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11. 发明申请

US20100189649A1 MONOCLONAL ANTIBODIES TO ACTIVATED ERBB FAMILY MEMBERS AND METHODS OF USE 审中-公开
标题翻译：活化ERBB家族成员的单克隆抗体及其使用方法
公开(公告)号：US20100189649A1
公开(公告)日：2010-07-29
申请号：US12651527
申请日：2010-01-04
申请人： Mark I. Greene , Hongtao Zhang , Mark Richter , Ramachandran Murali
发明人： Mark I. Greene , Hongtao Zhang , Mark Richter , Ramachandran Murali
IPC分类号： A61K39/395 , C07K16/00 , A61K49/00 , A61P35/00
CPC分类号： C07K14/71 , A61K38/00 , A61K39/00 , A61K47/62 , A61K47/646 , C07K14/7151 , C07K14/82
摘要： Antibodies which bind to activated members of the erbB, TNF, and IgSF family of receptors and pharmaceutical compositions comprising the same are disclosed. Peptides and mimetics of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are also described. Methods of using such antibodies, peptides, and mimetics in tumor therapeutic, prophylactic, imaging and diagnostic applications are disclosed.
摘要翻译：公开了结合erbB，TNF和IgSF受体家族的活化成员的抗体和包含其的药物组合物的抗体。还描述了erbB，TNF和IgSF受体的肽和模拟物以及包含其的药物组合物。公开了在肿瘤治疗，预防，成像和诊断应用中使用这些抗体，肽和模拟物的方法。

12. 发明授权

US07303203B1 Ergonomic wheelchair hand rim 有权
标题翻译：符合人体工程学的轮椅手轮
公开(公告)号：US07303203B1
公开(公告)日：2007-12-04
申请号：US10861016
申请日：2004-06-04
申请人： William Mark Richter , Jamie Hameed Noon , Peter William Axelson
发明人： William Mark Richter , Jamie Hameed Noon , Peter William Axelson
IPC分类号： B62M1/14
CPC分类号： A61G5/028 , A61G5/02 , B33Y80/00
摘要： Wheelchair hand rim device comprised of a heat conducting tubular hand rim and a continuous circumferential elastomeric interface that has a cross-sectional contour comprised of an outwardly extending horizontal member having a proximal end coupled to an outboard side of a wheel rim transitioning into a downwardly depending member terminating to a distal end coupled to an inboard upper portion of the tubular hand rim such that a majority of the tubular hand rim is exposed and devoid of the elastomeric interface. When braking, a user only uses the heat conducting tubular hand rim. When pushing, the user grips across both the tubular hand rim and the contoured elastomeric interface, which deforms to fit the hand, thereby providing improved comfort, frictional coupling, and impact attenuation.
摘要翻译：轮椅手轮装置包括导热管状手边缘和连续的圆周弹性体界面，其具有横截面轮廓，该横截面轮廓包括向外延伸的水平构件，其具有联接到轮缘的外侧的过渡到向下垂直端部终止于耦合到管状手轮边缘的内侧上部的远端，使得大部分管状手边缘暴露并且没有弹性体界面。制动时，用户只能使用导热管状手轮。当推动时，使用者夹住管状手边和成型的弹性体界面，其变形以适合手，从而提供改善的舒适性，摩擦耦合和冲击衰减。

13. 发明申请

US20060035248A1 Assays employing electrochemiluminescent labels and electrochemiluminescence quenchers 审中-公开
标题翻译：测定采用电化学发光标记和电化学发光淬灭剂
公开(公告)号：US20060035248A1
公开(公告)日：2006-02-16
申请号：US11124407
申请日：2005-05-09
申请人： Mark Richter , Michael Powell , Christopher Belisle
发明人： Mark Richter , Michael Powell , Christopher Belisle
IPC分类号： C12Q1/68
CPC分类号： G01N33/542 , C09B57/10 , C09B69/109 , G01N33/582
摘要： This invention pertains to the general field of chemical and biological assays which employ electrochemiluminescence (ECL), also referred to as electrogenerated chemiliminescence. More particularly, the present invention pertains to certain classes of chemical moieties which strongly quench ECL, and the use of these ECL quenchers in combination with ECL labels, for example, in ECL assay methods which employ an ECL quencher and an ECL label. One class of such quenching moieties are those which comprise at least one benzene moiety. Sub-classes of such quenching moieties are those which comprise at least one phenol moiety, quinone moiety, benzene carboxylic acid, and/or benzene carboxylate moiety.
摘要翻译：本发明涉及使用电化学发光（ECL）的化学和生物测定的一般领域，也被称为电生化学发光。更具体地说，本发明涉及强烈猝灭ECL的某些类别的化学部分，以及这些ECL猝灭剂与ECL标记的组合的使用，例如在采用ECL猝灭剂和ECL标记的ECL测定方法中。一类这样的猝灭部分是包含至少一个苯部分的那些。这种猝灭部分的亚类是包含至少一个苯酚部分，醌部分，苯羧酸和/或苯羧酸酯部分的那些。

14. 发明授权

US6120047A Low impact hand rim apparatus for hand-propelled wheelchair 失效
标题翻译：手推轮椅的低冲击手轮装置
公开(公告)号：US6120047A
公开(公告)日：2000-09-19
申请号：US240101
申请日：1999-01-29
申请人： Peter W. Axelson , W. Mark Richter
发明人： Peter W. Axelson , W. Mark Richter
IPC分类号： A61G5/02 , A61G5/10 , B62M1/14
CPC分类号： A61G5/10 , A61G5/02 , A61G5/028
摘要： A hand rim assembly for a wheelchair wheel is disclosed, which includes an larger diameter hand rim and a smaller diameter hand rim. In one embodiment, the hand rim assembly is biasly coupled to the wheelchair wheel by a plurality of shock absorbing resilient fasteners. The shock absorbing resilient fasteners generally lessen the shock impact to the user's hands, arms, and shoulders, thus reducing the potential for repetitive stress injury and the like. In another embodiment, the smaller diameter hand rim has a different exterior coefficient of friction than that of the larger diameter rim so that users can use the hand rim with a higher coefficient of friction for propulsion and the rim with a lower coefficient of friction for braking. In addition, the rim used for braking, typically the smaller diameter rim, is formed of a thermally conductive material to reduce the potential for burning of the user's hands during braking.
摘要翻译：公开了一种用于轮椅轮的手轮组件，其包括较大直径的手轮边缘和较小直径的手轮边缘。在一个实施例中，手轮边缘组件通过多个减震弹性紧固件而偏置地联接到轮椅轮上。冲击吸收弹性紧固件通常减轻对使用者的手，手臂和肩部的冲击冲击，从而减少重复的应力损伤等的可能性。在另一个实施例中，较小直径的手轮边缘具有与较大直径轮辋不同的外部摩擦系数，使得用户可以使用具有较高摩擦系数的手轮用于推进，并且具有较低摩擦系数的轮辋用于制动。此外，用于制动的轮辋，通常为较小直径的轮辋，由导热材料形成，以减少在制动期间用户的灼烧的可能性。

15. 发明授权

US08057799B2 ErbB interface peptidomimetics and methods of use thereof 失效
标题翻译： ErbB界面肽模拟物及其使用方法
公开(公告)号：US08057799B2
公开(公告)日：2011-11-15
申请号：US12625706
申请日：2009-11-25
申请人： Mark I. Greene , Ramachandran Murali , Hongtao Zhang , Mark Richter , Alan Berezov , Qingdu Liu , Jinqiu Chen
发明人： Mark I. Greene , Ramachandran Murali , Hongtao Zhang , Mark Richter , Alan Berezov , Qingdu Liu , Jinqiu Chen
IPC分类号： A61K39/00
CPC分类号： C07K14/71 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K47/48238 , A61K47/4833 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/62 , A61K47/646 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K51/10 , C07K7/06 , C07K7/08 , C07K14/7151 , C07K14/82
摘要： Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed.
摘要翻译：描述了erbB，TNF和IgSF受体的肽，模拟物和抗体以及包含其的药物组合物。公开了在治疗，预防，成像和诊断应用中使用这些抗体，肽和模拟物的方法。

16. 发明授权

US08007407B2 Wheelchair accessible treadmill 有权
标题翻译：轮椅无障碍跑步机
公开(公告)号：US08007407B2
公开(公告)日：2011-08-30
申请号：US12422069
申请日：2009-04-10
申请人： Mark Richter
发明人： Mark Richter
IPC分类号： A63B22/02
CPC分类号： A63B71/0009 , A63B22/0235 , A63B22/0242 , A63B2024/0093 , A63B2071/0018 , A63B2071/0081 , A63B2220/13
摘要： A wheelchair-accessible treadmill with a safety system allowing wheelchair users to exercise without the risk off steering off-course, tipping over, or rolling backwards off the treadmill. The wheelchair is secured by straps or similar means to two or more linear bearings that move along the side of the treadmill on rods or in tracks. When securely fastened, these allow the wheelchair to move forward and backward on the treadmill belt. The treadmill belt may be wider than standard, the height may be lower than standard, and a ramp may be used for access. An optical sensor may be used to determine the forward and backward movement of the wheelchair user. Wheelchair specific programs may be available through the control panel.
摘要翻译：轮椅无障碍跑步机，带有安全系统，使轮椅使用者能够运动，而不会冒险离开，倾斜或者从跑步机向后滚动。轮椅通过带子或类似方式固定在两个或多个直线轴承上，这些直线轴承沿着跑步机的一侧在杆上或轨道上移动。当牢固固定时，轮椅可以在跑步机皮带上前后移动。跑步机皮带可能比标准宽，高度可能低于标准，并且斜坡可以用于进出。可以使用光学传感器来确定轮椅使用者的向前和向后的运动。可通过控制面板提供具体轮椅方案。

17. 发明申请

US20100076174A1 ErbB Interface Peptidomimetics And Methods Of Use Thereof 有权
公开(公告)号：US20100076174A1
公开(公告)日：2010-03-25
申请号：US12625650
申请日：2009-11-25
申请人： Mark I. Greene , Ramachandran Murali , Hongtao Zhang , Mark Richter , Alan Berezov , Qingdu Liu , Jinqiu Chen
发明人： Mark I. Greene , Ramachandran Murali , Hongtao Zhang , Mark Richter , Alan Berezov , Qingdu Liu , Jinqiu Chen
IPC分类号： C07K7/08 , C07K7/06 , C07K14/00
CPC分类号： C07K14/71 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K47/48238 , A61K47/4833 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/62 , A61K47/646 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K51/10 , C07K7/06 , C07K7/08 , C07K14/7151 , C07K14/82
摘要： Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed.

18. 发明申请

US20200223411A1 TRACTOR POWERED PRESSURIZED SEMI-TRACTOR AND TRAILER WASHER 审中-公开
公开(公告)号：US20200223411A1
公开(公告)日：2020-07-16
申请号：US16744535
申请日：2020-01-16
申请人： Mark RICHTER
发明人： Mark RICHTER
IPC分类号： B60T8/48 , B60S1/66 , B08B3/02
摘要： An on-board pressurized washing system that utilizes a semi-tractor or trailer's compressed air brake line as its source of compressed air. When the tractor is parked, the air brake lines may be disconnected from the trailer and hooked up to the pressurized washing system. The system is fully mobile and does not need an external power source or water line during operation. The water from the water tank and the compressed air are sprayed separately or together from a spray wand to meet cleaning and sanitation needs of truck drivers in any location when they may not have access to electricity or a water source.

19. 发明申请

US20170014286A1 ADJUSTABLE WHEELCHAIR HANDRIM WITH MOVABLE FRICTION BAND 审中-公开
标题翻译：可调节轮椅带可移动摩擦带
公开(公告)号：US20170014286A1
公开(公告)日：2017-01-19
申请号：US14325626
申请日：2014-07-08
申请人： MARK RICHTER
发明人： MARK RICHTER
IPC分类号： A61G5/02
CPC分类号： A61G5/028 , A61G5/10 , Y10T74/2087
摘要： An adjustable manual wheelchair handrim with a moveable elastomeric friction band. The position of the tubular handrim can be moved to a desired location relative to the wheel rim depending on the needs and limits of the user. The movable friction band is stretched around the drive surface of the handrim at a desired location preventing it from moving and providing increased frictional properties when gripped by the user during pushes. The friction band can be permanently affixed at a location to further prevent movement and slippage between the handrim and the friction band.
摘要翻译：一个可调节的手动轮椅扶手带有可移动的弹性摩擦带。根据用户的需要和限制，管状手指的位置可以相对于轮缘移动到期望的位置。可移动的摩擦带在所希望的位置处被拉伸在手指的驱动表面周围，从而防止它在移动时被使用者在推动时握住时提供增加的摩擦特性。摩擦带可以永久地固定在一个位置，以进一步防止手指和摩擦带之间的运动和滑动。

20. 发明授权

US08770611B2 Adjustable wheelchair handrim with movable friction band 有权
标题翻译：带可移动摩擦带的可调式轮椅扶手
公开(公告)号：US08770611B2
公开(公告)日：2014-07-08
申请号：US13409400
申请日：2012-03-01
申请人： W Mark Richter
发明人： W Mark Richter
IPC分类号： A61G5/10
CPC分类号： A61G5/028 , A61G5/10 , Y10T74/2087
摘要： An adjustable manual wheelchair handrim with a moveable elastomeric friction band. The position of the tubular handrim can be moved to a desired location relative to the wheel rim depending on the needs and limits of the user. The movable friction band is stretched around the drive surface of the handrim at a desired location preventing it from moving and providing increased frictional properties when gripped by the user during pushes. The friction band can be permanently affixed at a location to further prevent movement and slippage between the handrim and the friction band.
摘要翻译：一个可调节的手动轮椅扶手带有可移动的弹性摩擦带。根据用户的需要和限制，管状手指的位置可相对于轮辋移动到期望的位置。可移动的摩擦带在所希望的位置处被拉伸在手指的驱动表面周围，从而防止它在移动时被使用者在推动时握住时提供增加的摩擦特性。摩擦带可以永久地固定在一个位置，以进一步防止手指和摩擦带之间的运动和滑动。

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