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11. 发明申请

US20120259405A1 Radial Radiopaque Markers 审中-公开
标题翻译：径向不透射线标记
公开(公告)号：US20120259405A1
公开(公告)日：2012-10-11
申请号：US13431454
申请日：2012-03-27
申请人： Jan Weber , Aiden Flanagan
发明人： Jan Weber , Aiden Flanagan
IPC分类号： A61F2/82 , A61M29/02
CPC分类号： A61M25/104 , A61B90/39 , A61B2017/22061 , A61B2090/3966 , A61B2090/3987 , A61F2/848 , A61F2/86 , A61F2210/0004 , A61F2220/0016 , A61F2250/0098 , A61M2025/105 , A61M2025/1075 , A61M2025/1086
摘要： A deployable medical device having at least one radiopaque marker is herein disclosed. In particular, the deployable medical device comprises a bio-absorbable stent or expandable medical balloon. Upon insertion of the deployable medical device, the at least one radiopaque marker is inserted into adjacent tissue, where it will remain even after the deployable medical device has been removed.
摘要翻译：本文公开了具有至少一个不透射线标记的可部署医疗装置。特别地，可展开的医疗装置包括生物可吸收的支架或可扩张的医用气囊。在插入可部署的医疗装置时，至少一个不透射线的标记被插入到相邻的组织中，甚至在可部署的医疗装置已经被移除之后仍将保留。

12. 发明授权

US08089029B2 Bioabsorbable metal medical device and method of manufacture 有权
标题翻译：生物可吸收金属医疗器械及其制造方法
公开(公告)号：US08089029B2
公开(公告)日：2012-01-03
申请号：US11344761
申请日：2006-02-01
申请人： Aiden Flanagan
发明人： Aiden Flanagan
IPC分类号： B23K26/38
CPC分类号： B23K26/123 , A61F2210/0004 , A61F2240/001 , B23K26/142 , B23K26/40 , B23K2103/50
摘要： A method and apparatus is provided for processing a medical device formed from a bioabsorbable metallic material. The method begins by generating a beam of radiation onto the bioabsorbable metallic material. The radiation beam is transmitted through a fluid medium and onto a heat affected zone (HAZ) of the bioabsorbable metallic material to thereby cool the HAZ and reduce a concentration of oxygen surrounding the HAZ.
摘要翻译：提供了一种用于处理由生物可吸收金属材料形成的医疗装置的方法和装置。该方法通过在生物可吸收金属材料上产生辐射束开始。辐射束通过流体介质传播到生物可吸收金属材料的热影响区（HAZ）上，从而冷却HAZ并降低HAZ周围的氧浓度。

13. 发明申请

US20110275980A1 MEDICAL DEVICES EMPLOYING ELECTROACTIVE POLYMERS FOR DELIVERY OF PARTICULATE THERAPEUTIC AGENTS 有权
标题翻译：使用用于递送颗粒治疗剂的电聚合物的医疗装置
公开(公告)号：US20110275980A1
公开(公告)日：2011-11-10
申请号：US13101301
申请日：2011-05-05
申请人： Jan Weber , Aiden Flanagan
发明人： Jan Weber , Aiden Flanagan
IPC分类号： A61N1/00
CPC分类号： A61L29/14 , A61L29/04 , A61L29/16
摘要： In accordance with one aspect, medical devices are provided which comprise an electroactive polymer material and therapeutic-agent containing particles. The device is configured such that the particles are delivered from the device upon actuation of the electroactive polymer material.
摘要翻译：根据一个方面，提供了包括电活性聚合物材料和含有治疗剂的颗粒的医疗装置。该装置被构造成使得在电活性聚合物材料致动时颗粒从该装置输送。

14. 发明申请

US20080281409A1 STENTS WITH DRUG ELUTING COATINGS 审中-公开
标题翻译：带药液涂层的手套
公开(公告)号：US20080281409A1
公开(公告)日：2008-11-13
申请号：US11933517
申请日：2007-11-01
申请人： Anthony Malone , Tim O'Connor , Dave McMorrow , Aiden Flanagan
发明人： Anthony Malone , Tim O'Connor , Dave McMorrow , Aiden Flanagan
IPC分类号： A61F2/82
CPC分类号： A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/622
摘要： Provided is a coated medical device (e.g., a stent) comprising one or more surfaces having dispersed thereon a plurality of microparticles comprising an active pharmaceutical ingredient (API) and a polymer. Specifically, the microparticles are disposed on a device surface in a microparticulate phase coating, i.e., as discrete microparticles in the absence of a continuous phase coating. The medical device effectively adheres one or more APIs to its surface, and allows controlled release of the APIs from the device surface to a desired treatment area by using a minimal amount of polymer. The medical device is suitable for insertion or implantation into a subject, preferably a human. Also provided are methods for preparing and using the coated medical device.
摘要翻译：提供了包含一个或多个在其上分散有多个包含活性药物成分（API）和聚合物的微粒的表面的涂覆医疗装置（例如支架）。具体地，微粒在微粒相涂层中的器件表面上，即在不存在连续相涂覆的情况下作为离散微粒布置。医疗设备有效地将一个或多个API粘附到其表面，并且允许通过使用最少量的聚合物将API从设备表面控制释放到期望的治疗区域。医疗装置适于插入或植入受试者，优选人。还提供了制备和使用涂覆的医疗装置的方法。

15. 发明申请

US20080071351A1 ENDOPROSTHESIS WITH ADJUSTABLE SURFACE FEATURES 有权
标题翻译：具有可调节表面特征的内窥镜
公开(公告)号：US20080071351A1
公开(公告)日：2008-03-20
申请号：US11855541
申请日：2007-09-14
申请人： Aiden Flanagan , Dave McMorrow , Anthony Malone , Tim O'Connor , Barry Heaney
发明人： Aiden Flanagan , Dave McMorrow , Anthony Malone , Tim O'Connor , Barry Heaney
IPC分类号： A61F2/06
CPC分类号： A61L31/146 , A61F2/82 , A61F2/91 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/626
摘要： Endoprostheses (e.g., stents) containing adjustable surfaces are disclosed.
摘要翻译：公开了包含可调表面的内假体（例如，支架）。

16. 发明申请

US20060095123A1 Stent for delivering a therapeutic agent having increased body tissue contact surface 有权
公开(公告)号：US20060095123A1
公开(公告)日：2006-05-04
申请号：US10982356
申请日：2004-11-04
申请人： Aiden Flanagan
发明人： Aiden Flanagan
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2230/0013 , A61F2250/0067 , A61L31/10 , A61L31/16 , A61L2300/416
摘要： A stent for implantation in a body lumen is described comprising at least one strut having an inner surface, an outer surface, a first side surface disposed between the inner surface and the outer surface, and a second side surface disposed between the inner surface and the outer surface; wherein the first side surface and the second side surface converge toward one another in the direction of the outer surface; and a coating comprising a therapeutic agent disposed on at least a portion of a surface of the strut.

17. 发明授权

US09186209B2 Nerve modulation system having helical guide 有权
标题翻译：神经调制系统具有螺旋引导
公开(公告)号：US09186209B2
公开(公告)日：2015-11-17
申请号：US13554459
申请日：2012-07-20
申请人： Jan Weber , Aiden Flanagan , Tim O'Connor
发明人： Jan Weber , Aiden Flanagan , Tim O'Connor
IPC分类号： A61B18/14 , A61N1/05 , A61B18/00
CPC分类号： A61N1/0551 , A61B2018/00511 , A61B2018/00577 , F04C2270/0421
摘要： Systems for nerve modulation and methods for making and using the same are disclosed. An example system for nerve modulation may include a first elongate element having a distal end and a proximal end and having a helical guide having a proximal end and a distal end. The system may also include a second elongate element having a distal end and a proximal end and having a nerve modulation element proximate the distal end. A sheath may be disposed about both the first and second elongate elements. Pulling proximally on the proximal end of the first elongate element may cause simultaneous radial and longitudinal displacement of the nerve modulation element.
摘要翻译：公开了神经调制系统及其制造和使用方法。用于神经调节的示例性系统可以包括具有远端和近端的具有近端和远端的螺旋引导件的第一细长元件。该系统还可以包括具有远端和近端并且具有靠近远端的神经调制元件的第二细长元件。鞘可围绕第一和第二细长元件设置。在第一细长元件的近端上向近侧拉动可引起神经调制元件的同时径向和纵向位移。

18. 发明授权

US08864816B2 Implantable medical devices incorporating x-ray mirrors 有权
标题翻译：可植入的医疗设备，包含x射线镜
公开(公告)号：US08864816B2
公开(公告)日：2014-10-21
申请号：US13419864
申请日：2012-03-14
申请人： Jan Weber , Aiden Flanagan
发明人： Jan Weber , Aiden Flanagan
IPC分类号： A61F2/06 , A61L27/10 , A61L29/18 , A61L31/02 , A61L27/04 , A61L31/18 , G21K1/06 , A61F2/915
CPC分类号： A61L31/18 , A61F2/915 , A61F2002/91575 , A61F2230/0054 , A61L27/04 , A61L27/10 , A61L29/18 , A61L31/022 , A61L31/026 , B82Y10/00 , G21K1/062
摘要： An implantable medical device includes a radiolucent member provided with an x-ray mirror that reflects incident x-ray radiation to enable visualization of the device. The x-ray mirror includes a multilayer nanolaminate having alternating layers of a first metal or ceramic layer deposited by atomic layer deposition having a first refractive index, and a second metal or ceramic layer deposited by atomic layer deposition having a second refractive index that is different from the first refractive index. The nanolaminate includes a total of at least four layers.
摘要翻译：可植入医疗装置包括设置有x射线反射镜的射线可透射部件，该X射线反射镜反射入射的X射线辐射以使装置可视化。 x射线镜包括具有通过具有第一折射率的原子层沉积沉积的第一金属或陶瓷层的交替层的多层纳米材料，以及通过原子层沉积而沉积的第二金属或陶瓷层，其具有不同的第二折射率从第一折射率。纳米层压材料总共包括至少四层。

19. 发明授权

US08703168B2 Medical devices for releasing therapeutic agent and methods of making the same 有权
标题翻译：用于释放治疗剂的医疗装置及其制造方法
公开(公告)号：US08703168B2
公开(公告)日：2014-04-22
申请号：US12109677
申请日：2008-04-25
申请人： Aiden Flanagan , Robert Herrmann , Ken Merdan , Michael Kuehling , Barry O'Brien , Rajesh Radhakishnan , Torsten Scheuermann , Scott Schewe , Anurag Singhal , Young-Ho Song , Mary Joe Timm , Jan Weber , Yixin Xu
发明人： Aiden Flanagan , Robert Herrmann , Ken Merdan , Michael Kuehling , Barry O'Brien , Rajesh Radhakishnan , Torsten Scheuermann , Scott Schewe , Anurag Singhal , Young-Ho Song , Mary Joe Timm , Jan Weber , Yixin Xu
IPC分类号： A61F2/00
CPC分类号： A61F2/91 , A61F2/3094 , A61F2002/30677 , A61F2002/3068 , A61F2210/0076 , A61F2230/0013 , A61F2240/001 , A61F2250/0067 , A61F2250/0068
摘要： An implantable medical device for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures disposed on a surface of the body. A reservoir can be defined by the reservoir-defining structures and therapeutic agent may be located in the reservoir. A cover may extend over the reservoir so that the therapeutic agent is released from the reservoir when the medical device implanted. Methods for making the medical device may also include providing a medical device body, positioning a plurality of reservoir-defining structures on a surface of the body to form a reservoir, loading therapeutic agent into the reservoir, and covering the reservoir so that the therapeutic agent may release when the medical device is implanted. Alternatively, the reservoir may be covered with a cover and an opening formed in the cover so that the therapeutic agent may release when the medical device is implanted.
摘要翻译：一种用于释放具有医疗装置主体的治疗剂的可植入医疗装置和设置在身体表面上的多个储存器限定结构。储存器可以由储存器限定结构限定，并且治疗剂可以位于储存器中。覆盖物可以延伸到储存器上方，使得当植入医疗装置时治疗剂从储存器释放。用于制造医疗装置的方法还可以包括提供医疗装置主体，在身体的表面上定位多个储存器限定结构以形成储存器，将治疗剂装载到储存器中并覆盖储存器，使得治疗剂当植入医疗器械时可能释放。或者，储存器可覆盖有形成在盖中的盖和开口，使得治疗剂可以在植入医疗装置时释放。

20. 发明授权

US08586072B2 Medical devices having coatings for controlled therapeutic agent delivery 有权
公开(公告)号：US08586072B2
公开(公告)日：2013-11-19
申请号：US11983796
申请日：2007-11-09
申请人： Jan Weber , Aiden Flanagan , Tim O'Connor , Barry J. O'Brien , John Clarke , David McMorrow
发明人： Jan Weber , Aiden Flanagan , Tim O'Connor , Barry J. O'Brien , John Clarke , David McMorrow
IPC分类号： A61F2/00 , A61L27/30 , A61L31/16 , A61N1/05
CPC分类号： A61F2/06 , A61F2250/0068 , A61L27/30 , A61L27/54 , A61L31/082 , A61L31/16 , A61L2300/00 , A61L2400/12 , A61N1/05
摘要： According to an aspect of the invention, medical devices are provided, which include a nanoparticle-derived inorganic layer disposed over a least a portion of structure that includes a substrate, and optionally, a therapeutic-agent-containing layer disposed over at least a portion of the substrate. In some embodiments, the inorganic layer is a nanoporous inorganic layer. Other aspects of the invention comprise methods for forming such medical device.

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