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    • 11. 发明授权
    • Phase sensitively-detected reduced dimensionality nuclear magnetic resonance spectroscopy for rapid chemical shift assignment and secondary structure determination of proteins
    • 相位敏感检测降低维度核磁共振波谱用于蛋白质的快速化学位移分配和二级结构测定
    • US07396685B2
    • 2008-07-08
    • US10628818
    • 2003-07-28
    • Thomas A. SzyperskiSeho Kim
    • Thomas A. SzyperskiSeho Kim
    • G01N24/00
    • G01R33/4633G01R33/465Y10T436/24
    • The present invention discloses eleven reduced dimensionality (RD) triple resonance nuclear magnetic resonance (NMR) experiments for measuring chemical shift values of certain nuclei in a protein molecule, where the chemical shift values encoded in a peak pair of an NMR spectrum are detected in a phase sensitive manner. The RD 3D HA,CA,(CO),N,HN NMR and RD 3D H,C,(C-TOCSY-CO),N,HN NMR experiments are designed to yield “sequential” connectivities, while the RD 3D Hα/β,Cα/β,CO,HA NMR and RD 3D Hα/β,Cα/β,N,HN NMR experiments provide “intraresidue” connectivities. The RD 3D H,C,C,H-COSY NMR, RD 3D H,C,C,H-TOCSY NMR, and RD 2D H,C,H-COSY NMR experiments allow one to obtain assignments for aliphatic and aromatic side chain chemical shifts, while the RD 2D HB,CB,(CG,CD),HD NMR experiment provide information for the aromatic side chain chemical shifts. In addition, methods of conducting suites of RD triple resonance NMR experiments for high-throughput resonance assignment of proteins and determination of secondary structure elements are disclosed.
    • 本发明公开了一种用于测量蛋白质分子中某些核的化学位移值的十一维三维共振核磁共振(NMR)实验,其中在一个核磁共振谱的峰对中编码的化学位移值在 相位敏感的方式。 CA,(CO),N,HN NMR和RD 3D H, Hα/β, CO,HA NMR和RD 3D Hα/β, N,1 H NMR实验提供“残留”连接。 C,C,H-COZY NMR,RD 3D H, H, C,C,H-TOCSY NMR和RD 2D H, HB,(UC,CD),HD NMR实验提供了芳族侧链化学位移的信息。 此外,公开了用于蛋白质的高通量共振分配的RD三重共振NMR实验的套件的方法和二级结构元件的测定。
    • 14. 发明申请
    • PHASE-SENSITIVELY DETECTED REDUCED DIMENSIONALITY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY FOR RAPID CHEMICAL SHIFT ASSIGNMENT AND SECONDARY STRUCTURE DETERMINATION OF PROTEINS
    • 相敏检测减少尺寸核激光共振光谱快速化学转移分配和二级结构测定蛋白质
    • US20090115414A1
    • 2009-05-07
    • US12132320
    • 2008-06-03
    • Thomas A. SzyperskiSeho Kim
    • Thomas A. SzyperskiSeho Kim
    • G01R33/44
    • G01R33/4633G01R33/465Y10T436/24
    • The present invention discloses eleven reduced dimensionality (RD) triple resonance nuclear magnetic resonance (NMR) experiments for measuring chemical shift values of certain nuclei in a protein molecule, where the chemical shift values encoded in a peak pair of an NMR spectrum are detected in a phase sensitive manner. The RD 3D HA,CA,(CO),N,HN NMR and RD 3D H,C,(C-TOCSY-CO),N,HN NMR experiments are designed to yield “sequential” connectivities, while the RD 3D Hα/β,Cα/β, CO,HA NMR and RD 3D Hα/β,Cα/β,N,HN NMR experiments provide “intraresidue” connectivities. The RD 3D H,C,C,H-COSY NMR, RD 3D H,C,C,H-TOCSY NMR, and RD 2D H,C,H-COSY NMR experiments allow one to obtain assignments for aliphatic and aromatic side chain chemical shifts, while the RD 2D HB,CB,(CG,CD),HD NMR experiment provide information for the aromatic side chain chemical shifts. In addition, methods of conducting suites of RD triple resonance NMR experiments for high-throughput resonance assignment of proteins and determination of secondary structure elements are disclosed.
    • 本发明公开了一种用于测量蛋白质分子中某些核的化学位移值的十一维三维共振核磁共振(NMR)实验,其中在一个核磁共振谱的峰对中编码的化学位移值在 相位敏感的方式。 HA,CA,(CO),N,HN NMR和RD 3D H,单独的 “C,(C-TOCSY-CO),N,HN NMR实验被设计为产生”顺序“连接,而RD 3D Hal /β, Calpha / beta,CO,HA NMR和RD 3D氦/氦,Calpha /β,N,HN NMR实验提供了“残留”连接。 RD 3D H,C,C,H-COZY NMR,RD 3D,H, C,C,H-TOCSY NMR和RD 2D H,C,H-COZY NMR实验允许获得脂族和芳族侧链化学位移的分配 ,而DB 2D,CB,(CG,CD),HD NMR实验提供了芳族侧链化学位移的信息。 此外,公开了用于蛋白质的高通量共振分配的RD三重共振NMR实验的套件的方法和二级结构元件的测定。
    • 18. 发明申请
    • MOBILE TERMINAL AND CONTROLLING METHOD THEREOF
    • 移动终端及其控制方法
    • US20140035846A1
    • 2014-02-06
    • US13931217
    • 2013-06-28
    • Yeonhwa LEESeho Kim
    • Yeonhwa LEESeho Kim
    • G06F3/0488
    • G06F3/0488G06F3/04886
    • A mobile terminal and controlling method thereof are disclosed, which flexibly utilizes a display screen space of a mobile terminal in consideration of user's convenience and necessity. The present invention includes a touchscreen configured to display a main screen including at least one object, a memory configured to store an action corresponding to the at least one object, and a controller, if at least one of the at least one object is selected by a 1st touch input to the touchscreen and an action display region is designated within the main screen by a 2nd touch input, controlling an active action screen for the selected object to be displayed within the action display region.
    • 公开了一种移动终端及其控制方法,其考虑到用户的便利性和必要性,灵活地利用移动终端的显示屏空间。 本发明包括触摸屏,被配置为显示包括至少一个对象的主屏幕,被配置为存储与至少一个对象相对应的动作的存储器和控制器,如果至少一个对象中的至少一个被 通过第二触摸输入在主屏幕内指定触摸屏的第一触摸输入和动作显示区域,控制要在动作显示区域内显示的所选对象的主动动作画面。
    • 19. 发明申请
    • Linear Step Motor
    • 线性步进电机
    • US20130019704A1
    • 2013-01-24
    • US13483798
    • 2012-05-30
    • Seho Kim
    • Seho Kim
    • F16H25/24
    • H02K37/14F16C35/063H02K7/003H02K7/06H02K7/085Y10T74/18584Y10T74/186Y10T74/18664Y10T74/18688
    • Provided is a linear step motor, the motor including: a motor housing fixedly mounted at an inner surface of a ring-shaped stator and formed with an opening; a rotor rotatably mounted at a space centrally formed at the stator; a cover member coupled to a bearing to open/close the opening; a nut shaft centrally arranged at the rotor, coupled to an outside of the cover member by passing through a shaft hole centrally formed at an inner ring of the bearing, coupled at a periphery by a magnet and formed with a female screw gear-combined with a lead screw member formed at an inner surface with a male screw; and a fixing unit integrally formed with the nut shaft and fixed to the bearing coupled to the cover member.
    • 本发明提供线性步进电动机,该电动机包括:固定地安装在环形定子的内表面并形成开口的电动机壳体; 可旋转地安装在定子中心形成的空间的转子; 联接到轴承以打开/关闭所述开口的盖构件; 中心地布置在转子处的螺母轴通过中心形成在轴承的内圈上的轴孔联接到盖构件的外部,轴孔在周边处由磁体联接并形成有与内螺纹齿轮组合的内螺纹齿轮 导螺杆构件,在内表面上形成有外螺纹; 以及固定单元,与所述螺母轴一体地形成并且固定到联接到所述盖构件的轴承。