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11. 发明申请

US20110214678A1 Adjustable Support for Soft Palate and Implanting Method Thereof 有权
标题翻译：可调软支撑支撑及其植入方法
公开(公告)号：US20110214678A1
公开(公告)日：2011-09-08
申请号：US13129383
申请日：2009-11-16
申请人： Xiangmin Zhang , Xing Zhou
发明人： Xiangmin Zhang , Xing Zhou
IPC分类号： A61F5/56
CPC分类号： A61F2/20 , A61F5/566
摘要： An adjustable soft palate support and an implantation method are provided. The adjustable soft palate support is a flat implant made of a material capable of being implanted into a human body for a long term, including a hard palate connecting end and a support. The support is a flat implant capable of being inserted into a soft palate, and is connected to the hard palate connecting end. The hard palate connecting end includes a connecting structure and an adjustment mechanism connected to a hard palate. The connecting structure on the hard palate connecting end is configured to fix the support to the hard palate, and the adjustment mechanism on the hard palate connecting end is configured to control the movement or a curvature of the support or a lifting degree of the soft palate. Since the hard palate connecting end is fixed to the hard palate, and the support is implanted into a muscular layer of the soft palate, a relaxed and collapsed soft palate and a root portion of a tongue are lifted by using the hard palate as a supporting point. Since swallowing occurs frequently in a non-sleep state, the adjustment mechanism is set to be in an on state, so that the support implanted into the soft palate can move with the natural swinging of the soft palate, so as to reduce interference with swallowing; and before sleep, a control key of the adjustment mechanism on the hard palate is pushed with a finger or an apex of tongue to set the adjustment mechanism to be in an off state, so that the support implanted into the soft palate can lift the soft palate, and change a central axis of the soft palate during natural swinging by lifting the soft palate towards the tongue root, so as to enlarge an airway of a pharynx during breathing, thereby achieving the objectives of treating snoring and obstructive sleep apnea/hypopnea syndrome (OSAHS).
摘要翻译：提供了可调软腭支撑和植入方法。可调节的软腭支撑是由能够长期植入人体的材料制成的扁平植入物，包括硬腭连接端和支撑物。支撑体是能够插入软腭的扁平植入物，并连接到硬腭连接端。硬腭连接端包括连接结构和连接到硬腭的调节机构。硬腭连接端的连接结构被配置为将支撑件固定到硬腭上，并且硬腭连接端上的调节机构被配置为控制支撑件的运动或曲率或软腭的提升程度。由于硬腭连接端固定在硬腭上，并且将支撑植入软腭的肌肉层中，通过使用硬腭作为支撑来提升松弛和塌陷的软腭和舌部的根部部分点。由于在非睡眠状态下经常发生吞咽，所以调节机构被设定为开状态，使得植入软腭中的支撑体随着软腭的自然摆动而移动，以减少对吞咽的干扰 ; 在睡眠前，用手指或舌尖推动硬腭上的调节机构的控制键，将调节机构设定为关闭状态，使得植入软腭的支撑体能够提升软腭通过将软腭向舌根提起软腭，从而在呼吸过程中扩大咽喉气道，从而达到治疗打鼾和阻塞性睡眠呼吸暂停/呼吸不足综合征的目的，在自然摇摆过程中改变软腭的中心轴线（OSAHS）。

12. 发明授权

US10603206B2 Lateral pharyngeal wall tractor and implantation method 有权
公开(公告)号：US10603206B2
公开(公告)日：2020-03-31
申请号：US15600216
申请日：2017-05-19
申请人： Xing Zhou , Xiangmin Zhang
发明人： Xing Zhou , Xiangmin Zhang
IPC分类号： A61F5/56 , A61B17/04 , A61B17/24 , A61F2/20 , A61B17/02
摘要： A lateral pharyngeal wall tractor including a bone fixer, a traction mechanism and a lateral pharyngeal wall fixer; wherein the lateral pharyngeal wall fixer is configured to be fixed on an M. palatopharyngeus or other submucous tissues of a lateral pharyngeal wall; the bone fixer is configured to be fixed on a processus alveolaris or a hamulus pterygoideus or a processus pterygoideus as a supporting point; one end of the traction mechanism is connected to the bone fixer, the other end is connected to the lateral pharyngeal wall fixer; the elastic traction force produced by the traction mechanism is greater than the collapse force of the lateral pharyngeal wall which is produced by negative pressure during inspiration, but is less than the contraction force which is produced by the muscle of the lateral pharyngeal wall during deglutition.

13. 发明申请

US20110174315A1 Implanted Soft Palate Support and Implantation Method 有权
标题翻译：植入式软腭支持和植入方法
公开(公告)号：US20110174315A1
公开(公告)日：2011-07-21
申请号：US13060716
申请日：2009-06-18
申请人： Xiangmin Zhang , Xing Zhou
发明人： Xiangmin Zhang , Xing Zhou
IPC分类号： A61F5/56
CPC分类号： A61L31/14 , A61F5/56
摘要： An implanted soft palate support and an implantation method are provided. The implanted soft palate support is a flat implant made of a material capable of being implanted into human tissues for a long time period, and includes a hard palate connecting end and a support. The hard palate connecting end has a connecting structure connected with a hard palate; the support is a flat implant capable of being inserted into a soft palate; and the hard palate connecting end is connected to the support. The implanted soft palate support can achieve the objectives of treating OSAHS and snoring by effectively lifting the collapsed soft palate during sleep and thereby reducing an upper airway obstruction condition. In particular, the soft palate support can be adjusted within a certain range to calibrate its shape and curvature event after the surgery, so as to achieve optimal treatment and comfort.
摘要翻译：提供植入的软腭支撑和植入方法。植入的软腭支撑是由能够长时间植入人体组织的材料制成的扁平植入物，并且包括硬腭连接端和支撑体。硬腭连接端具有与硬腭连接的连接结构; 该支撑件是能够插入软腭的扁平植入物; 并且硬腭连接端连接到支撑。植入的软腭支撑可以通过在睡眠期间有效地抬起塌陷的软腭来实现治疗OSAHS和打鼾的目的，从而减少上呼吸道阻塞状况。特别地，软腭支撑可以在一定范围内进行调节，以校准手术后的形状和曲率事件，从而达到最佳的治疗和舒适度。

14. 发明申请

US20100285592A1 SINGLE EXPRESSION VECTOR FOR GENERATION OF A VIRUS WITH A SEGMENTED GENOME 有权
标题翻译：用于产生具有分离基因的病毒的单个表达载体
公开(公告)号：US20100285592A1
公开(公告)日：2010-11-11
申请号：US12759842
申请日：2010-04-14
申请人： Roy Curtiss, III , Xiangmin Zhang
发明人： Roy Curtiss, III , Xiangmin Zhang
IPC分类号： C12N15/64 , C12N15/63
CPC分类号： C12N7/00 , C07K14/005 , C12N15/85 , C12N2760/16051 , C12N2760/16122 , C12N2760/16151 , C12N2800/103 , C12N2830/36 , C12N2840/20
摘要： The present invention encompasses an expression vector that is capable of generating a virus from a segmented genome. In particular, a single expression vector may be utilized to produce influenza virus in cultured cells. The expression vector can be delivered in a purified DNA form or by a suitably designed bacterial carrier to cells in culture or to animals. This invention increases the virus generation efficiency, which benefits vaccine development. The bacterial carrier harboring such a plasmid encoding an attenuated virus may be used as a vaccine against corresponding viral disease.
摘要翻译：本发明包括能够从分段基因组产生病毒的表达载体。特别地，单个表达载体可用于在培养的细胞中产生流感病毒。表达载体可以纯化的DNA形式或适当设计的细菌载体递送至培养物或动物细胞。本发明增加病毒生成效率，有利于疫苗开发。携带这种编码减毒病毒的质粒的细菌载体可以用作针对相应病毒性疾病的疫苗。

15. 发明授权

US06310623B1 Method for manual editing of a closed contour 失效
标题翻译：手动编辑封闭轮廓的方法
公开(公告)号：US06310623B1
公开(公告)日：2001-10-30
申请号：US09086358
申请日：1998-05-28
申请人： Xiangmin Zhang
发明人： Xiangmin Zhang
IPC分类号： G06K936
CPC分类号： G06T11/60 , G06T7/0012 , G06T7/12 , G06T7/66 , G06T11/203 , G06T2207/10132 , G06T2207/30048
摘要： A closed contour editing method is provided for use in manually defining and changing an intravascular ultrasonic image segment consisting of a single lobe displayed on a computer screen comprises marking end points of the segment to be changed, drawing the change between the endpoints while leaving all segments displayed, calculating the three centroids for each of the three resultant segmentations of the contour and based on the results, selecting the preferred segment to close the contour while simultaneously deselecting the undesired segment.
摘要翻译：提供一种闭合轮廓编辑方法，用于手动定义和改变由计算机屏幕上显示的单瓣组成的血管内超声图像段，包括标记要改变的段的终点，绘制端点之间的变化，同时留下所有段显示，为轮廓的三个合成分割中的每一个计算三个质心，并且基于结果，选择优选的分段以关闭轮廓，同时取消选择不期望的分段。

16. 发明授权

US06181810B2 Method and apparatus for spatial and temporal filtering of intravascular ultrasonic image data 失效
标题翻译：血管内超声图像数据空间和时间过滤的方法和装置
公开(公告)号：US06181810B2
公开(公告)日：2001-01-30
申请号：US09127029
申请日：1998-07-30
申请人： Xiangmin Zhang , Tat-Jin Teo
发明人： Xiangmin Zhang , Tat-Jin Teo
IPC分类号： G06D900
CPC分类号： G06T5/10 , G01S7/52036 , G06T5/002 , G06T2207/20056 , G06T2207/20182
摘要： A method and an apparatus are provided for combining spatial and temporal filtering for blood speckle reduction in high frequency ultrasound images wherein a sequence of image frames is processed to produce a binary mask. In this mask, a first value is assigned to regions of identified blood speckles and a second value is assigned to regions of the remainder. The images are then modulated with the mask, i.e., by applying different filtering techniques to assigned blood regions and assigned nonblood (i.e., tissue) regions, the filtering techniques having been selected to optimize images for the type of feature to be highlighted based on differences in frequency sensitivity between blood and tissue. The images are preferably in polar coordinate format. The degree of blood speckle suppression can be determined based on the actual values of the pixels at the same spatial location in given frames.
摘要翻译：提供一种用于组合高频超声图像中的血斑散射的空间和时间滤波的方法和装置，其中处理一系列图像帧以产生二进制掩模。在该掩模中，将第一值分配给所识别的血斑的区域，并且将第二值分配给剩余部分的区域。然后，利用掩模调制图像，即通过对分配的血液区域和分配的非血液（即组织）区域应用不同的滤波技术，已经选择了滤波技术以根据差异来优化要强调的特征类型的图像在血液和组织之间的频率敏感性。图像优选地是极坐标格式。可以基于给定帧中相同空间位置处的像素的实际值来确定血斑散布度。

17. 发明申请

US20170252204A1 LATERAL PHARYNGEAL WALL TRACTOR AND IMPLANTATION METHOD 审中-公开
公开(公告)号：US20170252204A1
公开(公告)日：2017-09-07
申请号：US15600216
申请日：2017-05-19
申请人： Xing ZHOU , Xiangmin ZHANG
发明人： Xing ZHOU , Xiangmin ZHANG
IPC分类号： A61F5/56 , A61B17/04 , A61B17/24 , A61F2/20
CPC分类号： A61F5/566 , A61B17/02 , A61B17/0401 , A61B17/24 , A61B2017/0417 , A61B2017/044 , A61B2017/0448 , A61B2017/0464 , A61B2017/0496 , A61B2017/248 , A61F2/20 , A61F5/56
摘要： A lateral pharyngeal wall tractor comprises a bone fixer, a traction mechanism and a lateral pharyngeal wall fixer. The lateral pharyngeal wall fixer is fixed on an M. palatopharyngeus or other submucous tissues of a lateral pharyngeal wall. With the bone fixer fixed on a processus alveolaris or a hamulus pterygoideus or a processus pterygoideus as a supporting point, one end of the traction mechanism is connected to the bone fixer, the other end is connected to the lateral pharyngeal wall fixer, and as a result, the submucous tissue of the lateral pharyngeal wall is pulled outward. The elastic traction force produced by the traction mechanism is greater than the collapse force of the lateral pharyngeal wall which is produced by negative pressure during inspiration, but is less than the contraction force which is produced by the muscle of the lateral pharyngeal wall during deglutition.

18. 发明申请

US20170252203A1 IMPLANTED TONGUE SEPTUM FASCIA RETRACTION DEVICE AND IMPLANTATION METHOD 审中-公开
公开(公告)号：US20170252203A1
公开(公告)日：2017-09-07
申请号：US15600185
申请日：2017-05-19
申请人： Xing ZHOU , Xiangmin ZHANG
发明人： Xing ZHOU , Xiangmin ZHANG
IPC分类号： A61F5/56 , A61B17/04 , A61B17/24 , A61F2/20
CPC分类号： A61F5/566 , A61B17/02 , A61B17/0401 , A61B17/24 , A61B2017/0417 , A61B2017/044 , A61B2017/0448 , A61B2017/0464 , A61B2017/0496 , A61B2017/248 , A61F2/20 , A61F5/56
摘要： An implanted tongue septum fascia retraction device includes a fascia fixer, a pull line and a mandible fixer. The fascia fixer is fixed to a tongue septum fascia by means of a fixing clamp, a fixing hook or a fixing ring, and the mandible fixer is fixed to a mandible. One end of the pull line is connected to the fascia fixer, and the other end of the pull line is fixed to the mandible fixer. By adjusting the tightness of a pull line, a tongue septum fascia may be retracted forwards, thus pulling a falling tongue base forwards, opening an obstructed upper airway, and fulfilling the aim of treating snoring and obstructive sleep apnea/hypopnea syndrome (OSA) caused by glossoptosis.

19. 发明授权

US09163219B2 Single expression vector for generation of a virus with a segmented genome 有权
标题翻译：用于产生具有分段基因组的病毒的单一表达载体
公开(公告)号：US09163219B2
公开(公告)日：2015-10-20
申请号：US12759842
申请日：2010-04-14
申请人： Roy Curtiss, III , Xiangmin Zhang
发明人： Roy Curtiss, III , Xiangmin Zhang
IPC分类号： C12N15/63 , C12N1/21 , C12N7/00 , C07K14/005 , C12N15/85
CPC分类号： C12N7/00 , C07K14/005 , C12N15/85 , C12N2760/16051 , C12N2760/16122 , C12N2760/16151 , C12N2800/103 , C12N2830/36 , C12N2840/20
摘要： The present invention encompasses an expression vector that is capable of generating a virus from a segmented genome. In particular, a single expression vector may be utilized to produce influenza virus in cultured cells. The expression vector can be delivered in a purified DNA form or by a suitably designed bacterial carrier to cells in culture or to animals. This invention increases the virus generation efficiency, which benefits vaccine development. The bacterial carrier harboring such a plasmid encoding an attenuated virus may be used as a vaccine against corresponding viral disease.
摘要翻译：本发明包括能够从分段基因组产生病毒的表达载体。特别地，单个表达载体可用于在培养的细胞中产生流感病毒。表达载体可以纯化的DNA形式或适当设计的细菌载体递送至培养物或动物细胞。本发明增加病毒生成效率，有利于疫苗开发。携带这种编码减毒病毒的质粒的细菌载体可以用作针对相应病毒性疾病的疫苗。

20. 发明申请

US20130327341A1 LAYERED SOFT PALATE SUPPORT AND IMPLANTATION METHOD 有权
标题翻译：层状软木支撑和植被方法
公开(公告)号：US20130327341A1
公开(公告)日：2013-12-12
申请号：US14000598
申请日：2012-05-09
申请人： Xiangmin Zhang , Xing Zhou
发明人： Xiangmin Zhang , Xing Zhou
IPC分类号： A61F5/56
CPC分类号： A61F5/566
摘要： The present invention relates to a layered soft palate support and an implantation method for treating sleep apnea/hypopnea syndrome or snoring. The layered soft palate support is a flat implant made of a material capable of being implanted into a human body for a long term, and includes a hard palate connecting end and a support. The support is a layered structure formed by stacking two or more layers of supporting plates and capable of being inserted into a soft palate, and is removably or irremovably fixed to the hard palate connecting end. The hard palate connecting end has a connecting structure connected with a hard palate, and is fixed to the hard palate through the connecting structure. The support is implanted into a muscular layer of the soft palate, and is inserted into the soft palate by a length equal to ⅕ to ⅘ of its total length.
摘要翻译：本发明涉及一种分层软腭支架和一种治疗睡眠呼吸暂停/呼吸不足综合征或打鼾的植入方法。分层软腭支撑是由能够长期植入人体的材料制成的扁平植入物，并且包括硬腭连接端和支撑体。支撑体是通过层叠两层或更多层支撑板并且能够插入软腭而形成的分层结构，并且可移除地或不可移除地固定到硬腭连接端。硬腭连接端具有与硬腭连接的连接结构，并通过连接结构固定到硬腭。将支撑植入软腭的肌肉层中，并将其插入软腭中的长度等于其总长度的1/5至4/5的长度。

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