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11. 发明申请

US20100134335A1 APPARATUS FOR COMPENSATING FOR ERROR OF TIME-TO-DIGITAL CONVERTER 有权
标题翻译：用于补偿时间到数字转换器错误的装置
公开(公告)号：US20100134335A1
公开(公告)日：2010-06-03
申请号：US12629020
申请日：2009-12-01
申请人： Mi Jeong Park , Byung Hun Min , Ja Yol Lee , Hyun Kyu Yu
发明人： Mi Jeong Park , Byung Hun Min , Ja Yol Lee , Hyun Kyu Yu
IPC分类号： H03M1/06
CPC分类号： G04F10/06 , H03L7/085 , H03L2207/50
摘要： An apparatus for compensating for an error of a time-to-digital converter (TDC) is disclosed to receive a delay phase from a phase detector including the TDC and a phase error including a TDC error and compensate for the TDC error to have a time resolution higher by N times (N is a natural number). The apparatus includes: a fragmenting and multiplying unit fragmenting the delay phase by N times (N is a natural number) to generate first to (N−1)th fragmented delay phases; an adding unit adding each of the first to the (N−1)th fragmented delay phases to the phase error to generate first to (N−1)th phase errors; and a comparison unit acquiring a phase error compensation value nearest to an actual phase error from the phase error and the first to (N−1)th phase errors.
摘要翻译：公开了用于补偿时间 - 数字转换器（TDC）的误差的装置，以从包括TDC的相位检测器和包括TDC误差的相位误差接收延迟相位并补偿TDC误差以具有时间分辨率提高N倍（N是自然数）。该装置包括：分段和乘法单元，将延迟相位分片N次（N是自然数），以产生第一到第（N-1）个分段延迟相位; 加法单元将第一到第（N-1）个分段延迟相位中的每一个相加到相位误差，以产生第一到第（N-1）个相位误差; 以及比较单元从相位误差和第一到第（N-1）个相位误差获取最接近实际相位误差的相位误差补偿值。

12. 发明申请

US20060223848A1 Caspase inhibitors containing isoxazoline ring 有权
标题翻译：含有异恶唑啉环的胱天蛋白酶抑制剂
公开(公告)号：US20060223848A1
公开(公告)日：2006-10-05
申请号：US10568503
申请日：2004-08-26
申请人： Hye-Kyung Chang , Yeong-Soo Oh , Cheol-Won Park , Yong-Jin Jang , Tae-Kyo Park , Sung-Sub Kim , Min-Jung Kim , Mi-Jeong Park , Jung-Gyu Park , Hee-Dong Park , Kyeong-Sik Min , Tae-Soo Lee , Sang-Kyun Lee , Soo-Hyeon Kim , Hee-Kyung Jeong , Sun-Hwa Lee , Hwa-Dong Kim , Ae-Ri Kim , Ki-Sook Park , Hyun-Ik Shin , Hyeong-Wook Choi , Kyu-Woong Lee , Jae-Hoon Lee , Tae-Ho Heo , Ho-Jun Kim , Tae-Sik Kwon
发明人： Hye-Kyung Chang , Yeong-Soo Oh , Cheol-Won Park , Yong-Jin Jang , Tae-Kyo Park , Sung-Sub Kim , Min-Jung Kim , Mi-Jeong Park , Jung-Gyu Park , Hee-Dong Park , Kyeong-Sik Min , Tae-Soo Lee , Sang-Kyun Lee , Soo-Hyeon Kim , Hee-Kyung Jeong , Sun-Hwa Lee , Hwa-Dong Kim , Ae-Ri Kim , Ki-Sook Park , Hyun-Ik Shin , Hyeong-Wook Choi , Kyu-Woong Lee , Jae-Hoon Lee , Tae-Ho Heo , Ho-Jun Kim , Tae-Sik Kwon
IPC分类号： A61K31/4709 , A61K31/42 , C07D413/02
CPC分类号： C07D261/04 , C07D413/04 , C07D413/12 , C07D413/14
摘要： The present invention relates to an isoxazoline derivative as an inhibitor against various caspases, a process for preparing the same, and a therapeutic composition for preventing inflammation and apoptosis comprising the same
摘要翻译：本发明涉及作为对各种胱天蛋白酶的抑制剂的异恶唑啉衍生物，其制备方法以及用于预防包含其的炎症和凋亡的治疗组合物

13. 发明授权

US06747050B1 Isoxazoline derivative and a process for the preparation thereof 失效
标题翻译：异恶唑啉衍生物及其制备方法
公开(公告)号：US06747050B1
公开(公告)日：2004-06-08
申请号：US10088288
申请日：2002-03-15
申请人： Eunice Eun-Kyeong Kim , Mi-Jeong Park , Tae-Hee Lee , Hye-Kyung Chang , Tae-Kyo Park , Chang-Yuil Kang , Young-Myeong Kim , Kwang-Yul Moon , Young-Leem Oh , Chang-Hee Min , Hyun-Ho Chung
发明人： Eunice Eun-Kyeong Kim , Mi-Jeong Park , Tae-Hee Lee , Hye-Kyung Chang , Tae-Kyo Park , Chang-Yuil Kang , Young-Myeong Kim , Kwang-Yul Moon , Young-Leem Oh , Chang-Hee Min , Hyun-Ho Chung
IPC分类号： A61K3142
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D261/18 , C07D413/12
摘要： The present invention provides to an isoxazoline derivative of formula (I), the pharmaceutically acceptable salts, esters and stereochemically isomeric forms thereof, and the use of the derivative in inhibiting the activity of caspases. The present invention also provides a pharmaceutical composition for preventing inflammation and apoptosis which comprise the isoxazoline derivative, pharmaceutically acceptable salts, esters and stereochemically isomeric forms thereof and the process for preparing the same. The derivative according to the present invention can be effectively used in treating diseases due to caspases, such as, for example the disease in which cells are abnormally died, dementia, cerebral stroke, AIDS, diabetes, gastric ulcer, hepatic injury by hepatitis, sepsis, organ transplantation rejection reaction and anti-inflammation.
摘要翻译：本发明提供了式（I）的异恶唑啉衍生物，其药学上可接受的盐，酯和立体化学异构形式，以及该衍生物在抑制胱天蛋白酶活性方面的用途。本发明还提供了包含异恶唑啉衍生物，其药学上可接受的盐，酯和立体化学异构形式的用于预防炎症和细胞凋亡的药物组合物及其制备方法。根据本发明的衍生物可以有效地用于治疗由于胱天蛋白酶引起的疾病，例如细胞异常死亡的疾病，痴呆，脑卒中，艾滋病，糖尿病，胃溃疡，肝炎肝损伤，败血症器官移植排斥反应和抗炎。

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