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11. 发明授权

US09561893B2 System and method for freeze-drying and packaging 有权
标题翻译：用于冷冻干燥和包装的系统和方法
公开(公告)号：US09561893B2
公开(公告)日：2017-02-07
申请号：US14553722
申请日：2014-11-25
申请人： Vascular Solutions, Inc.
发明人： Howard Root , Stephen Anthony Penegor , James Arnold Murto
IPC分类号： F26B5/06 , B65D81/24 , A61J1/10 , A61J1/14 , A61J1/20 , B65B3/00
CPC分类号： B65B63/08 , A61J1/10 , A61J1/1475 , A61J1/2093 , A61M5/14 , A61M2202/0415 , B65B3/003 , B65B7/02 , B65B51/225 , B65C1/02 , B65D81/245
摘要： A system and method for protecting biological or other material from contamination through the steps of filling, freeze-drying, packaging, storing and use are disclosed. A system can include a flexible container, a membrane configured to transmit air or solvent vapor out of the flexible container, and a membrane frame supporting the membrane and engaged with at least one column member. The at least one column member can be configured to maintain the membrane and the membrane frame a spaced distance from one or more contents received within the flexible container. Upon application of a downward force, the at least one column member can assume a collapsed configuration. A method can include inserting a biological material, for example, into a flexible container, freeze-drying the biological material, moving the freeze-dried biological material to a portion of the flexible container that includes at least one port, and sealing the biological material within the portion.
摘要翻译：公开了一种通过填充，冷冻干燥，包装，储存和使用步骤来保护生物或其他材料免受污染的系统和方法。系统可以包括柔性容器，被配置为将空气或溶剂蒸气从柔性容器中传出的膜，以及支撑膜并与至少一个柱构件接合的膜框架。至少一个柱构件可以构造成将膜和膜框架与容纳在柔性容器内的一个或多个内容物保持间隔开。在施加向下的力时，至少一个柱构件可以呈现收缩构型。一种方法可以包括将生物材料例如插入柔性容器中，冷冻干燥生物材料，将冷冻干燥的生物材料移动到包括至少一个端口的柔性容器的一部分，并密封生物材料在该部分内。

12. 发明授权

US09351747B2 Capture assembly and method 有权
标题翻译：捕获装配和方法
公开(公告)号：US09351747B2
公开(公告)日：2016-05-31
申请号：US14849774
申请日：2015-09-10
申请人： Vascular Solutions, Inc.
发明人： Chad Kugler , Steve Michael , Alexander Marine
IPC分类号： A61M5/00 , A61B17/22 , A61M1/00 , A61M5/315 , A61B17/3207
CPC分类号： A61B17/22031 , A61B17/22 , A61B17/3207 , A61B2017/22038 , A61B2017/22039 , A61B2017/22041 , A61B2017/22079 , A61B2017/22094 , A61B2217/005 , A61M1/0035 , A61M5/31511 , A61M25/005 , A61M25/09
摘要： This patent document discloses assemblies and methods for removing obstructive material from a body vessel or other cavity. An assembly can include an elongate inner member, an elongate outer member, an aspirator, one or more valves, and a waste collection reservoir. Each of the elongate members can extend from a proximal end portion to a distal end portion and can include a lumen therethrough. The elongate inner member can be partially disposed in the lumen of the elongate outer member and can be moveable along its longitudinal axis relative to the elongate outer member. The aspirator can be in flow communication with the proximal end portion of the elongate inner member for drawing the obstructive material into or through its lumen. The one or more valves can be configured and positioned to allow obstructive material removed from the body vessel or cavity to be urged toward the waste collection reservoir.
摘要翻译：该专利文献公开了用于从身体容器或其它空腔去除阻塞物质的组件和方法。组件可以包括细长内部构件，细长外部构件，抽吸器，一个或多个阀和废物收集容器。每个细长构件可以从近端部分延伸到远端部分，并且可以包括穿过其中的内腔。细长的内部构件可以部分地设置在细长的外部构件的内腔中，并且可以沿其纵向轴线相对于细长的外部构件移动。抽吸器可以与细长内部构件的近端部分流动连通，以将阻塞物材料吸入或通过其内腔。一个或多个阀可被构造和定位成允许从身体容器或空腔移除的阻塞物质被朝向废物收集容器推动。

13. 发明申请

US20160101262A1 CATHETER 有权
标题翻译：导管
公开(公告)号：US20160101262A1
公开(公告)日：2016-04-14
申请号：US14673966
申请日：2015-03-31
申请人： Vascular Solutions, Inc.
发明人： Howard C. Root , John Bridgeman , Steve Michael
IPC分类号： A61M25/00 , A61M25/09
CPC分类号： A61B17/320758 , A61M25/0043 , A61M25/0045 , A61M25/005 , A61M2025/006
摘要： Catheters and methods for supporting a guidewire or delivering a radiopaque, diagnostic or therapeutic agent through a vessel stenosis or other tortuous anatomy are disclosed. A catheter can comprise an elongate shaft body and a tip member disposed at a distal end of the shaft body. The shaft body can extend from a proximal end to the distal end and can define an inner lumen. The shaft body can include a liner, a braid member surrounding the liner, a multi-layer coil surrounding the braid member, and a polymer cover surrounding the multi-layer coil. The multi-layer coil can include first and second coil layers wound in opposing directions. An outer surface portion of the polymer cover can include one or more helical threads. In an example, the one or more helical threads are positioned around a distal end portion of the shaft body. The tip member can be made from a metal or a polymer and can also include one or more helical threads around its outer surface.
摘要翻译：公开了用于支撑导丝或通过血管狭窄或其他曲折解剖结构递送不透射线的诊断或治疗剂的导管和方法。导管可以包括细长轴体和设置在轴体的远端处的末端构件。轴体可以从近端延伸到远端并且可以限定内腔。轴体可以包括衬垫，围绕衬垫的编织构件，围绕编织构件的多层线圈和围绕多层线圈的聚合物盖。多层线圈可以包括沿相反方向缠绕的第一和第二线圈层。聚合物盖的外表面部分可以包括一个或多个螺旋形螺纹。在一个示例中，一个或多个螺旋形螺纹围绕轴体的远端部分定位。尖端构件可以由金属或聚合物制成，并且还可以包括围绕其外表面的一个或多个螺旋形螺纹。

14. 发明申请

US20150151081A1 GUIDE WIRE CONTROL CATHETER FOR CROSSING OCCLUSIONS AND RELATED METHODS OF USE 审中-公开
公开(公告)号：US20150151081A1
公开(公告)日：2015-06-04
申请号：US14619730
申请日：2015-02-11
申请人： Vascular Solutions, Inc.
发明人： Peter T. Keith , Dennis W. Wahr , Thomas V. Ressemann , David J. Blaeser , Timothy B. Petrick , Steven S. Hackett
IPC分类号： A61M25/01
CPC分类号： A61M25/0147 , A61B2017/22094 , A61M25/01 , A61M25/0136 , A61M25/0138 , A61M25/0144 , A61M25/0172 , A61M2025/0183 , A61M2025/1047
摘要： A wire control catheter for aligning and guiding a guide wire through a lesion in a vessel is provided. The wire control catheter includes a shaft having a guide wire lumen and a control wire lumen. A control wire passes through the control wire lumen and is used in combination with an articulation structure to deflect or curve a distal tip portion of the catheter. The distal catheter shaft may include a centering device for centering the catheter within the vessel. The distal catheter shaft may also include a pre-dilation balloon for dilating the lesion prior to performing angioplasty or other treatment on the lesion. A method of treatment of a blood vessel includes inserting a guide wire into the blood vessel and advancing a control wire over the guide wire until the distal tip of the catheter is near the occlusion in the blood vessel. The tip of the catheter then is deflected via a control wire and an articulation structure. The guide wire is then advanced across the occlusion. The control wire also may be advanced across the occlusion simultaneously with the guide wire or subsequent to the guide wire crossing. Prior to crossing the occlusion, the wire control catheter may be centered using a centering device. Subsequent to crossing the occlusion, the occlusion may be pre-dilated with a pre-dilation balloon of the wire control catheter.

15. 发明申请

US20140276628A1 DRAINAGE OR FEEDING CATHETER ASSEMBLY 有权
标题翻译：排水或进料管总成
公开(公告)号：US20140276628A1
公开(公告)日：2014-09-18
申请号：US14206940
申请日：2014-03-12
申请人： Vascular Solutions, Inc.
发明人： Eric Gandras , Howard Root , Dean Peterson
IPC分类号： A61M25/04 , A61J15/00 , A61M25/00
CPC分类号： A61M25/04 , A61J1/10 , A61J15/0046 , A61J15/0069 , A61M25/0017 , A61M2025/0024 , A61M2025/0063
摘要： Catheter assemblies, kits and methods allowing for the drainage or administration of fluid or small particles are disclosed. A catheter assembly can include a shaft with a lumen, an expandable retention member, an elongate actuation member and a locking mechanism. The expandable retention member can be positioned at a shaft distal end portion and can include one or more filaments forming a plurality of drainage or administration interstices of variable or uniform size. The elongate actuation member can include an actuation member distal end, directly or indirectly engaged with the expandable retention member, and an actuation member proximal end. Movement of the actuation member proximal end relative to a proximal end of the shaft can cause the expandable retention member to change from a lower-profile configuration to a higher-profile configuration. A moved position of the elongate actuation member can be secured by rotating, sliding or otherwise manipulating the locking mechanism.
摘要翻译：公开了允许流体或小颗粒的排放或给药的导管组件，试剂盒和方法。导管组件可以包括具有内腔的轴，可扩张保持构件，细长致动构件和锁定机构。可扩张保持构件可以定位在轴远端部分处，并且可以包括形成多个可变或均匀尺寸的排水管或管腔的一个或多个长丝。细长致动构件可以包括直接或间接地与可扩张保持构件接合的致动构件远端和致动构件近端。致动构件近端相对于轴的近端的运动可以使可扩张保持构件从小轮廓构型改变到更高轮廓的构造。可以通过旋转，滑动或以其他方式操纵锁定机构来固定细长致动构件的移动位置。

16. 发明申请

US20140249562A1 VASCULAR DILATOR SYSTEMS, KITS, AND METHODS 有权
标题翻译：血管扩张系统，套件和方法
公开(公告)号：US20140249562A1
公开(公告)日：2014-09-04
申请号：US13784073
申请日：2013-03-04
申请人： Vascular Solutions, Inc.
发明人： Howard Root , Thomas Holman , Doug Fraser , Deepa Deepa
IPC分类号： A61M29/00
CPC分类号： A61M29/00 , A61M25/0662 , A61M2025/0681
摘要： Vascular dilator systems, kits, and methods allowing for sheathless introduction of a treatment device into a body vessel or body cavity are disclosed. A vascular dilator system can include a dilator assembly, including a tubular shaft and a deformable member, and optionally, the treatment device. The deformable member can include a non-biodegradable material and can have a diameter at a proximal end portion that is greater than a diameter at a distal end portion. The distal end portion of the deformable member can be coupled to an outer surface of the tubular shaft, at or near a shaft distal end portion. The proximal end portion of the deformable member can include a diameter configured to receive or stretch around a distal end portion of the treatment device. In use, the deformable member can provide a tapered bridge between the outer surface of the tubular shaft and an outer surface of the treatment device.
摘要翻译：公开了一种允许将治疗装置无鞘管引入体腔或体腔的血管扩张器系统，试剂盒和方法。血管扩张器系统可以包括扩张器组件，包括管状轴和可变形构件，以及可选地，治疗装置。可变形构件可以包括不可生物降解的材料，并且可以在近端部分具有大于远端部分处的直径的直径。可变形构件的远端部分可以在轴远端部分处或附近联接到管状轴的外表面。可变形构件的近端部分可以包括构造成围绕治疗装置的远端部分接收或拉伸的直径。在使用中，可变形构件可以在管状轴的外表面和处理装置的外表面之间提供锥形桥。

17. 发明授权

US09782561B2 Catheter tip 有权
公开(公告)号：US09782561B2
公开(公告)日：2017-10-10
申请号：US14860997
申请日：2015-09-22
申请人： Vascular Solutions, Inc.
发明人： Chad Kugler , John Bridgeman , Derek Stratton , Steve Michael , Howard Root
IPC分类号： A61M25/00 , A61M5/00 , A61M25/09 , A61B5/00
CPC分类号： A61M25/005 , A61M25/0053 , A61M25/0068
摘要： Catheters and related methods for supporting a guidewire or delivering an agent through a vessel stenosis or other tortuous anatomy are disclosed. A catheter can comprise an elongate shaft body and a polymer tip member disposed at a distal end of the shaft body. The shaft body and the tip member can include a liner, one or both of a braid member or a coil member surrounding the liner, and a polymer cover surrounding the braid member or the coil member. The tip member can further include one or more filaments extending from a position overlapping, underlapping, or abutting a distal end of the braid member or the coil member on their proximal ends to a position distal to the braid member or the coil member on their distal ends. The one or more filaments can include a plurality of filaments arranged in a series of contacting helical windings about the liner, the braid member, or the coil member.

18. 发明申请

US20170050003A1 PERFUSION CATHETERS AND RELATED METHODS 有权
标题翻译：灌注导管及相关方法
公开(公告)号：US20170050003A1
公开(公告)日：2017-02-23
申请号：US15296183
申请日：2016-10-18
申请人： Vascular Solutions, Inc.
发明人： Howard Root , Chad Kugler , Dean Peterson , Joshua Brenizer
IPC分类号： A61M25/10 , A61B17/12
CPC分类号： A61M25/1002 , A61B17/12036 , A61B17/1204 , A61B17/12109 , A61B17/12136 , A61B2017/22001 , A61B2017/22051 , A61B2017/22094 , A61M25/104 , A61M2025/1097
摘要： This patent document discloses perfusion catheters and related methods for treating complications related to CTO interventions or dilating a vessel occlusion while maintaining a passage through the treated vessel segment. A perfusion catheter can include a balloon formed of an inflatable tube and an elongate shaft having a lumen for providing inflation fluid to, or withdrawing inflation fluid from, the balloon. The inflatable tube can be coiled in a helical manner around a central axis into a series of windings. Adjacent windings can be stacked against and bonded to each other, and an inner surface of the series of windings, when inflated, can define the passage. The elongate shaft can be eccentrically attached to a proximal portion of the balloon and the shaft's lumen can be in fluid communication with the interior of the balloon, specifically the inflatable tube. The inflatable tube can include two different polymer tubes, one slightly smaller than the other.
摘要翻译：该专利文献公开了用于治疗与CTO干预有关的并发症或扩张血管闭塞同时保持通过经处理的血管段的灌注导管和相关方法。灌注导管可以包括由可充气管形成的气囊和具有用于向气囊提供充气流体或从气囊排出充气流体的内腔的细长轴。可充气管可以围绕中心轴以螺旋方式卷绕成一系列绕组。相邻的绕组可以彼此堆叠并且彼此结合，并且当膨胀时，该系列绕组的内表面可以限定通道。细长轴可以偏心地附接到球囊的近端部分，并且轴的内腔可以与气囊的内部，特别是可充气管流体连通。可膨胀管可以包括两个不同的聚合物管，一个稍微小于另一个。

19. 发明申请

US20160066933A1 Guidewire Capture 审中-公开
标题翻译：导丝捕获
公开(公告)号：US20160066933A1
公开(公告)日：2016-03-10
申请号：US14709531
申请日：2015-05-12
申请人： Vascular Solutions, Inc.
发明人： Howard C. Root , Dean Peterson , Joshua Brenizer
IPC分类号： A61B17/221 , A61M25/09 , A61M25/06 , A61B17/50 , A61M25/00
摘要： Assemblies and methods for capturing a guidewire advanced through a blood vessel in a retrograde direction are disclosed. An assembly can include a constraining catheter and a capture catheter. The constraining catheter can include a first longitudinal member and a tubular member; the tubular member can be eccentrically coupled with a distal end portion of the first longitudinal member. The capture catheter can include a second longitudinal member and a funnel member; the funnel member can be eccentrically coupled with a distal end portion of the second longitudinal member. The funnel member can be moved between a collapsed configuration and an expanded configuration through relative movement between the first and second longitudinal members. In the collapsed configuration, at least a portion of the funnel member is disposed within a lumen of the tubular member. In the expanded configuration, the portion of the funnel member projects from an end of the tubular member.
摘要翻译：公开了用于捕获沿逆行方向通过血管前进的导丝的组件和方法。组件可以包括约束导管和捕获导管。约束导管可以包括第一纵向构件和管状构件; 管状构件可以与第一纵向构件的远端部分偏心联接。捕获导管可以包括第二纵向构件和漏斗构件; 漏斗构件可以与第二纵向构件的远端部分偏心联接。漏斗构件可以通过第一和第二纵向构件之间的相对运动在折叠构型和膨胀构型之间移动。在折叠构型中，漏斗构件的至少一部分设置在管状构件的管腔内。在扩展构造中，漏斗构件的一部分从管状构件的端部突出。

20. 再颁专利

USRE45760E1 Coaxial guide catheter for interventional cardiology procedures 有权
标题翻译：同轴导管用于介入心脏病学程序
公开(公告)号：USRE45760E1
公开(公告)日：2015-10-20
申请号：US14195385
申请日：2014-03-03
申请人： VASCULAR SOLUTIONS, INC.
发明人： Howard C. Root , Gregg Sutton , Jeffrey M. Welch , Jason M. Garrity
IPC分类号： A61M5/178 , A61M25/00 , A61M25/06
CPC分类号： A61M25/01 , A61M25/0026 , A61M25/0051 , A61M25/0052 , A61M25/0068 , A61M25/0069 , A61M25/008 , A61M25/0662 , A61M2025/0081
摘要： A coaxial guide catheter to be passed through guide catheter having a first lumen, for use with interventional cardiology devices that are insertable into a branch artery that branches off from a main artery. The coaxial guide catheter is extended through the lumen of the guide catheter and beyond the distal end of the guide catheter and inserted into the branch artery. The device assists in resisting axial and shear forces exerted by an interventional cardiology device passed through the second lumen and beyond the flexible distal tip portion that would otherwise tend to dislodge the guide catheter from the branch artery.
摘要翻译：要穿过具有第一腔的引导导管的同轴引导导管，用于可插入从主动脉分支的分支动脉的介入心脏病学装置。同轴引导导管延伸穿过引导导管的内腔并超过引导导管的远端并插入分支动脉。该装置有助于抵抗由介入心脏病学装置施加的轴向和剪切力，所述介入心脏病学装置通过第二腔并超出柔性远侧末端部分，否则其将倾向于将引导导管从分支动脉移开。

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