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11. 发明申请

US20060057568A1 Method of identifying compounds that alter bag-1 mediated down-regulation of glucocorticoid-receptor transactivation 审中-公开
标题翻译：鉴定化合物的方法，该化合物改变了袋-1介导的糖皮质激素受体反式激活的下调
公开(公告)号：US20060057568A1
公开(公告)日：2006-03-16
申请号：US10495472
申请日：2002-11-14
申请人： Ulrike Schmidt , Theo Rein , Florian Holsboer
发明人： Ulrike Schmidt , Theo Rein , Florian Holsboer
IPC分类号： C40B40/08 , C40B40/10
CPC分类号： C12Q1/6897 , C12Q1/6883 , G01N2333/726 , C12Q2537/143 , C12Q2525/205 , C12Q2522/101
摘要： The present invention relates to new methods of identifying compounds that inhibit or reduce bag-1 mediated down-regulation of gluocorticoid-receptor (GR) tansactivation. These methods rely on the surprising findings, that first, a (poly)peptide comprising the motif X-Lys-Lys-Lys-Y-Arg-Arg-Arg also present is the cochaperone bag-1 is sufficient for DNA binding of this cochaperone and, second, this motif but not the E2X4 domain of bag-1 is required for inhibition or reduction of FR transactivation. The present invention also relates to methods of refining the compounds identified with the above method as well as to methods of producing pharmaceutical compositions wherein compounds identified or compounds refined by the above-recited methods of the invention are formulated with a pharmaceutically acceptable carrier or diluent.
摘要翻译：本发明涉及鉴定化合物的新方法，所述化合物抑制或减少药物-1介导的糖皮质激素受体（GR）去激活的下调。这些方法依赖于令人惊奇的发现，首先，还存在包含基序X-Lys-Lys-Lys-Y-Arg-Arg-Arg的（多）肽，其中cochaperone bag-1足以使该相关蛋白的DNA结合并且第二，为了抑制或减少FR反式激活，需要袋-1的该基序而不是E-2×X 4个结构域。本发明还涉及精制通过上述方法鉴定的化合物的方法以及生产药物组合物的方法，其中通过本发明的上述方法精制的化合物或化合物与药学上可接受的载体或稀释剂配制。

12. 发明申请

US20050186224A1 Attenuated bovine respiratory syncytial virus 失效
标题翻译：减毒牛呼吸道合胞病毒
公开(公告)号：US20050186224A1
公开(公告)日：2005-08-25
申请号：US11112261
申请日：2005-04-21
申请人： Ursula Buchholz , Ulrike Schmidt
发明人： Ursula Buchholz , Ulrike Schmidt
IPC分类号： A61K39/155 , C07K14/135 , C12N7/04 , G01N33/569 , C12N7/00 , C12Q1/70
CPC分类号： C07K14/005 , A61K2039/5254 , C12N7/00 , C12N2740/16122 , C12N2760/18522 , C12N2760/18561
摘要： The present invention relates i.a. to Bovine Respiratory Syncytial Viruses that are not capable of expressing a functional SH-protein and/or G-protein due to a mutation in the genes encoding the said proteins. Also the invention relates to diagnostic test kits for discriminating wild-type Bovine Respiratory Syncytial Viruses from Bovine Respiratory Syncytial Viruses according to the invention and to methods for the discrimination between those viruses.
摘要翻译：本发明涉及到对于由于编码所述蛋白质的基因的突变而不能表达功能性SH蛋白和/或G蛋白的牛呼吸道合胞病毒。本发明还涉及用于区分根据本发明的牛呼吸道合胞病毒的野生型牛呼吸道合胞病毒和用于区分这些病毒的方法的诊断测试试剂盒。

13. 发明申请

US20140249090A1 PEPTIDES AND PHARMACEUTICAL COMPOSITIONS FOR USE IN THE TREATMENT BY NASAL ADMINISTRATION OF PATIENTS SUFFERING FROM ANXIETY AND SLEEP DISORDERS 审中-公开
标题翻译：鼻炎和药物组合物用于治疗来自放射性疾病和睡眠障碍患者的NASAL治疗
公开(公告)号：US20140249090A1
公开(公告)日：2014-09-04
申请号：US14009234
申请日：2012-04-02
申请人： Yi-Chun Yen , Axel Steiger , Florian Holsboer , Rainer Landgraf , Irina Alexandra Ionescu , Ulrike Schmidt
发明人： Yi-Chun Yen , Axel Steiger , Florian Holsboer , Rainer Landgraf , Irina Alexandra Ionescu , Ulrike Schmidt
IPC分类号： A61K38/10 , A61K9/00
CPC分类号： A61K38/2271 , A61K9/0043 , A61K38/10 , A61K38/22 , C07K14/57545
摘要： The present invention provides peptides for use in a medicament which is administered nasally, wherein the peptide is an agonist of neuropeptide S receptor (NPSR), of the receptor TGR23 and/or of vasopressin receptor-related receptor 1 (VRR1) or for use in the treatment of a patient by causing, promoting or increasing relieve or healing of phobic anxiety, avoidance anxiety, dissociative anxiety such as flashbacks, depersonalization, derealization, intrusions, vegetative symptoms related to anxiety symptoms, especially in panic attacks, in posttraumatic stress disorder, in generalised anxiety disorder and in anxiety accompanying depressive, or psychotic episodes, arousal, awakening, alertness, activity, spontaneous movement, an anxiolytic effect or a combination thereof in the patient, wherein the peptide is administered nasally or for use in the prophylaxis and/or treatment of an anxiety or sleep disorder, especially in any type of hypersomnia like idiopathic hypersomnia, wherein the peptide is administered nasally. Further provided are pharmaceutical compositions for nasal administration comprising at least one of said peptides, uses of said peptide or said pharmaceutical composition. The invention also provides a method for identifying target neurons of a peptide in an animal, wherein the peptide is administered nasally.
摘要翻译：本发明提供用于鼻内给药的药物中的肽，其中肽是受体TGR23和/或加压素受体相关受体1（VRR1）的神经肽S受体（NPSR）的激动剂或用于通过引发，促进或增加恐惧焦虑的缓解或愈合，避免焦虑，解体焦虑如反光，人格解体，去实现，入侵，与焦虑症状相关的营养症状，特别是恐慌发作中的创伤后应激障碍，广泛性焦虑症和伴随着患者的抑郁或精神病发作，觉醒，觉醒，警觉，活动，自发运动，抗焦虑作用或其组合的焦虑，其中所述肽经鼻给药或用于预防和/ 或治疗焦虑或睡眠障碍，特别是在任何类型的特发性睡眠过度睡眠中的睡眠过多，其中p 耳鼻喉管还提供了用于鼻腔给药的药物组合物，其包含至少一种所述肽，所述肽或所述药物组合物的用途。本发明还提供了一种用于鉴定动物中肽的靶神经元的方法，其中所述肽经鼻施用。

14. 发明申请

US20050124818A1 Process 有权
标题翻译：处理
公开(公告)号：US20050124818A1
公开(公告)日：2005-06-09
申请号：US10880080
申请日：2004-06-30
申请人： Youchan Yan , Krishnadath Bhaggan , Ulrike Schmidt , Victoria Taran
发明人： Youchan Yan , Krishnadath Bhaggan , Ulrike Schmidt , Victoria Taran
IPC分类号： C11C3/14 , C07C51/347
CPC分类号： C11C3/14
摘要： A process for producing a conjugated di- or poly-unsaturated fatty acid having from 12 to 24 carbon atoms, or a salt or ester thereof, comprises reacting a non-conjugated free fatty acid, or a salt or ester thereof with a base in the presence of a solvent comprising a monohydric alcohol having from 1 to 6 carbon atoms, wherein the reaction is carried out at a temperature of from 120° C. to 200° C. in the presence of water in an amount of at least 4% by weight based on alcohol.
摘要翻译：制备具有12至24个碳原子的共轭二 - 或多不饱和脂肪酸或其盐或酯的方法包括使非共轭游离脂肪酸或其盐或酯与碱在存在包含具有1至6个碳原子的一元醇的溶剂，其中反应在水的存在下在120℃至200℃的温度下进行，其量为至少4％，通过基于酒精的重量

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