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11. 发明申请

US20050032176A1 Modular polyketide synthases with altered activity 审中-公开
标题翻译：具有改变活性的模块化聚酮化合物合酶
公开(公告)号：US20050032176A1
公开(公告)日：2005-02-10
申请号：US10850308
申请日：2004-05-19
申请人： Chaitan Khosla , Gary Ashley , Hong Fu , Camilla Kao , Robert McDaniel
发明人： Chaitan Khosla , Gary Ashley , Hong Fu , Camilla Kao , Robert McDaniel
IPC分类号： C12N15/09 , C07B61/00 , C07D309/36 , C07D309/38 , C07D311/02 , C07D311/86 , C07D311/92 , C07D323/00 , C07D407/06 , C07H17/08 , C12N1/15 , C12N1/21 , C12N9/00 , C12N15/52 , C12P7/26 , C12P17/06 , C12P17/08 , C12P17/16 , C12R1/465 , C12P19/60 , C07H21/04 , C12N9/10 , C12N15/74 , C12Q1/68
CPC分类号： C12N9/93 , C07D309/36 , C07D311/92 , C07D323/00 , C07D407/06 , C07H17/08 , C12N15/52 , C12P7/26 , C12P17/06 , C12P17/08 , C12P17/162 , C40B40/00
摘要： The substrate specificity of modular polyketide synthases is altered by mutating or replacing acyltransferase regions thereof.
摘要翻译：模块化聚酮化合物合成酶的底物特异性通过突变或替换其酰基转移酶区而改变。

12. 发明授权

US06593302B2 Macrolide antiinfective agents 有权
标题翻译：大环内酯类抗感染药
公开(公告)号：US06593302B2
公开(公告)日：2003-07-15
申请号：US10075466
申请日：2002-02-13
申请人： Daniel Chu , Gary Ashley
发明人： Daniel Chu , Gary Ashley
IPC分类号： A61K3170
CPC分类号： C07H17/08 , Y02P20/55
摘要： Compounds of the formula wherein Ra is H; substituted or unsubstituted alkyl (1-10C); substituted or unsubstituted alkenyl (2-10C); substituted or unsubstituted alkynyl (2-10C); substituted or unsubstituted aryl (4-14C); substituted or unsubstituted arylalkyl (5-20C); or ORa is replaced by H; Rb is H or halogen; Rc is H or a protecting group; Rd is methyl, unsubstituted alkyl (3-10C); substituted alkyl (1-10C); substituted or unsubstituted alkynyl (2-10C); substituted or unsubstituted aryl (4-14C); substituted or unsubstituted arylalkyl (5-20C); substituted or unsubstituted arylalkenyl (5-20C); substituted or unsubstituted arylalkynyl (5-20C); substituted or unsubstituted amidoarylalkyl (5-20C); substituted or unsubstituted amidoarylalkenyl (5-20C); or substituted or unsubstituted amidoarylalkynyl (5-20C); Re is H or a protecting group; L is methylene or carbonyl; T is —O—, —N(R)—, —N(OR)—, —N(NHCOR)—, —N(N═CHR)—, or —N(NHR)— wherein R is H or Ra as defined above, with the proviso that when L is methylene, T is —O—; one of Z and Y is H and the other is OH, protected OH, or amino, mono- or dialkylamino, protected amino, or an amino heterocycle or Z and Y together are ═O, ═NOH or a derivatized oxime; including any pharmaceutically acceptable salts thereof and any stereoisomeric forms and mixtures of stereoisomeric forms thereof, are antimicrobial agents.
摘要翻译：化学式R a的化合物是H; 取代或未取代的烷基（1-10C）; 取代或未取代的烯基（2-10C）; 取代或未取代的炔基（2-10C）; 取代或未取代的芳基（4-14C）; 取代或未取代的芳基烷基（5-20℃）; 或ORa被H代替; Rb是H或卤素; Rc是H或保护基; Rd是甲基，未取代的烷基（3-10C）; 取代的烷基（1-10C）; 取代或未取代的炔基（2-10C）; 取代或未取代的芳基（4-14C）; 取代或未取代的芳基烷基（5-20℃）; 取代或未取代的芳基烯基（5-20℃）; 取代或未取代的芳基炔基（5-20℃）; 取代或未取代的酰氨基芳基烷基（5-20℃）; 取代或未取代的酰氨基芳基烯基（5-20℃）; 或取代或未取代的酰氨基芳基炔基（5-20℃）; Re是H或保护基; L是亚甲基或羰基; T是-O-，-N（R） - ， - N（OR） - ， - N（NHCOR） - ，-N（N = CHR） - 或-N（NHR） - ，其中R是如上定义的H或Ra，条件是当L是亚甲基时，T是-O-; Z和Y之一是H 另一个是OH，保护的OH或氨基，单或二烷基氨基，保护的氨基或氨基杂环，或Z和Y一起为= O，= NOH或衍生的肟;包括其任何药学上可接受的盐和任何立体异构形式，其立体异构形式的混合物是抗微生物剂。

13. 发明授权

US06503741B1 Polyketide synthase genes from Streptomyces venezuelae 失效
标题翻译：来自维他命C链球菌的聚酮化合物合成酶基因
公开(公告)号：US06503741B1
公开(公告)日：2003-01-07
申请号：US09141908
申请日：1998-08-28
申请人： Gary Ashley , Melanie C. Betlach , Mary Betlach , Robert McDaniel , Li Tang
发明人： Gary Ashley , Melanie C. Betlach , Mary Betlach , Robert McDaniel , Li Tang
IPC分类号： C12N900
CPC分类号： C12N9/14 , C12N15/65
摘要： Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for picromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
摘要翻译：聚酮化合物的组合文库可以通过适当操作宿主模块化的聚酮化合物合酶基因簇（例如编码picromycin的PKS的簇）来获得。组合文库可用作药物活性化合物的来源。此外，使用该方法制备新的聚酮化合物和抗生素。

14. 发明授权

US06179854B2 Apparatus and method for dissecting and retracting elongate structures 有权
标题翻译：用于解剖和缩回细长结构的装置和方法
公开(公告)号：US06179854B2
公开(公告)日：2001-01-30
申请号：US09187879
申请日：1998-11-06
申请人： Michael F. Nash , Gary Ashley Stafford
发明人： Michael F. Nash , Gary Ashley Stafford
IPC分类号： A61M2900
CPC分类号： A61B17/00008 , A61B1/00082 , A61B1/00096 , A61B1/00154 , A61B1/32 , A61B17/0218 , A61B2017/00243 , A61B2017/00336 , A61B2017/00469 , A61B2017/00557 , A61B2017/22072 , A61B2017/320044 , A61B2017/320048 , A61B2090/3614 , A61M25/10 , A61M25/1002 , A61M25/1011 , A61M29/02 , A61M2025/0197 , A61M2025/09183 , A61M2025/1075 , A61M2025/1093
摘要： A dissector/retractor device comprising a balloon having a deflated state and an inflated state is described for performing minimally invasive surgical procedures by creating a tunnel alongside a target tissue in the body. The balloon in its inflated state forms an open space extending transversely through the balloon. The balloon is carried by an insertion assembly. The balloon may be an elongate torus shape with an elongate open area in its interior. The insertion assembly includes a blunt dissection device and a handle. In use, the dissector retractor is inserted through a small incision and bluntly tunneled through body tissue to a desired location. The balloon is inflated to create a space in the body tissue and may also dissect tissue as necessary away from the tissue to be treated. The balloon is left in place inflated to retract the space. Another incision may be made to provide more direct access to the target tissue than the original incision. The target tissue may then be diagnosed and/or treated through the direct access incision, through the overlying tissue and through the open space in the balloon.
摘要翻译：描述了包括具有放气状态和膨胀状态的球囊的解剖器/牵开器装置，用于通过在身体中的靶组织旁边创建隧道来执行微创外科手术。处于膨胀状态的气囊形成横向延伸穿过气囊的开放空间。气囊由插入组件承载。气球可以是细长的环形，其内部具有细长的开放区域。插入组件包括钝器解剖装置和手柄。在使用中，解剖器牵开器通过小切口插入，并且通过身体组织直线穿透到期望的位置。气囊被充气以在身体组织中产生空间，并且还可以根据需要将组织切除离开待治疗组织。气球留在原地充气以缩回空间。可以进行另一切口以提供比原始切口更直接地进入目标组织。然后可以通过直接进入切口，通过上覆组织和气囊中的开放空间来诊断和/或治疗目标组织。

15. 发明授权

US08852101B2 Method and apparatus for providing analyte sensor insertion 有权
标题翻译：用于提供分析物传感器插入的方法和装置
公开(公告)号：US08852101B2
公开(公告)日：2014-10-07
申请号：US12571349
申请日：2009-09-30
申请人： Gary Ashley Stafford
发明人： Gary Ashley Stafford
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1486
CPC分类号： A61B5/1473 , A61B5/0002 , A61B5/0015 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/14865
摘要： Devices and methods for positioning a portion of a sensor at a first predetermined location, displacing the portion of the sensor from the first predetermined location to a second predetermined location, and detecting one or signals associated with an analyte level of a patient at the second predetermined location are disclosed. Also provided are systems and kits for use in analyte monitoring.
摘要翻译：用于将传感器的一部分定位在第一预定位置处的装置和方法，将传感器的该部分从第一预定位置移位到第二预定位置，以及在第二预定位置处检测与患者的分析物水平相关联的一个或信号公开位置。还提供了用于分析物监测的系统和试剂盒。

16. 发明授权

US08512243B2 Integrated introducer and transmitter assembly and methods of use 失效
标题翻译：集成导引器和变送器组件及使用方法
公开(公告)号：US08512243B2
公开(公告)日：2013-08-20
申请号：US11240259
申请日：2005-09-30
申请人： Gary Ashley Stafford
发明人： Gary Ashley Stafford
IPC分类号： A61B5/00 , A61B5/04 , A61B17/34
CPC分类号： A61B5/6849 , A61B5/0002 , A61B5/0004 , A61B5/0022 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14542 , A61B5/14546 , A61B2560/063
摘要： Method and apparatus for inserting at least a portion of a sensor into a patient is provided.
摘要翻译：提供了用于将传感器的至少一部分插入患者体内的方法和装置。

17. 发明申请

US20130123461A1 CONTROLLED DRUG RELEASE FROM DENDRIMERS 有权
标题翻译：控制药物从DENDRIMERS发布
公开(公告)号：US20130123461A1
公开(公告)日：2013-05-16
申请号：US13696301
申请日：2011-05-05
申请人： Gary Ashley , Daniel V. Santi
发明人： Gary Ashley , Daniel V. Santi
IPC分类号： A61K47/48
CPC分类号： A61K47/48315 , A61K38/2242 , A61K38/26 , A61K38/50 , A61K47/60 , A61K47/641 , A61K47/645 , C08G83/003 , C08G83/004
摘要： The invention relates to compositions that comprise dendrimers useful in medical and veterinary applications that provide controlled release of drugs, such as peptides, nucleic acids and small molecules. The drugs are covalently coupled to the dendrimer through a linkage that releases the drug or a prodrug through controlled beta elimination.
摘要翻译：本发明涉及包含用于医学和兽医学应用中的树枝状大分子的组合物，其提供药物（例如肽，核酸和小分子）的受控释放。这些药物通过通过对照β消除释放药物或前药的连接共价偶联到树状聚合物上。

18. 发明申请

US20110184264A1 Universal Test Strip Port 有权
标题翻译：通用测试带端口
公开(公告)号：US20110184264A1
公开(公告)日：2011-07-28
申请号：US12695947
申请日：2010-01-28
申请人： John R. Galasso , Matthew Simmons , Gary Ashley Stafford , Cherie Bulala , Christopher Myles , Philip Justus Wunderle, III , Bonita Song
发明人： John R. Galasso , Matthew Simmons , Gary Ashley Stafford , Cherie Bulala , Christopher Myles , Philip Justus Wunderle, III , Bonita Song
IPC分类号： A61B5/145 , G01N33/00 , G08B9/00
CPC分类号： G01N27/327 , A61B5/14532 , A61B5/1473 , A61B2560/045 , A61B2562/0295 , A61M5/1723 , G01N33/48785 , G06F19/00
摘要： The present disclosure provides a sensor port configured to receive a plurality of analyte sensors having different sizes, shapes and/or electrode configurations. Also provided are analyte meters, analyte monitoring devices and/or systems and drug delivery devices and/or systems utilizing the disclosed sensor ports.
摘要翻译：本公开提供了一种被配置为接收具有不同尺寸，形状和/或电极配置的多个分析物传感器的传感器端口。还提供了分析物计量器，分析物监测装置和/或系统以及利用所公开的传感器端口的药物输送装置和/或系统。

19. 发明授权

US07914335B2 Strip connectors for measurement devices 有权
公开(公告)号：US07914335B2
公开(公告)日：2011-03-29
申请号：US12861691
申请日：2010-08-23
申请人： Gary Ashley Stafford , Richard G. Ries
发明人： Gary Ashley Stafford , Richard G. Ries
IPC分类号： H01R25/00
CPC分类号： H01R43/24 , G01N33/48785 , H01R12/727 , H01R13/5224 , H01R31/06 , Y10S439/909 , Y10T29/49002
摘要： Devices including strip connectors in measurement devices are provided. Also provided are systems, kits and methods.

20. 发明申请

US20090105569A1 Introducer Assembly and Methods of Use 审中-公开
标题翻译：介绍人组装和使用方法
公开(公告)号：US20090105569A1
公开(公告)日：2009-04-23
申请号：US11380883
申请日：2006-04-28
申请人： Gary Ashley Stafford
发明人： Gary Ashley Stafford
IPC分类号： A61B5/145
CPC分类号： A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/6833 , A61B2562/12 , Y10T29/4978
摘要： Method and apparatus for inserting at least a portion of a sensor into a patient is provided.
摘要翻译：提供了用于将传感器的至少一部分插入患者体内的方法和装置。

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