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11. 发明申请

US20100057164A1 MULTIPLE TUNABLE CENTRAL CATHODES ON A PADDLE FOR INCREASED MEDIAL-LATERAL AND ROSTRAL-CAUDAL FLEXIBILITY VIA CURRENT STEERING 有权
公开(公告)号：US20100057164A1
公开(公告)日：2010-03-04
申请号：US12204154
申请日：2008-09-04
申请人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K.L. Peterson
发明人： Michael Moffitt , Dongchul Lee , Kerry Bradley , David K.L. Peterson
IPC分类号： A61N1/34
CPC分类号： A61N1/0551 , A61N1/36071
摘要： A neurostimulation paddle lead, method of neurostimulation, and neurostimulation system are provided. The neurostimulation paddle lead carries a plurality of electrodes comprising at least four columns of electrodes having a spacing between two inner electrode columns less than a spacing between the inner electrode columns and adjacent outer electrode columns. The inner electrode columns may also be longitudinally offset from the outer electrode columns. The methods and neurostimulation systems steer current between the electrodes to modify a medial-lateral electrical field created adjacent spinal cord tissue.

12. 发明申请

US20100023070A1 SYSTEM AND METHOD FOR MAINTAINING A DISTRIBUTION OF CURRENTS IN AN ELECTRODE ARRAY USING INDEPENDENT VOLTAGE SOURCES 有权
标题翻译：使用独立电压源在电极阵列中维持电流分配的系统和方法
公开(公告)号：US20100023070A1
公开(公告)日：2010-01-28
申请号：US12508290
申请日：2009-07-23
申请人： Michael Moffitt , David K.L. Peterson
发明人： Michael Moffitt , David K.L. Peterson
IPC分类号： A61N1/08
CPC分类号： A61N1/36071 , A61N1/0551
摘要： In one technique, a desired electrical current distribution on at least three active electrodes is selected. An electrical energy perturbation is generated on at least one electrode. A current-to-voltage relationship at each active electrode is estimated based on the energy perturbation. The current-to-voltage relationship for each active electrode takes into account current flow through other active electrodes. The voltage distribution necessary to achieve the desired current distribution is determined based on the estimated current-to-voltage relationship. Voltage-regulated energy is conveyed between the electrodes and tissue in accordance with the determined electrical voltage distribution. In another technique, an electrical energy perturbation on at least one of the electrodes is generated. Network resistances for each of at least three active electrodes are computed in response to the energy perturbation. The network resistances represent the resistances between the electrodes and common node to which the electrodes are connected.
摘要翻译：在一种技术中，选择在至少三个有效电极上的期望的电流分布。在至少一个电极上产生电能扰动。基于能量扰动来估计每个有源电极处的电流 - 电压关系。每个有源电极的电流 - 电压关系考虑到通过其他有源电极的电流。基于估计的电流 - 电压关系确定实现所需电流分布所需的电压分布。电压调节能量根据确定的电压分布在电极和组织之间传送。在另一技术中，产生至少一个电极上的电能扰动。响应于能量扰动计算至少三个有效电极中的每一个的网络电阻。网络电阻表示电极与电极连接的公共节点之间的电阻。

13. 发明申请

US20100010566A1 SYSTEM AND METHOD FOR CONVERTING TISSUE STIMULATION PROGRAMS IN A FORMAT USABLE BY AN ELECTRICAL CURRENT STEERING NAVIGATOR 有权
标题翻译：用于电流转向导管可用的格式转换组织刺激方案的系统和方法
公开(公告)号：US20100010566A1
公开(公告)日：2010-01-14
申请号：US12501282
申请日：2009-07-10
申请人： James R. Thacker , Michael Moffitt , Kerry Bradley , David K.L. Peterson
发明人： James R. Thacker , Michael Moffitt , Kerry Bradley , David K.L. Peterson
IPC分类号： A61N1/08 , A61N1/34
CPC分类号： A61N1/37264 , A61N1/36071 , A61N1/36146 , A61N1/3615 , A61N1/36167 , A61N1/36185 , A61N1/37247 , G06F19/00 , G16H40/63
摘要： A method, computer medium, and system for programming a controller is provided. The controller controls electrical stimulation energy output to electrodes, and stores a set of programmed stimulation parameters associated with the electrodes. The programmed stimulation parameter set is compared with sets of reference stimulation parameters, each of the reference sets of stimulation parameters being associated with the electrodes. If an identical match is determined between the programmed stimulation parameter set and any one of the reference stimulation parameter sets exists based on the comparison, the identically matched stimulation parameter set is selected as an initial stimulation parameter set. If an identical match does not exist, a best between the programmed stimulation parameter set and the reference stimulation parameter sets is determined and selected as the initial stimulation parameter set. The controller is then programmed with a new set of programmable stimulation parameters based on the initial stimulation parameter set.
摘要翻译：提供了一种用于编程控制器的方法，计算机介质和系统。控制器控制对电极的电刺激能量输出，并且存储与电极相关联的一组编程的刺激参数。将编程的刺激参数集与参考刺激参数的集合进行比较，每个参考组的刺激参数与电极相关联。如果在编程的刺激参数集之间确定相同的匹配，并且基于比较存在参考刺激参数集中的任一个，则选择相同匹配的刺激参数集作为初始刺激参数集。如果不存在相同的匹配，则确定编程的刺激参数集和参考刺激参数集之间的最佳值，并将其选为初始刺激参数集。然后基于初始刺激参数集，控制器用一组新的可编程刺激参数进行编程。

14. 发明申请

US20080319514A1 Techniques for Sensing and Adjusting a Compliance Voltage in an Implantable Stimulator Device 有权
标题翻译：用于感测和调整可植入刺激器装置中的合规电压的技术
公开(公告)号：US20080319514A1
公开(公告)日：2008-12-25
申请号：US12199312
申请日：2008-08-27
申请人： Jess Weigiao Shi , Yuping He , Que T. Doan , David K.L. Peterson
发明人： Jess Weigiao Shi , Yuping He , Que T. Doan , David K.L. Peterson
IPC分类号： A61N1/00
CPC分类号： A61N1/36125 , A61N1/36071 , A61N1/37
摘要： Disclosed herein are methods and circuitry for monitoring and adjusting a compliance voltage in an implantable stimulator devices to an optimal value that is sufficiently high to allow for proper circuit performance (i.e., sufficient current output), but low enough that power is not needlessly wasted via excessive voltage drops across the current output circuitry. The algorithm measures output voltages across the current source and sink circuitry during at least periods of actual stimulation when both the current sources and sinks are operable, and adjusts the compliance voltage so as to reduce these output voltages to within guard band values preferably indicative for operation in transistor saturation. The output voltages can additionally be monitored during periods between stimulation pulses to improve the accuracy of the measurement, and is further beneficial in that such additional measurements are not perceptible to the patient.
摘要翻译：本文公开了用于监测和调整可植入式刺激器装置中的顺应性电压的方法和电路，以达到足够高以允许适当的电路性能（即，足够的电流输出）的最佳值，但是足够低以使得功率不会被无用地浪费通过电流输出电路上的电压过大。当电流源和接收器都可操作时，该算法在至少实际刺激期间测量电流源和接收电路两端的输出电压，并且调整顺从电压，以便将这些输出电压降低到优选地指示操作的保护带值内晶体管饱和。在刺激脉冲之间的周期期间可以另外监视输出电压，以提高测量的准确度，并且进一步有益的是，这种附加测量对于患者是不可察觉的。

15. 发明申请

US20080221637A1 IMPLANTABLE PULSE GENERATOR HAVING CURRENT STEERING MEANS 有权
标题翻译：具有电流转向方式的可植入脉冲发生器
公开(公告)号：US20080221637A1
公开(公告)日：2008-09-11
申请号：US12120182
申请日：2008-05-13
申请人： Carla Mann Woods , David K.L. Peterson , Paul M. Meadows , Gerald E. Loeb
发明人： Carla Mann Woods , David K.L. Peterson , Paul M. Meadows , Gerald E. Loeb
IPC分类号： A61N1/00
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0553 , A61N1/36071 , A61N1/37235 , A61N1/37247
摘要： An implantable pulse generator includes a current steering capability that allows a clinician or patient to quickly determine a desired electrode stimulation pattern, including which electrodes of a group of electrodes within an electrode array should receive a stimulation current, including the amplitude, width and pulse repetition rate of such current. Movement of the selected group of electrodes is facilitated through the use of remotely generated directional signals, generated by a pointing device, such as a joystick. As movement of the selected group of electrodes occurs, current redistribution amongst the various electrode contacts takes place. The redistribution of stimulus amplitudes utilizes re-normalization of amplitudes so that the perceptual level remains fairly constant. This prevents the resulting paresthesia from falling below the perceptual threshold or above the comfort threshold.
摘要翻译：可植入脉冲发生器包括电流转向能力，其允许临床医生或患者快速确定期望的电极刺激图案，包括电极阵列内的一组电极中的哪些电极应接收刺激电流，包括振幅，宽度和脉冲重复这样的比率。所选择的电极组的移动通过使用由诸如操纵杆的指示装置产生的远程产生的方向信号来促进。随着所选择的电极组的移动发生，各种电极接触件之间的电流再分配发生。刺激幅度的再分配利用振幅的再归一化，使得感知水平保持相当恒定。这可以防止由此产生的感觉异常降低到感知阈值以下或高于舒适阈值。

16. 发明申请

US20120290039A1 MANAGEMENT OF STIMULATION SAFETY LIMITS IN A NEUROSTIMULATION SYSTEM 有权
标题翻译：神经系统中刺激安全限制的管理
公开(公告)号：US20120290039A1
公开(公告)日：2012-11-15
申请号：US13470326
申请日：2012-05-13
申请人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
发明人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
IPC分类号： A61N1/36
CPC分类号： A61N1/36142 , A61N1/36185 , A61N1/37241
摘要： A neurostimulation system for management of stimulation safety limits. The system determines a tissue charge injection metric at each electrode, compares the metric to the hard stop charge limit, and prevents the neurostimulator from delivering stimulation energy to the tissue region in accordance based on the comparison. The hard stop limit may be user-programmable or may be automatically modified in response to detection of electrode characteristics. The system may quantitatively notify a user of a value of the injected charge injected into the tissue. The electrodes may be organized into different sets, in which case, the system may directly control tissue charge independently at each of the electrode sets. If current steering is provided, the system may displace the electrical stimulation energy along the tissue region in one direction, while preventing the charge injection value at each of the electrodes from meeting or exceeding the hard stop charge limit.
摘要翻译：用于管理刺激安全限值的神经刺激系统。系统确定每个电极处的组织电荷注入度量，将该度量与硬停止电荷限制进行比较，并且根据比较来防止神经刺激器将刺激能量递送至组织区域。硬停止极限可以是用户可编程的，或者可以响应于电极特性的检测而被自动修改。该系统可以定量地向使用者通知注入到组织中的注入电荷的值。电极可以组织成不同的组，在这种情况下，系统可以在每个电极组中独立地直接控制组织电荷。如果提供电流转向，则系统可以沿着一个方向沿着组织区域移位电刺激能量，同时防止每个电极处的电荷注入值达到或超过硬停止充电极限。

17. 发明申请

US20120019201A1 SMART CHARGER ALIGNMENT INDICATOR 有权
标题翻译： SMART CHARGER对准指示灯
公开(公告)号：US20120019201A1
公开(公告)日：2012-01-26
申请号：US13247642
申请日：2011-09-28
申请人： David K.L. Peterson
发明人： David K.L. Peterson
IPC分类号： H02J7/00
CPC分类号： A61N1/3787
摘要： Electrical energy is transmitted to charge the implanted medical device, and an electrical parameter (e.g., a steady-state voltage) indicating a rate at which the implanted medical device is charged by the electrical energy is detected. A threshold (e.g., by modifying a stored threshold value) at which the charge strength indicator generates a user-discernible signal is adjusted based on the detected electrical parameter.
摘要翻译：传输电能以对植入的医疗装置充电，并且检测指示通过电能对植入的医疗装置充电的速率的电参数（例如，稳态电压）。基于检测到的电参数来调整充电强度指示器产生用户可识别信号的阈值（例如，通过修改存储的阈值）。

18. 发明申请

US20110112609A1 AUTOMATIC LEAD IDENTIFICATION USING ELECTRIC FIELD FINGERPRINTING 有权
标题翻译：使用电场指纹自动识别
公开(公告)号：US20110112609A1
公开(公告)日：2011-05-12
申请号：US12941657
申请日：2010-11-08
申请人： David K.L. Peterson
发明人： David K.L. Peterson
IPC分类号： A61N1/08 , A61N1/05 , G01R19/00 , G06F19/00
CPC分类号： A61N1/025 , A61N1/0553 , A61N1/36185 , A61N1/37241 , A61N1/37247
摘要： A method, programmer for a neurostimulator, and neurostimulation kit are provided. The kit comprises a neurostimulator, and a plurality of elongated lead bodies configured for being coupled to the neurostimulator, each having a plurality of proximal contacts and a plurality of distal electrodes respectively electrically coupled to the proximal contacts, wherein an in-line connectivity between the electrodes and proximal contacts carried by the different lead bodies differs from each other. Electrical energy is conveyed between the electrodes of the selected lead body and the tissue, an electrical fingerprint is measured at the proximal contacts of the selected lead body in response to the conveyed electrical energy, and the selected lead body is identified based on the measured electrical fingerprint. These steps can be performed by the programmer.
摘要翻译：提供了一种神经刺激仪的程序员和神经刺激试剂盒。该套件包括神经刺激器和多个细长引线体，其被配置为耦合到神经刺激器，每个具有多个近端触点和分别电耦合到近端触点的多个远端电极，其中，由不同引线体承载的电极和近端触点彼此不同。电能在所选引线体的电极和组织之间传送，响应于输送的电能，在所选引线体的近端触点处测量电指纹，并且基于所测量的电指纹。这些步骤可以由程序员执行。

19. 发明申请

US20110054568A1 METHODS TO AVOID FREQUENCY LOCKING IN A MULTI-CHANNEL NEUROSTIMULATION SYSTEM USING PULSE PLACEMENT 有权
标题翻译：使用脉冲放置在多通道神经元系统中避免频率锁定的方法
公开(公告)号：US20110054568A1
公开(公告)日：2011-03-03
申请号：US12550237
申请日：2009-08-28
申请人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K.L. Peterson , Andrew DiGiore , Michael Moffitt
发明人： Courtney Lane , Rafael Carbunaru , Kerry Bradley , David K.L. Peterson , Andrew DiGiore , Michael Moffitt
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/08 , A61N1/36071 , A61N1/36082
摘要： A method and neurostimulation system for treating a patient are provided. A plurality of pulsed electrical waveforms are respectively delivered within a plurality of timing channels of the neurostimulation system, thereby treating the patient. Sets of stimulation pulses within the electrical waveforms that will potentially overlap temporally are predicted. Each of the potentially overlapping pulse sets is substituted with a replacement stimulation pulse, such that each replacement stimulation pulse is delivered within at least one of the respective timing channels, thereby preventing temporal overlap between the stimulation pulses of the respective electrical waveforms while preventing frequency locking between the timing channels.
摘要翻译：提供了一种用于治疗患者的方法和神经刺激系统。多个脉冲电波形分别在神经刺激系统的多个定时通道内递送，从而治疗患者。预测可能在时间上潜在重叠的电波形内的一组刺激脉冲。每个可能重叠的脉冲组被替换刺激脉冲代替，使得每个替换刺激脉冲在相应的定时通道中的至少一个内递送，从而防止各个电波形的刺激脉冲之间的时间重叠，同时防止频率锁定在定时通道之间。

20. 发明申请

US20100331926A1 REVERSING RECRUITMENT ORDER BY ANODE INTENSIFICATION 审中-公开
标题翻译：通过阳极强化反向招聘订单
公开(公告)号：US20100331926A1
公开(公告)日：2010-12-30
申请号：US12821005
申请日：2010-06-22
申请人： Dongchul Lee , Kerry Bradley , David K.L. Peterson
发明人： Dongchul Lee , Kerry Bradley , David K.L. Peterson
IPC分类号： A61N1/36
CPC分类号： A61N1/36071 , A61N1/36185 , A61N1/37241 , A61N1/375 , A61N1/3787
摘要： A method of providing therapy to a patient using a plurality of electrodes is provided. The electrodes are located adjacent a target neural tissue region having a first nerve fiber of a relatively small diameter and a second nerve fiber of a relatively large diameter. The method comprises sourcing electrical current from a local anode into the target neural tissue region. The method further comprises therapeutically sinking a first portion of the electrical current from the target neural tissue region into a local cathode. The method further comprises sinking a second portion of the electrical current into a cathode remote from the target neural tissue region. The ratio of the sourced electrical current over the first sunk electrical current portion has a value that allows the first nerve fiber to be recruited by the electrical current while preventing the second nerve fiber from being recruited by the electrical current.
摘要翻译：提供了一种使用多个电极向患者提供治疗的方法。电极位于具有相对小直径的第一神经纤维和相对较大直径的第二神经纤维的靶神经组织区域附近。该方法包括将电流从局部阳极引入目标神经组织区域。该方法还包括将来自目标神经组织区域的电流的第一部分治疗性地吸入局部阴极。该方法还包括将电流的第二部分吸收到远离目标神经组织区域的阴极中。源头电流与第一沉没电流部分的比率具有允许第一神经纤维通过电流招募的值，同时防止第二神经纤维被电流招募。

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