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11. 发明授权

US5972597A Methods using modified vaccinia virus 失效
标题翻译：使用修饰的痘苗病毒的方法
公开(公告)号：US5972597A
公开(公告)日：1999-10-26
申请号：US456023
申请日：1995-05-13
申请人： Enzo Paoletti , Dennis Panicali
发明人： Enzo Paoletti , Dennis Panicali
IPC分类号： C12N15/09 , A61K39/00 , A61K39/285 , C07H21/04 , C07K14/035 , C07K14/11 , C12N5/10 , C12N7/00 , C12N15/00 , C12N15/63 , C12N15/863 , C12P21/00 , C12Q1/70 , C12R1/19 , C12R1/91 , C12R1/92
CPC分类号： C12N15/86 , C07K14/005 , A61K39/00 , C12N2710/16622 , C12N2710/24143 , C12N2760/16122
摘要： What are disclosed are methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous DNA; modified vaccinia prepared by such methods; certain DNA sequences and unmodified and genetically modified microorganisms involved as intermediates in such methods; and methods for infecting cells and host animals with such vaccinia mutants to provoke the amplification of exogenous DNA and proteins encoded by the exogenous DNA, including antigenic proteins, by said cells and host animals.
摘要翻译：公开的是用于修饰痘苗病毒基因组以产生痘苗突变体的方法，特别是通过引入外源DNA的痘苗基因组; 通过这种方法制备的改良牛痘; 某些DNA序列和未修饰的和遗传修饰的微生物作为中间体参与这些方法; 以及用这种痘苗突变体感染细胞和宿主动物的方法，以引发由所述细胞和宿主动物扩增由外源DNA（包括抗原蛋白）编码的外源DNA和蛋白质。

12. 发明授权

US4769330A Modified vaccinia virus and methods for making and using the same 失效
标题翻译：修饰的痘苗病毒及其制备和使用方法
公开(公告)号：US4769330A
公开(公告)日：1988-09-06
申请号：US334456
申请日：1981-12-24
申请人： Enzo Paoletti , Dennis Panicali
发明人： Enzo Paoletti , Dennis Panicali
IPC分类号： A61K39/00 , A61K39/29 , C07K14/035 , C07K14/11 , C12N15/00 , C12N5/00 , C12N7/00 , C12N7/04 , C12P19/34 , C12P21/00 , C12R1/91
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/16622 , C12N2760/16122 , Y10S435/948
摘要： What are disclosed are methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous DNA; modified vaccinia prepared by such methods; certain DNA sequences and unmodified and genetically modified microorganisms involved as intermediates in such methods; and methods for infecting cells and host animals with such vaccinia mutants to provoke the amplification of exogenous DNA and proteins encoded by the exogenous DNA, including antigenic proteins, by said cells and host animals.
摘要翻译：公开的是用于修饰痘苗病毒基因组以产生痘苗突变体的方法，特别是通过引入外源DNA的痘苗基因组; 通过这种方法制备的改良牛痘; 某些DNA序列和未修饰的和遗传修饰的微生物作为中间体参与这些方法; 以及用这种痘苗突变体感染细胞和宿主动物的方法，以引发由所述细胞和宿主动物扩增由外源DNA（包括抗原蛋白）编码的外源DNA和蛋白质。

13. 发明授权

US4722848A Method for immunizing animals with synthetically modified vaccinia virus 失效
标题翻译：用合成修饰的痘苗病毒免疫动物的方法
公开(公告)号：US4722848A
公开(公告)日：1988-02-02
申请号：US622135
申请日：1984-06-19
申请人： Enzo Paoletti , Dennis Panicali
发明人： Enzo Paoletti , Dennis Panicali
IPC分类号： A61K39/00 , A61K39/29 , C07K14/035 , C07K14/11 , A61K39/285
CPC分类号： C07K14/005 , A61K39/12 , A61K39/292 , A61K39/00 , C12N2710/16622 , C12N2710/16634 , C12N2710/24143 , C12N2730/10134 , C12N2760/16122 , C12N2760/16134 , Y10S424/822
摘要： What are disclosed are methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous DNA; modified vaccinia prepared by such methods; certain DNA sequences and unmodified and genetically modified microorganisms involved as intermediates in such methods; and methods for infecting cells and host animals with such vaccinia mutants to provoke the amplification of exogenous DNA and proteins encoded by the exogenous DNA, including antigenic proteins, by said cells and host animals.
摘要翻译：公开的是用于修饰痘苗病毒基因组以产生痘苗突变体的方法，特别是通过引入外源DNA的痘苗基因组; 通过这种方法制备的改良牛痘; 某些DNA序列和未修饰的和遗传修饰的微生物作为中间体参与这些方法; 以及用这种痘苗突变体感染细胞和宿主动物的方法，以引发由所述细胞和宿主动物扩增由外源DNA（包括抗原蛋白）编码的外源DNA和蛋白质。

14. 发明授权

US07211432B2 Recombinant vector expressing multiple costimulatory molecules and uses thereof 有权
标题翻译：表达多种共刺激分子的重组载体及其用途
公开(公告)号：US07211432B2
公开(公告)日：2007-05-01
申请号：US10406317
申请日：2003-04-04
申请人： Jeffrey Schlom , James Hodge , Dennis Panicali
发明人： Jeffrey Schlom , James Hodge , Dennis Panicali
IPC分类号： C12N15/00 , C12N15/39 , C12N15/19 , C12N7/00
CPC分类号： C12N15/86 , A61K35/12 , A61K39/00 , A61K48/00 , A61K2039/57 , C07K14/70503 , C07K14/70525 , C07K14/70528 , C07K14/70532 , C12N2710/24043 , C12N2710/24143 , Y02A50/41 , Y02A50/412 , Y02A50/464 , Y02A50/478
摘要： The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect of these costimulatory molecules on the enhanced activation of T cells is demonstrated. The degree of T-cell activation using recombinant vectors containing genes encoding three costimulatory molecules was far greater than the sum of recombinant vector constructs containing one costimulatory molecule and greater than the use of two costimulatory molecules. Results employing the triple costimulatory vectors were most dramatic under conditions of either low levels of first signal or low stimulator to T-cell ratios. This phenomenon was observed with both isolated CD4+ and CD8+ T cells. The recombinant vectors of the present invention are useful as immunogenes and vaccines against cancer and pathogenic micro-organisms, and in providing host cells, including dendritic cells and splenocytes with enhanced antigen-presenting functions.
摘要翻译：本发明是编码并表达至少三种或更多共刺激分子的重组载体。重组载体可另外含有编码一种或多种靶抗原或其免疫表位的基因。证明了这些共刺激分子对增强的T细胞活化的协同作用。使用含有编码三个共刺激分子的基因的重组载体的T细胞活化程度远远大于含有一个共刺激分子并且大于使用两个共刺激分子的重组载体构建体的总和。使用三重共刺激载体的结果在低水平的第一信号或低刺激剂与T细胞比率的条件下最显着。在分离的CD4 +和/或CD8 + T细胞中都观察到这种现象。本发明的重组载体可用作抗癌和致病微生物的免疫原和疫苗，以及提供宿主细胞，包括具有增强的抗原呈递功能的树突状细胞和脾细胞。

15. 发明授权

US07118738B2 Recombinant pox virus for immunization against MUC1 tumor-associated antigen 有权
公开(公告)号：US07118738B2
公开(公告)日：2006-10-10
申请号：US10057136
申请日：2002-01-25
申请人： Jeffrey Schlom , Judith Kantor , Donald Kufe , Dennis Panicali , Linda Gritz
发明人： Jeffrey Schlom , Judith Kantor , Donald Kufe , Dennis Panicali , Linda Gritz
IPC分类号： A01N63/00 , A61K48/00 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74
CPC分类号： C12Q1/6897 , A61K39/00 , C07K14/4727 , C07K14/705 , C07K14/70532 , C12N2799/021 , C12N2799/023 , C12Q1/6883 , C12Q1/6886
摘要： Recombinant pox viruses capable of expressing an immunogenic fragment of the MUC1 tumor-associated antigen are disclosed. The recombinant viruses can be used as vaccines to prevent the establishment of or treat tumors or pre-tumorous cells expressing the MUC1 tumor-associated antigen. The vaccines can be provided as an admixture comprising: (1) a recombinant pox virus encoding the immunogenic fragment of the MUC1 tumor-associated antigen, and (2) a recombinant pox virus encoding a T-cell co-stimulatory factor. The vaccine admixture can be used, e.g., to prevent establishment of tumors or pre-tumorous cells expressing the MUC1 tumor-associated antigen. The MUC1 specific cytotoxic T-cells can be isolated and expanded and used in a method for treating a host having a tumor expressing MCU1 positive tumor cells.

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