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11. 发明授权

US07166464B2 Method of culturing cells to produce a tissue sheet 有权
标题翻译：培养细胞以生产薄页纸的方法
公开(公告)号：US07166464B2
公开(公告)日：2007-01-23
申请号：US10318279
申请日：2002-12-11
申请人： Todd N. McAllister , Nicolas L'Heureux
发明人： Todd N. McAllister , Nicolas L'Heureux
IPC分类号： C12N5/00 , C12N5/06 , C12N5/08 , C12N15/63 , C12N15/85 , A61F2/00
CPC分类号： A61L27/3886 , A61L27/3895 , A61L31/005 , A61L31/16 , C12N5/0062
摘要： The disclosure provides methods and systems for tissue engineering including an apparatus and methods for the growth, maintenance, and use of robust tissue sheets using tissue manipulation devices. The tissue manipulation devices provide a method of anchoring the tissue sheets to the cell culture substrate to promote prolonged maturation and subsequent increased mechanical strength. The tissue manipulation devices also provide a technique to facilitate removal of the sheet from the culture container and subsequent production steps to assemble more complex three dimensional organs from the robust sheet. The tissue manipulation devices also facilitate automated handling of the sheets in the assembly processes. The disclosure provides methods and composition derived from robust human sheets to build tissue engineered blood vessels, heart valves, stents, and endarterectomy patches and the like. The use of these tissue manipulation devices facilitates the assembly of complex tissue engineered organs using the novel sheet-based tissue engineering approach.
摘要翻译：本公开提供了用于组织工程的方法和系统，包括使用组织操纵装置来生长，维护和使用强健的薄页纸的装置和方法。组织操作装置提供将组织片材固定到细胞培养基底以促进长期成熟和随后增加的机械强度的方法。组织操作装置还提供了便于从培养容器中去除片材的技术，并且随后的生产步骤从坚固的片材组装更复杂的三维器官。组织操作装置还便于在组装过程中纸张的自动处理。本公开提供了从健壮的人体片材衍生的构建组织工程化血管，心脏瓣膜，支架和内膜切除术补片等的方法和组合。使用这些组织操作装置有助于使用新颖的基于片材的组织工程方法来组装复杂的组织工程化器官。

12. 发明授权

US07112218B2 Tissue engineered blood vessels and apparatus for their manufacture 有权
公开(公告)号：US07112218B2
公开(公告)日：2006-09-26
申请号：US10210952
申请日：2002-08-01
申请人： Todd N. McAllister , Nicolas L'Heureux
发明人： Todd N. McAllister , Nicolas L'Heureux
IPC分类号： A61F2/06 , C12M1/00
CPC分类号： A61L27/3886 , A61F2/06 , A61K35/12 , A61L27/3804 , A61L27/3808 , A61L27/507 , C12M21/08 , C12M23/06 , C12M27/12 , C12N5/0691 , C12N2502/1323 , Y10S623/916
摘要： The invention is a tissue engineered blood vessel (TEBV) made from a cultured fibroblast sheet rolled into a multilayer vessel which has sufficient burst strength to withstand physiological blood pressure without the inclusion of smooth muscle cells or synthetic scaffolding. The TEBV is made in a bioreactor having an enclosed chamber, a sheet growth module, a rollable mandrel, and a clamp for holding the sheet to the mandrel for rolling.

13. 发明授权

US06503273B1 Tissue engineered blood vessels and methods and apparatus for their manufacture 有权
标题翻译：组织工程血管及其制造方法和装置
公开(公告)号：US06503273B1
公开(公告)日：2003-01-07
申请号：US09444520
申请日：1999-11-22
申请人： Todd N. McAllister , Nicolas L'Heureux
发明人： Todd N. McAllister , Nicolas L'Heureux
IPC分类号： A61F206
CPC分类号： A61L27/3886 , A61F2/06 , A61K35/12 , A61L27/3804 , A61L27/3808 , A61L27/507 , C12M21/08 , C12M23/06 , C12M27/12 , C12N5/0691 , C12N2502/1323 , Y10S623/916
摘要： The invention is a tissue engineered blood vessel (TEBV) made from a cultured fibroblast sheet rolled into a multilayer vessel which has sufficient burst strength to withstand physiological blood pressure without the inclusion of smooth muscle cells or synthetic scaffolding. The TEBV is made in a bioreactor having an enclosed chamber, a sheet growth module, a rollable mandrel and a clamp for holding the sheet to the mandrel for rolling.
摘要翻译：本发明是由培养的成纤维细胞片制成的组织工程化血管（TEBV），其被卷成多层容器，其具有足够的破裂强度以抵抗生理血压而不包括平滑肌细胞或合成脚手架。 TEBV在具有封闭室的生物反应器中制造，片材生长模块，可卷起的心轴和用于将片材保持在心轴上用于滚动的夹具。

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