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11. 发明授权

US4166127A Benzo[b,f]thiepin derivatives and process for producing the same 失效
标题翻译：苯并（B，F）硫蛋白衍生物及其生产方法
公开(公告)号：US4166127A
公开(公告)日：1979-08-28
申请号：US869767
申请日：1978-01-16
申请人： Shigeru Yamabe , Yasuo Fujimoto , Shoji Ryu , Yoshio Suzuki , Yoshihiro Tanaka , Toru Yamanaka , Kiyosato Nyu
发明人： Shigeru Yamabe , Yasuo Fujimoto , Shoji Ryu , Yoshio Suzuki , Yoshihiro Tanaka , Toru Yamanaka , Kiyosato Nyu
IPC分类号： C07D337/14 , A61K31/38
CPC分类号： C07D337/14
摘要： Novel benzo [b,f] thiepin derivatives possessing strong anti-flammatory action and presenting few adverse reactions, of the formula (I) ##STR1## wherein R represents a fluorine atom, or a trifluoromethyl or 1-5C lower alkoxy group, and R.sub.3 and R.sub.4 each represent a 1-4C lower alkyl group or R.sub.3 and R.sub.4 together with the adjacent nitrogen atom to which they are attached form a heterocyclic group. Pharmaceutical compositions comprising an anti-inflammatory effective amount of the compound according to formula (I) in the presence of an inert carrier.

12. 发明授权

US4529592A Penicillin derivatives 失效
标题翻译：青霉素衍生物
公开(公告)号：US4529592A
公开(公告)日：1985-07-16
申请号：US501560
申请日：1983-06-06
申请人： Ronald G. Micetich , Shigeru Yamabe , Tomio Yamazaki , Naobumi Ishida , Takeshi Ishizawa
发明人： Ronald G. Micetich , Shigeru Yamabe , Tomio Yamazaki , Naobumi Ishida , Takeshi Ishizawa
IPC分类号： C07D499/87 , A61K31/425 , A61K31/43 , A61P31/04 , A61P43/00 , C07D499/00 , C07D499/86 , C07D499/897 , C07F7/10
CPC分类号： C07D499/00 , C07F7/10
摘要： A penicillin derivative represented by the following formula ##STR1## wherein R.sub.1 and R.sub.2 are each the same or different and represent hydrogen, C.sub.1-18 alkyl, mononitro-substituted benzyl or group for forming a pharmaceutically acceptable salt and R.sub.3 is selected from the group consisting of hydrogen, C.sub.1-6 alkyl, C.sub.2-7 alkoxymethyl, C.sub.3-8 alkylcarbonyloxymethyl, C.sub.4-9 alkylcarbonyloxyethyl, (C.sub.5-7 cycloalkyl)carbonyloxymethyl, C.sub.9-14 benzylcarbonyloxyalkyl, C.sub.3-8 alkoxycarbonylmethyl, C.sub.4-9 alkoxycarbonylethyl, phthalidyl, crotonolacton-4-yl, .gamma.-butyrolacton-4-yl, halogenated C.sub.1-6 alkyl substituted with 1 to 3 halogen atoms, C.sub.1-6 alkoxy- or nitro-substituted or unsubstituted benzyl, benzhydryl, tetrahydropyranyl, dimethylaminoethyl, dimethylchlorosilyl, trichlorosilyl, (5-substituted C.sub.1-6 alkyl or phenyl or unsubstituted-2-oxo-1,3-dioxoden-4-yl)methyl, C.sub.8-13 benzoyloxyalkyl and group for forming a pharmaceutically acceptable salt.
摘要翻译：由下式（IMAGE）表示的青霉素衍生物，其中R 1和R 2各自相同或不同，表示氢，C 1-18烷基，一硝基取代的苄基或用于形成药学上可接受的盐的基团，R 3选自氢，C 1-6烷基，C 2-7烷氧基甲基，C 3-8烷基羰基氧基甲基，C 4-9烷基羰基氧基乙基，（C 5-7环烷基）羰基氧基甲基，C 9-14苄基羰氧基烷基，C 3-8烷氧基羰基甲基，C 4-9烷氧基羰基乙基，吡啶-4-基，γ-丁内酯-4-基，被1至3个卤素原子取代的卤代C 1-6烷基，C 1-6烷氧基或硝基取代或未取代的苄基，二苯甲基，四氢吡喃基，二甲基氨基乙基，二甲基氯甲硅烷基，三氯硅烷基（5 取代的C 1-6烷基或苯基或未取代的-2-氧代-1,3-二氧杂环己烯-4-基）甲基，C 13-13苯甲酰氧基烷基和用于形成药学上可接受的盐的基团。

13. 发明授权

US4282245A Dibenzothiepin derivatives and a process for producing the same 失效
标题翻译：二苯并噻吩衍生物及其制备方法
公开(公告)号：US4282245A
公开(公告)日：1981-08-04
申请号：US041560
申请日：1979-05-23
申请人： Yasuo Fujimoto , Shigeru Yamabe
发明人： Yasuo Fujimoto , Shigeru Yamabe
IPC分类号： A61K31/38 , A61P29/00 , C07D337/14
CPC分类号： C07D337/14
摘要： A compound of the formula (I), ##STR1## wherein R.sub.1 represents a halogen atom, or a hydroxy, nitro, amino, trihalogenomethyl or lower alkoxy group having 1 to 5 carbon atoms, and R.sub.2 represents a hydroxy or amino group is an antiinflammatory agent.
摘要翻译：式（I）化合物，其中R1表示卤素原子，或羟基，硝基，氨基，三卤代甲基或碳原子数1〜5的低级烷氧基，R2表示羟基或氨基，为抗炎剂代理商

14. 发明授权

US4263437A Acetic acid derivatives of 5,6-dihydrobenzo[b]pyrido[3,2-f]thiepine and oxepine 失效
标题翻译： 5,6-二氢苯并[b]吡啶并[3,2-f]噻吩和氧杂吖庚因的乙酸衍生物
公开(公告)号：US4263437A
公开(公告)日：1981-04-21
申请号：US15610
申请日：1979-02-27
申请人： Yasuo Fujimoto , Shigeru Yamabe
发明人： Yasuo Fujimoto , Shigeru Yamabe
IPC分类号： A61K31/335 , A61K31/38 , A61K31/435 , A61P29/00 , C07D313/14 , C07D337/14 , C07D491/04 , C07D491/044 , C07D495/04
CPC分类号： C07D491/04 , C07D313/14 , C07D337/14 , C07D495/04
摘要： Acetic acid derivatives having the formula, ##STR1## wherein X represents an oxygen or two hydrogen atoms, Y represents CH or N, A represents an oxygen or sulfur atom, and R represents hydroxy, amino or a lower alkoxy group having 1 to 5 carbon atoms possess excellent antiinflammatory activities.
摘要翻译：具有下式的乙酸衍生物，其中X表示氧或两个氢原子，Y表示CH或N，A表示氧或硫原子，R表示羟基，氨基或具有1至5个碳原子的低级烷氧基原子具有优异的抗炎活性。

15. 发明授权

US4101667A Benzo[b,f]thiepin derivatives 失效
标题翻译：苯并{8b，f {9 thiepin衍生物
公开(公告)号：US4101667A
公开(公告)日：1978-07-18
申请号：US689908
申请日：1976-05-25
申请人： Shigeru Yamabe , Yasuo Fujimoto , Shoji Ryu , Yoshio Suzuki , Yoshihiro Tanaka , Toru Yamanaka , Kiyosato Nyu
发明人： Shigeru Yamabe , Yasuo Fujimoto , Shoji Ryu , Yoshio Suzuki , Yoshihiro Tanaka , Toru Yamanaka , Kiyosato Nyu
IPC分类号： C07D337/14 , A61K31/38 , A61K31/495 , C07D409/10
CPC分类号： C07D337/14
摘要： Dihydrodibenzo[b,f]thiepin compounds of formula (I) and process for making them. These compounds have antiinflammatory action. ##STR1## wherein R represents a hydrogen, fluorine atom, a trifluoromethyl, 1-5C lower alkoxy, hydroxy, hydroxyethoxy, aminoethoxy group or the group of the formula --OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OH, Y represents a hydroxy group or the group of the formula ##STR2## (R.sub.3 and R.sub.4 represent a 1-4C lower alkyl group or R.sub.3 and R.sub.4 may jointly form a heterocyclic group together with an adjacent nitrogen atom.
摘要翻译：二氢二苯并[b，f] thiepin化合物及其制备方法。这些化合物具有抗炎作用。（I）其中R表示氢，氟原子，三氟甲基，1-5C低级烷氧基，羟基，羟基乙氧基，氨基乙氧基或式-OCH2CH2OCH2CH2OH的基团，Y表示羟基或式（R 3和R 4表示1-4C的低级烷基，或者R 3和R 4可以与相邻的氮原子一起共同形成杂环基。

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