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11. 发明申请

US20100041848A1 AMPHIPHILIC POLYMER AND METHOD FOR PREPARING THE SAME 审中-公开
标题翻译：聚合聚合物及其制备方法
公开(公告)号：US20100041848A1
公开(公告)日：2010-02-18
申请号：US12352274
申请日：2009-01-12
申请人： Chia-Chang Liu , Ken-Yuan Chang , Fa-Chen Chi
发明人： Chia-Chang Liu , Ken-Yuan Chang , Fa-Chen Chi
IPC分类号： C08F251/00
CPC分类号： C08G63/08 , C07H15/02 , C08G63/912 , C08G2261/126
摘要： An amphiphilic polymer having the following formula (I): wherein Z is a hydroxyl-substituted aliphatic group having formula (Z1) or (Z2): wherein R11 and R21 are independently hydrogen, hydroxyl, hydroxymethyl, methyl, or a C1-C20 alkyl group, and R12, R13, R14, R22, R23, and R24 are independently hydrogen, hydroxyl, or a sugar moiety;X is a C1-C6 divalent aliphatic group; andY is a biodegradable group having the following formula (II): wherein R′ is a hydrocarbyl group or a polyester block having the following formula (II-A), wherein, in each occurrence, R is hydrogen or a C1-C18 alkyl group, m is an integer ranging from 0 to 5, and n is an integer ranging from 10 to 300.
摘要翻译：具有下式（I）的两亲性聚合物：其中Z是具有式（Z1）或（Z2）的羟基取代的脂族基团：其中R11和R21独立地是氢，羟基，羟甲基，甲基或C1-C20烷基基团，R 12，R 13，R 14，R 22，R 23和R 24独立地为氢，羟基或糖部分; X是C1-C6二价脂族基团; Y为具有下式（II）的生物降解基团：其中R'为烃基或具有下式（II-A）的聚酯嵌段，其中R为氢或C 1 -C 18烷基组，m为0〜5的整数，n为10〜300的整数。

12. 发明申请

US20090170976A1 Polysiloxane-based prepolymer and hydrogel 有权
标题翻译：聚硅氧烷基预聚物和水凝胶
公开(公告)号：US20090170976A1
公开(公告)日：2009-07-02
申请号：US12292929
申请日：2008-12-01
申请人： Ching-Ping Huang , Roy Wu , Ken-Yuan Chang
发明人： Ching-Ping Huang , Roy Wu , Ken-Yuan Chang
IPC分类号： G02B1/04 , B31B1/62
CPC分类号： C08G77/20 , A61L27/18 , A61L27/52 , C08G77/44 , C08L83/10 , C08L83/04
摘要： A polysiloxane-based prepolymer of a three-dimensional network structure produced by hydrolysis-condensation of a first mixture having a tetra-alkoxysilane compound, an ethylenically unsaturated organosiloxane monomer, and a hydrophilic silicon-containing polyfunctional monomer. A hydrogel is prepared by polymerizing a second mixture having the aforesaid polysiloxane-based prepolymer, an acrylated silicon-containing monomer, and an ethylenically unsaturated hydrophilic monomer.
摘要翻译：通过具有四烷氧基硅烷化合物，烯键式不饱和有机硅氧烷单体和亲水性含硅多官能单体的第一混合物的水解缩合制备的三维网状结构体的聚硅氧烷类预聚物。通过聚合具有上述聚硅氧烷类预聚物，丙烯酸酯化含硅单体和烯属不饱和亲水单体的第二混合物制备水凝胶。

13. 发明授权

US08530405B2 Method of preparing water-soluble and biodegradable antimicrobial agent 失效
标题翻译：制备水溶性和生物可降解抗微生物剂的方法
公开(公告)号：US08530405B2
公开(公告)日：2013-09-10
申请号：US13098814
申请日：2011-05-02
申请人： Chun-Yi Li , Ken-Yuan Chang , Chia-Chang Liu , Ying-Nan Tsai
发明人： Chun-Yi Li , Ken-Yuan Chang , Chia-Chang Liu , Ying-Nan Tsai
IPC分类号： A01N37/18 , A61K38/00 , A61P31/00
CPC分类号： A01N37/46 , A01N59/00 , A01N2300/00
摘要： A method of preparing a water-soluble and biodegradable antimicrobial agent is provided. The method includes treating a polypeptide compound with sodium hypochlorite for at least 1 min, such that the polypeptide compound has at least one N-halamine group and has good antimicrobial effect. By using the method of the present invention, a chemical synthesis process is not required and an organic solvent is not required either, and thus, an antimicrobial agent having high water solubility, biodegradability, non-toxicity, good sterilization effect, and regeneration can be prepared with reduced harms to the environment.
摘要翻译：提供了制备水溶性和可生物降解的抗微生物剂的方法。该方法包括用次氯酸钠处理多肽化合物至少1分钟，使得多肽化合物具有至少一个N-卤代胺基团并且具有良好的抗微生物作用。通过使用本发明的方法，不需要化学合成方法，也不需要有机溶剂，因此具有高水溶性，生物降解性，无毒性，良好灭菌效果和再生的抗菌剂可以是准备减少对环境的危害。

14. 发明申请

US20120161067A1 DENTAL ETCHING GEL COMPOSITION AND METHOD OF USE THEREOF 审中-公开
标题翻译：牙齿蚀刻凝胶组合物及其使用方法
公开(公告)号：US20120161067A1
公开(公告)日：2012-06-28
申请号：US12976264
申请日：2010-12-22
申请人： Chih-Ta Lee , Ken-Yuan Chang
发明人： Chih-Ta Lee , Ken-Yuan Chang
IPC分类号： C09K13/06 , C09K13/08
CPC分类号： A61K8/24 , A61K8/731 , A61K2800/48 , A61Q11/00
摘要： The present invention provides a dental etching gel composition including phosphoric acid in aqueous solution form, a viscosity-enhancing agent and optionally additives, in which the viscosity-enhancing agent is carboxymethyl cellulose (CMC) with the following properties: (a) having a viscosity of about 100 to about 2000 cps when formulated as an aqueous solution containing 1 wt % of CMC; and (b) having an average degree of substitution of sodium salts in molecular formula of about 21% to about 33%. The dental etching gel composition of the present invention can be used to pre-treat the surface of teeth prior to repair or filling. The etching gel formed by combining phosphoric acid in aqueous solution form with CMC viscosity-enhancing agent having the specific properties stated above is less fluid and thus can be used to etch the specific surface of the tooth so as to obtain a rough surface which improves the close adhesion between teeth and filling resins in the subsequent repairing or filling process.
摘要翻译：本发明提供一种包含水溶液形式的磷酸，粘度增强剂和任选的添加剂的牙科蚀刻凝胶组合物，其中粘度增强剂是具有以下性质的羧甲基纤维素（CMC）：（a）具有粘度当配制成含有1重量％CMC的水溶液时约100至约2000cps; 和（b）分子式中钠盐的平均取代度为约21％至约33％。本发明的牙科蚀刻凝胶组合物可用于在修复或填充之前预处理牙齿表面。通过将水溶液形式的磷酸与具有上述特定性质的CMC粘度增强剂组合形成的蚀刻凝胶较少，因此可用于蚀刻齿的比表面，从而获得粗糙表面，从而改善在随后的修复或填充过程中，牙齿和填充树脂之间的紧密粘合。

15. 发明授权

US08034892B2 Biocidal polymer and process for preparing the same 有权
标题翻译：杀生物聚合物及其制备方法
公开(公告)号：US08034892B2
公开(公告)日：2011-10-11
申请号：US12484793
申请日：2009-06-15
申请人： Ken-Yuan Chang , Cheng-Tar Wu , Fa-Chen Chi , Kuo-Cheng Lu , Lin-Chien Yu
发明人： Ken-Yuan Chang , Cheng-Tar Wu , Fa-Chen Chi , Kuo-Cheng Lu , Lin-Chien Yu
IPC分类号： C08G63/00 , C08G63/02
CPC分类号： C08G69/00 , C08G18/3829 , C08G18/4854 , C08G18/6681 , C08G18/831 , Y10T428/31504 , Y10T428/31507
摘要： A biocidal polymer including at least one repeating unit of formula (A): wherein: R1 in each occurrence independently represents a divalent aromatic group containing 6 to 30 carbon atoms, a C2-C16 alkylene group or an alkylene biscyclohexyl; Y in each occurrence independently represents an oxygen atom or a sulfur atom; and Z1, Z2, Z3 and Z4 in each occurrence independently represent a hydrogen atom or a halogen atom; wherein at least one of Z1, Z2, Z3 and Z4 in the at least one repeating unit of formula (A) is a halogen atom.
摘要翻译：一种杀生物聚合物，其包含至少一种式（A）的重复单元：其中：每次出现的R 1独立地表示含有6至30个碳原子的二价芳族基团，C 2 -C 16亚烷基或亚烷基双环己基; 每次出现Y独立地表示氧原子或硫原子; 并且Z1，Z2，Z3和Z4各自独立地表示氢原子或卤素原子; 其中所述至少一个式（A）重复单元中的Z 1，Z 2，Z 3和Z 4中的至少一个为卤素原子。

16. 发明申请

US20090098177A1 Methods and devices for tissue repair 审中-公开
标题翻译：组织修复的方法和装置
公开(公告)号：US20090098177A1
公开(公告)日：2009-04-16
申请号：US12292169
申请日：2008-11-13
申请人： Jerome Anthony Werkmeister , Wei-Bor Tsai , John Alan Maurice Ramshaw , Helmut Werner Thissen , Ken-Yuan Chang
发明人： Jerome Anthony Werkmeister , Wei-Bor Tsai , John Alan Maurice Ramshaw , Helmut Werner Thissen , Ken-Yuan Chang
IPC分类号： A61K9/00 , A61K35/12
CPC分类号： A61L27/3886 , A61K35/12 , A61L27/3608 , A61L27/3804 , A61L27/3817 , A61L27/3852 , A61L27/3895 , A61L27/52 , A61L2400/06 , A61L2430/06 , C12N5/0075 , C12N5/0653 , C12N5/0654 , C12N5/0655 , C12N5/0656 , C12N2533/40 , C12N2533/54
摘要： Methods for treating diseased or damaged tissue in a subject are disclosed, involving administering to said subject at a site wherein diseased or damaged tissue occurs, cells of a type(s) normally found in healthy tissue corresponding to the diseased or damaged tissue, and/or suitable progenitor cells thereof, in association with bioresorbable beads or particles and optionally a gel and/or gel-forming substance. Where the cells an/or suitable progenitor cells thereof are chondrocytes, embryonic stem cells and/or bone marrow stromal cells, the methods of the invention are suitable for treating, for example, articular cartilage degeneration associated with primary osteoarthritis. Also disclosed is a device having tissue-like characteristics for treating diseased or damaged tissue in a subject, wherein the device comprises cells of a type(s) normally found in healthy tissue corresponding to the diseased or damaged tissue, and/or suitable progenitor cells thereof, in association with bioresorbable beads or particles and optionally a gel and/or gel-forming substance.
摘要翻译：公开了用于治疗受试者中的患病或受损组织的方法，包括在发生病变或损伤的组织的部位施用所述受试者，通常在对应于患病或损伤的组织的健康组织中发现的细胞和/ 或其合适的祖细胞，其与生物可再吸收的珠粒或颗粒以及任选的凝胶和/或凝胶形成物质结合。在细胞/或其合适的祖细胞是软骨细胞，胚胎干细胞和/或骨髓基质细胞的情况下，本发明的方法适用于治疗例如与原发性骨关节炎相关的关节软骨变性。还公开了一种具有用于治疗受试者中的患病或受损组织的组织样特征的装置，其中该装置包括通常存在于对应于患病或受损组织的健康组织中的类型的细胞和/或合适的祖细胞与生物可再吸收的珠粒或颗粒以及任选的凝胶和/或凝胶形成物质结合。

17. 发明申请

US20050089578A1 Methods and devices for tissue repair 审中-公开
标题翻译：组织修复的方法和装置
公开(公告)号：US20050089578A1
公开(公告)日：2005-04-28
申请号：US10470946
申请日：2002-02-05
申请人： Jerome Werkmeister , Wei-Bor Tsai , John Ramshaw , Helmut Thissen , Ken-Yuan Chang
发明人： Jerome Werkmeister , Wei-Bor Tsai , John Ramshaw , Helmut Thissen , Ken-Yuan Chang
IPC分类号： A61K47/34 , A61F2/30 , A61K31/726 , A61K35/12 , A61K35/32 , A61K45/00 , A61K47/36 , A61K47/42 , A61K47/46 , A61K47/48 , A61L27/00 , A61L27/38 , A61L27/52 , A61P19/00 , A61P19/02 , A61P19/04 , C12N5/00 , C12N5/077 , A61K9/14
CPC分类号： A61L27/3886 , A61K35/12 , A61L27/3608 , A61L27/3804 , A61L27/3817 , A61L27/3852 , A61L27/3895 , A61L27/52 , A61L2400/06 , A61L2430/06 , C12N5/0075 , C12N5/0653 , C12N5/0654 , C12N5/0655 , C12N5/0656 , C12N2533/40 , C12N2533/54
摘要： Methods for treating diseased or damaged tissue in a subject are disclosed, involving administering to said subject at a site wherein diseased or damaged tissue occurs, cells of a type(s) normally found in healthy tissue corresponding to the diseased or damaged tissue, and/or suitable progenitor cells thereof, in association with bioresorbable beads or particles and optionally a gel and/or gel-forming substance. Where the cells and/or suitable progenitor cells thereof are chondrocytes, embryonic stem cells and/or bone marrow stromal cells, the methods of the invention are suitable for treating, for example, articular cartilage degeneration associated with primary osteoarthritis. Also disclosed is a device having tissue-like characteristics for treating diseased or damaged tissue in a subject, wherein the device comprises cells of a type(s) normally found in healthy tissue corresponding to the diseased or damaged tissue, and/or suitable progenitor cells thereof, in association with bioresorbable beads or particles and optionally a gel and/or gel-forming substance.
摘要翻译：公开了用于治疗受试者中的患病或受损组织的方法，包括在发生病变或损伤的组织的部位施用所述受试者，通常在对应于患病或损伤的组织的健康组织中发现的细胞和/ 或其合适的祖细胞，其与生物可再吸收的珠粒或颗粒以及任选的凝胶和/或凝胶形成物质结合。当细胞和/或其合适的祖细胞是软骨细胞，胚胎干细胞和/或骨髓基质细胞时，本发明的方法适用于治疗例如与原发性骨关节炎相关的关节软骨变性。还公开了一种具有用于治疗受试者中的患病或受损组织的组织样特征的装置，其中该装置包括通常存在于对应于患病或受损组织的健康组织中的类型的细胞和/或合适的祖细胞与生物可再吸收的珠粒或颗粒以及任选的凝胶和/或凝胶形成物质结合。

18. 发明申请

US20110129437A1 PLATELET ADHESION-RESISTANT MATERIAL 审中-公开
标题翻译：钢板耐粘结材料
公开(公告)号：US20110129437A1
公开(公告)日：2011-06-02
申请号：US12956179
申请日：2010-11-30
申请人： Ying-nan TSAI , Ken-Yuan Chang , Fa Chen Chi , Po-Yang Chen , Cheng-Tar Wu
发明人： Ying-nan TSAI , Ken-Yuan Chang , Fa Chen Chi , Po-Yang Chen , Cheng-Tar Wu
IPC分类号： A61K31/785 , A61P7/02 , C08F222/40 , C08G71/04
CPC分类号： C08G18/7671 , A61K31/785 , C08G18/3829 , C08G18/4833 , C08G18/6685 , C08G18/755 , C08G18/758
摘要： A platelet adhesion-resistant material is provided, which includes polytriuret-urethane consisting essentially of repeating structural units of formulae (I) to (III) in a random order, in which when the total number of the three repeating structural units in the polytriuret-urethane is 100, the number of the repeating structural units (I) is about 5 to about 50: in which each R independently represents a C2-C16 alkylene group, a C6-C30 aromatic group, a C6-C30 alicyclic group; n is an integer of 2 to 16; and R1 represents —(OCmH2m)p, in which m is an integer of 2 to 5, and p is an integer of 3 to 150.
摘要翻译：提供了一种抗血小板粘合性材料，其包括基本上由随机顺序的式（I）至（III）的重复结构单元组成的多核苷酸 - 氨基甲酸酯，其中当多萜类化合物的三个重复结构单元的总数，氨基甲酸酯为100，重复结构单元（I）的数量为约5至约50：其中各R独立地表示C2-C16亚烷基，C6-C30芳族基团，C6-C30脂环族基团; n为2〜16的整数。并且R 1表示 - （OC m H 2n）p，其中m为2至5的整数，p为3至150的整数。

19. 发明授权

US07906563B2 Polysiloxane-based prepolymer and hydrogel 有权
标题翻译：聚硅氧烷基预聚物和水凝胶
公开(公告)号：US07906563B2
公开(公告)日：2011-03-15
申请号：US12292929
申请日：2008-12-01
申请人： Ching-Ping Huang , Roy Wu , Ken-Yuan Chang
发明人： Ching-Ping Huang , Roy Wu , Ken-Yuan Chang
IPC分类号： C08F290/06 , C07F7/04
CPC分类号： C08G77/20 , A61L27/18 , A61L27/52 , C08G77/44 , C08L83/10 , C08L83/04
摘要： A polysiloxane-based prepolymer of a three-dimensional network structure produced by hydrolysis-condensation of a first mixture having a tetra-alkoxysilane compound, an ethylenically unsaturated organosiloxane monomer, and a hydrophilic silicon-containing polyfunctional monomer. A hydrogel is prepared by polymerizing a second mixture having the aforesaid polysiloxane-based prepolymer, an acrylated silicon-containing monomer, and an ethylenically unsaturated hydrophilic monomer.
摘要翻译：通过具有四烷氧基硅烷化合物，烯键式不饱和有机硅氧烷单体和亲水性含硅多官能单体的第一混合物的水解缩合制备的三维网状结构体的聚硅氧烷类预聚物。通过聚合具有上述聚硅氧烷类预聚物，丙烯酸酯化含硅单体和烯属不饱和亲水单体的第二混合物制备水凝胶。

20. 发明申请

US20090318659A1 BIOCIDAL POLYMER AND PROCESS FOR PREPARING THE SAME 有权
标题翻译：生物聚合物及其制备方法
公开(公告)号：US20090318659A1
公开(公告)日：2009-12-24
申请号：US12484793
申请日：2009-06-15
申请人： Ken-Yuan CHANG , Cheng-Tar Wu , Fa-Chen Chi , Kuo-Cheng Lu , Lin-Chien Yu
发明人： Ken-Yuan CHANG , Cheng-Tar Wu , Fa-Chen Chi , Kuo-Cheng Lu , Lin-Chien Yu
IPC分类号： C08G69/00
CPC分类号： C08G69/00 , C08G18/3829 , C08G18/4854 , C08G18/6681 , C08G18/831 , Y10T428/31504 , Y10T428/31507
摘要： Disclosed herein is a biocidal polymer including at least one repeating unit of formula (A): wherein: R1 in each occurrence independently represents a divalent aromatic group containing 6 to 30 carbon atoms, a C2-C16 alkylene group or an alkylene biscyclohexyl; Y in each occurrence independently represents an oxygen atom or a sulfur atom; and Z1, Z2, Z3 and Z4 in each occurrence independently represent a hydrogen atom or a halogen atom; wherein at least one of Z1, Z2, Z3 and Z4 in the at least one repeating unit of formula (A) is a halogen atom. The preparation process and applications of the biocidal polymer are also disclosed.
摘要翻译：本文公开了包含至少一种式（A）的重复单元的杀生物聚合物：其中：每次出现的R 1独立地表示含有6至30个碳原子的二价芳族基团，C 2 -C 16亚烷基或亚烷基双环己基; 每次出现的Y独立地表示氧原子或硫原子; 并且Z1，Z2，Z3和Z4各自独立地表示氢原子或卤素原子; 其中所述至少一个式（A）重复单元中的Z 1，Z 2，Z 3和Z 4中的至少一个为卤素原子。还公开了杀生物聚合物的制备方法和应用。

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