糖皮质激素受体调节剂治疗炎症性疾病的新型双环磺酰胺
公开(公告)号：US20090124607A1
公开(公告)日：2009-05-14
申请号：US12090442
申请日：2006-10-18
申请人： Hakan Bladh , Jan Dahmen , Thomas Hansson , Krister Henriksson , Matti Lepisto , Stinabritt Nilsson
发明人： Hakan Bladh , Jan Dahmen , Thomas Hansson , Krister Henriksson , Matti Lepisto , Stinabritt Nilsson
IPC分类号： A61K31/55 , C07D231/56 , A61K31/416 , C07D401/02 , A61K31/4439 , A61K31/437 , A61P29/00 , C07D239/24 , A61K31/506 , C07D487/02 , A61K31/519
CPC分类号： C07D231/56 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D407/14 , C07D487/04
摘要： Compounds of formula (I): or a pharmaceutically acceptable salt thereof; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating the glucocorticoid receptor in a warm blooded animal).
摘要翻译：式（I）化合物或其药学上可接受的盐; 包含它们的组合物，其制备方法及其在药物治疗中的用途（例如调节温血动物中的糖皮质激素受体）。

17. 发明申请

US20080188666A1 LINEAR PHENYL-SUBSTITUTED INDAZOLES AND INDOLES, A PROCESS FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：线性苯基取代的吲哚和吲哚，其生产过程及其作为抗炎剂的用途
公开(公告)号：US20080188666A1
公开(公告)日：2008-08-07
申请号：US11936395
申请日：2007-11-07
申请人： Markus Berger , Hartmut Rehwinkel , Heike Schaecke , Matti Lepisto , Karl Edmann
发明人： Markus Berger , Hartmut Rehwinkel , Heike Schaecke , Matti Lepisto , Karl Edmann
IPC分类号： C07D401/04 , C07D231/56 , C07D209/14
CPC分类号： C07D405/12 , C07D231/56 , C07D401/04 , C07D405/14
摘要： The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
摘要翻译：本发明涉及式I化合物，其制备方法及其作为抗炎剂的用途。

18. 发明授权

US06962791B2 Treatment or prophylaxis of diseases caused by pilus-forming bacteria 失效
公开(公告)号：US06962791B2
公开(公告)日：2005-11-08
申请号：US09799608
申请日：2001-03-07
申请人： Scott Hultgren , Meta Kuehn , Zheng Xu , Derek Ogg , Mark Harris , Matti Lepisto , Charles Hal Jones , Jan Kihlberg
发明人： Scott Hultgren , Meta Kuehn , Zheng Xu , Derek Ogg , Mark Harris , Matti Lepisto , Charles Hal Jones , Jan Kihlberg
IPC分类号： A61K31/00 , A61K31/70 , C07H1/00 , G01N33/68 , G01N33/569 , A61K39/108 , A61K39/02
CPC分类号： A61K31/7004 , A61K31/00 , A61K31/70 , C07H1/00 , G01N33/68 , G01N2333/195 , G01N2500/10 , G01N2500/20 , Y02A50/481 , Y10S435/849
摘要： Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.

19. 发明授权

US06420127B1 Compounds and pharmaceutical compositions for the treatment and prophylaxis of bacterial infections 失效
标题翻译：用于治疗和预防细菌感染的化合物和药物组合物
公开(公告)号：US06420127B1
公开(公告)日：2002-07-16
申请号：US08640877
申请日：1996-10-10
申请人： Scott Hultgren , Meta Kuehn , Zheng Xu , Derek Ogg , Mark Harris , Matti Lepisto , Charles Hal Jones , Jan Kihlberg
发明人： Scott Hultgren , Meta Kuehn , Zheng Xu , Derek Ogg , Mark Harris , Matti Lepisto , Charles Hal Jones , Jan Kihlberg
IPC分类号： G01N33569
CPC分类号： A61K31/7004 , A61K31/00 , A61K31/70 , C07H1/00 , G01N33/68 , G01N2333/195 , G01N2500/10 , G01N2500/20 , Y02A50/481 , Y10S435/849
摘要： Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.
摘要翻译：公开了用于治疗和/或预防由组织粘附细菌引起的疾病的新方法。通过与周质分子伴侣相互作用，可以防止或抑制毛细血管的组装，从而减少细菌的感染性。还公开了用于筛选药物的方法以及用于从头设计这些药物的方法，这些方法依赖于涉及大分子之间的结合自由能的近似计算的新型计算机药物建模方法。最后，还公开了被认为能够与周质分子伴侣相互作用的新型吡喃糖苷。

20. 发明申请

US20090131486A1 2-PYRIDONE DERIVATIVES FOR THE TREATMENT OF DISEASE OR CONDITION IN WHICH INHIBITION OF NEUTROPHIL ELASTASE ACTIVITY IS BENEFICIAL 失效
标题翻译：用于治疗抑制中性粒细胞活化的疾病或病症的2-吡啶酮衍生物是有益的
公开(公告)号：US20090131486A1
公开(公告)日：2009-05-21
申请号：US12299879
申请日：2007-05-07
申请人： Peter Hansen , Karolina Lawitz , Matti Lepisto , Hans Lonn , Asim Ray
发明人： Peter Hansen , Karolina Lawitz , Matti Lepisto , Hans Lonn , Asim Ray
IPC分类号： A61K31/44 , C07D213/78 , A61P11/08
CPC分类号： C07D401/04 , C07D413/04 , C07D417/04
摘要： The invention provides compounds of formula wherein R1, R3, R4, R5, R6, R14, X and W are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
摘要翻译：本发明提供下式的化合物其中R 1，R 3，R 4，R 5，R 6，R 14，X和W如说明书和光学异构体，外消旋体和互变异构体及其药学上可接受的盐所定义; 以及其制备方法，含有它们的药物组合物及其在治疗中的用途。这些化合物是人嗜中性粒细胞弹性蛋白酶的抑制剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式