专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US06180352B2 Nucleic acid mediated electron transfer 有权
公开(公告)号：US06180352B2
公开(公告)日：2001-01-30
申请号：US09459191
申请日：1999-12-10
申请人： Thomas J. Meade , Jon Faiz Kayyem , Scott E. Fraser
发明人： Thomas J. Meade , Jon Faiz Kayyem , Scott E. Fraser
IPC分类号： C12Q168
CPC分类号： C07H21/00 , C07H23/00 , C12Q1/6818 , C12Q1/6825 , Y02A50/52 , C12Q2565/607 , C12Q2565/401 , C12Q2563/137 , C12Q2563/113 , C12Q2565/101 , C12Q2565/1015
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.

12. 发明申请

US20100285981A1 Devices and methods for biochip multiplexing 审中-公开
标题翻译：生物芯片复用的设备和方法
公开(公告)号：US20100285981A1
公开(公告)日：2010-11-11
申请号：US11982334
申请日：2007-10-31
申请人： Jon Faiz Kayyem
发明人： Jon Faiz Kayyem
IPC分类号： C40B30/04 , C40B60/12 , G01N27/26
CPC分类号： G01N27/44791 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L9/527 , B01L2200/10 , B01L2300/021 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0418 , B01L2400/0439 , B01L2400/0442 , B01L2400/0481 , B01L2400/0487 , B01L2400/0611 , B01L2400/0633 , B01L2400/0638 , B01L2400/0677 , B82Y30/00 , B82Y35/00 , B82Y40/00 , C12Q1/6813 , C12Q1/6825 , G01N27/3275 , G01N27/3276 , G01N27/447 , G01N27/4473 , G01N27/44752 , G01N33/5302 , G01N33/5438 , G01N33/54386 , G01N2035/00158 , G01N2610/00 , C12Q2565/629 , C12Q2563/113
摘要： The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.
摘要翻译：本发明涉及允许同时进行多个生物芯片分析的装置。特别地，这些装置被配置为容纳包含生物芯片的多个盒，所述生物芯片包括诸如核酸阵列之类的阵列，并允许样品的高通量分析。

13. 发明授权

US07393645B2 Compositions for the electronic detection of analytes utilizing monolayers 有权
标题翻译：使用单层电子检测分析物的组合物
公开(公告)号：US07393645B2
公开(公告)日：2008-07-01
申请号：US11208384
申请日：2005-08-19
申请人： Jon Faiz Kayyem , Stephen D. O'Connor
发明人： Jon Faiz Kayyem , Stephen D. O'Connor
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： G01N33/54353 , C12Q1/6825 , G01N2610/00 , C12Q2565/519 , C12Q2563/113
摘要： The present invention relates to the use of self-assembled monolayers with mixtures of conductive oligomers and insulators to detect target analytes.
摘要翻译：本发明涉及使用具有导电低聚物和绝缘体的混合物的自组装单层来检测目标分析物。

14. 发明授权

US06686150B1 Amplification of nucleic acids with electronic detection 失效
标题翻译：用电子检测扩增核酸
公开(公告)号：US06686150B1
公开(公告)日：2004-02-03
申请号：US09621275
申请日：2000-07-20
申请人： Gary Blackburn , Bruce D. Irvine , Jon Faiz Kayyem , Edward Lewis Sheldon, III , Robert H. Terbrueggen
发明人： Gary Blackburn , Bruce D. Irvine , Jon Faiz Kayyem , Edward Lewis Sheldon, III , Robert H. Terbrueggen
IPC分类号： C12Q168
CPC分类号： B82Y30/00 , B82Y15/00 , C12Q1/6825 , G01N27/3277 , C12Q2565/607
摘要： The invention relates to compositions and methods useful in the detection of nucleic acids using a variety of amplification techniques, including both signal amplification and target amplification. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the nucleic acid, either directly or indirectly, to allow electronic detection of the ETM using an electrode.
摘要翻译：本发明涉及用于使用多种扩增技术检测核酸的组合物和方法，包括信号放大和靶扩增两者。检测通过直接或间接使用与核酸相关联的电子转移部分（ETM）进行，以允许使用电极电子检测ETM。

15. 发明授权

US06432723B1 Biosensors utilizing ligand induced conformation changes 有权
标题翻译：利用配体诱导构象变化的生物传感器
公开(公告)号：US06432723B1
公开(公告)日：2002-08-13
申请号：US09489459
申请日：2000-01-21
申请人： Kevin W. Plaxco , Jon Faiz Kayyem
发明人： Kevin W. Plaxco , Jon Faiz Kayyem
IPC分类号： G01N33543
CPC分类号： B82Y30/00 , G01N33/532 , G01N33/5438 , G01N33/582 , G01N2458/30 , Y10S436/806
摘要： A method for detecting the presence of a target analyte comprising binding a target analyte to a binding ligand comprising at least a first electron donor moiety and a second electron acceptor moiety; and detecting the electron transfer between the donor and acceptor, wherein there is a change in the amount of electron transfer between the donor and acceptor as a result of altering the structured state of the donor and acceptor caused by a conformational change in the binding ligand upon binding of the target ligand.
摘要翻译：一种用于检测目标分析物的存在的方法，包括将靶分析物结合至包含至少第一电子供体部分和第二电子受体部分的结合配体; 并且检测供体和受体之间的电子转移，其中由于改变由结合配体的构象变化引起的供体和受体的结构化状态的结果，供体和受体之间的电子转移量发生变化，靶配体的结合。

16. 发明授权

US06290839B1 Systems for electrophoretic transport and detection of analytes 失效
标题翻译：电泳运输和检测分析物系统
公开(公告)号：US06290839B1
公开(公告)日：2001-09-18
申请号：US09134058
申请日：1998-08-14
申请人： Jon Faiz Kayyem , Gary Blackburn , Stephen D. O'Connor
发明人： Jon Faiz Kayyem , Gary Blackburn , Stephen D. O'Connor
IPC分类号： G01N2726
CPC分类号： B82Y15/00 , B82Y30/00 , C12Q1/6825 , C12Q2565/501 , C12Q2565/107
摘要： The invention relates to compositions and methods useful in the electrophoretic transport of target analytes to a detection electrode comprising a self-assembled monolayer (SAM). Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.
摘要翻译：本发明涉及用于将目标分析物电泳转运到包括自组装单层（SAM）的检测电极的组合物和方法。检测通过直接或间接使用与目标分析物相关的电子转移部分（ETM）进行，以允许电子检测ETM。

17. 发明授权

US06277576B1 Nucleic acid mediated electron transfer 有权
公开(公告)号：US06277576B1
公开(公告)日：2001-08-21
申请号：US09306768
申请日：1999-05-07
申请人： Thomas J. Meade , Jon Faiz Kayyem , Scott E. Fraser
发明人： Thomas J. Meade , Jon Faiz Kayyem , Scott E. Fraser
IPC分类号： C12Q168
CPC分类号： C07H21/00 , C07H23/00 , C12Q1/6818 , C12Q1/6825 , Y02A50/52 , C12Q2565/607 , C12Q2565/401 , C12Q2563/137 , C12Q2563/113 , C12Q2565/101 , C12Q2565/1015
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.

18. 发明授权

US06268150B1 Nucleic acid mediated electron transfer 有权
公开(公告)号：US06268150B1
公开(公告)日：2001-07-31
申请号：US09459751
申请日：1999-12-10
申请人： Thomas J. Meade , Jon Faiz Kayyem , Scott E. Fraser
发明人： Thomas J. Meade , Jon Faiz Kayyem , Scott E. Fraser
IPC分类号： C12Q168
CPC分类号： C07H21/00 , C07H23/00 , C12Q1/6818 , C12Q1/6825 , Y02A50/52 , C12Q2565/607 , C12Q2565/401 , C12Q2563/137 , C12Q2563/113 , C12Q2565/101 , C12Q2565/1015
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.

19. 发明授权

US06238870B1 Nucleic acid mediated electron transfer 失效
公开(公告)号：US06238870B1
公开(公告)日：2001-05-29
申请号：US09458187
申请日：1999-12-08
申请人： Thomas J. Meade , Jon Faiz Kayyem , Scott E. Fraser
发明人： Thomas J. Meade , Jon Faiz Kayyem , Scott E. Fraser
IPC分类号： C12Q168
CPC分类号： C07H21/00 , C07H23/00 , C12Q1/6818 , C12Q1/6825 , Y02A50/52 , C12Q2565/607 , C12Q2565/401 , C12Q2563/137 , C12Q2563/113 , C12Q2565/101 , C12Q2565/1015
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.

20. 发明授权

US06232295B1 Cell-specific contrast agent and gene delivery vehicles 失效
标题翻译：细胞特异性造影剂和基因递送载体
公开(公告)号：US06232295B1
公开(公告)日：2001-05-15
申请号：US08321552
申请日：1994-10-12
申请人： Jon Faiz Kayyem , Thomas J. Meade , Scott E. Fraser
发明人： Jon Faiz Kayyem , Thomas J. Meade , Scott E. Fraser
IPC分类号： A61K4800
CPC分类号： A61K49/146 , A61K47/645 , A61K49/085 , Y10S977/808 , Y10S977/927 , Y10S977/93
摘要： A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule having a net positive charge complexed with another polymeric molecule having a net negative charge. Cell targeting moieties and MRI contrast agents are attached to one or both of the polymeric molecules. In one embodiment, the polymeric molecule having a net negative charge is a nucleic acid. Thus, the delivery vehicles can be used in clinical protocols in which nucleic acids for gene therapy and agents for MRI contrast are co-transported to specific cells allowing medical imaging monitoring of nucleic acid delivery.
摘要翻译：描述了能够特异性结合并进入目标细胞的递送载体，为细胞的磁共振成像（MRI）递送许多顺磁离子。递送载体包含具有与具有净负电荷的另一个聚合物分子络合的净正电荷的聚合物分子。细胞靶向部分和MRI造影剂连接到一个或两个聚合物分子。在一个实施方案中，具有净负电荷的聚合物分子是核酸。因此，递送载体可以用于其中用于基因治疗的核酸和用于MRI对比的药剂共同转运到特定细胞的临床方案，允许对核酸递送进行医学成像监测。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式