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    • 17. 发明申请
    • Method for assessing progression of clinical state of malignant neoplasm by quantitative detection of DNA in blood
    • 通过定量检测血液中的DNA来评估恶性肿瘤临床状态进展的方法
    • US20140227706A1
    • 2014-08-14
    • US14118098
    • 2012-05-16
    • Kikuya KatoFumio ImamuraKazuya TaniguchiToru KumagaiJunji UchidaKazumi Nishino
    • Kikuya KatoFumio ImamuraKazuya TaniguchiToru KumagaiJunji UchidaKazumi Nishino
    • C12Q1/68
    • C12Q1/6881C12Q1/6886C12Q2600/112C12Q2600/118C12Q2600/156
    • The object of the invention is to provide a method for quantitatively assessing the degree of progression of a malignant neoplasm in a patient who has been medicated. Provided is a method for assessing the progression of the clinical state of a malignant neoplasm in a subject who has been administered with a medicine for treating the malignant neoplasm, the method being characterized by comprising: (1) a step of determining the ratio of DNA molecules having an activation mutation that serves as an activation marker for the medicine to DNA molecules having a normal marker gene in DNA in the blood from the subject; (2) a step of determining the ratio of DNA molecules having a resistance mutation that serves as a resistance marker for the medicine to DNA molecules having a normal marker gene in the DNA in the blood from the subject; and (3) a step of comparing a value obtained in the step (2) with a value obtained in the step (1) to thereby assess whether or not the malignant neoplasm in the subject has acquired resistance to the treatment with the medicine.
    • 本发明的目的是提供一种用于定量评价已被给药的患者中的恶性肿瘤的进展程度的方法。 本发明提供了一种用于评估已经给予恶性肿瘤治疗药物的受试者的恶性肿瘤的临床状态进展的方法,其特征在于包括:(1)测定DNA比例的步骤 具有激活突变的分子,其用作药物的活化标记物,其具有来自受试者的血液中DNA中具有正常标记基因的DNA分子; (2)确定作为药物抗性标记的抗性突变的DNA分子与来自受试者的血液中的DNA中具有正常标记基因的DNA分子的比例的步骤; 和(3)将步骤(2)中获得的值与步骤(1)中获得的值进行比较的步骤,从而评估受试者的恶性肿瘤是否具有药物治疗的抵抗力。
    • 18. 发明申请
    • BRAKING/DRIVING CONTROL APPARATUS FOR VEHICLE
    • 汽车制动/驾驶控制装置
    • US20110307154A1
    • 2011-12-15
    • US13156621
    • 2011-06-09
    • Masayoshi TAKEDAMasaki MARUYAMAYukio MORIKazuya TANIGUCHIDaisuke TOKUMOCHI
    • Masayoshi TAKEDAMasaki MARUYAMAYukio MORIKazuya TANIGUCHIDaisuke TOKUMOCHI
    • B60T8/17
    • B60T7/122B60T2201/06B60W10/06B60W10/188B60W30/18027B60W30/18118B60W2510/0657B60W2510/1005B60W2510/105B60W2510/182B60W2550/142Y10T477/6422
    • A braking/driving control apparatus for a vehicle includes a basic control unit which calculates and outputs a target axle torque based on a target acceleration and a driving resistance of the vehicle and which determines an axle torque for a power train of the vehicle and an axle torque for a braking apparatus of the vehicle based on the calculated target axle torque, a sliding-down prediction determining unit which determines whether there is a possibility that the vehicle slides down rearwards on an uphill road, and a sliding-down preventing process executing unit which performs a process for reducing a possibility that the vehicle slides down, based on a determination result of the sliding-down prediction determining unit. After the sliding-down prediction determining unit determines that there is the possibility, the sliding-down preventing process executing unit controls the basic control unit to calculate and output the target axle torque so as to reach an axle torque which is obtained by reducing a predetermined positive amount form an estimated value of an axle torque necessary for the vehicle to achieve the target acceleration against the driving resistance.
    • 一种用于车辆的制动/驱动控制装置,包括基本控制单元,该基本控制单元基于车辆的目标加速度和驾驶阻力来计算并输出目标车轴扭矩,并且确定车辆和车轴的动力传动系的车轴扭矩 基于计算出的目标车轴转矩的用于车辆的制动装置的转矩,确定车辆是否存在在上坡路上向后滑动的可能性的滑落预测确定单元,以及下滑防止处理执行单元 其基于滑下预测判定单元的判定结果,进行用于降低车辆下滑的可能性的处理。 在滑下预测确定单元确定存在可能性之后,下滑防止处理执行单元控制基本控制单元以计算和输出目标车轴扭矩,以达到通过减少预定的 正值形成车辆相对于驱动阻力实现目标加速度所需的车轴转矩的估计值。