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11. 发明授权

US08660353B2 Function-based representation of N-dimensional structures 有权
标题翻译：基于功能的N维结构表示
公开(公告)号：US08660353B2
公开(公告)日：2014-02-25
申请号：US13554978
申请日：2012-07-20
申请人： Duane W. Storti , Mark A. Ganter
发明人： Duane W. Storti , Mark A. Ganter
IPC分类号： G06K9/34
CPC分类号： G06K9/342 , B33Y50/00 , G06T7/12 , G06T7/149 , G06T7/60 , G06T17/10 , G06T2200/04 , G06T2207/10072 , G06T2207/20016 , G06T2207/20044 , G06T2207/20064 , G06T2207/20161 , G06T2207/30004
摘要： A method for modeling an object, particularly suited to complex objects such as anatomical objects, and manipulating the modeled object in a CAD environment includes obtaining volumetric scan data of a region and segmenting the scan data to identify a first object to produce a first set of signed distance values on a grid. Wavelet analysis of the first set of signed distance values provides a function-based representation of the object. A signed distance value model of a second object is obtained, and one or both sets of signed distance values are manipulated to perform a CAD operation.
摘要翻译：一种用于建模对象的方法，特别适用于诸如解剖学对象的复杂对象，以及在CAD环境中操纵所建模的对象，包括获取区域的体积扫描数据并分割扫描数据以识别第一对象以产生第一组网格上的有符号距离值。第一组有符号距离值的小波分析提供了对象的基于函数的表示。获得第二物体的带符号距离值模型，并且操作一个或两组有符号距离值以执行CAD操作。

12. 发明授权

US6100893A Constructing solid models using implicit functions defining connectivity relationships among layers of an object to be modeled 失效
标题翻译：使用隐式函数构建实体模型，定义要建模的对象的层之间的连接关系
公开(公告)号：US6100893A
公开(公告)日：2000-08-08
申请号：US862216
申请日：1997-05-23
申请人： Mark T. Ensz , Mark A. Ganter , Chek T. Lim , Duane W. Storti , George M. Turkiyyah
发明人： Mark T. Ensz , Mark A. Ganter , Chek T. Lim , Duane W. Storti , George M. Turkiyyah
IPC分类号： G06T17/20 , G06T17/00
CPC分类号： G06T17/20
摘要： A solid model is constructed from surface point data that represent layers of an object. The model is represented as the level set of an implicit function that is fitted to the surface point data. In the two-dimensional application of the technique, a Delaunay triangulation is performed for each layer. In this step, surface points are connected to form Delaunay triangles; the data points are the vertices of the Delaunay triangles. A circumcircle is then created around each Delaunay triangle, passing through the three vertices of the triangle. To decimate the circumcircle data, overlapping circumspheres are merged according to a merging criterion. A pseudo-union of implicit functions for the reduced number of circumcircles provides an initial implicit function for the layer. Errors in the implicit function are substantially reduced by optimizing the position and/or radii of the circumcircles. The implicit functions for a plurality of adjacent layers are blended to define an implicit function for the object that is used for reconstruction or modeling of the object. The technique is generally extended to n dimensional objects by using simplices instead of the Delaunay triangles and hyperspheres instead of the circumcircles. The method is capable of constructing solid models with highly localized surface curvature.
摘要翻译：实体模型由表示对象层的表面点数据构成。该模型表示为拟合到表面点数据的隐式函数的级别集合。在该技术的二维应用中，对于每个层执行Delaunay三角测量。在此步骤中，表面点连接形成Delaunay三角形; 数据点是Delaunay三角形的顶点。然后在每个Delaunay三角形周围创建一个外接圆，穿过三角形的三个顶点。为了抽取外接圆周数据，根据合并标准合并重叠的圆周。减少数量的外接圆的隐式函数的伪联合提供了层的初始隐式函数。通过优化外接圆的位置和/或半径来显着减少隐含函数中的错误。混合多个相邻层的隐含函数以定义用于对象的重构或建模的对象的隐式函数。该技术通常通过使用简单代替Delaunay三角形和超球体而不是外接圆来扩展到n维对象。该方法能够构建具有高度局部化表面曲率的实体模型。

13. 发明授权

US6094199A 3D objects morphing employing skeletons indicating symmetric differences to define intermediate objects used in morphing 失效
标题翻译： 3D对象变形使用指示对称差异的骨架来定义在变形中使用的中间对象
公开(公告)号：US6094199A
公开(公告)日：2000-07-25
申请号：US862621
申请日：1997-05-23
申请人： George M. Turkiyyah , Duane W. Storti , Mark A. Ganter
发明人： George M. Turkiyyah , Duane W. Storti , Mark A. Ganter
IPC分类号： G06T3/40 , G06T15/00
CPC分类号： G06T3/0093 , G06T3/4007
摘要： The present invention provides a unified, automated approach to 3D object interpolation and 3D morphing based on a geometric descriptor known as the skeleton. The skeleton of an object consists of the closure of the set of points minimally equidistant from two points on the object's boundary. An "intermediate 3D object" between a pair of two other 3D objects is obtained as the (trimmed) skeleton of the symmetric difference of the pair of objects. By applying this process recursively, any desired number of intermediate 3D objects between a first and a last object may be obtained to produce a discrete 3D morph. A discrete morph can be thought of as an animation starting from the initial object and ending with the final object after a given number of the intermediate objects. Alternatively, the skeleton is used to identify corresponding points on the surfaces of the objects. Interpolation between the location of the corresponding points is then used to determine a continuum of intermediate 3D objects.
摘要翻译：本发明提供了一种基于被称为骨架的几何描述的3D对象插值和3D变形的统一的自动化方法。对象的骨架包括从对象边界上的两个点最小等距的点集合的闭合。获得一对另外的3D对象之间的“中间3D对象”作为该对对象的对称差异的（修剪）骨架。通过递归地应用该过程，可以获得在第一和最后一个对象之间的任何期望数量的中间3D对象以产生离散的3D变形。离散变体可以被认为是从初始对象开始的动画，并在给定数量的中间对象之后以最终对象结束。或者，骨架用于识别对象表面上的相应点。然后使用对应点的位置之间的插值来确定中间3D对象的连续体。

14. 发明申请

US20120196320A1 Optical Projection Tomography Microscopy (OPTM) for Large Specimen Sizes 有权
标题翻译：光学投影断层扫描（OPTM）用于大样本尺寸
公开(公告)号：US20120196320A1
公开(公告)日：2012-08-02
申请号：US13091088
申请日：2011-04-20
申请人： Eric J. Seibel , Qin Miao , Ryan Lee Coe , Per G. Reinhall , Duane W. Storti
发明人： Eric J. Seibel , Qin Miao , Ryan Lee Coe , Per G. Reinhall , Duane W. Storti
IPC分类号： G01N1/30 , H04N13/02 , G01N1/31 , H04N7/18
CPC分类号： G01N1/30
摘要： Claimed is an imaging and diagnostic system and method for focal scanning of a specimen using optical projection tomographic microscopy and computer generation of three-dimensional images. One embodiment comprises a light source and an imaging system having an adjustable focal position which acquires a plurality of digital 2D projection images of biological tissue placed within a specimen tube that translates and rotates past an optical lens in a helical pattern. A computer captures the images and generates a 3D composite image. Also claimed is a system and method for preparing a specimen for optical microscopy. One embodiment comprises fixing, staining, and/or optically clearing biological tissue within a microfluidic specimen chamber prior to placement in a specimen tube.
摘要翻译：声称是使用光学投影断层显微镜和计算机生成三维图像的样本的焦点扫描的成像和诊断系统和方法。一个实施例包括光源和具有可调节焦点位置的成像系统，其获取放置在以螺旋图案转动和旋转经过光学透镜的样本管内的生物组织的多个数字2D投影图像。计算机捕获图像并生成3D合成图像。还要求的是用于制备用于光学显微镜的样品的系统和方法。一个实施方案包括在放置在样品管中之前固定，染色和/或光学清除微流体样品室内的生物组织。

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