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11. 发明授权

US4957110A Steerable guidewire having electrodes for measuring vessel cross-section and blood flow 失效
标题翻译：具有用于测量血管横截面和血流量的电极的可导向导丝
公开(公告)号：US4957110A
公开(公告)日：1990-09-18
申请号：US325223
申请日：1989-03-17
申请人： Robert A. Vogel , William A. Berthiaume , Thomas J. Palermo
发明人： Robert A. Vogel , William A. Berthiaume , Thomas J. Palermo
IPC分类号： A61B5/026 , A61B5/027 , A61B5/042
CPC分类号： A61B5/6855 , A61B5/027 , A61B5/0295 , A61B5/0422 , A61B5/6851 , A61B5/6853
摘要： A small diameter steerable guidewire that is used to guide a catheter in transluminal coronary angioplasty is provided with a pair of electrodes for measuring the cross-sectional area of a blood vessel and for measuring blood flow. The guidewire includes a shaft and a tip attached to the distal end of the shaft. The shaft is torsionally rigid along its length and includes a conductive tube and a wire extending through the tube. The tip, which can be bent to a prescribed curve when relaxed, is sufficiently flexible to adapt to and follow the contours of a blood vessel. The tip includes a tapered extension of the wire in the shaft. A proximal electrode and a distal electrode are coaxially mounted on the tapered wire and are electrically connected to the tube and the wire, respectively. The electrodes are axially spaced apart by a predetermined distance. Each electrode is preferably a conductive, helically-wound spring. The outside diameter of the steerable guidewire preferably does not exceed about 0.020-inch for coronary use.

12. 发明申请

US20130103047A1 DELIVERY SYSTEM ASSEMBLIES AND ASSOCIATED METHODS FOR IMPLANTABLE MEDICAL DEVICES 有权
公开(公告)号：US20130103047A1
公开(公告)日：2013-04-25
申请号：US13279835
申请日：2011-10-24
申请人： H. Allan Steingisser , Don H. Tran , William A. Berthiaume , Brent L. Locsin
发明人： H. Allan Steingisser , Don H. Tran , William A. Berthiaume , Brent L. Locsin
IPC分类号： A61B19/00
CPC分类号： A61N1/37205 , A61N1/3622 , A61N1/3756 , A61N2001/0578
摘要： A delivery system assembly includes an outer tube, an inner member, extending within a lumen of the outer tube, and a deflectable shaft, extending within the outer tube lumen and around the inner member; the tube and inner member are longitudinally moveable with respect to the shaft, and a distal end of the inner member is located distal to the shaft within the tube lumen. A medical device can be loaded into the tube lumen, along a distal-most portion of the tube, and contained between the inner member and a distal opening of the tube lumen. Deflecting the shaft orients the distal-most portion for navigation of the assembly, and, when the distal end of the inner member is engaged within the tube lumen, distal movement of the tube, with respect to the shaft, causes similar distal movement of the inner member and the loaded medical device toward an implant site.

13. 发明授权

US5591194A Telescoping balloon catheter and method of use 失效
标题翻译：伸缩气囊导管及使用方法
公开(公告)号：US5591194A
公开(公告)日：1997-01-07
申请号：US485655
申请日：1995-06-07
申请人： William A. Berthiaume
发明人： William A. Berthiaume
IPC分类号： A61F2/958 , A61M25/00 , A61M25/01 , A61M29/00
CPC分类号： A61M25/00 , A61M25/10 , A61M2025/0175 , A61M25/0169
摘要： A catheter wherein the "effective over-the-wire" length is adjustable. The catheter includes an elongated inflation shaft having a longitudinal inflation lumen, an extension shaft disposed distal to the inflation shaft and through which the inflation lumen is continued, a balloon element disposed at the distal end of the extension shaft and in fluid communication with the inflation lumen, a guidewire shaft having a longitudinal guidewire lumen which extends from the distal end of the balloon member, through the balloon member and the extension shaft, to the proximal end of the extension shaft, and a telescoping portion. The telescoping portion comprising first and second telescoping tubes which are slidably mounted on the inflation shaft and the extension shaft. The first and second telescoping tubes are sized so that the first telescoping tube can be retracted into the second telescoping tube. The extension shaft is sized so that it can be retracted into the first telescoping tube. The effective "over-the-wire length" of the telescoping balloon catheter can be reduced by retracting the first telescoping tube and the extension tube into the second telescoping tube. In another embodiment, the telescoping portion comprises three telescoping tubes, which results in a greater reduction of the effective "over-the-wire length."
摘要翻译：导管，其中“有效的线上”长度是可调节的。导管包括细长的充气轴，其具有纵向充气腔，延伸轴设置在充气轴的远侧并且充气腔持续通过该延伸轴，球囊元件设置在延伸轴的远端处并与膨胀流体连通具有从球囊构件的远端延伸通过气囊构件和延伸轴的纵向导丝管的导丝轴到延伸轴的近端以及伸缩部分。伸缩部分包括可滑动地安装在膨胀轴和延伸轴上的第一和第二伸缩管。第一和第二伸缩管的尺寸使得第一伸缩管能够缩回到第二伸缩管中。延伸轴的尺寸使得其可以缩回到第一伸缩管中。可以通过将第一伸缩管和延伸管缩回到第二伸缩管中来缩小伸缩气囊导管的有效“超线长度”。在另一个实施例中，伸缩部分包括三个伸缩管，其导致有效的“在线长度”的更大的减小。

14. 发明授权

US5409470A Dilatation catheter and guidewire with threaded tip connection 失效
标题翻译：扩张导管和带螺纹尖端连接的导丝
公开(公告)号：US5409470A
公开(公告)日：1995-04-25
申请号：US58644
申请日：1993-05-07
申请人： Jon T. McIntyre , William A. Berthiaume
发明人： Jon T. McIntyre , William A. Berthiaume
IPC分类号： A61M29/02 , A61M25/00
CPC分类号： A61M25/104 , A61M25/09 , A61M2025/0004 , A61M2025/09175 , A61M2025/1093
摘要： A guidewire and catheter are adapted for advancement through tight or tortuous vascular anatomy by providing detachably connectible threaded elements at the distal ends of each of the catheter and guidewire. When threaded together, the combined catheter and guidewire provide enhanced column strength to facilitate pushing the two together through the vascular anatomy. Alternately, the guidewire may be rotated in a manner that draws the catheter in screw-like fashion in a distal direction.
摘要翻译：通过在每个导管和导丝的远端提供可拆卸地连接的螺纹元件，导丝和导管适于通过紧密或曲折的血管解剖进展。当组合在一起时，组合的导管和导丝提供增强的柱强度以便于将两者一起推动通过血管解剖结构。或者，导丝可以以沿螺旋状的方式在远侧方向上拉动导管的方式旋转。

15. 发明授权

US5377690A Guidewire with round forming wire 失效
标题翻译：导丝带圆形丝
公开(公告)号：US5377690A
公开(公告)日：1995-01-03
申请号：US15642
申请日：1993-02-09
申请人： William A. Berthiaume
发明人： William A. Berthiaume
IPC分类号： A61M25/01 , A61B5/00 , A61M25/09
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09175
摘要： A guidewire including a core wire extending into a lumen of a helical coil and having a proximal end of the helical coil fixedly attached thereto. At least one round forming wire is fixedly attached to a distal region of the core wire and extends through the lumen of the helical coil. A rounded protrusion is provided at a distal end of the helical coil with the round forming wire(s) and the helical coil fixedly attached thereto.
摘要翻译：导线，其包括延伸到螺旋线圈的内腔中并具有固定地附接到其上的螺旋线圈的近端的芯线。至少一个圆形的丝线固定地附接到芯线的远侧区域并延伸穿过螺旋线圈的内腔。在螺旋形线圈的远端处设置有圆形突起，其中圆形成线和螺旋线圈固定地附接到其上。

16. 发明申请

US20130079798A1 DELIVERY SYSTEM ASSEMBLIES FOR IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：用于可植入医疗器械的输送系统组件
公开(公告)号：US20130079798A1
公开(公告)日：2013-03-28
申请号：US13239990
申请日：2011-09-22
申请人： Don H. Tran , William A. Berthiaume , H. Allan Steingisser , Maria Valdovinos , Brent L. Locsin , Suruchi Anand
发明人： Don H. Tran , William A. Berthiaume , H. Allan Steingisser , Maria Valdovinos , Brent L. Locsin , Suruchi Anand
IPC分类号： A61B19/00
CPC分类号： A61B17/3468 , A61N1/362 , A61N1/37205 , A61N1/3756
摘要： A delivery system assembly includes an elongate inner member that extends distally through a lumen of an elongate outer tube of the assembly; the outer tube is moveable relative to the inner member between first and second positions to deploy an implantable medical device that is held within the outer tube lumen. The inner member may include a flared distal end that abuts, and preferably conforms to, the proximal end of the device, when the device is held within the outer tube lumen. The assembly further includes a stability sheath that surrounds a limited length of the outer tube, in proximity to the handle, to provide an interface for both an operator, who handles the assembly, and for an introducer sheath that provides passage for the assembly into the venous system, so that movement of the outer tube is not hindered by either during device deployment.
摘要翻译：输送系统组件包括细长的内部构件，其向远侧延伸穿过组件的细长外管的内腔; 外管可在第一和第二位置之间相对于内部构件移动以展开保持在外管内腔内的可植入医疗装置。当装置保持在外管腔内时，内部构件可以包括邻近并且优选地符合装置的近端的扩口远端。组件还包括稳定的护套，其围绕外管的有限长度围绕手柄，以提供用于处理组件的操作者和导引器护套的接口，所述引导器护套为组件提供通道静脉系统，使得在设备部署期间外部管的运动不会受到阻碍。

17. 发明申请

US20130053921A1 HOLDING MEMBERS FOR IMPLANTABLE CARDIAC STIMULATION DEVICES 有权
标题翻译：用于可植入心脏刺激装置的控股成员
公开(公告)号：US20130053921A1
公开(公告)日：2013-02-28
申请号：US13219279
申请日：2011-08-26
申请人： Matthew D. Bonner , Thomas A. Anderson , William A. Berthiaume , Noelle C. Hurtig
发明人： Matthew D. Bonner , Thomas A. Anderson , William A. Berthiaume , Noelle C. Hurtig
IPC分类号： A61N1/362
CPC分类号： A61N1/37205 , A61N1/0573 , A61N1/362 , A61N1/3756
摘要： A holding member for an implantable cardiac device facilitates tether attachment and removal, at time of implant, and snaring, or otherwise capturing, for subsequent explant. Preferably located in proximity to a proximal end wall of a shell of the device, the holding member includes a strut portion, being spaced proximally apart from the proximal end wall, a waist portion, defining a recess, and an engagement section, extending between the strut portion and the waist portion and overhanging the recess. The waist portion may either extend between the strut portion and the proximal end wall, or be formed in the shell, distal to the proximal end wall. Alternately, the holding member includes a loop element and an engagement element coupled thereto, between first and second segments thereof. The segments are initially formed to give the loop element an opening, and have a flexibility to be compressed together.
摘要翻译：用于可植入心脏装置的保持构件促进在植入时的系链附着和移除，并且用于后续外植体的瘢痕或其它捕获。优选地，所述保持构件优选地位于所述装置的壳体的近端壁附近，所述支撑构件包括支撑部分，所述支柱部分与所述近端壁向近侧间隔开，限定凹部的腰部和接合部分支撑部分和腰部，并且突出于凹部。腰部可以在支柱部分和近端壁之间延伸，或者形成在远离近端壁的壳体中。或者，保持构件包括环形元件和联接到其上的接合元件，在其第一和第二段之间。这些段最初形成为使环形元件成为开口，并且具有被压缩在一起的柔性。

18. 发明授权

US6053313A Catheter packaging system 失效
标题翻译：导管包装系统
公开(公告)号：US6053313A
公开(公告)日：2000-04-25
申请号：US91923
申请日：1998-06-24
申请人： Thomas Farrell , Kevin Treacy , William A. Berthiaume , Randall W. Davis
发明人： Thomas Farrell , Kevin Treacy , William A. Berthiaume , Randall W. Davis
IPC分类号： A61M25/00 , A61M25/16 , B65D85/671 , A61M29/00
CPC分类号： A61M25/002
摘要： A package is provided for a catheter which comprises an elongate tube, having a proximal end and a distal end, for receiving a catheter shaft. The proximal end includes a sleeve element sized to accommodate one or more catheter shaft accessories located on the proximal end of the catheter, and a retainer portion for releasably retaining the catheter and catheter shaft accessories. The retainer portion is engageable with the sleeve element and is axially slidable relative thereto, between a storage state in which the retainer portion and the retained catheter shaft accessories are located substantially within the sleeve element and a usable state in which the retainer portion and the retained catheter shaft accessories are withdrawn from the sleeve element.
摘要翻译： PCT No.PCT / IE97 / 00070 Sec。 371日期：1998年6月24日 102（e）1998年6月24日PCT PCT 1997年10月22日PCT公布。出版物WO98 / 日期1998年5月7日提供一种用于导管的包装件，其包括具有近端和远端的细长管，用于接收导管轴。近端包括尺寸适于容纳位于导管的近端上的一个或多个导管轴附件的套筒元件和用于可释放地保持导管和导管轴附件的保持器部分。所述保持器部分可与所述套筒元件接合并且在所述保持器部分和所述保持的导管轴附件基本位于所述套筒元件内的储存状态之间可相对于其轴向滑动，以及保持器部分和所述保持器部分的可使用状态导管轴附件从套筒元件中取出。

19. 发明授权

US5658309A Guidewire/inflation tube locking apparatus and method of use 失效
标题翻译：导丝/充气管锁定装置及使用方法
公开(公告)号：US5658309A
公开(公告)日：1997-08-19
申请号：US431546
申请日：1995-05-01
申请人： William A. Berthiaume , Nareak Douk
发明人： William A. Berthiaume , Nareak Douk
IPC分类号： A61M25/00 , A61M29/02 , A61M29/00
CPC分类号： A61M25/0169 , A61M25/0097 , A61M25/09 , A61M25/104 , A61M2025/0175 , A61M2025/0183 , A61M2025/09008 , A61M2025/09125
摘要： A locking apparatus for use with a catheter which includes a catheter body, first and second slidable components which are slidable with respect to the catheter body, and a hub disposed at the proximal end of the catheter body, and a method of using the locking apparatus. The locking apparatus includes a locking device engageable with the hub for locking the first slidable component in a fixed position relative to the hub, and an extension member that is integral with the hub and engageable with the locking device for locking the second slidable component in a fixed position relative to the hub.
摘要翻译：一种与导管一起使用的锁定装置，其包括导管主体，可相对于导管主体滑动的第一和第二可滑动部件以及设置在导管主体的近端的毂，以及使用该锁定装置的方法。锁定装置包括可与轮毂接合的锁定装置，用于将第一可滑动部件相对于轮毂锁定在固定位置;以及延伸部件，其与轮毂成一体并可与锁定装置接合，以将第二可滑动部件锁定在相对于轮毂的固定位置。

20. 发明授权

US5184621A Steerable guidewire having electrodes for measuring vessel cross-section and blood flow 失效
标题翻译：具有用于测量血管横截面和血流量的电极的可导向导丝
公开(公告)号：US5184621A
公开(公告)日：1993-02-09
申请号：US706776
申请日：1991-05-29
申请人： Robert A. Vogel , William A. Berthiaume , Carol A. Bertrand
发明人： Robert A. Vogel , William A. Berthiaume , Carol A. Bertrand
IPC分类号： A61B5/027
CPC分类号： A61B5/6851 , A61B5/027 , A61B5/0295 , A61M25/09
摘要： A small diameter steerable guidewire that is used to guide a catheter in transluminal coronary angioplasty is provided with a pair of electrodes for measuring the cross-sectional area of a blood vessel and for measuring blood flow. The guidewire includes a shaft and a tip attached to the distal end of the shaft. The shaft is torsionally rigid along its length and includes a conductive main tube and a wire extending through the main tube. The tip, which can be bent to a prescribed curve when relaxed, is sufficiently flexible to adapt to and follow the contours of a blood vessel. The tip includes a tapered extension of the wire in the shaft. A proximal electrode and a distal electrode are coaxially mounted on the tapered wire and are electrically connected to the main tube and the wire, respectively. The electrodes are axially spaced apart by a predetermined distance. The distal electrode is preferably a conductive, helically-wound spring. The proximal electrode can be a conductive electrode tube or a conductive, helically-wound spring. The outside diameter of the steerable guidewire preferably does not exceed about 0.020-inch for coronary use.
摘要翻译：用于引导导管在经腔冠状动脉血管成形术中的小直径导向导线设置有一对用于测量血管横截面积并用于测量血流量的电极。导丝包括轴和附接到轴的远端的尖端。轴沿其长度是扭转刚性的，并且包括导电主管和延伸穿过主管的线。当松弛时可以弯曲到规定曲线的尖端具有足够的柔性以适应和跟随血管的轮廓。尖端包括在轴中的线的锥形延伸部。近端电极和远端电极同轴地安装在锥形导线上并分别电连接到主管和电线。电极轴向间隔开预定距离。远端电极优选为导电的螺旋缠绕弹簧。近端电极可以是导电电极管或导电的螺旋缠绕弹簧。对于冠状动脉使用，可转向导丝的外径优选不超过约0.020英寸。

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