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11. 发明授权

US5773228A Activation-dependent protein expressed on the surface of activated platelets and antibodies thereto 失效
标题翻译：在活化的血小板表面上表达的活化依赖性蛋白及其抗体
公开(公告)号：US5773228A
公开(公告)日：1998-06-30
申请号：US460808
申请日：1995-06-02
申请人： Guy L. Reed , Gary R. Matsueda
发明人： Guy L. Reed , Gary R. Matsueda
IPC分类号： A61K39/395 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/28 , C07K16/30 , C07K19/00 , G01N33/53 , A61K51/00 , G01N33/50
CPC分类号： C07K14/705 , C07K16/28 , C07K16/3061
摘要： The present invention provides a thrombin-activated platelet protein (TAPP). The protein is selectively expressed on the surface of thrombin-activated platelets. Antibodies which selectively bind to the thrombin-activated platelet protein are also provided. These compositions find use in the detection and treatment of blood clots.
摘要翻译：本发明提供凝血酶活化的血小板蛋白（TAPP）。蛋白质在凝血酶活化血小板的表面上选择性表达。还提供选择性结合凝血酶活化的血小板蛋白的抗体。这些组合物可用于检测和治疗血块。

12. 发明授权

US5571708A Thrombin-activatable plasminogen activator 失效
标题翻译：凝血酶激活性纤溶酶原激活物
公开(公告)号：US5571708A
公开(公告)日：1996-11-05
申请号：US49195
申请日：1993-04-19
申请人： Wen-Pin Yang , Gary R. Matsueda , Shyh-Yu Shaw
发明人： Wen-Pin Yang , Gary R. Matsueda , Shyh-Yu Shaw
IPC分类号： A61K38/00 , C07K16/18 , C12N9/72 , C12P21/08 , A61K38/48 , C07H19/00 , C07K16/00
CPC分类号： C12N9/6462 , C07K16/18 , C12Y304/21073 , A61K38/00 , C07K2319/00
摘要： A new chimeric plasminogen activator with high fibrin affinity was designed to bind to a fibrin clot and initiate clot destruction in the presence of thrombin, but not plasmin. The chimeric molecule has an antibody variable region having a fibrin-specific antigen binding site and a single chain urokinase region having a thrombin activation site but not a plasmin activation site. The preferred embodiment, 59D8-ScuPA-T, has an N-terminal fragment of an anti-fibrin antibody (59DB) and a C-terminal thrombin-activatable low molecular weight single-chain urokinase plasminogen activator (scuPA-T). The scuPA-T portion was obtained by deletion of two amino acids (Phe157 and Lys 158) that make up the plasmin activation site from low molecular weight single chain urokinase-type plasminogen activator (scuPA).
摘要翻译：设计具有高纤维蛋白亲和力的新的嵌合纤溶酶原激活物结合纤维蛋白凝块，并在凝血酶存在下引发凝块破坏，而不是纤溶酶。嵌合分子具有具有纤维蛋白特异性抗原结合位点的抗体可变区和具有凝血酶活化位点而不是纤溶酶活化位点的单链尿激酶区。优选的实施方案59D8-ScuPA-T具有抗纤维蛋白抗体（59DB）和C末端凝血酶激活的低分子量单链尿激酶纤溶酶原激活物（scuPA-T）的N-末端片段。通过从低分子量单链尿激酶型纤溶酶原激活物（scuPA）中缺失构成纤溶酶活化位点的两个氨基酸（Phe157和Lys158）获得scuPA-T部分。

13. 发明授权

US5446132A Thrombin-activated platelet protein-2 (TAPP-2) 失效
标题翻译：凝血酶激活的血小板蛋白-2（TAPP-2）
公开(公告)号：US5446132A
公开(公告)日：1995-08-29
申请号：US86472
申请日：1992-10-01
申请人： Guy L. Reed , Gary R. Matsueda
发明人： Guy L. Reed , Gary R. Matsueda
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C07K16/28 , C07K14/435 , C07K14/46 , C07K14/52
CPC分类号： C07K14/705 , C07K14/47 , C07K16/28 , A61K38/00
摘要： The present invention provides a thrombin-activated platelet protein (TAPP). The protein is selectively expressed on the surface of thrombin-activated platelets. Antibodies which selectively bind to the thrombin-activated platelet protein are also provided. These compositions find use in the detection and treatment of blood clots.
摘要翻译：本发明提供凝血酶活化的血小板蛋白（TAPP）。蛋白质在凝血酶活化血小板的表面上选择性表达。还提供选择性结合凝血酶活化的血小板蛋白的抗体。这些组合物可用于检测和治疗血块。

14. 发明授权

US5256413A Method and use for site-specific activation of substances 失效
标题翻译：物质特异性活化的方法和用途
公开(公告)号：US5256413A
公开(公告)日：1993-10-26
申请号：US946015
申请日：1992-09-15
申请人： Edgar Haber , Gary R. Matsueda
发明人： Edgar Haber , Gary R. Matsueda
IPC分类号： A61K47/48 , A61K39/395 , C07K15/28
CPC分类号： A61K47/4843
摘要： Disclosed is a method for the in vivo lysis of a thrombus in a host by administration of a conjugate consisting of a monoclonal antibody specific for fibrin coupled to a plasminogen activator such as tissue plasminogen activator, urokinase or streptokinase.
摘要翻译：公开了一种通过施用由对纤维蛋白特异性的纤维蛋白特异性的单克隆抗体组合的缀合物体内裂解宿主中的血栓的方法，所述结合纤维蛋白偶联于纤溶酶原激活剂如组织纤溶酶原激活剂，尿激酶或链激酶。

15. 发明授权

US3954709A Phenylethyl group containing resins for the synthesis of peptides 失效
标题翻译：含苯乙基的树脂用于合成肽
公开(公告)号：US3954709A
公开(公告)日：1976-05-04
申请号：US364908
申请日：1973-05-29
申请人： John M. Stewart , Gary R. Matsueda
发明人： John M. Stewart , Gary R. Matsueda
IPC分类号： C07K1/04 , C08F8/00 , C08F12/08 , C08F12/36
CPC分类号： C07K1/042 , C08F8/00
摘要： The phenylethyl group, ##SPC1##In polymer carriers for the synthesis of peptides and peptide amides, particularly polymer carriers such as styrene-1% divinyl benzene polymers for use in solid phase peptide synthesis.The invention described herein was made in the course of work under a grant or award from the Department of Health, Education and Welfare.
摘要翻译：苯乙基，用于合成肽和肽类的聚合物载体，特别是聚合物载体，如用于固相肽合成的苯乙烯-1％二苯乙烯聚合物。

16. 发明授权

US07091331B2 Nucleic acid molecules and polypeptides encoding baboon TAFI 有权
标题翻译：编码狒狒TAFI的核酸分子和多肽
公开(公告)号：US07091331B2
公开(公告)日：2006-08-15
申请号：US10379836
申请日：2003-03-04
申请人： James K. Tamura , Gary R. Matsueda , Mei-Yin Hsu , Akbar Nayeem
发明人： James K. Tamura , Gary R. Matsueda , Mei-Yin Hsu , Akbar Nayeem
IPC分类号： C07H21/01 , C07H21/04 , C07K1/14
CPC分类号： C12N9/48 , A61K38/00
摘要： The present invention relates to the isolation and identification of novel baboon nucleic acid molecules and proteins and polypeptides encoded by such nucleic acid molecules, or degenerate variants thereof, which proteins and polypeptides comprise novel baboon thrombin-activatable fibrinolysis inhibitors or “TAFI” enzyme molecules. Because the novel baboon TAFI proteins and polypeptides of the invention inhibit the breakdown of blood clots, they may be therapeutically useful for the treatment of blood disorders wherein clotting needs to be regulated or promoted, such as hemophilia or von Willebrand's disease or in other situations, such as trauma, wherein blood clotting or coagulation needs to be regulated or promoted. The sequences of the invention are also useful in screening methods for the identification of compounds that modulate the expression of the baboon TAFI nucleic acids and/or the activity of the baboon TAFI proteins and polypeptides of the invention. Such agonist or antagonist compounds may be useful in the treatment of various blood clotting disorders and conditions requiring hemostatic control such as hemophilia or various thrombotic diseases such as deep venous thrombosis, coronary artery disease, stroke associated with atrial fibrillation and recurrent thrombosis following stroke or myocardial infarction.
摘要翻译：本发明涉及分离和鉴定由这种核酸分子或其简并变体编码的新型狒狒核酸分子和蛋白质和多肽，其蛋白质和多肽包含新型狒狒凝血酶可激活的纤维蛋白溶解抑制剂或“TAFI”酶分子。因为本发明的新型狒狒TAFI蛋白质和多肽抑制血凝块的分解，所以它们可用于治疗需要调节或促进凝血的血液病症，例如血友病或血管性血友病或其他情况，例如创伤，其中需要调节或促进凝血或凝血。本发明的序列也可用于鉴定调节狒狒TAFI核酸表达的化合物和/或本发明的狒狒TAFI蛋白和多肽的活性的筛选方法。这样的激动剂或拮抗剂化合物可用于治疗各种血液凝固病症和需要止血控制的病症，例如血友病或各种血栓形成疾病如深静脉血栓形成，冠状动脉疾病，与心房颤动相关的中风和中风或心肌复发性血栓形成梗死。

17. 发明授权

US4916070A Fibrin-specific antibodies and method of screening for the antibodies 失效
标题翻译：纤维蛋白特异性抗体和筛选抗体的方法
公开(公告)号：US4916070A
公开(公告)日：1990-04-10
申请号：US851514
申请日：1986-04-14
申请人： Gary R. Matsueda , Edgar Haber
发明人： Gary R. Matsueda , Edgar Haber
IPC分类号： G01N33/53 , A61K38/00 , A61K38/46 , A61K38/48 , A61K39/395 , A61K45/00 , A61K49/00 , A61K49/16 , A61K51/00 , A61K51/10 , A61P7/02 , C07H21/04 , C07K16/00 , C07K16/18 , C07K16/36 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/577 , G01N33/58 , G01N33/86
CPC分类号： A61K51/1018 , A61K49/16 , C07K16/18 , G01N33/58 , G01N33/86 , A61K2123/00 , G01N2333/75 , Y10S530/808 , Y10S530/809
摘要： The invention relates to a method of screening for fibrin clot-specific monoclonal antibodies and to the monoclonal antibodies screened by this method. The invention also relates to immundiagnostic and immunotherapeutic applications of the screened fibrin clot-specific monoclonal antibodies.
摘要翻译：本发明涉及筛选纤维蛋白凝块特异性单克隆抗体的方法和通过该方法筛选的单克隆抗体。本发明还涉及筛选的纤维蛋白凝块特异性单克隆抗体的无证和免疫治疗应用。

18. 发明授权

US4355023A Antibody fragment compositions and process 失效
标题翻译：抗体片段组成和方法
公开(公告)号：US4355023A
公开(公告)日：1982-10-19
申请号：US192696
申请日：1980-09-30
申请人： Paul H. Ehrlich , Gary R. Matsueda , Michael N. Margolies , Edgar Haber
发明人： Paul H. Ehrlich , Gary R. Matsueda , Michael N. Margolies , Edgar Haber
IPC分类号： A61K38/00 , C07K16/06 , A61K39/395
CPC分类号： C07K16/065 , A61K38/00 , Y10S424/809 , Y10S530/866
摘要： Immunologically active rabbit IgG antibody fragment compositions are produced by isolating the anti-light variable chain of rabbit IgG and/or the anti-heavy variable chain of rabbit IgG and combining them with each other or with the complementary heavy or light chain of rabbit IgG.
摘要翻译：通过分离兔IgG的抗轻链可变链和/或兔IgG的抗重链可变链并将它们彼此或与兔IgG的互补重链或轻链相结合而产生免疫活性的兔IgG抗体片段组合物。

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