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11. 发明授权

US06682543B2 Methods for aortic artherectomy 有权
标题翻译：主动脉切除术的方法
公开(公告)号：US06682543B2
公开(公告)日：2004-01-27
申请号：US10055216
申请日：2001-10-24
申请人： Denise R. Barbut , Jonathan D. Root , Giovanni Pastrone
发明人： Denise R. Barbut , Jonathan D. Root , Giovanni Pastrone
IPC分类号： A61B1722
CPC分类号： A61B17/320783 , A61B8/0808 , A61B10/06 , A61B17/22031 , A61B17/221 , A61B17/32056 , A61B17/3207 , A61B17/32075 , A61B2010/0225 , A61B2017/00287 , A61B2017/22068 , A61B2017/22069 , A61B2017/2215 , A61B2017/306 , A61B2017/32004 , A61B2017/320064 , A61F2/01 , A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0071 , A61F2230/008 , A61M25/00 , A61M2210/127
摘要： A method for removing plaque from the aorta is disclosed. A filter is introduced into a region of interest within the patient's aorta. The filter is deployed downstream of a mobile aortic plaque within the aorta. An atherectomy assembly is operated to excise the plaque from the aorta. Emboli are captured by the filter. The filter and plaque are removed from the region of interest.
摘要翻译：公开了一种从主动脉中去除斑块的方法。将过滤器引入患者主动脉内的感兴趣区域。过滤器部署在主动脉内的移动主动脉斑块的下游。操作粥样斑块组件以从主动脉切除斑块。 Emboli被过滤器捕获。从感兴趣的区域去除过滤器和斑块。

12. 发明授权

US06592546B1 Aortic occluder with associated filter and methods of use during cardiac surgery 失效
标题翻译：主动脉夹闭器与相关过滤器和心脏手术中使用的方法
公开(公告)号：US06592546B1
公开(公告)日：2003-07-15
申请号：US09016714
申请日：1998-01-30
申请人： Denise Barbut , Jonathan D. Root , Giovanni Pastrone , Tracy D. Maahs , Ross S. Tsugita
发明人： Denise Barbut , Jonathan D. Root , Giovanni Pastrone , Tracy D. Maahs , Ross S. Tsugita
IPC分类号： A61M2900
CPC分类号： A61F2/013 , A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/12172 , A61B2017/00243 , A61F2/01 , A61F2002/018 , A61F2230/0006 , A61F2230/0065 , A61F2230/0067 , A61F2250/0003 , A61M2025/0073 , A61M2025/1052 , A61M2210/127
摘要： A balloon arterial cannula and methods for filtering blood. The devices generally include a mesh for filtering blood flowing within a blood vessel, particularly within an artery such as the aorta, a structure adapted to open and close the mesh within the blood vessel, a means to actuate the structure, and a balloon occluder which typically includes a flexible material enclosing a chamber. The methods generally include the steps of introducing a mesh into a blood vessel to capture embolic material, adjusting the mesh, if necessary, during the course of filtration, inflating the balloon occluder to occlude the vessel upstream of the mesh, and thereafter deflating the balloon occluder and removing the mesh and the captured foreign matter from the blood vessel. Additionally, visualization techniques are used to ensure effective filtration.
摘要翻译：气囊动脉插管和血液过滤方法。这些装置通常包括用于过滤血管内的血液的网格，特别是在诸如主动脉的动脉内，适于打开和关闭血管内的网状物的结构，致动结构的装置和气囊封堵器通常包括围绕室的柔性材料。所述方法通常包括以下步骤：将网状物引入血管以捕获栓塞材料，如果需要，在过滤过程中调整网孔，使球囊封堵器膨胀以封闭网孔上游的容器，然后使气囊放气闭塞器并从血管中除去网状物和捕获的异物。此外，可视化技术用于确保有效的过滤。

13. 发明授权

US06589264B1 Aortic occluder with associated filter and methods of use during cardiac surgery 有权
公开(公告)号：US06589264B1
公开(公告)日：2003-07-08
申请号：US09478818
申请日：2000-01-07
申请人： Denise Barbut , Giovanni Pastrone , Tracy D. Maahs , Ross S. Tsugita
发明人： Denise Barbut , Giovanni Pastrone , Tracy D. Maahs , Ross S. Tsugita
IPC分类号： A61M2900
CPC分类号： A61F2/013 , A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/12172 , A61B2017/00243 , A61F2/01 , A61F2002/018 , A61F2230/0006 , A61F2230/0065 , A61F2230/0067 , A61F2250/0003 , A61M2025/0073 , A61M2025/1052 , A61M2210/127
摘要： A balloon arterial cannula and methods for filtering blood. The devices generally include a mesh for filtering blood flowing within a blood vessel, particularly within an artery such as the aorta, a structure adapted to open and close the mesh within the blood vessel, a means to actuate the structure, and a balloon occluder which typically includes a flexible material enclosing a chamber. The methods generally include the steps of introducing a mesh into a blood vessel to capture embolic material, adjusting the mesh, if necessary, during the course of filtration, inflating the balloon occluder to occlude the vessel upstream of the mesh, and thereafter deflating the balloon occluder and removing the mesh and the captured foreign matter from the blood vessel. Additionally, visualization techniques are used to ensure effective filtration.

14. 发明授权

US6010522A Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries 失效
标题翻译：动脉粥样硬化切除装置具有用于从主动脉和其他动脉移除斑块的捕获和切除装置
公开(公告)号：US6010522A
公开(公告)日：2000-01-04
申请号：US685577
申请日：1996-07-24
申请人： Denise Barbut , Jonathan D Root , Robert Rizzari , James M Sellers , Giovanni Pastrone , John McKenzie
发明人： Denise Barbut , Jonathan D Root , Robert Rizzari , James M Sellers , Giovanni Pastrone , John McKenzie
IPC分类号： A61B10/00 , A61B10/02 , A61B10/06 , A61B17/00 , A61B17/22 , A61B17/30 , A61B17/32 , A61F2/01 , A61M25/00 , A61M29/00
CPC分类号： A61B17/320783 , A61B17/22031 , A61B17/221 , A61B17/3207 , A61F2/01 , A61F2/013 , A61B10/06 , A61B17/32056 , A61B17/32075 , A61B2010/0225 , A61B2017/00287 , A61B2017/22068 , A61B2017/22069 , A61B2017/2215 , A61B2017/306 , A61B2017/32004 , A61B2017/320064 , A61B8/0808 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0071 , A61F2230/008 , A61M2210/127 , A61M25/00
摘要： An arterial catheter system for removing plaque from the aorta and other arteries is disclosed. The system typically includes an elongate catheter member, a filtration apparatus disposed within the distal region, and an atherectomy assembly which includes a mechanism for trapping and holding mobile or fixed plaque and an excising mechanism for removing the plaque. In use, the catheter is positioned so that the atherectomy assembly lies within a region of interest, the filtration apparatus is deployed downstream of the region of interest, the plaque is trapped and held by a snare, vacuum, or other trapping means, and then the excising mechanism is activated to remove the plaque. Methods are also disclosed for removing plaque from the aorta and other arteries.
摘要翻译：公开了用于从主动脉和其它动脉移除斑块的动脉导管系统。该系统通常包括细长导管构件，设置在远侧区域内的过滤装置，以及动脉粥样组织切除组件，其包括用于捕获和保持移动或固定噬菌斑的机构和用于去除斑块的切除机构。在使用中，定位导管，使得动脉切除术组件位于感兴趣的区域内，过滤装置部署在感兴趣区域的下游，斑块被圈套，真空或其它捕获装置捕获并保持，然后激活切除机制以去除斑块。还公开了从主动脉和其他动脉中除去斑块的方法。

15. 发明授权

US5000664A Apparatus and method to test for valve leakage in a pump assembly 失效
标题翻译：在泵组件中测试阀门泄漏的装置和方法
公开(公告)号：US5000664A
公开(公告)日：1991-03-19
申请号：US362888
申请日：1989-06-07
申请人： Michael W. Lawless , Walter L. Jimison , Giovanni Pastrone , Anthony C. Yung
发明人： Michael W. Lawless , Walter L. Jimison , Giovanni Pastrone , Anthony C. Yung
IPC分类号： F04B49/10 , A61M1/10 , A61M5/00 , A61M5/168
CPC分类号： A61M5/16831 , A61M2205/15 , A61M2205/702
摘要： Apparatus and method for determining leakage, particularly of valves, in a pumping cassette. A cassette (70) includes a primary valve (34) and a secondary valve (36), which may be selectively activated to control the source of fluid input to the cassette. The cassette also includes an inlet valve (48) and an outlet valve (56) disposed on each side of a pumping chamber (52). Downstream of the outlet valve is disposed a pressure sensor (60) which produces a signal indicative of the pressure of fluid within the cassette at that point. The cassette also includes an air-in-line sensor (40), disposed between a manifold line (38) that connects the primary and secondary valve in fluid communication with an air trap reservoir (44). Leakage in the inlet or outlet valves is detected by closing both valves, pressurizing fluid in the pumping chamber for a predetermined period of time, and then opening the outlet valve. If a pressure pulse having an amplitude less than a predetermined level is detected downstream of the outlet valve when it is opened, either the inlet or outlet valve has leaked. The primary and secondary valves are checked for leakage either by pressurizing fluid in the pumping chamber and checking for retrograde flow of air trapped in the air trap reservoir through the air-in-line sensor, or by pressurizing fluid trapped in the cassette, holding the pressure for a period of time before closing the inlet valve, and then opening the outlet valve to detect a pressure pulse propagating downstream of the outlet valve, using the pressure sensor. If a pressure pulse of less than the predetermined magnitude is detected, one of the primary or secondary outlet valves is leaking. Both tests also detect leakage of other portions of the pumping cassette.

16. 发明授权

US4453932A Intravenous metering device 失效
标题翻译：静脉计量装置
公开(公告)号：US4453932A
公开(公告)日：1984-06-12
申请号：US350361
申请日：1982-02-19
申请人： Giovanni Pastrone
发明人： Giovanni Pastrone
IPC分类号： A61M5/142 , A61M5/36 , G01F11/08 , A61M5/00
CPC分类号： A61M5/36 , A61M5/14224 , G01F11/08 , Y10S128/12
摘要： A device for precise metering of liquids for intravenous delivery to a patient, the device including a pumping chamber with a reciprocable diaphragm positioned therein. The device also includes check valves positioned at the pumping chamber inlet and outlet, and a gas retention chamber located upstream of the pumping chamber and having an upper portion providing for the formation of a gas-liquid interface and a lower portion from which liquid free of gas bubbles may be removed and directed into the pumping chamber.
摘要翻译：一种用于精确计量用于静脉内输送给患者的液体的装置，该装置包括具有定位在其中的可往复运动的隔膜的泵送室。该装置还包括位于泵送室入口和出口处的止回阀，以及位于泵送室上游的气体保持室，并具有提供用于形成气 - 液界面和下部的上部，气泡可以被去除并被引导到泵送室中。

17. 发明授权

US4453931A Intravenous metering device 失效
标题翻译：静脉计量装置
公开(公告)号：US4453931A
公开(公告)日：1984-06-12
申请号：US278954
申请日：1981-06-30
申请人： Giovanni Pastrone
发明人： Giovanni Pastrone
IPC分类号： A61M5/168 , A61M1/00 , A61M5/142 , A61M5/175 , G11B33/12 , A61M5/00
CPC分类号： A61M5/14224
摘要： A device for precise metering of liquids for intravenous delivery to a patient, the device including a pumping chamber with a reciprocable diaphragm positioned therein. The device also includes valves positioned at the pumping chamber inlet and outlet, the valve at the pumping chamber inlet being operated independently of the pressure within the pumping chamber. The device also includes a gas retention chamber having an upper portion providing for the formation of the gas-liquid interface and a lower portion from which liquid free of gas bubbles may be removed.
摘要翻译：一种用于精确计量用于静脉内输送给患者的液体的装置，该装置包括具有定位在其中的可往复运动的隔膜的泵送室。该装置还包括位于泵送室入口和出口处的阀，泵送室入口处的阀独立于泵送室内的压力来操作。该装置还包括气体保持室，其具有提供用于形成气液界面的上部部分和可以从其中去除不含气泡的液体的下部分。

18. 发明授权

US6118854A Method of making x-ray beam hardening filter and assembly 有权
标题翻译：制造x射线束硬化过滤器和组装的方法
公开(公告)号：US6118854A
公开(公告)日：2000-09-12
申请号：US167638
申请日：1998-10-06
申请人： Edward G. Solomon , Giovanni Pastrone
发明人： Edward G. Solomon , Giovanni Pastrone
IPC分类号： G21K1/10 , G21K3/00
CPC分类号： G21K1/10
摘要： An x-ray beam hardening filter and method for making the same is disclosed. According to an embodiment, the method comprises etching a plurality of regularly spaced pits into a surface area of a sheet having an x-ray beam hardening quality, aligning the sheet to a support member and bonding the sheet to the support member. An x-ray beam hardening filter can be made and used which is not only compact and useful in diagnostic x-ray imaging, but which is capable of shaping an x-ray energy spectrum envelope in a highly controllable manner.
摘要翻译：公开了一种X射线束硬化过滤器及其制造方法。根据实施例，该方法包括将多个规则间隔的凹坑蚀刻成具有x射线束硬化质量的片材的表面区域，将片材对准支撑构件并将片材粘合到支撑构件上。可以制造和使用X射线束硬化过滤器，其不仅在诊断X射线成像中是紧凑且有用的，而且能够以高度可控的方式成形X射线能谱包络。

19. 发明授权

US5895399A Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries 失效
公开(公告)号：US5895399A
公开(公告)日：1999-04-20
申请号：US728035
申请日：1996-10-09
申请人： Denise Barbut , Jonathan D Root , Robert Rizzari , James M Sellers , Giovanni Pastrone , John McKenzie
发明人： Denise Barbut , Jonathan D Root , Robert Rizzari , James M Sellers , Giovanni Pastrone , John McKenzie
IPC分类号： A61B10/00 , A61B10/02 , A61B10/06 , A61B17/00 , A61B17/22 , A61B17/30 , A61B17/32 , A61F2/01 , A61M25/00
CPC分类号： A61B17/320783 , A61B17/22031 , A61B17/221 , A61B17/3207 , A61F2/01 , A61F2/013 , A61B10/06 , A61B17/32056 , A61B17/32075 , A61B2010/0225 , A61B2017/00287 , A61B2017/22068 , A61B2017/22069 , A61B2017/2215 , A61B2017/306 , A61B2017/32004 , A61B2017/320064 , A61B8/0808 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0071 , A61F2230/008 , A61M2210/127 , A61M25/00
摘要： An arterial catheter system for removing plaque from the aorta and other arteries is disclosed. The system typically includes an elongate catheter member, a filtration apparatus disposed within the distal region, and an atherectomy assembly which includes a mechanism for trapping and holding mobile or fixed plaque and an excising mechanism for removing the plaque. In use, the catheter is positioned so that the atherectomy assembly lies within a region of interest, the filtration apparatus is deployed downstream of the region of interest, the plaque is trapped and held by a snare, vacuum, or other trapping means, and then the excising mechanism is activated to remove the plaque. Methods are also disclosed for removing plaque from the aorta and other arteries.

20. 发明授权

US5808306A X-ray detector 失效
标题翻译： X射线探测器
公开(公告)号：US5808306A
公开(公告)日：1998-09-15
申请号：US703044
申请日：1996-08-26
申请人： Brian Skillicorn , Giovanni Pastrone
发明人： Brian Skillicorn , Giovanni Pastrone
IPC分类号： A61B6/03 , A61B6/06 , A61B6/12 , G01T1/20 , G01T1/202 , G01T1/29 , G21K1/02 , H01J35/14 , H05G1/10 , H05G1/64 , G01T1/208
CPC分类号： H05G1/64 , A61B6/06 , A61B6/12 , A61B6/4028 , G01T1/2018 , G01T1/202 , G01T1/2971 , G21K1/025 , H01J35/14 , H05G1/10 , A61B6/4488 , A61B6/487
摘要： The detector of the present invention comprises a plurality of densely packed x-ray detectors arranged into an array. Each detector preferably comprises a scintillator element which is optically coupled to a photodetector element, preferably with a fiber optic link. Each photodetector element is preferably optically separate from adjacent photodetector elements. The detector array preferably includes integral alignment means to align the scintillator elements with the photodetector elements. The scintillator array elements are preferably formed from materials which possess a fast response and a minimum afterglow time.
摘要翻译：本发明的检测器包括布置成阵列的多个密集堆积的x射线检测器。每个检测器优选地包括闪光体元件，该闪烁器元件光学耦合到光电检测器元件，优选地具有光纤链路。每个光检测器元件优选地与相邻光电检测器元件光学分离。检测器阵列优选地包括使闪烁体元件与光电检测器元件对准的整体对准装置。闪烁体阵列元件优选由具有快速响应和最小余辉时间的材料形成。

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