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    • 11. 发明授权
    • Extended release formulation of levetiracetam
    • 左乙拉西坦的延长释放制剂
    • US07858122B2
    • 2010-12-28
    • US11215947
    • 2005-08-31
    • Rajesh KshirsagarMayank JoshiYogesh Raichandani
    • Rajesh KshirsagarMayank JoshiYogesh Raichandani
    • A01N43/36A61K31/40A61K9/22
    • A61K31/4015A61K9/1635A61K9/2054A61K9/2077A61K9/2866
    • An extended release pharmaceutical composition of Levetiracetam with once a day dosage regime and the process of preparing it. The extended release tablet of Levetiracetam is with the core comprising of Levetiracetam and water dispersible rate controlling polymer, and the tablet core is optionally functional coated comprising a combination of water non-dispersible and/or water dispersible polymer. It provides extended therapeutically effective plasma levels over a twenty four hour period with diminished incidences of neuropsychiatric adverse events by eliminating the troughs and peaks of drug concentration in a patients blood plasma, which comprises administering orally to a patient in need thereof, an extended release tablet that provides a peak blood plasma level of Levetiracetam in from about eight to about Sixteen hours. The core is prepared by Wet granulation, Dry granulation or Direct compression and optionally the tablet core is coated either in an coating pan or in and Fluidized bed system.
    • 延长释放的左乙拉西坦药物组合物,每日一次剂量方案及其制备方法。 左乙拉西坦的延长释放片剂包含左乙拉西坦和水分散速率控制聚合物的核心,并且片芯任选地功能性涂覆,包括水不可分散和/或水分散性聚合物的组合。 它通过消除患者血浆中药物浓度的波谷和峰值,在二十四小时内提供延长的治疗有效血浆水平,减少神经精神不良事件的发生率,其包括向有需要的患者口服延长释放片剂 其提供左乙拉西坦的血浆血浆水平高达约8至16小时。 核心通过湿法造粒,干法制粒或直接压片制备,并且任选地,片芯包被在涂布盘或流化床系统中。
    • 13. 发明申请
    • Extended release osmo-microsealed formulation
    • 延长释放的渗透微密封制剂
    • US20070110808A1
    • 2007-05-17
    • US10563631
    • 2004-05-14
    • Sampad BhattacharyaSridhar GummudavelliMayank JoshiJohn Egbert
    • Sampad BhattacharyaSridhar GummudavelliMayank JoshiJohn Egbert
    • A61K31/137A61K9/24
    • A61K9/2846A61K9/0004A61K9/2077A61K9/2081A61K9/5042A61K9/5047
    • The extended release osmo-microsealed formulation includes three controlled release systems associated in series. First, there is an inner solid particulate phase containing Venlafaxine Hydrochloride (Active), and one or more hydrophobic polymers, one or more diluents required to increase the bulk one or more osmogen (agents which can generate osmotic pressure across the hydrophobic coating) and one or more binder polymers essentially to provide strength/hardness to the particle. Second, there is an outer solid continuous phase including one or more hydrophilic polymers, that is further compressed into a tablet. Third, there is an optional functional coat surrounding the tablet. The process/method for forming the Osmo-microsealed extended release delivery system and the process for using such system for treating human ailment/depression are also provided.
    • 延长释放的渗透微密封制剂包括三个相互联系的控制释放系统。 首先,存在含有盐酸文拉法辛(活性)的内固体颗粒相和一种或多种疏水性聚合物,一种或多种稀释剂,以增加体积的一种或多种渗透剂(可以在疏水涂层上产生渗透压的试剂)和一种 或更多的粘合剂聚合物基本上为颗粒提供强度/硬度。 第二,存在包含一种或多种亲水性聚合物的外部固体连续相,其进一步压缩成片剂。 第三,围绕平板电脑有一个可选的功能外套。 还提供了用于形成Osmo-微密封延长释放递送系统的方法/方法以及使用该系统治疗人类疾病/抑郁症的方法。
    • 15. 发明申请
    • EXTENDED RELEASE FORMULATION OF LEVETIRACETAM
    • 延长释放配方的利多卡因
    • US20110064807A1
    • 2011-03-17
    • US12942585
    • 2010-11-09
    • Rajesh KshirsagarMayank JoshiYogesh Raichandani
    • Rajesh KshirsagarMayank JoshiYogesh Raichandani
    • A61K9/28A61K31/4015A61K9/36A61P25/08
    • A61K31/4015A61K9/1635A61K9/2054A61K9/2077A61K9/2866
    • An extended release pharmaceutical composition of Levetiracetam with once a day dosage regime and the process of preparing it. The extended release tablet of Levetiracetam is with the core comprising of Levetiracetam and water dispersible rate controlling polymer, and the tablet core is optionally functional coated comprising a combination of water non-dispersible and/or water dispersible polymer. It provides extended therapeutically effective plasma levels over a twenty four hour period with diminished incidences of neuropsychiatric adverse events by eliminating the troughs and peaks of drug concentration in a patients blood plasma, which comprises administering orally to a patient in need thereof, an extended release tablet that provides a peak blood plasma level of Levetiracetam in from about eight to about Sixteen hours. The core is prepared by Wet granulation, Dry granulation or Direct compression and optionally the tablet core is coated either in an coating pan or in and Fluidized bed system.
    • 延长释放的左乙拉西坦药物组合物,每日一次剂量方案及其制备方法。 左乙拉西坦的延长释放片剂包含左乙拉西坦和水分散速率控制聚合物的核心,并且片芯任选地功能性涂覆,包括水不可分散和/或水分散性聚合物的组合。 它通过消除患者血浆中药物浓度的波谷和峰值,在二十四小时内提供延长的治疗有效血浆水平,减少神经精神不良事件的发生率,其包括向有需要的患者口服延长释放片剂 其提供左乙拉西坦的血浆血浆水平高达约8至16小时。 核心通过湿法造粒,干法制粒或直接压片制备,并且任选地,片芯包被在涂布盘或流化床系统中。
    • 18. 发明申请
    • Extended release formulation of levetiracetam
    • 左乙拉西坦的延长释放制剂
    • US20060165796A1
    • 2006-07-27
    • US11215947
    • 2005-08-31
    • Rajesh KshirsagarMayank JoshiYogesh Raichandani
    • Rajesh KshirsagarMayank JoshiYogesh Raichandani
    • A61K31/4015A61K9/24
    • A61K31/4015A61K9/1635A61K9/2054A61K9/2077A61K9/2866
    • An extended release pharmaceutical composition of Levetiracetam with once a day dosage regime and the process of preparing it. The extended release tablet of Levetiracetam is with the core comprising of Levetiracetam and water dispersible rate controlling polymer, and the tablet core is optionally functional coated comprising a combination of water non-dispersible and/or water dispersible polymer. It provides extended therapeutically effective plasma levels over a twenty four hour period with diminished incidences of neuropsychiatric adverse events by eliminating the troughs and peaks of drug concentration in a patients blood plasma, which comprises administering orally to a patient in need thereof, an extended release tablet that provides a peak blood plasma level of Levetiracetam in from about eight to about Sixteen hours. The core is prepared by Wet granulation, Dry granulation or Direct compression and optionally the tablet core is coated either in an coating pan or in and Fluidized bed system.
    • 延长释放的左乙拉西坦药物组合物,每日一次剂量方案及其制备方法。 左乙拉西坦的延长释放片剂包含左乙拉西坦和水分散速率控制聚合物的核心,并且片芯任选地功能性涂覆,包括水不可分散和/或水分散性聚合物的组合。 它通过消除患者血浆中药物浓度的波谷和峰值,在二十四小时内提供延长的治疗有效血浆水平,减少神经精神不良事件的发生率,其包括向有需要的患者口服延长释放片剂 其提供左乙拉西坦的血浆血浆水平高达约8至16小时。 核心通过湿法造粒,干法制粒或直接压片制备,并且任选地,片芯包被在涂布盘或流化床系统中。