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11. 发明申请

US20090030506A1 ENDOPROSTHESIS AND METHOD FOR MANUFACTURING SAME 审中-公开
标题翻译：内部生物学及其制造方法
公开(公告)号：US20090030506A1
公开(公告)日：2009-01-29
申请号：US12178343
申请日：2008-07-23
申请人： Bjoern Klocke , Nina Adden , Ullrich Bayer
发明人： Bjoern Klocke , Nina Adden , Ullrich Bayer
IPC分类号： A61F2/06
CPC分类号： A61L31/08 , A61F2/86 , A61F2/91 , A61F2210/0004 , A61F2250/0031 , A61L31/148
摘要： A stent with a basic mesh comprising an at least largely biodegradable material and a coating (30) arranged on the biodegradable material. The basic mesh is covered completely by a coating, except for at least one degradation area (23, 25, 32), whereby the at least one degradation area (23, 25, 32) is designed as a recess in the coating (30).
摘要翻译：具有基本网格的支架，其包括至少大部分可生物降解的材料和布置在生物可降解材料上的涂层（30）。除了至少一个降解区域（23,25,32）之外，基本网眼完全被涂层覆盖，由此将至少一个降解区域（23,25,32）设计为涂层（30）中的凹部，。

12. 发明授权

US10357596B2 Biocorrodible implants having a functionalized coating 有权
公开(公告)号：US10357596B2
公开(公告)日：2019-07-23
申请号：US12972703
申请日：2010-12-20
申请人： Laura Sager , Nina Adden
发明人： Laura Sager , Nina Adden
IPC分类号： A61F2/06 , A61L31/02 , A61L31/08 , A61L31/10 , A61L31/14
摘要： An implant includes a biocorrodible metallic material having a coating. The coating contains at least one layer in which ionic channels are embedded.

13. 发明申请

US20120150282A1 IMPLANT HAVING A PACLITAXEL-RELEASING COATING 审中-公开
标题翻译：具有PACLITAXEL-RELEASING涂层的植入物
公开(公告)号：US20120150282A1
公开(公告)日：2012-06-14
申请号：US13182786
申请日：2011-07-14
申请人： Nina Adden , Mark Steckel
发明人： Nina Adden , Mark Steckel
IPC分类号： A61F2/82
CPC分类号： A61L27/047 , A61L27/18 , A61L27/54 , A61L27/58 , A61L31/022 , A61L31/10 , A61L31/16 , A61L2300/416 , C08L67/04
摘要： An implant having a coating or a cavity filling comprising a PLGA polymer and taxane embedded therein, the release rate of the taxane after day two after implantation being ≦400 ng/day for a period of more than 10 consecutive days, characterized in that the PLGA polymer has a ratio of monomer units to each other of 60-99% lactic acid units to 40-1% glycolic acid units.
摘要翻译：具有包含PLGA聚合物和紫杉烷的紫外线涂层或腔体填充物的植入物，植入后第二天后紫杉烷的释放速率为400ng /天，连续10天以上，其特征在于， PLGA聚合物的单体单元相对于60-99％的乳酸单元相对于40-1％的乙醇酸单元。

14. 发明申请

US20110153006A1 Biocorrodible implants having a functionalized coating 审中-公开
标题翻译：具有功能化涂层的生物防腐植入物
公开(公告)号：US20110153006A1
公开(公告)日：2011-06-23
申请号：US12972703
申请日：2010-12-20
申请人： Laura Sager , Nina Adden
发明人： Laura Sager , Nina Adden
IPC分类号： A61F2/82
CPC分类号： A61L31/022 , A61L31/08 , A61L31/10 , A61L31/148 , C08L67/04
摘要： One example embodiment of the present invention relates to an implant comprising a biocorrodible metallic material and having a coating, characterized in that the coating contains at least one layer in which ionic channels are embedded.
摘要翻译：本发明的一个示例性实施方案涉及包含生物可腐蚀金属材料并具有涂层的植入物，其特征在于，所述涂层包含至少一个其中嵌入有离子通道的层。

15. 发明申请

US20100023112A1 BIOCORRODIBLE IMPLANT WITH A COATING COMPRISING A HYDROGEL 审中-公开
标题翻译：具有包含水凝胶的涂层的生物可蚀性植入物
公开(公告)号：US20100023112A1
公开(公告)日：2010-01-28
申请号：US12507216
申请日：2009-07-22
申请人： Alexander Borck , Nina Adden
发明人： Alexander Borck , Nina Adden
IPC分类号： A61F2/06
CPC分类号： A61L31/022 , A61L31/10 , A61L31/145 , A61L31/148
摘要： The invention relates to an implant having a base body consisting completely or partially of a biocorrodible metallic material, the material being such that it decomposes in an aqueous environment to yield an alkaline product and the base body has a coating comprising or containing a hydrogel, characterized in that the hydrogel has a reduced swelling capacity at an elevated pH.
摘要翻译：本发明涉及具有完全或部分由生物可腐蚀金属材料组成的基体的植入物，该材料使得其在水性环境中分解以产生碱性产物，并且基体具有包含或含有水凝胶的涂层，其特征在于因为水凝胶在升高的pH下具有降低的溶胀能力。

16. 发明申请

US20090192596A1 IMPLANT HAVING A BASE BODY OF A BIOCORRODIBLE ALLOY 审中-公开
标题翻译：具有生物可降解合金基体的植入物
公开(公告)号：US20090192596A1
公开(公告)日：2009-07-30
申请号：US12362659
申请日：2009-01-30
申请人： Nina Adden
发明人： Nina Adden
IPC分类号： A61F2/06 , A61F2/02
CPC分类号： A61L31/10 , A61L31/022 , A61L31/148
摘要： An implant having a base body comprised entirely or partially of a biocorrodible metallic material and in which at least the parts of the base body comprising the biocorrodible metallic material are covered entirely or partially with a coating which contains or is comprised of the polymer. At least 90% of the total number of polymer units of the polymer comprise polymer units of formula (1) and polymer units of formula (2) wherein R1 is alkyl, hydroxyalkyl, alkoxyalkyl or cycloalkyl; R2 is a silyl radical that is hydrolyzable in artificial plasma; R3 is hydrogen or methyl, and n+m=10 to 20,000, such that the ratio of n to m is in the range of 1:9 to 9:1.
摘要翻译：植入物具有完全或部分由生物可腐蚀的金属材料构成的基体，其中至少包含生物可腐蚀金属材料的基体的部分全部或部分被包含或由聚合物构成的涂层覆盖。聚合物聚合物单元总数的至少90％包含式（1）的聚合物单元和式（2）的聚合物单元，其中R 1是烷基，羟基烷基，烷氧基烷基或环烷基; R2是在人造血浆中可水解的甲硅烷基; R3是氢或甲基，n + m = 10〜20,000，使得n与m的比例在1:9至9:1的范围内。

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