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11. 发明授权

US07419984B2 Pyrimidines and uses thereof 失效
标题翻译：嘧啶类及其用途
公开(公告)号：US07419984B2
公开(公告)日：2008-09-02
申请号：US10671070
申请日：2003-09-24
申请人： Rama Bhatt , Baoqing Gong , Feng Hong , Scott A Jenkins , J Peter Klein , Cory T Kohm , John Tulinsky
发明人： Rama Bhatt , Baoqing Gong , Feng Hong , Scott A Jenkins , J Peter Klein , Cory T Kohm , John Tulinsky
IPC分类号： C07D239/48 , A61K31/505
CPC分类号： C07D239/48 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： The invention relates to pyrimidines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor-cells.
摘要翻译：本发明涉及嘧啶及其用途，包括抑制溶血磷脂酸酰基转移酶β（LPAAT-β）活性和/或细胞例如肿瘤细胞的增殖。

12. 发明申请

US20080069870A1 Controlled Release Compositions Comprising a Cephalosporin for the Treatment of a Bacterial Infection 审中-公开
标题翻译：包含头孢菌素用于治疗细菌感染的控制释放组合物
公开(公告)号：US20080069870A1
公开(公告)日：2008-03-20
申请号：US11571379
申请日：2006-04-12
申请人： Scott A. Jenkins , Gary Liversidge
发明人： Scott A. Jenkins , Gary Liversidge
IPC分类号： A61K31/546 , A61K9/10 , A61K9/14 , A61K9/24 , A61K9/58 , A61P31/04
CPC分类号： A61K9/5084 , A61K9/1676 , A61K9/5026 , A61K9/5078
摘要： The invention relates to a controlled release composition comprising a cephalosporin that in operation delivers the drug in a pulsed or bimodal manner for the treatment of bacterial infection. The controlled release composition comprises an immediate release component and a modified release component; the immediate release component comprising a first population of cephalosporin-containing particles and the modified release component comprising a second population of cephalosporin-containing particles coated with a controlled release coating; wherein the combination of the immediate release and modified release components in operation deliver the active ingredient in a pulsed or bi-modal manner. Preferably, the cephalosporin is cefcapene pivoxil or a salt thereof which can be released from the dosage form in an erodable, diffusion and/or osmotic-controlled release profile.
摘要翻译：本发明涉及包含头孢菌素的控释组合物，其在操作中以脉冲或双峰方式递送药物用于治疗细菌感染。控释组合物包含立即释放组分和改性释放组分; 所述立即释放组分包含含有头孢菌素的颗粒的第一群体，所述改性释放组分包含涂覆有控释层的第二群含头孢菌素的颗粒; 其中操作中的立即释放组分和修饰释放组分的组合以脉冲或双向方式递送活性成分。优选地，头孢菌素是头孢烯酮匹托酯或其盐，其可以以可侵蚀，扩散和/或渗透控制释放曲线从剂型释放。

13. 发明授权

US07291616B2 Aryl triazines as LPAAT-β inhibitors and uses thereof 失效
标题翻译：芳基三嗪作为LPAAT-β抑制剂及其用途
公开(公告)号：US07291616B2
公开(公告)日：2007-11-06
申请号：US10285364
申请日：2002-10-30
申请人： Rama Bhatt , Baoqing Gong , Feng Hong , Scott A. Jenkins , J. Peter Klein , Anil M. Kumar , John Tulinsky
发明人： Rama Bhatt , Baoqing Gong , Feng Hong , Scott A. Jenkins , J. Peter Klein , Anil M. Kumar , John Tulinsky
IPC分类号： A61K31/53 , C07D251/48
CPC分类号： C07D403/12 , C07D251/16 , C07D251/18 , C07D251/22 , C07D405/12
摘要： The invention relates to aryl triazines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor cells.
摘要翻译：本发明涉及芳基三嗪及其用途，包括抑制溶血磷脂酸酰基转移酶β（LPAAT-β）活性和/或细胞例如肿瘤细胞的增殖。

14. 发明授权

US5558460A Apparatus for enhancing wave height in ocean waves 失效
标题翻译：用于提高海浪波高的装置
公开(公告)号：US5558460A
公开(公告)日：1996-09-24
申请号：US206501
申请日：1994-03-03
申请人： Scott A. Jenkins , Joseph Wasyl , Charles Robins
发明人： Scott A. Jenkins , Joseph Wasyl , Charles Robins
IPC分类号： E02B3/12 , E02B9/08 , E02B3/06
CPC分类号： E02B9/08 , E02B3/127 , Y02E10/28
摘要： The artificial reef of the present invention is constructed from a plurality of structural units each of which is a tetrahedron-shaped sandbag, which are arranged in a talus pile. The reefs are formed by dropping the structural units in the desired locations. The tetrahedron-shape of the structural units provides a self-interlocking structure which can be placed en mass on the sea floor without individual alignment of each bag. The geometry of the reef structure is a sloped bar, a parallel bar, or a V-shaped bar, or combinations thereof. The parallel bars, which run parallel to the shoreline, trap standing waves between the bars to reinforce the incoming waves with a maximum energy focused where the rays of trapped waves cross the wave rays of the incoming swell. A multiple V-shaped bar configuration, with the apex of the V pointing diagonal to the incoming waves creates Bragg reflection patterns which cause crossing wave rays to form local concentrations of wave energy.
摘要翻译：本发明的人造珊瑚礁由多个结构单元构成，每个结构单元都是四面体形状的沙袋，其布置在距离桩中。通过将结构单元放置在所需位置来形成珊瑚礁。结构单元的四面体形状提供了一种自锁结构，其可以在海底上放置，而不需要对每个袋进行单独对准。礁结构的几何形状是倾斜的杆，平行杆或V形杆，或其组合。平行于海岸线的平行杆在杆之间捕获驻波，以加强入射波，以最大能量聚焦，其中捕获的光线与入射的波浪的波束交叉。具有与入射波的V指向对角线的顶点的多个V形条形状产生布拉格反射图案，其导致交叉波射线形成局部的波能量浓度。

15. 发明授权

US4957392A Method and apparatus for the active prevention of sedimentation in harbors and waterways 失效
标题翻译：积极防止港口和水路沉淀的方法和装置
公开(公告)号：US4957392A
公开(公告)日：1990-09-18
申请号：US344079
申请日：1989-04-27
申请人： James A. Bailard , Scott A. Jenkins
发明人： James A. Bailard , Scott A. Jenkins
IPC分类号： E02B3/02 , E02F3/88 , E02F5/28
CPC分类号： E02F3/8858 , E02B3/023 , E02F3/8808 , E02F5/287
摘要： An apparatus for preventing sedimentation buildup in waterways having a current, the apparatus being submergible at a location proximate the edge of the waterway and adapted to produce a scour pattern of predetermined configuration. The apparatus includes an elongated, substantially vertical tubular member having an inlet assembly connected proximate the upper end of the tubular member; a turbine fan unit mounted interiorly of the inlet assembly for controllably drawing water into the apparatus; and a discharge assembly connected to the tubular member proximate its lower end for directing the flow of water outwardly from the tubular member in generally horizontal direction at an optimum flow rate.
摘要翻译：一种用于防止在具有电流的水路中的沉积物积聚的装置，该装置在靠近水路边缘的位置处不稳定，并且适于产生预定构造的冲刷图案。该装置包括细长的，基本垂直的管状构件，其具有靠近管状构件的上端连接的入口组件; 安装在入口组件内部的涡轮风扇单元，用于可控地将水吸入设备中; 以及排出组件，其连接到靠近其下端的管状构件，用于沿水平方向以最佳流速从管状构件向外引导水流。

16. 发明授权

US4661013A Apparatus for impeding fine sediment deposition in harbors and navigational channels 失效
标题翻译：用于阻止港口和航行通道中沉积物沉积的装置
公开(公告)号：US4661013A
公开(公告)日：1987-04-28
申请号：US751332
申请日：1985-07-02
申请人： Scott A. Jenkins
发明人： Scott A. Jenkins
IPC分类号： E02F5/28 , B01D21/24 , E02B3/02 , E02B8/02
CPC分类号： E02B3/023
摘要： An apparatus for mounting adjacent the bottom of a waterway having a current for impeding the deposition of suspended sediments upon the bottom of the waterway. A buoyant wing member having leading and trailing edges with substantially flat top and bottom surfaces includes a flap member spanning the wing member and extends at a predetermined upward angle away from the top surface towards the leading edge. The apparatus is mounted with the flap member facing the bottom of the waterway wherein the fluid in the wake is accelerated upwards away from the waterway bottom so as to resuspend fine sediments. When the wing member is mounted with the flap member directed away from the waterway bottom the wake is directed downwards against the bottom causing scouring of the waterway bottom.
摘要翻译：用于安装在具有用于阻止悬浮沉积物沉积在水路底部上的电流的水道底部附近的装置。具有前缘和后缘的浮力翼构件具有基本上平坦的顶表面和底表面，包括跨过翼构件的翼片构件，并以预定的向上的角度离开顶表面向前缘延伸。装置安装有挡板构件面向水路的底部，其中尾流中的流体向上远离水路底部加速，以便重悬浮沉积物。当翼片构件安装成使得挡板构件指向远离水路底部时，尾迹向下指向底部，引起水路底部的冲刷。

17. 发明申请

US20100280066A1 ACYLATED AMINO ACID AMIDYL PYRAZOLES AND RELATED COMPOUNDS 审中-公开
标题翻译：酰胺化氨基亚氨基吡咯及相关化合物
公开(公告)号：US20100280066A1
公开(公告)日：2010-11-04
申请号：US12833758
申请日：2010-07-09
申请人： Jay S. Tung , Lee H. Latimer , Jing Wu , Albert Garofalo , Michael A. Pleiss , Darren Dressen , Ashley Guinn , Scott A. Jenkins , Jennifer Sealy , John Tucker , David W.G. Wone
发明人： Jay S. Tung , Lee H. Latimer , Jing Wu , Albert Garofalo , Michael A. Pleiss , Darren Dressen , Ashley Guinn , Scott A. Jenkins , Jennifer Sealy , John Tucker , David W.G. Wone
IPC分类号： A61K31/4725 , C07D231/38 , C07D401/12 , C07D407/04 , C07D401/04 , C07D403/12 , A61P25/28 , A61K31/415 , A61K31/4439 , A61K31/454 , C12N5/07
CPC分类号： C07D231/40 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/12
摘要： This invention is directed to acylated amino acid amidyl pyrazoles and related compounds of Formula I. The invention is also directed to a pharmaceutical formation comprising such compound or in a pharmaceutically acceptable salt form thereof. The invention is further directed to a method for inhibiting β-amyloid peptide release and/or synthesis, a method for inhibiting γ-secretase activity, and a method for treating neurological disorders associated with β-amyloid peptide production. The method comprises administering to a host a pharmaceutical formulation comprising an effective amount of a compound of Formula I. The compounds of Formula I are useful in the prevention and treatment of Alzheimer's disease.
摘要翻译：本发明涉及酰化氨基酸酰氨基吡唑和式I的相关化合物。本发明还涉及包含这种化合物或其药学上可接受的盐形式的药物组合物。本发明进一步涉及一种抑制β-淀粉样蛋白肽释放和/或合成的方法，一种抑制γ-分泌酶活性的方法，以及用于治疗与β-淀粉样蛋白肽生产相关的神经障碍的方法。该方法包括向宿主施用包含有效量的式I化合物的药物制剂。式I化合物可用于预防和治疗阿尔茨海默氏病。

18. 发明申请

US20100247636A1 Nanoparticulate and controlled release compositions comprising nilvadipine 审中-公开
标题翻译：包含尼伐地平的纳米颗粒和控释组合物
公开(公告)号：US20100247636A1
公开(公告)日：2010-09-30
申请号：US11479013
申请日：2006-06-30
申请人： John G. Devane , Paul Stark , Niall M.M. Fanning , Gurvinder Singh Rekhi , Scott A. Jenkins , Gary Liversidge
发明人： John G. Devane , Paul Stark , Niall M.M. Fanning , Gurvinder Singh Rekhi , Scott A. Jenkins , Gary Liversidge
IPC分类号： A61K9/48 , A61K31/4422 , A61K9/14 , A61K9/50 , A61K9/26 , A61K9/22 , A61P9/12 , A61P9/00
CPC分类号： A61K9/5026 , A61K9/5047 , A61K9/5084 , A61K31/192 , A61K31/485
摘要： The present invention provides a composition comprising nilvadipine, or a salt, derivative, prodrug, or polymorph thereof, useful in the treatment and prevention of hypertension or related cardiovascular disorders. In one embodiment, the composition comprises nanoparticulate particles comprising nilvadipine, or a salt, derivative, prodrug, or polymorph thereof, and at least one surface stabilizer. The nanoparticulate particles have an effective average particle size of less than about 2000 nm. In another embodiment, the composition comprises a modified release composition that, upon administration to a patient, delivers nilvadipine, or a salt, derivative, prodrug, or polymorph thereof, in a bimodal, multimodal or continuous manner. The invention also relates to dosage forms containing such compositions, and to methods for the treatment and prevention of hypertension or related cardiovascular disorders.
摘要翻译：本发明提供一种组合物，其包含可用于治疗和预防高血压或相关心血管疾病的尼伐地平或其盐，衍生物，前药或多晶型物。在一个实施方案中，组合物包含包含尼伐地平或其盐，衍生物，前药或多晶型物和至少一种表面稳定剂的纳米颗粒颗粒。纳米颗粒具有小于约2000nm的有效平均粒度。在另一个实施方案中，组合物包含改性释放组合物，其在给予患者时以双峰，多峰或连续方式递送尼伐地平或其盐，衍生物，前药或多晶型物。本发明还涉及含有这种组合物的剂型，以及治疗和预防高血压或相关心血管疾病的方法。

19. 发明申请

US20080317843A1 NANOPARTICULATE FORMULATIONS OF MODAFINIL 审中-公开
标题翻译： MODAFINIL的纳米制剂配方
公开(公告)号：US20080317843A1
公开(公告)日：2008-12-25
申请号：US11776770
申请日：2007-07-12
申请人： Scott A. Jenkins , Gary Liversidge , David Manser
发明人： Scott A. Jenkins , Gary Liversidge , David Manser
IPC分类号： A61K9/48 , A61K31/165 , A61K9/14 , A61P25/00 , A61K9/00
CPC分类号： A61K9/145 , A61K9/146
摘要： The present invention is directed to compositions comprising a nanoparticulate modafinil compositions, or a salt(s), or an enantiomer(s), or a prodrug(s), or a polymorph(s) or derivative thereof, having improved bioavailability. The nanoparticulate modafinil composition formulation particles of the composition have an effective average particle size of less than about 2000 nm and are useful in the treatment of dyssomnias, including but not limited to, narcolepsy, chronic fatigue, eating disorders, compulsive behaviors, ADHD, addictions, substance abuse, sleepiness, nervous system diseases, conditions, syndromes, and symptoms and related diseases, conditions, and symptoms.
摘要翻译：本发明涉及包含具有改善的生物利用度的纳米微粒莫达非尼组合物或其一种或多种或多种或多种或多种或多种或多种或多种形式的衍生物的组合物。组合物的纳米微粒莫达非尼组合物制剂颗粒具有小于约2000nm的有效平均粒度，并且可用于治疗睡眠障碍，包括但不限于发作性睡病，慢性疲劳，进食障碍，强迫行为，ADHD，成瘾，药物滥用，嗜睡，神经系统疾病，病症，综合征，症状及相关疾病，病症和症状。

20. 发明申请

US20080279929A1 Nanoparticulate and Controlled Release Compositions Comprising Cefditoren 有权
标题翻译：包含头孢托仑的纳米颗粒和对照释放组合物
公开(公告)号：US20080279929A1
公开(公告)日：2008-11-13
申请号：US11671276
申请日：2007-02-05
申请人： John G. Devane , Paul Stark , Nial M. N. Fanning , Gurvinder Singh Rekhi , Scott A. Jenkins , Gary Liversidge
发明人： John G. Devane , Paul Stark , Nial M. N. Fanning , Gurvinder Singh Rekhi , Scott A. Jenkins , Gary Liversidge
IPC分类号： A61K9/52 , A61K31/546 , A61K9/14 , A61K9/20 , A61K9/48 , A61P31/00 , A61K9/00
CPC分类号： A61K9/5084
摘要： The present invention provides a composition comprising a cefditoren, or a salt, derivative, prodrug, or other form thereof, for example, cefditoren pivoxil, useful in the treatment and prevention of infections and related conditions. The invention provides a composition which comprises nanoparticulate particles comprising the cefditoren, or a salt, derivative, prodrug, or other form thereof and at least one surface stabilizer. The nanoparticulate particles have an effective average particle size of less than about 2000 nm. The invention provides also a composition that delivers a cefditoren, or a salt, derivative, prodrug, or other form thereof, or nanoparticles comprising the same, in a pulsatile or continuous manner.
摘要翻译：本发明提供一种组合物，其包含可用于治疗和预防感染和相关病症的头孢托仑或其盐，衍生物，前药或其他形式，例如匹戊头孢托仑。本发明提供一种组合物，其包含包含头孢托仑或其盐，衍生物，前药或其它形式的纳米颗粒颗粒和至少一种表面稳定剂。纳米颗粒具有小于约2000nm的有效平均粒度。本发明还提供以脉动或连续方式递送头孢托仑或其盐衍生物，前药或其它形式或包含其的纳米颗粒的组合物。

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