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11. 发明申请

US20100204311A1 NORMAL-TENSION GLAUCOMA MODEL AND METHOD FOR EVALUATION OF TEST SUBSTANCES BY USING SAME 失效
标题翻译：用于评估试验物质的正常拉曼光学模型和方法
公开(公告)号：US20100204311A1
公开(公告)日：2010-08-12
申请号：US12668838
申请日：2008-07-11
申请人： Takuma Hayashi , Yasuko Takahashi , Tomoko Yanagidaira , Shunichiro Taniguchi , Toshinori Murata
发明人： Takuma Hayashi , Yasuko Takahashi , Tomoko Yanagidaira , Shunichiro Taniguchi , Toshinori Murata
IPC分类号： A61K31/7088 , A01K67/00 , C12N5/00 , A01N1/00 , G01N33/00 , C12Q1/02 , C12Q1/68 , A61P27/06
CPC分类号： G01N33/5088 , A01K67/0276 , A01K2227/105 , A01K2267/03 , A61K49/0008 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N2800/168
摘要： It is intended to provide a simple normal-tension glaucoma model capable of spontaneously, age-dependently and surly developing conditions similar to symptoms of normal-tension glaucoma which occurs more frequently in elder people, and a method of evaluating therapeutic effect on normal-tension glaucoma whereby a drug useful in treating and diagnosing can be conveniently screened by using the normal-tension glaucoma model. A normal-tension glaucoma model comprising a nonhuman mammal, which is deficient in a transcriptional regulator NF-κBp50 and thus spontaneously develops the normal-tension glaucoma symptom age-relatedly, an organ or a tissue thereof or cells collected from any of the same. A method of evaluating therapeutic effect on normal-tension glaucoma of a test substance which comprises administering or adding the test substance to the above-described nonhuman mammal, an organ or a tissue thereof or cells collected from any of the same, and measuring a morphological defect, cell count, pressure, the expression amount or activity strength of a protein, the expression amount of a nucleic acid and/or the activity strength of an antibody in the organ, tissue and/or cells as indication(s) for the evaluation.
摘要翻译：旨在提供一种能够自发地，年龄依赖性地和显着地发展类似于老年人更频繁发生的正常张力性青光眼症状的正常张力青光眼模型，以及评估对正常张力的治疗效果的方法通过使用正常张力性青光眼模型，可以容易地筛选可用于治疗和诊断的药物的青光眼。包含非转基因哺乳动物的正常张力性青光眼模型，其在转录调节因子NF-κBp50中是不足的，因此自发地发生与其相关的正常张力性青光眼症状年龄的器官或其组织或从任何相同。评价对被检物质的正常张力性青光眼的治疗效果的方法，其包括向所述非人类哺乳动物，器官或组织施用或添加测试物质或从其中任一种收集的细胞，并测量形态学缺陷，细胞计数，压力，蛋白质的表达量或活性强度，核酸的表达量和/或器官，组织和/或细胞中抗体的活性强度作为评价指标。

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