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11. 发明申请

US20150211053A1 BIOMARKERS FOR DIABETES AND USAGES THEREOF 审中-公开
标题翻译：糖尿病生物标志物及其用途
公开(公告)号：US20150211053A1
公开(公告)日：2015-07-30
申请号：US13639781
申请日：2012-09-03
申请人： Shenghui Li , Qiang Feng , Junjie Qin , Jianfeng Zhu , Dongya Zhang , Zhuye Jie , Jun Wang , Jian Wang , Huanming Yang
发明人： Shenghui Li , Qiang Feng , Junjie Qin , Jianfeng Zhu , Dongya Zhang , Zhuye Jie , Jun Wang , Jian Wang , Huanming Yang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , A61K35/74 , C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , Y02A50/473
摘要： Biomarkers for diabetes and usages thereof are provided. And the biomarkers are Akkermansia muciniphila, Bacteroides intestinalis, Bacteroides sp. 20_3, Clostridium bolteae, Clostridium hathewayi, Clostridium ramosum, Clostridium sp. HGF2, Clostridium symbiosum, Desulfovibrio sp. 3_1_syn3, Eggerthella lenta, Escherichia coli, Clostridiales sp. SS3/4, Eubacterium rectale, Faecalibacterium prausnitzii, Haemophilus parainfluenzae, Roseburia intestinalis and Roseburia inulinivorans.
摘要翻译：提供糖尿病生物标记物及其用途。生物标志物是Akkermansia muciniphila，肠杆菌拟杆菌，拟杆菌属 20_3，Clostridium bolteae，Clostridium hathewayi，Clostridium ramosum，Clostridium sp。 HGF2，共生梭菌，脱硫弧菌 3_1_syn3，Eggerthella lenta，Escherichia coli，Clostridiales sp。 SS3 / 4，直肠杆菌，普鲁布菌，副流感嗜血杆菌，肠炎沙门氏菌和玫瑰红霉素。

12. 发明申请

US20150205913A1 PARENTAL GENOME ASSEMBLY METHOD 审中-公开
标题翻译：亲本基因组装方法
公开(公告)号：US20150205913A1
公开(公告)日：2015-07-23
申请号：US14361865
申请日：2011-12-02
申请人： Weiming He , Shancen Zhao , Xuemei Zhang , Yingrui Li , Jun Wang , Jian Wang , Huanming Yang
发明人： Weiming He , Shancen Zhao , Xuemei Zhang , Yingrui Li , Jun Wang , Jian Wang , Huanming Yang
IPC分类号： G06F19/18 , C12Q1/68
CPC分类号： G16B20/00 , C12Q1/6869 , C12Q1/6895 , C12Q2535/122 , G16C99/00
摘要： Provided is a parental genome assembly method, comprising: using the sequencing data of parental selfing line progeny population to assemble and perfect the parental genome data. Also provided is a device for implementing the method.
摘要翻译：提供了一种亲本基因组装配方法，其包括：使用亲本自交系后代群体的测序数据来组合和完善亲本基因组数据。还提供了一种用于实现该方法的装置。

13. 发明申请

US20150120210A1 METHOD AND DEVICE FOR LABELLING SINGLE NUCLEOTIDE POLYMORPHISM SITES IN GENOME 审中-公开
标题翻译：在基因组中标记单个核苷酸多态性位点的方法和装置
公开(公告)号：US20150120210A1
公开(公告)日：2015-04-30
申请号：US14369318
申请日：2011-12-29
申请人： Ye Tao , Zequn Zheng , Zihao Feng , Yingrui Li , Huanming Yang , Jun Wang , Jian Wang
发明人： Ye Tao , Zequn Zheng , Zihao Feng , Yingrui Li , Huanming Yang , Jun Wang , Jian Wang
IPC分类号： G06F19/22
CPC分类号： G16B30/00 , C12Q1/6869 , G16B20/00 , C12Q2535/131
摘要： Disclosed are a method and a device for labelling single nucleotide polymorphism site in a genome. The above-mentioned method comprises: the single-end RAD sequences from the genomes of two individuals are obtained; the single-end RAD sequences are filtered to remove unqualified sequences; the sequencing depth of the sequences from the genomes of two individuals is aligned in pairs and without gaps to determine the SNP sites.
摘要翻译：公开了用于在基因组中标记单核苷酸多态性位点的方法和装置。上述方法包括：获得来自两个个体的基因组的单末端RAD序列; 过滤单端RAD序列以除去不合格序列; 来自两个个体的基因组的序列的测序深度成对排列并且没有间隙以确定SNP位点。

14. 发明申请

US20150105264A1 METHOD AND SYSTEM FOR IDENTIFYING TYPES OF TWINS 审中-公开
标题翻译：识别TWINS类型的方法和系统
公开(公告)号：US20150105264A1
公开(公告)日：2015-04-16
申请号：US14395074
申请日：2012-05-23
申请人： Huijuan Ge , Jing Zheng , Shang Yi , Xuchao Li , Jian Wang , Jun Wang , Huanming Yang , Xiuqing Zhang
发明人： Huijuan Ge , Jing Zheng , Shang Yi , Xuchao Li , Jian Wang , Jun Wang , Huanming Yang , Xiuqing Zhang
IPC分类号： C12Q1/68 , C12N15/10
CPC分类号： C12Q1/6876 , C12N15/1003 , C12Q1/6806 , C12Q1/6888 , C12Q2600/156 , C12Q2600/16
摘要： Provided are a method and a system for identifying whether the twins are dizygotic twins, the method comprising: typing at least one polymorphic loci of the twins fetuses to obtain the fetal polymorphism types, comparing the fetal polymorphism types with the corresponding polymorphism types of their parents, determining whether the twins are dizygotic twins on the basis of the comparison result.
摘要翻译：提供了一种用于识别双胞胎是否是双卵双胞胎的方法和系统，所述方法包括：输入双胎胎儿的至少一个多态性位点以获得胎儿多态性类型，将胎儿多态性类型与其父母的相应多态性类型进行比较根据比较结果确定双胞胎是否是异卵双胞胎。

15. 发明申请

US20150056619A1 METHOD AND SYSTEM FOR DETERMINING COPY NUMBER VARIATION 审中-公开
标题翻译：用于确定复制数变化的方法和系统
公开(公告)号：US20150056619A1
公开(公告)日：2015-02-26
申请号：US14389898
申请日：2012-04-05
申请人： Xuchao Li , Shengpei Chen , Fang Chen , Weiwei Xie , Jian Wang , Jun Wang , Huanming Yang , Xiuqing Zhang
发明人： Xuchao Li , Shengpei Chen , Fang Chen , Weiwei Xie , Jian Wang , Jun Wang , Huanming Yang , Xiuqing Zhang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , C12Q1/6869 , C12Q2535/122 , C12Q2537/165 , G16B15/00 , G16B30/00 , G16C99/00
摘要： Disclosed are a method and a system for determining genome copy number variation, which relates to the technical field of bioinformatics. The method comprises obtaining reads; determining sequence labels according to the reads; counting the number of sequence labels falling into each window; performing GC correction on the sequence label number of each window and a correction according to an expected sequence label number adjusted by a control set to obtain a corrected sequence label number; selecting a demarcation point with a small significance value as a candidate CNV breaking point; rejecting the least significant candidate CNV breaking point at every turn, updating difference significance values of two candidate CNV breaking points on the left and right of the rejected candidate CNV breaking point and performing cyclic iteration until difference significance values of all candidate CNV breaking points are smaller than a termination threshold value, thereby determining a CNV breaking point. The method and the system the present invention have clinical feasibility, and can precisely detect a micro-deletion/micro-duplication area of 0.5 M under the situation of using data of about 50 M.
摘要翻译：公开了用于确定与生物信息学技术领域有关的基因组拷贝数变异的方法和系统。该方法包括获取读数; 根据读数确定序列标签; 计算落入每个窗口的序列标签的数量; 对每个窗口的序列标签号执行GC校正，并根据由控制集调整的预期序列标号进行校正，以获得校正的序列标号; 选择具有较小重要性值的分界点作为候选CNV断点; 拒绝每一回合中最不重要的候选CNV断点，更新拒绝的候选CNV断点左侧和右侧的两个候选CNV断点的差异有效值，并执行循环迭代，直到所有候选CNV断点的差值显着值较小比终止阈值，从而确定CNV断点。本发明的方法和系统具有临床可行性，并且可以在使用约50M的数据的情况下精确地检测到0.5M的微缺失/微复制区域。

16. 发明申请

US20140227227A1 USE OF ROSEBURIA IN THE PREVENTION AND TREATMENT FOR OBESITY RELATED DISEASES 审中-公开
标题翻译： ROSEBURIA在预防和治疗肥胖相关疾病中的应用
公开(公告)号：US20140227227A1
公开(公告)日：2014-08-14
申请号：US13497043
申请日：2011-12-22
申请人： Junjie Qin , Shenghui Li , Jianfeng Zhu , Xiaoping Li , Suisha Liang , Jun Wang , Jian Wang , Huanming Yang , Qiang Feng
发明人： Junjie Qin , Shenghui Li , Jianfeng Zhu , Xiaoping Li , Suisha Liang , Jun Wang , Jian Wang , Huanming Yang , Qiang Feng
IPC分类号： A61K35/74 , A23L1/30
CPC分类号： A61K35/74 , A23L33/135 , A23V2002/00 , A61K9/19 , C12N1/20 , Y02A50/481
摘要： The present invention provides use of Roseburia in the preparation of composition for prevention and/or treatment of obesity related diseases. Also provided are a composition used in the treatment and prevention for obesity related diseases, comprising pharmaceutical, drink, food, and/or animal feed composition, etc; and a method of reducing body weight and/or blood glucose.
摘要翻译：本发明提供玫瑰红利用于预防和/或治疗肥胖相关疾病的组合物的制备中的用途。还提供了用于治疗和预防肥胖相关疾病的组合物，包括药物，饮料，食物和/或动物饲料组合物等; 以及降低体重和/或血糖的方法。

17. 发明申请

US20110288845A1 CONSTRUCTION METHOD AND SYSTEM OF FRAGMENTS ASSEMBLING SCAFFOLD, AND GENOME SEQUENCING DEVICE 审中-公开
标题翻译：构建方法和组装系统，组装程序和基因测序装置
公开(公告)号：US20110288845A1
公开(公告)日：2011-11-24
申请号：US13132027
申请日：2009-12-11
申请人： Peixiang Ni , Xiaodong Fang , Jun Wang , Huanming Yang , Jian Wang
发明人： Peixiang Ni , Xiaodong Fang , Jun Wang , Huanming Yang , Jian Wang
IPC分类号： G06G7/48
CPC分类号： G16B30/00
摘要： The present invention relates to gene engineering filed, and provides a genome sequencing device, construction method of fragments assembling scaffold and system thereof. The method comprises the following steps: mapping the double-barreled data obtained through sequencing to contigs; calculating the mean length between contigs based on multiple pairs of double-barreled data mapped to contigs, which is taken as the gap size between contigs; constructing scaffold based on gap size between contigs and the double-barreled relation between contigs; and obtaining complete scaffold graph. Since the mean length between contigs is calculated from multiple pairs of double-barreled data and is taken as the gap size between contigs, the estimation precision of gap size between contigs is improved greatly. It can be used for genome sequencing including short sequencing read length to finish task of assembling sequencing fragments.
摘要翻译：本发明涉及基因工程，提供基因组测序装置，片段组装脚手架及其系统的构建方法。该方法包括以下步骤：将通过测序获得的双筒数据映射到重叠群; 基于映射到重叠群的多对双筒数据计算重叠群之间的平均长度，其被认为是重叠群之间的间隙大小; 基于重叠群之间的间隙大小和重叠群之间的双筒关系构建脚手架; 并获得完整的支架图。由于重叠群之间的平均长度是由多对双筒数据计算的，作为重叠群之间的间隙大小，重叠群之间的间隙大小的估计精度大大提高。它可用于基因组测序，包括短序列读取长度以完成组装测序片段的任务。

18. 发明授权

US09238840B2 Method for single cell genome analysis and kit therefor 有权
标题翻译：单细胞基因组分析方法及其试剂盒
公开(公告)号：US09238840B2
公开(公告)日：2016-01-19
申请号：US13976845
申请日：2011-12-29
申请人： Xuyang Yin , Li Bao , Xun Xu , Hanjie Wu , Xiaoyu Liu , Xiuqing Zhang , Huanming Yang
发明人： Xuyang Yin , Li Bao , Xun Xu , Hanjie Wu , Xiaoyu Liu , Xiuqing Zhang , Huanming Yang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6888 , C12Q1/6806 , C12Q1/6851 , C12Q1/6869 , C12Q1/6876 , C12Q2600/166 , C12Q2531/119 , C12Q2545/101
摘要： A method for analyzing a genome of a single cell is provided, and a kit is also provided. The method for analyzing the genome of the single cell may comprise separating and lysing the single cell to obtain a whole-genome DNA of the cell; subjecting the whole-genome DNA to a whole-genome amplification to obtain a whole-genome amplification product; performing a PCR amplification using the whole-genome amplification product as template and using housekeeping-gene-specific primers to detect the housekeeping gene of the whole-genome amplification product; and determining whether the whole genome amplification product meets a requirement for sequencing based on the detection result, wherein a uniform distribution of the amplification product in each chromosome is an indication of the amplification product meeting the requirement for sequencing.
摘要翻译：提供了用于分析单细胞的基因组的方法，并且还提供了试剂盒。用于分析单细胞基因组的方法可以包括分离和裂解单细胞以获得细胞的全基因组DNA; 对全基因组DNA进行全基因组扩增以获得全基因组扩增产物; 使用全基因组扩增产物作为模板进行PCR扩增，并使用管家基因特异性引物检测全基因组扩增产物的管家基因; 并且基于检测结果确定全基因组扩增产物是否满足测序要求，其中扩增产物在每个染色体中的均匀分布是满足测序要求的扩增产物的指示。

19. 发明申请

US20150242565A1 METHOD AND DEVICE FOR ANALYZING MICROBIAL COMMUNITY COMPOSITION 审中-公开
标题翻译：用于分析微生物群落组成的方法和装置
公开(公告)号：US20150242565A1
公开(公告)日：2015-08-27
申请号：US14419060
申请日：2012-08-01
申请人： Shenghui Li , Qiang Feng , Junjie Qin , Jianfeng Zhu , Yuanlin Guan , Jun Wang , Jian Wang , Huanming Yang
发明人： Shenghui Li , Qiang Feng , Junjie Qin , Jianfeng Zhu , Yuanlin Guan , Jun Wang , Jian Wang , Huanming Yang
IPC分类号： G06F19/16
CPC分类号： G16B15/00 , C12Q1/6809 , C12Q1/689 , G16B20/00 , G16B30/00 , C12Q2535/122 , C12Q2537/165
摘要： The present teachings relate to analysis of a sample including a plurality of species. In one example, sequences of fragments of polynucleotides of the sample are obtained. A reference set comprising a plurality of sequences is obtained. An initial bin for each of the plurality of sequences of the reference set is determined based on a relative abundance of each sequence of the reference set in the sample. At least one final bin is obtained by modifying the initial bins for the plurality of sequences based on a model.
摘要翻译：本教导涉及包括多个物种的样品的分析。在一个实例中，获得样品的多核苷酸的片段序列。获得包括多个序列的参考集。基于样本中的参考集合的每个序列的相对丰度来确定参考集合的多个序列中的每一个的初始bin。通过基于模型修改多个序列的初始仓，获得至少一个最终仓。

20. 发明申请

US20150141290A1 METHOD FOR QUANTIFICATION OF PROTEOME 有权
标题翻译：保护方法
公开(公告)号：US20150141290A1
公开(公告)日：2015-05-21
申请号：US14369825
申请日：2011-12-31
申请人： Haiyi Zhao , Dahai Jiang , Bo Wen , Jian Wang , Jun Wang , Huanming Yang
发明人： Haiyi Zhao , Dahai Jiang , Bo Wen , Jian Wang , Jun Wang , Huanming Yang
IPC分类号： G01N33/68 , H01J49/00
CPC分类号： G01N33/6848 , G01N33/68 , G01N2570/00 , G06F19/18 , H01J49/0036
摘要： The present invention relates to a method for quantifying the relative content of a protein in a sample. The present invention also relates to a method for comprising the relative content of a protein in at least two samples.
摘要翻译：本发明涉及量化样品中蛋白质相对含量的方法。本发明还涉及在至少两个样品中包含蛋白质的相对含量的方法。

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