专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US06596545B1 Microdevices for screening biomolecules 失效
标题翻译：用于筛选生物分子的微型设备
公开(公告)号：US06596545B1
公开(公告)日：2003-07-22
申请号：US09353554
申请日：1999-07-14
申请人： Peter Wagner , Dana Ault-Riche , Steffen Nock , Christian Itin
发明人： Peter Wagner , Dana Ault-Riche , Steffen Nock , Christian Itin
IPC分类号： G01N33543
CPC分类号： B82Y30/00 , Y10S435/805 , Y10S435/81 , Y10T436/143333
摘要： Devices for the parallel, in vitro screening of biomolecular activity using miniaturized microfabricated devices are provided. The biomolecules immobilized on the surface of the devices of the present invention include proteins, polypeptides, polynucleotides, polysaccharides, phospolipids, and related unnatural polymers of biological relevance. These devices are useful drug development, functional proteomics and clinical diagnostics and are preferably used for the parallel screening of families of related proteins.
摘要翻译：提供了使用微型微加工装置并行，体外筛选生物分子活性的装置。固定在本发明装置表面上的生物分子包括具有生物相关性的蛋白质，多肽，多核苷酸，多糖，磷脂和相关的非天然聚合物。这些装置是有用的药物开发，功能蛋白质组学和临床诊断，并且优选用于相关蛋白家族的并行筛选。

12. 发明申请

US20090042744A1 MICRODEVICES FOR SCREENING BIOMOLECULES 审中-公开
标题翻译：用于筛选生物分子的MICRODEVICES
公开(公告)号：US20090042744A1
公开(公告)日：2009-02-12
申请号：US12171217
申请日：2008-07-10
申请人： Peter Wagner , Dana Ault-Riche , Steffen Nock , Christian Itin , Ming Tan
发明人： Peter Wagner , Dana Ault-Riche , Steffen Nock , Christian Itin , Ming Tan
IPC分类号： C40B60/12
CPC分类号： B82Y15/00 , B01J19/0046 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00657 , B01J2219/00722 , B01J2219/00725 , B01J2219/00727 , B01J2219/00731 , B01J2219/00734 , B01L3/5025 , B01L3/502707 , B01L2200/0689 , B01L2300/0636 , B01L2300/0816 , B01L2300/0825 , B82Y30/00 , G01N33/54366
摘要： Methods and devices for the parallel, in vitro screening of biomolecular activity using miniaturized microfabricated devices are provided. The biomolecules immobilized on the surface of the devices of the present invention include proteins, polypeptides, polynucleotides, polysaccharides, phospholipids, and related unnatural polymers of biological relevance. These devices are useful drug development, functional proteomics and clinical diagnostics and are preferably used for the parallel screening of families of related proteins.
摘要翻译：提供了使用微型微加工装置并行，体外筛选生物分子活性的方法和装置。固定在本发明装置表面上的生物分子包括具有生物相关性的蛋白质，多肽，多核苷酸，多糖，磷脂和相关的非天然聚合物。这些装置是有用的药物开发，功能蛋白质组学和临床诊断，并且优选用于相关蛋白家族的并行筛选。

13. 发明授权

US07438856B2 Microfluidic devices and methods 失效
标题翻译：微流体装置和方法
公开(公告)号：US07438856B2
公开(公告)日：2008-10-21
申请号：US10603339
申请日：2003-06-24
申请人： Paul Jedrzejewski , Steffen Nock , Peter Wagner , Pierre Indermuhle , Frank G. Zaugg
发明人： Paul Jedrzejewski , Steffen Nock , Peter Wagner , Pierre Indermuhle , Frank G. Zaugg
IPC分类号： B01L3/02 , B01L11/00 , G01N21/00 , G01N31/00 , G01N33/00
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00317 , B01J2219/00351 , B01J2219/00367 , B01J2219/00369 , B01J2219/00382 , B01J2219/00497 , B01J2219/00504 , B01J2219/00509 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00725 , B01L3/0241 , B01L3/0248 , B01L3/0262 , B01L3/5085 , B01L3/5088 , B01L2300/0809 , B01L2300/0848 , B01L2400/022 , B01L2400/0688 , B33Y80/00 , B82Y30/00 , C40B40/10 , C40B60/14 , Y10T436/11 , Y10T436/114165 , Y10T436/117497 , Y10T436/118339 , Y10T436/143333 , Y10T436/156666 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： Embodiments of the invention are directed to microfluidic devices. In one embodiment, a microanalysis chip comprises a body having at least one transfer-separation channel with a channel bottom that has a bottom opening. The transfer-separation channel terminates in a discharge aperture.
摘要翻译：本发明的实施例涉及微流体装置。在一个实施例中，微量分析芯片包括具有至少一个具有底部开口的通道底部的转移分离通道的主体。转印分离通道终止于放电孔。

14. 发明申请

US20080076673A1 ENGINEERED BINDING PROTEINS 审中-公开
标题翻译：工程结合蛋白
公开(公告)号：US20080076673A1
公开(公告)日：2008-03-27
申请号：US11781188
申请日：2007-07-20
申请人： David Wilson , Steffen Nock
发明人： David Wilson , Steffen Nock
IPC分类号： C40B30/04 , C07K1/00 , C07K14/00 , C12N15/00 , C40B50/06 , C40B40/10 , C12N15/11 , C12N5/06
CPC分类号： C12N15/1093 , B82Y30/00 , C07K14/195 , C12N9/0095
摘要： Engineered binding proteins are provided. In some cases, the parent protein corresponding to the engineered protein has a three-layer swiveling β/β/α domain. In other cases, the parent protein corresponding to the engineered protein has a rubredoxin-like fold. At least one portion of the primary sequence of the engineered protein is determined by an engineering scheme. In some case, the engineered protein is characterized by an ability to bind to a compound that the parent protein does not bind. In some cases, the parent protein is derived from a domain of a chaperonin or a rubredoxin. One form of engineering scheme used is a randomization scheme. A method for making libraries of engineered proteins, all based on a single parent protein is provided. Methods to identify proteins that bind to compounds of interest in libraries of engineered libraries are provided. An array of engineered proteins immobilized on a support is provided. Each engineered protein in the array is a chaperonin domain or a rubredoxin that has been subjected to an engineering scheme.
摘要翻译：提供工程结合蛋白。在某些情况下，对应于工程化蛋白质的亲本蛋白质具有三层旋转β/β/α结构域。在其他情况下，对应于工程改造的蛋白质的亲本蛋白具有类似于rubredoxin的折叠。工程化蛋白质的初级序列的至少一部分由工程方案确定。在某些情况下，工程改造的蛋白质的特征在于与母体蛋白不结合的化合物结合的能力。在一些情况下，母体蛋白质衍生自伴侣蛋白或红蛋白的结构域。使用的一种工程方案是一种随机化方案。提供了基于单亲蛋白的制备工程蛋白的文库的方法。提供了在工程化文库库中鉴定与目的化合物结合的蛋白质的方法。提供固定在载体上的工程蛋白阵列。阵列中的每种工程化蛋白质都是经过工程方案的伴侣蛋白结构域或红霉素。

15. 发明授权

US06960457B1 Reversible immobilization of arginine-tagged moieties on a silicate surface 失效
标题翻译：精氨酸标记的部分在硅酸盐表面上的可逆固定化
公开(公告)号：US06960457B1
公开(公告)日：2005-11-01
申请号：US09486480
申请日：1998-09-03
申请人： James A. Spudich , Steffen Nock , Peter Wagner
发明人： James A. Spudich , Steffen Nock , Peter Wagner
IPC分类号： C07K1/00 , C07K1/10 , C07K17/14 , C12N11/14 , C12N15/62 , C12Q1/68 , G01N33/531 , G01N33/543 , G01N33/551 , G01N33/552
CPC分类号： C07K17/14 , C07K2319/20 , C12N11/14 , C12N15/62 , G01N33/54353 , G01N33/552 , Y10S435/961 , Y10S530/807 , Y10S530/81 , Y10S530/811 , Y10S530/816
摘要： This invention provides materials and methods for the site specific attachment of virtually any moiety to a layered silicate surface. The methods involve covalently attaching the moiety to an arginine tag; and contacting the arginine tag with the layered silicate (e.g., mica) surface.
摘要翻译：本发明提供了用于实际上任何部分与层状硅酸盐表面的特异性连接的材料和方法。该方法涉及将该部分共价连接至精氨酸标签; 并将精氨酸标签与层状硅酸盐（例如云母）表面接触。

16. 发明授权

US06582969B1 Microdevices for high-throughput screening of biomolecules 失效
标题翻译：用于生物分子高通量筛选的微型设备
公开(公告)号：US06582969B1
公开(公告)日：2003-06-24
申请号：US09570586
申请日：2000-05-12
申请人： Peter Wagner , Dana Ault-Riche , Steffen Nock , Christian Itin
发明人： Peter Wagner , Dana Ault-Riche , Steffen Nock , Christian Itin
IPC分类号： G01N33543
CPC分类号： B82Y30/00 , Y10S435/805 , Y10S435/81 , Y10T436/143333
摘要： Methods for the parallel, in vitro screening of biomolecular activity using miniaturized microfabricated devices are provided. The biomolecules that can be immobilized on the surface of the devices of the present invention include proteins, polypeptides, nucleic acids, polysaccharides, phospholipids, and related unnatural plyomers of biological relevance. These devices are useful in high-throughput drug screening and clinical diagnostics and are preferably used for the parallel screening of families of related proteins.
摘要翻译：提供了使用微型微型加工装置平行体外筛选生物分子活性的方法。可固定在本发明装置表面上的生物分子包括具有生物相关性的蛋白质，多肽，核酸，多糖，磷脂和相关的非天然多聚物。这些装置在高通量药物筛选和临床诊断中是有用的，并且优选用于相关蛋白家族的并行筛选。

17. 发明授权

US06576478B1 Microdevices for high-throughput screening of biomolecules 失效
标题翻译：用于生物分子高通量筛选的微型设备
公开(公告)号：US06576478B1
公开(公告)日：2003-06-10
申请号：US09115397
申请日：1998-07-14
申请人： Peter Wagner , Dana Ault-Riche , Steffen Nock , Christian Itin
发明人： Peter Wagner , Dana Ault-Riche , Steffen Nock , Christian Itin
IPC分类号： G01N33543
CPC分类号： B82Y30/00 , Y10S435/805 , Y10S435/81 , Y10T436/143333
摘要： Devices for the parallel, in vitro screening of biomolecular activity using miniaturized microfabricated devices are provided. The biomolecules that can be immobilized on the surface of the devices of the present invention include proteins, polypeptides, nucleic acids, polysaccharides, phospolipids, and related unnatural polymers of biological relevance. These devices are useful in high-throughput drug screening and clinical diagnostics and are preferably used for the parallel screening of families of related proteins.
摘要翻译：提供了使用微型微加工装置并行，体外筛选生物分子活性的装置。可以固定在本发明的装置表面上的生物分子包括具有生物相关性的蛋白质，多肽，核酸，多糖，磷脂和相关的非天然聚合物。这些装置在高通量药物筛选和临床诊断中是有用的，并且优选用于相关蛋白家族的并行筛选。

18. 发明授权

US07183392B2 Site-specific, covalent bioconjugation of proteins 失效
标题翻译：蛋白质的位点特异性共价生物缀合
公开(公告)号：US07183392B2
公开(公告)日：2007-02-27
申请号：US09820210
申请日：2001-03-27
申请人： Peter Wagner , Lifu Ma , Steffen Nock , David Wilson , Jens Sydor
发明人： Peter Wagner , Lifu Ma , Steffen Nock , David Wilson , Jens Sydor
IPC分类号： C07K17/06 , C07K1/13
CPC分类号： G01N33/54353 , B82Y30/00 , G01N33/52
摘要： Heterofunctional crosslinking groups are provided having the formula: wherein W is a covalent core component; L1, L2 and L3 are independently linking groups; X is a non-covalent or reversibly covalent protein tag binder; Y is a activatable covalent linking group; and Z is a protected or unprotected covalent crosslinking group.
摘要翻译：提供具有下式的异官能交联基团：其中W是共价核心组分; L 1，L 2和L 3独立地是连接基团; X是非共价或可逆共价蛋白质标签结合物; Y是可活化的共价连接基团; Z是保护或未保护的共价交联基团。

19. 发明申请

US20060228701A1 Arrays of protein-capture agents and methods of use thereof 审中-公开
公开(公告)号：US20060228701A1
公开(公告)日：2006-10-12
申请号：US11392262
申请日：2006-03-28
申请人： Peter Wagner , Steffen Nock , Dana Ault-Riche , Christian Itin
发明人： Peter Wagner , Steffen Nock , Dana Ault-Riche , Christian Itin
IPC分类号： C12Q1/70 , G01N33/53 , C12M1/34 , C40B30/04
CPC分类号： G01N33/6845 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B82Y5/00 , B82Y30/00 , C07K2319/20 , C40B40/10 , G01N33/54393 , G01N33/551
摘要： Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the arrays of protein-capture agents are also disclosed. The invention arrays are particularly useful for various proteomics applications including assessing patterns of protein expression and modification in cells.

20. 发明申请

US20050014292A1 Protein arrays for high-throughput screening 审中-公开
公开(公告)号：US20050014292A1
公开(公告)日：2005-01-20
申请号：US10911877
申请日：2004-08-04
申请人： Peter Wagner , Dana Ault-Riche , Steffen Nock , Christian Itin
发明人： Peter Wagner , Dana Ault-Riche , Steffen Nock , Christian Itin
IPC分类号： C40B40/10 , G01N33/543 , G01N33/551 , G01N33/68 , G01N37/00
CPC分类号： G01N33/6845 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B82Y5/00 , B82Y30/00 , C07K2319/20 , C40B40/10 , G01N33/54393 , G01N33/551
摘要： Protein arrays and protein-coated substrates for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein-coated substrates and protein arrays are also disclosed. A plurality of different members of a single protein family may be immobilized on the protein-coated substrate or array. The protein-coated substrates and protein arrays are particularly useful in high-throughput drug screening and clinical diagnostics.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式