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11. 发明授权

US06420140B1 Production of multimeric protein by cell fusion method 有权
标题翻译：通过细胞融合法制备多聚体蛋白
公开(公告)号：US06420140B1
公开(公告)日：2002-07-16
申请号：US09769070
申请日：2001-01-24
申请人： Nobuaki Hori , Claude Geoffrey Davis , Krisztina M. Zsebo , Ava Jakobovits
发明人： Nobuaki Hori , Claude Geoffrey Davis , Krisztina M. Zsebo , Ava Jakobovits
IPC分类号： C12P2104
CPC分类号： C07K14/00 , C07K16/00 , C07K16/244 , C07K2317/21 , C12N5/16 , C12N5/166 , C12N15/62 , C12N2510/02
摘要： The present invention features a method of producing a multimeric protein from a hybrid cell formed from the fusion of two or more cells, each of which cell is engineered to express one component of the multimeric protein, as well as a method for screening for successful fusion of the cells to produce a desired hybrid cell. The methods of the invention are widely applicable to the production of proteins having two or more components.
摘要翻译：本发明的特征在于从由两个或多个细胞的融合形成的杂交细胞产生多聚体蛋白质的方法，每个细胞被工程化以表达多聚体蛋白质的一个组分，以及筛选成功融合的方法的细胞以产生所需的杂交细胞。本发明的方法可广泛用于生产具有两种或多种组分的蛋白质。

12. 发明授权

US06207418B1 Production of a multimeric protein by cell fusion method 有权
标题翻译：通过细胞融合法制备多聚体蛋白
公开(公告)号：US06207418B1
公开(公告)日：2001-03-27
申请号：US09342301
申请日：1999-06-29
申请人： Nobuaki Hori , Claude Geoffrey Davis , Krisztina M. Zsebo , Aya Jakobovits
发明人： Nobuaki Hori , Claude Geoffrey Davis , Krisztina M. Zsebo , Aya Jakobovits
IPC分类号： C12P2104
CPC分类号： C07K16/244 , C07K14/00 , C07K16/00 , C07K2317/21 , C12N5/16 , C12N5/166 , C12N2510/02
摘要： The present invention features a method of producing a multimeric protein from a hybrid cell formed from the fusion of two or more cells, each of which cell is engineered to express one component of the multimeric protein, as well as a method for screening for successful fusion of the cells to produce a desired hybrid cell. The methods of the invention are widely applicable to the production of proteins having two or more components.
摘要翻译：本发明的特征在于从由两个或多个细胞的融合形成的杂交细胞产生多聚体蛋白质的方法，每个细胞被工程化以表达多聚体蛋白质的一个组分，以及筛选成功融合的方法的细胞以产生所需的杂交细胞。本发明的方法可广泛用于生产具有两种或多种组分的蛋白质。

13. 发明授权

US5549223A Pump with back suction phase 失效
标题翻译：泵具有背吸相
公开(公告)号：US5549223A
公开(公告)日：1996-08-27
申请号：US285386
申请日：1994-08-03
申请人： Nobuaki Hori
发明人： Nobuaki Hori
IPC分类号： B05B11/00 , B67D5/42 , G01F11/04
CPC分类号： B05B11/3001 , B05B11/0005 , B05B11/0062 , B05B11/3047 , B05B11/306 , B05B11/3067 , B05B11/3097
摘要： The present invention provides a pump for pumping fluids, especially highly viscous fluids such as shampoo, from a main fluid container through a nozzle without unwanted dripping, plugging, or mess. A piston reciprocates in a pump chamber, creating positive and negative pressure alternately in the pump chamber. Positive pressure in the pump chamber initiates a discharge phase of operation, wherein the fluid in the pump chamber is forced from the pump chamber through a discharge valve. Negative pressure in the pump chamber causes both a back-suction phase and a suction phase of operation. Back-suction occurs in the pump chamber immediately following the discharge phase, drawing any fluid remaining in an exit passage back through the discharge valve into the pump chamber. The suction phase starts immediately after the discharge valve closes at the end of the back-suction phase. During the suction phase, the negative pressure in the pump chamber draws fluid from the main fluid container through the suction valve and into the pump chamber. A resilient spring member biases the suction valve into a closed position during periods of non-use, especially when the pressure in the main fluid container increases due to an increase in temperature. The strength of the resilient spring member is established at a value which maintains the suction valve closed until a predetermined negative pressure is established across it.
摘要翻译：本发明提供一种用于从主流体容器通过喷嘴泵送流体，特别是高粘性流体如洗发剂的泵，而不会有不必要的滴落，堵塞或混乱。活塞在泵室中往复运动，在泵室中交替产生正压和负压。泵室中的正压开启排放操作阶段，其中泵室中的流体通过排出阀从泵室被迫动。泵室中的负压导致操作的背吸相和抽吸相。在泵室中立即在排放阶段发生背吸，将出口通道中剩余的任何流体通过排放阀返回到泵室中。在抽吸阶段结束后，排放阀关闭后立即开始抽吸阶段。在抽吸阶段期间，泵室中的负压通过吸入阀从主流体容器吸入流体并进入泵室。弹性弹簧构件在不使用期间将吸入阀偏压到关闭位置，特别是当主流体容器中的压力由于温度升高而增加时。弹性弹簧构件的强度建立在使吸气阀保持关闭直到在其周围建立预定的负压之前的值。

14. 发明申请

US20120039874A1 HUMAN MONOCLONAL ANTIBODY AGAINST A COSTIMULATORY SIGNAL TRANSDUCTION MOLECULE AILIM AND PHARMACEUTICAL USE THEREOF 审中-公开
标题翻译：人体单抗抗体信号转导分子AILIM及其药物应用
公开(公告)号：US20120039874A1
公开(公告)日：2012-02-16
申请号：US13166288
申请日：2011-06-22
申请人： Takashi Tsuji , Katsunari Tezuka , Nobuaki Hori
发明人： Takashi Tsuji , Katsunari Tezuka , Nobuaki Hori
IPC分类号： A61K39/395 , A61P3/10 , A61P37/06 , A61P29/00 , A61P17/06
CPC分类号： C07K16/18 , A01K2217/05 , A61K2039/505 , C07K16/28 , C07K16/2818 , C07K2317/21 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要： Immunization of human antibody-producing transgenic mice, which have been created using genetic engineering techniques, with AILIM molecule as an antigen resulted in various human monoclonal antibodies capable of binding to AILIM and capable of controlling a variety of biological reactions (for example, cell proliferation, cytokine production, immune cytolysis, cell death, induction of ADCC, etc.) associated with AILIM-mediated costimulatory signal (secondary signal) transduction. Furthermore, it has been revealed that the human monoclonal antibody is effective to treat and prevent various diseases associated with AILIM-mediated costimulatory signal transduction, being capable of inhibiting the onset and/or advancement of the diseases.
摘要翻译：用AILIM分子作为抗原，使用基因工程技术产生的产生抗体的转基因小鼠的免疫导致能够结合AILIM并能够控制多种生物反应的各种人单克隆抗体（例如，细胞增殖，细胞因子产生，免疫细胞溶解，细胞死亡，诱导ADCC等）与AILIM介导的共刺激信号（二级信号）转导相关。此外，已经揭示了人单克隆抗体有效治疗和预防与AILIM介导的共刺激信号转导相关的各种疾病，能够抑制疾病的发病和/或进展。

15. 发明授权

US5916771A Production of a multimeric protein by cell fusion method 失效
公开(公告)号：US5916771A
公开(公告)日：1999-06-29
申请号：US730639
申请日：1996-10-11
申请人： Nobuaki Hori , Claude Geoffrey Davis , Krisztina M. Zsebo , Aya Jakobovits
发明人： Nobuaki Hori , Claude Geoffrey Davis , Krisztina M. Zsebo , Aya Jakobovits
IPC分类号： C12N15/09 , C07K14/00 , C07K16/00 , C07K16/24 , C07K19/00 , C12N5/16 , C12N5/26 , C12P21/00 , C12P21/02 , C12P21/04 , C12P21/08 , C12N5/06 , C12N5/12 , C12N15/00
CPC分类号： C07K16/244 , C07K14/00 , C07K16/00 , C12N5/16 , C12N5/166 , C07K2317/21 , C12N2510/02
摘要： The present invention features a method of producing a multimeric protein from a hybrid cell formed from the fusion of two or more cells, each of which cell is engineered to express one component of the multimeric protein, as well as a method for screening for successful fusion of the cells to produce a desired hybrid cell. The methods of the invention are widely applicable to the production of proteins having two or more components.

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