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11. 发明申请

US20100129795A1 AGENTS AND METHODS FOR SPECTROMETRIC ANALYSIS 审中-公开
标题翻译：用于光谱分析的试剂和方法
公开(公告)号：US20100129795A1
公开(公告)日：2010-05-27
申请号：US12275753
申请日：2008-11-21
申请人： Andrew David Pris , Tracy Lynn Paxon , Anthony John Murray
发明人： Andrew David Pris , Tracy Lynn Paxon , Anthony John Murray
IPC分类号： C12Q1/68 , G01N33/566
CPC分类号： G01N33/54306
摘要： Disclosed herein are agents, methods, and kits for determining the presence or concentration of a target, or multiple targets, in a sample, in a uniplexed or multiplexed fashion. In general, the methods enable the analysis of small molecules produced or consumed in liquid-phase that may be analyzed using gas or vapor phase detection methods.
摘要翻译：本文公开了用于以单一或多路复用的方式确定样品中靶或多个靶的存在或浓度的试剂，方法和试剂盒。通常，这些方法可以分析在液相中产生或消耗的小分子，这些分子可以使用气相或气相检测方法进行分析。

12. 发明申请

US20100101951A1 ELECTROPHORESIS SYSTEM AND METHOD 失效
标题翻译：电泳系统和方法
公开(公告)号：US20100101951A1
公开(公告)日：2010-04-29
申请号：US12258657
申请日：2008-10-27
申请人： Wei-Cheng Tian , Shashi Thutupalli , Li Zhu , Anthony John Murray , Erin Jean Finehout , Jun Xie
发明人： Wei-Cheng Tian , Shashi Thutupalli , Li Zhu , Anthony John Murray , Erin Jean Finehout , Jun Xie
IPC分类号： B01D57/02
CPC分类号： B01D57/02 , B01L3/502715 , G01N27/44743
摘要： Electrophoresis systems and methods comprise an electrophoresis device, wherein the electrophoresis device comprises a loading channel, an injection channel, and a separation channel. The loading channel is in fluid communication with a first and second sample port. The injection channel is connected to the loading channel to form a first intersection. The separation channel is connected to the injection channel to form a second intersection and in fluid communication with a first and second reservoir, and wherein the injection channel is in fluid communication with a third reservoir. The electrophoresis system further comprises electrodes coupled to the first sample port and the third reservoir, and the first reservoir and the second reservoir, respectively, that are adapted to move the sample into the loading channel towards the third reservoir and form a sample plug in the second intersection, and to further move the sample plug into the separation channel towards the second reservoir.
摘要翻译：电泳系统和方法包括电泳装置，其中电泳装置包括装载通道，注射通道和分离通道。装载通道与第一和第二采样端口流体连通。注入通道连接到装载通道以形成第一交叉。分离通道连接到注入通道以形成第二交叉并且与第一和第二储存器流体连通，并且其中注入通道与第三储存器流体连通。电泳系统还包括分别耦合到第一样品端口和第三储存器的电极，以及分别适于将样品移动到装载通道中的第一储存器和第二储存器，以朝向第三储存器形成样品塞并且将样品塞进一步朝向第二储存器移动到分离通道中。

13. 发明授权

US10046995B2 Wastewater treatment plant online monitoring and control 有权
公开(公告)号：US10046995B2
公开(公告)日：2018-08-14
申请号：US14234955
申请日：2012-07-25
申请人： Aditya Kumar , Anthony John Murray , Ruijie Shi , Zhaoyang Wan , Mustafa Tekin Dokucu , Vijaysai Prasad
发明人： Aditya Kumar , Anthony John Murray , Ruijie Shi , Zhaoyang Wan , Mustafa Tekin Dokucu , Vijaysai Prasad
IPC分类号： C02F3/00 , C02F3/12 , C02F3/28 , C02F3/30 , C02F1/66 , G01N33/18 , G01N21/00 , G01N33/00 , G01N31/00
摘要： A method of operating a waste water treatment plant (WWTP) having at least one of an aerobic digester (AD) and a membrane bioreactor (MBR) is described. The method of operating AD is comprised of monitoring and controlling AD in real-time using an online extended Kalman filter (EKF) having a online dynamic model of AD. The EKF uses real-time AD measured data, and online dynamic model of AD to update adapted model parameters and estimate model based inferred variables for AD, which are used for AD control by AD control system having supervisory and low-level control layers. The method of operating MBR is similar to that of AD. The supervisory control ensures the WWTP satisfying the effluent quality requirement while minimize the operation cost. A WWTP having at least one of AD or MBR is disclosed. The method of operating a WWTP can be implemented using a computer.

14. 发明申请

US20150034553A1 WASTEWATER TREATMENT PLANT ONLINE MONITORING AND CONTROL 审中-公开
标题翻译：废水处理厂在线监测与控制
公开(公告)号：US20150034553A1
公开(公告)日：2015-02-05
申请号：US14234955
申请日：2012-07-25
申请人： Aditya Kumar , Anthony John Murray , Ruijie Shi , Zhaoyang Wan , Mustafa Tekin Dokucu , Vijaysai Prasad
发明人： Aditya Kumar , Anthony John Murray , Ruijie Shi , Zhaoyang Wan , Mustafa Tekin Dokucu , Vijaysai Prasad
IPC分类号： C02F3/00 , G01N33/18 , C02F3/30 , C02F1/66 , C02F3/12 , C02F3/28
CPC分类号： C02F3/006 , C02F1/66 , C02F3/1268 , C02F3/28 , C02F3/2853 , C02F3/286 , C02F3/30 , C02F2209/001 , C02F2209/006 , C02F2209/02 , C02F2209/04 , C02F2209/06 , C02F2209/07 , C02F2209/08 , C02F2209/10 , C02F2209/14 , C02F2209/15 , C02F2209/20 , C02F2209/22 , C02F2209/36 , C02F2209/38 , C02F2209/40 , C02F2209/42 , C02F2305/06 , G01N33/1826 , G01N33/1866 , Y02A20/206 , Y02E50/343 , Y02W10/15
摘要： A method of operating a waste water treatment plant (WWTP) having at least one of an aerobic digester (AD) and a membrane bioreactor (MBR) is described. The method of operating AD is comprised of monitoring and controlling AD in real-time using an online extended Kalman filter (EKF) having a online dynamic model of AD. The EKF uses real-time AD measured data, and online dynamic model of AD to update adapted model parameters and estimate model based inferred variables for AD, which are used for AD control by AD control system having supervisory and low-level control layers. The method of operating MBR is similar to that of AD. The supervisory control ensures the WWTP satisfying the effluent quality requirement while minimize the operation cost. A WWTP having at least one of AD or MBR is disclosed. The method of operating a WWTP can be implemented using a computer.
摘要翻译：描述了具有有氧消化器（AD）和膜生物反应器（MBR）中的至少一种的废水处理设备（WWTP）的操作方法。操作AD的方法包括使用具有在线动态模型AD的在线扩展卡尔曼滤波器（EKF）来实时监控和控制AD。 EKF使用实时AD测量数据，AD在线动态模型更新适应的模型参数，并估计AD的推断变量，用于具有监控和低级控制层的AD控制系统的AD控制。操作MBR的方法与AD类似。监督控制确保污水处理厂满足污水质量要求，同时最大限度地降低运行成本。公开了具有AD或MBR中的至少一个的污水处理厂。可以使用计算机来实现污水处理厂的操作方法。

15. 发明申请

US20100096267A1 SYSTEM AND METHOD FOR PERFORMING MICROFLUIDIC MANIPULATION 失效
标题翻译：用于执行微流控制的系统和方法
公开(公告)号：US20100096267A1
公开(公告)日：2010-04-22
申请号：US12255962
申请日：2008-10-22
申请人： Jun Xie , Wei-Cheng Tian , Shashi Thutupalli , Li Zhu , Anthony John Murray , Erin Jean Finehout
发明人： Jun Xie , Wei-Cheng Tian , Shashi Thutupalli , Li Zhu , Anthony John Murray , Erin Jean Finehout
IPC分类号： G01N27/26
CPC分类号： G01N27/44791
摘要： Electrophoresis systems and methods comprise an electrophoresis device, wherein the electrophoresis comprises a loading channel, a separation channel, and an injection channel. The loading channel is in fluid communication with a first and second sample port. The separation channel is connected to the loading channel to form a first intersection, and an injection channel connected to the separation channel to form a second intersection and in fluid communication with a first reservoir, and wherein the separation channel is in fluid communication with a second reservoir. The electrophoresis system further comprises two electrodes coupled to the first sample port and the first reservoir, and the first sample port and the second reservoir, respectively, that are adapted to move the sample into the loading channel towards the first reservoir and form a sample plug in the separation channel, and to further move the sample plug into the separation channel towards the second reservoir.
摘要翻译：电泳系统和方法包括电泳装置，其中电泳包括加载通道，分离通道和注射通道。装载通道与第一和第二采样端口流体连通。分离通道连接到装载通道以形成第一交叉点，以及连接到分离通道以形成第二交叉并与第一储存器流体连通的注入通道，并且其中分离通道与第二交换流体连通水库电泳系统还包括分别耦合到第一样品端口和第一储存器的两个电极以及适于将样品移动到装载通道中以朝向第一储存器形成样品塞的第一样品端口和第二储存器在分离通道中，并且进一步将样品塞进入分离通道朝向第二储存器。

16. 发明申请

US20110070596A1 AGENTS AND METHODS FOR ANALYZING PROTEIN INTERACTIONS 审中-公开
标题翻译：用于分析蛋白质相互作用的试剂和方法
公开(公告)号：US20110070596A1
公开(公告)日：2011-03-24
申请号：US12705828
申请日：2010-02-15
申请人： Nichole Lea Wood , Mohan Mark Amaratunga , Hans Grade , Faisal Ahmed Syud , Anup Sood , Reginald Donovan Smith , Ayse Betul Dinc , Amy Casey Williams , Anthony John Murray , Gregory Daryll Goddard
发明人： Nichole Lea Wood , Mohan Mark Amaratunga , Hans Grade , Faisal Ahmed Syud , Anup Sood , Reginald Donovan Smith , Ayse Betul Dinc , Amy Casey Williams , Anthony John Murray , Gregory Daryll Goddard
IPC分类号： G01N33/68 , C07D403/12 , G01N33/53
CPC分类号： G01N33/6845 , G01N33/6848
摘要： Agents and methods for qualitative and quantitative analysis a protein complex or protein complexes using isotope-labeled symmetrical bifunctional crosslinkers and mass spectrometry are provided. Targeting moieties, cell permeability moieties, or affinity moieties, may be appended to the bifunctional crosslinkers. The isotope-labeled symmetrical bifunctional crosslinkers may be used in a kit or as a library.
摘要翻译：提供了使用同位素标记的对称双功能交联剂和质谱定性和定量分析蛋白质复合物或蛋白质复合物的试剂和方法。靶向部分，细胞渗透性部分或亲和部分可附加到双功能交联剂上。同位素标记的对称双功能交联剂可用于试剂盒或文库。

17. 发明授权

US08377277B2 System and method for performing microfluidic manipulation 失效
标题翻译：用于执行微流体操作的系统和方法
公开(公告)号：US08377277B2
公开(公告)日：2013-02-19
申请号：US12255962
申请日：2008-10-22
申请人： Jun Xie , Wei-Cheng Tian , Shashi Thutupalli , Li Zhu , Anthony John Murray , Erin Jean Finehout
发明人： Jun Xie , Wei-Cheng Tian , Shashi Thutupalli , Li Zhu , Anthony John Murray , Erin Jean Finehout
IPC分类号： B01D57/02
CPC分类号： G01N27/44791
摘要： Electrophoresis systems and methods comprise an electrophoresis device, wherein the electrophoresis comprises a loading channel, a separation channel, and an injection channel. The loading channel is in fluid communication with a first and second sample port. The separation channel is connected to the loading channel to form a first intersection, and an injection channel connected to the separation channel to form a second intersection and in fluid communication with a first reservoir, and wherein the separation channel is in fluid communication with a second reservoir. The electrophoresis system further comprises two electrodes coupled to the first sample port and the first reservoir, and the first sample port and the second reservoir, respectively, that are adapted to move the sample into the loading channel towards the first reservoir and form a sample plug in the separation channel, and to further move the sample plug into the separation channel towards the second reservoir.
摘要翻译：电泳系统和方法包括电泳装置，其中电泳包括加载通道，分离通道和注射通道。装载通道与第一和第二采样端口流体连通。分离通道连接到装载通道以形成第一交叉点，以及连接到分离通道以形成第二交叉并与第一储存器流体连通的注入通道，并且其中分离通道与第二交换流体连通水库电泳系统还包括分别耦合到第一样品端口和第一储存器的两个电极以及适于将样品移动到装载通道中以朝向第一储存器形成样品塞的第一样品端口和第二储存器在分离通道中，并且进一步将样品塞进入分离通道朝向第二储存器。

18. 发明申请

US20110122412A1 DEVICES AND METHODS FOR OPTICAL DETECTION 审中-公开
标题翻译：用于光学检测的装置和方法
公开(公告)号：US20110122412A1
公开(公告)日：2011-05-26
申请号：US12623714
申请日：2009-11-23
申请人： Chulmin Joo , Anthony John Murray , Masako Yamada
发明人： Chulmin Joo , Anthony John Murray , Masako Yamada
IPC分类号： G01J3/45
CPC分类号： G01N33/6845 , G01N21/0332 , G01N21/05 , G01N21/45 , G01N21/53 , G01N2021/0346
摘要： An optical detection system for sensing one or more samples is provided. The optical detection system comprises a broadband light source that emits a beam comprising a continuous spectrum over a range of wavelengths; a fluidic cell comprising one or more channels that positions the sample so that at least a portion of the beam is directed on the sample to produce a back reflected beam; and a spectrometer that analyzes an interference spectrum of the beam back reflected from the sample.
摘要翻译：提供了用于感测一个或多个样品的光学检测系统。光学检测系统包括宽带光源，其发射包括波长范围上的连续光谱的光束; 流体单元包括一个或多个通道，其定位样品，使得至少一部分光束被引导到样品上以产生反射反射光束; 以及分析从样品反射的光束的干涉光谱的光谱仪。

19. 发明申请

US20100129785A1 AGENTS AND METHODS FOR SPECTROMETRIC ANALYSIS 审中-公开
公开(公告)号：US20100129785A1
公开(公告)日：2010-05-27
申请号：US12275734
申请日：2008-11-21
申请人： Andrew David Pris , Tracy Lynn Paxon , Ronald James Wroczynski , Anthony John Murray
发明人： Andrew David Pris , Tracy Lynn Paxon , Ronald James Wroczynski , Anthony John Murray
IPC分类号： C12Q1/70 , G01N33/543 , G01N33/553 , G01N33/53 , G01N33/569 , G01N33/545 , G01N33/544
CPC分类号： G01N33/54393
摘要： Disclosed herein are agents, methods, and kits for determining the presence or concentration of a target, or multiple targets, in a sample, in a uniplexed or multiplexed fashion. In general, the methods enable the analysis of small molecules produced or consumed in liquid-phase that may be analyzed using gas or vapor phase detection methods.

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