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    • 11. 发明申请
    • OLIGONUCLEOTIDE PROBE RETRIEVAL ASSAY FOR DNA TRANSACTIONS IN MAMMALIAN CELLS
    • 乳腺细胞DNA交换的寡核苷酸检测检测方法
    • US20130115598A1
    • 2013-05-09
    • US13652431
    • 2012-10-15
    • Lawrence LoebJiang-Cheng ShenEdward J. Fox
    • Lawrence LoebJiang-Cheng ShenEdward J. Fox
    • C12Q1/68
    • C12Q1/6827C12N15/1082C12Q1/6858C12Q1/6886C12Q2600/106C12Q2521/514C12Q2525/101C12Q2545/114
    • Methods to measure a variety of DNA synthetic processes in live human cells by introducing and retrieving exogenous DNA probes are provided herein. Using fragments of bacterial plasmid or phage DNA, a wide array of DNA constructs may be assembled to mimic the intermediates of DNA transactions, including replication, translation synthesis, and end-joining. These DNA probes may be transfected into human cells and retrieved for mutational analysis using a modified Random Mutation Capture assay or NextGen DNA sequencing. These assays require only a small number of cells, such as might be available from biopsy material. Thus, the methods described herein may be applied to the early detection of cancer, predicting the responsiveness of individual cancers to chemotherapy, and measuring the DNA repair capacity of individuals to environmental DNA damaging agents. This approach may be automated and used for screening human populations for variations in DNA synthetic and repair activities.
    • 本文提供了通过引入和回收外源DNA探针来测量活细胞中各种DNA合成过程的方法。 使用细菌质粒或噬菌体DNA的片段,可以组合各种DNA构建体以模拟DNA事务的中间体,包括复制,翻译合成和末端连接。 可以将这些DNA探针转染到人细胞中并使用修饰的随机突变捕获测定法或NextGen DNA测序法进行突变分析。 这些测定仅需要少量的细胞,例如可以从活检材料获得。 因此,本文描述的方法可以应用于癌症的早期检测,预测个体癌症对化疗的反应性,以及测量个体对环境DNA损伤剂的DNA修复能力。 这种方法可以是自动化的,并用于筛选人类DNA合成和修复活动的变化。
    • 14. 发明申请
    • R-bambuterol, its preparation and therapeutic uses
    • R-班布特罗,其制备和治疗用途
    • US20050171197A1
    • 2005-08-04
    • US11053014
    • 2005-02-08
    • Wen TanJiang Cheng
    • Wen TanJiang Cheng
    • A61K31/325C07C271/10C07C271/44
    • C07C271/44Y02P20/55
    • R-enantiomer of Bambuterol, its preparation and therapeutic uses are disclosed. A composition includes R-Bambuterol or its therapeutically acceptable salt. A composition of R-Bambuterol includes at least 80% by weight of the R-enantiomer and not more than 20% by weight of the S-enantiomer based on a total weight of the Bmbuterol. A process includes: (a) asymmetrically reducing a suitably substituted and suitably protected bromoacetophenone compound to a chiral phenyl-bromoethanol comprising a primary bromo group and a secondary hydroxyl group; (b) displacing the bromo group by a suitably substituted and optionally protected primary amine to produce a protected chiral phenylethanolamine, and (c) removing the protecting groups to convert the protected chiral phenylethanolamine to a chiral phenylethanolamine.
    • 班布特罗的R-对映异构体,其制备和治疗用途被公开。 组合物包括R-班布特罗或其治疗上可接受的盐。 R-班布特罗的组合物包含至少80重量%的R-对映异构体和不超过20重量%的S-对映异构体,基于布替托罗的总重量。 方法包括:(a)将适当取代的适当保护的溴乙酰苯化合物不对称地还原成包含伯溴基和仲羟基的手性苯基 - 溴乙醇; (b)通过适当取代的和任选保护的伯胺置换溴基以产生受保护的手性苯乙醇胺,和(c)除去保护基团以将被保护的手性苯乙醇胺转化为手性苯乙醇胺。
    • 15. 发明申请
    • Method and apparatus for soft switching
    • 软切换的方法和装置
    • US20070153747A1
    • 2007-07-05
    • US10557626
    • 2004-05-06
    • Sheng PanLi SunNi MaJiang Cheng
    • Sheng PanLi SunNi MaJiang Cheng
    • H04Q7/24
    • H04W52/383H04W36/14H04W36/30H04W76/23H04W84/18H04W88/06
    • A method in wireless communication systems is provided for switching from P2P (Peer to Peer) communication mode to UP-UTRAN-DOWN (conventional communication mode) and from conventional communication mode to P2P mode, wherein the method performed by a user equipment for switching from P2P communication mode to conventional communication mode comprising steps of: detecting the direct link used by the user equipment in P2P communication with the other user equipment; sending a request for switching to conventional communication mode to a wireless communication network system if the detecting result indicates that the communication quality of the direct link can't satisfy the requirement for P2P communication; and establishing conventional communication connection so as to communicate with said the other user equipment in conventional mode, after receiving the acknowledge (ACK) message of the request for switching sent by the network system.
    • 提供了一种无线通信系统中的方法,用于从P2P(对等)通信模式切换到UP-UTRAN-DOWN(常规通信模式)和从常规通信模式切换到P2P模式,其中由用户设备执行的切换 P2P通信模式包括以下步骤:检测用户设备在与其他用户设备的P2P通信中使用的直接链路; 如果检测结果指示直接链路的通信质量不能满足P2P通信的要求,则向无线通信网络系统发送切换到常规通信模式的请求; 以及在接收到由网络系统发送的切换请求的确认(ACK)消息之后,建立常规通信连接以便以常规模式与所述其他用户设备进行通信。
    • 16. 发明申请
    • Adaptive step size method for power control in wireless communication system and system for the same
    • 用于无线通信系统和系统中功率控制的自适应步长方法
    • US20060183493A1
    • 2006-08-17
    • US10540693
    • 2003-12-29
    • Ni MaXuejun ZhangJiang Cheng
    • Ni MaXuejun ZhangJiang Cheng
    • H04B7/00H04Q7/20
    • H04W52/221H04W52/362
    • The present invention relates to an adaptive step size method for power control in wireless communication systems and a system for the same. The method includes the steps: obtaining the power control information whose number is previously set in previous power control cycle and that in current power control cycle; Determining the power control step size in current power control cycle according to the obtained power control information whose number is previously set in previous power control cycle and that in current power control cycle. Employing the method to determine a suitable step size in current PC cycle, we can overcome the defect that the change of the PC step size in current wireless communication system is a fixed value, thereby make the power change more smooth, and ensure that wireless communication holds better communication quality.
    • 本发明涉及一种用于无线通信系统中的功率控制的自适应步长方法及其系统。 该方法包括以下步骤:获得先前功率控制周期中先前设置的功率控制信息和当前功率控制周期中的功率控制信息; 根据所获得的功率控制信息确定当前功率控制周期中的功率控制步长,该功率控制信息的数量是在先前的功率控制周期中预先设定的,而在当前的功率控制周期中。 采用该方法确定当前PC周期中的合适步长,可以克服当前无线通信系统中PC步长变化为固定值的缺陷,从而使功率变化更加平稳,确保无线通信 拥有更好的沟通质量。
    • 17. 发明申请
    • System for allocating channels to calls via updatable priorities
    • 通过可更新优先级将通道分配给呼叫的系统
    • US20050170840A1
    • 2005-08-04
    • US10515695
    • 2003-04-29
    • Jiang Cheng
    • Jiang Cheng
    • H03F1/08H04L12/56H04W16/04H04W16/06H04W72/02H04W72/10H04W84/18H04Q7/20
    • H04W16/04H04W16/06H04W72/02H04W72/10H04W84/18
    • Systems (1) for allocating channels to calls by firstly searching its own cluster of channels and then searching subsequent clusters of channels until a free channel has been found are provided with updating options for updating cluster priorities in dependence of searching results. These systems (1) have integrated the updating and the call handling, which improves the efficiency of the self-organizing capabilities compared to separated updating and call handling. Said updating may comprise the increasing of a cluster priority for a cluster comprising an available channel and the decreasing of a cluster priority for a cluster not comprising an available channel. An original cluster may correspond with a cell receiving a request for allocating a channel to a call, and a subsequent cluster or borrowed cluster may then correspond with a neighboring cell. Said updating may be done for borrowed clusters and may not be done for original clusters.
    • 用于通过首先搜索其自己的信道簇然后搜索后续的信道簇直到找到空闲信道的系统(1)为根据搜索结果更新簇优先级提供更新选项。 这些系统(1)集成了更新和呼叫处理,与分离的更新和呼叫处理相比,这提高了自组织能力的效率。 所述更新可以包括对于包括可用信道的集群的集群优先级的增加以及用于不包括可用信道的集群的集群优先级的减少。 原始集群可以对应于接收到向呼叫分配信道的请求的小区,并且随后的集群或借用集群然后可以与相邻小区相对应。 可以对所借用的簇进行所述更新,并且可能不对原始簇进行更新。
    • 18. 发明申请
    • Allocation of channelisation code based on cost function
    • 基于成本函数分配渠道化代码
    • US20050148318A1
    • 2005-07-07
    • US10509231
    • 2003-03-05
    • Jiang Cheng
    • Jiang Cheng
    • H04B1/707H04J13/00H04J13/16H04J13/20H04W4/12H04W36/06H04W72/04H04M11/00
    • H04W36/06H04J13/0044H04J13/20H04W4/12H04W72/0466
    • Telecommunication systems comprising base stations (1) and mobile terminals (11) generate channelization codes like Orthogonal Variable Spreading Factor codes or OVSF codes defining channels used for communication between base stations (1) and mobile terminals (11) and calculate cost functions for these channelization codes. The base stations (1) are provided with transferors (7) for transferring ongoing calls from first channels defined by first channelization codes to second channels defined by second channelization codes in dependence of calculated cost functions, to be able to treat ongoing calls dynamically, by allocating channels dynamically to ongoing calls. Said transferring is realized via transferring messages. Preferably a low complex cost function is a function of a sum of products of an occupation parameter and a data rate for at least a specific level and divided by a data rate for a neighboring level, to reduce the processing capacity.
    • 包括基站(1)和移动终端(11)的电信系统生成诸如正交可变扩频因子码或定义用于基站(1)和移动终端(11)之间的通信的信道的OVSF码的信道化码,并计算这些信道化的成本函数 代码。 基站(1)设置有用于将正在进行的呼叫从第一信道化码定义的第一信道转移到根据计算出的成本函数由第二信道化码定义的第二信道的转移器(7),以便能够动态地对待正在进行的呼叫 将频道动态分配到正在进行的呼叫。 所述传送通过传送消息来实现。 优选地,低复杂成本函数是占用参数和至少特定级别的数据速率的乘积之和除以邻近级别的数据速率的函数,以减少处理能力。