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    • 13. 发明授权
    • 1,2,4-triazol-1-yl bisphenyl derivatives for use in the treatment of endocrine-dependent tumors
    • 1,2,4-三唑-1-基双苯基衍生物,用于治疗内分泌依赖性肿瘤
    • US08022224B2
    • 2011-09-20
    • US12139237
    • 2008-06-13
    • Lok Wai Lawrence WooToby JacksonAtul PurohitMichael John ReedBarry Victor Lloyd Potter
    • Lok Wai Lawrence WooToby JacksonAtul PurohitMichael John ReedBarry Victor Lloyd Potter
    • C07D249/00
    • C07D249/08C07D405/10
    • There is provided a compound of Formula I wherein R3, R4, R5, R6 and R7 are independently selected from H and —Y—R8; wherein each R8 is independently selected from —OH, hydrocarbyl groups, oxyhydrocarbyl groups, cyano (—CN), nitro (—NO2), H-bond acceptors, and halogens; wherein at least one of R3, R4, R5, R6 and R7 is —Y—R8 wherein R8 is selected from substituted and unsubstituted heterocyclic rings and amino substituted phenyl groups, wherein X is a bond or a linker group; wherein Y is an optional linker group; and wherein ring A is optionally further substituted; wherein R9 is selected from H, —OH and —OSO2NR1R2; wherein R1 and R2 are independently selected from H and hydrocarbyl; wherein (a) X is a bond and at least one of R3, R4, R5, R6 and R7 is —Y—R8; OR (b) R9 is —OSO2NR1R2 or —OH and four of R3, R4, R5, R6 and R7 are H and one of R3, R4, R5, R6 and R7 is —Y—R8. These compounds inhibit steroid sulphatase and aromatase activity and are useful in the treatment of endocrine-dependent tumors.
    • 提供式I的化合物,其中R 3,R 4,R 5,R 6和R 7独立地选自H和-Y-R 8; 其中每个R 8独立地选自-OH,烃基,羟基烃基,氰基(-CN),硝基(-NO 2),H-键受体和卤素; 其中R 3,R 4,R 5,R 6和R 7中的至少一个是-Y-R 8,其中R 8选自取代和未取代的杂环和氨基取代的苯基,其中X是键或连接基团; 其中Y是任选的连接基团; 并且其中环A任选进一步被取代; 其中R9选自H,-OH和-OSO2NR1R2; 其中R1和R2独立地选自H和烃基; 其中(a)X是键,并且R 3,R 4,R 5,R 6和R 7中的至少一个是-Y-R 8; 或(b)R9为-OSO2NR1R2或-OH,R3,R4,R5,R6和R7中的4个为H,R3,R4,R5,R6和R7之一为-Y-R8。 这些化合物抑制类固醇硫酸酯酶和芳香酶活性,并且可用于治疗内分泌依赖性肿瘤。
    • 15. 发明授权
    • Method of roll-forming an automotive support member
    • 滚动形成汽车支撑构件的方法
    • US07963019B2
    • 2011-06-21
    • US11508061
    • 2006-08-22
    • John ReedJames LoweLawrence QueenerHikmat MahmoodHenry HauslerJoe Weishaar
    • John ReedJames LoweLawrence QueenerHikmat MahmoodHenry HauslerJoe Weishaar
    • B23P11/00
    • B62D25/04Y10T29/49622Y10T29/49629Y10T29/49968
    • A roll-forming process for the manufacture of a structural member can be used in the manufacture of an automotive vehicle. The roll-forming process creates a component that has multiple cells with an integral internal web separating the cells, enhancing the strength, rigidity and stiffness of the component for any given size and shape. The roll-forming process starts with a piece of sheet metal and rolls the sheet metal into a desired shape and then rolls the tube back over on itself to create a second cell with the internal reinforcing web positioned between two structural cells of the beam. The rolled form is then welded into the formed shape to create the structural beam. The two cells of the beam can be the same general size or be formed as completely disparate sizes, depending on the design requirements of the structural member.
    • 用于制造结构件的辊成型方法可用于制造汽车。 辊成型工艺产生具有多个单元的组件,该单元具有分离单元的整体内部网,增强了组件对于任何给定尺寸和形状的强度,刚度和刚度。 辊轧成型过程从一块金属片开始,并将金属板卷成所需的形状,然后将管子卷回自身上,以产生第二电池,其中内部增强纤维网位于梁的两个结构电池之间。 然后将轧制形式焊接成形成形状以形成结构梁。 根据结构构件的设计要求,梁的两个单元可以是相同的一般尺寸或形成为完全不同的尺寸。