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    • 12. 发明申请
    • METHODS AND DEVICES FOR MICRO-ISOLATION, EXTRACTION, AND/OR ANALYSIS OF MICROSCALE COMPONENTS
    • MICROSCALE组件的微分离,提取和/或分析的方法和设备
    • US20110177518A1
    • 2011-07-21
    • US13010761
    • 2011-01-20
    • Emil P. KartalovDarryl ShibataClive TaylorLawrence A. Wade
    • Emil P. KartalovDarryl ShibataClive TaylorLawrence A. Wade
    • C12Q1/68C12M1/00C12N13/00C12Q1/02G01N33/53G03F7/20
    • C12M23/16C12M23/12C12M23/22C12M25/04C12M25/14C12M35/02C12M37/04C12M47/04C12N13/00G01N33/54366
    • Provided herein are devices and methods for the micro-isolation of biological cellular material. A micro-isolation apparatus described can comprise a photomask that protects regions of interest against DNA-destroying illumination. The micro-isolation apparatus can further comprise photosensitive material defining access wells following illumination and subsequent developing of the photosensitive material. The micro-isolation apparatus can further comprise a chambered microfluidic device comprising channels providing access to wells defined in photosensitive material. The micro-isolation apparatus can comprise a chambered microfluidic device without access wells defined in photosensitive material where valves control the flow of gases or liquids through the channels of the microfluidic device. Also included are methods for selectively isolating cellular material using the apparatuses described herein, as are methods for biochemical analysis of individual regions of interest of cellular material using the devices described herein. Further included are methods of making masking arrays useful for the methods described herein.
    • 本文提供用于微生物细胞材料的微分离的装置和方法。 所描述的微分离装置可以包括保护感兴趣区域以防止DNA破坏照明的光掩模。 微型隔离装置还可以包括感光材料,该感光材料在照射之后界定存取孔,随后显影感光材料。 微隔离装置还可以包括腔室微流体装置,其包括通道,其提供对感光材料中限定的孔的通路。 微型隔离装置可以包括腔室微流体装置,其无感光材料中限定的通路孔,阀门通过微流体装置的通道控制气体或液体的流动。 还包括使用本文所述的装置选择性分离细胞材料的方法,以及使用本文所述的装置的细胞材料的各个感兴趣区域的生物化学分析的方法。 还包括制备用于本文所述方法的掩蔽阵列的方法。
    • 20. 发明申请
    • Auto-Extensible Device
    • 自动扩展设备
    • US20080172063A1
    • 2008-07-17
    • US11571102
    • 2005-07-28
    • Andrew Clive Taylor
    • Andrew Clive Taylor
    • A61B17/60
    • A61B17/66
    • An auto-extensible device has an electrorestrictive device. Upon applying a voltage to the electrorestrictive device, a linear bearing guide together with a second body member is caused to move distally with respect to a first body member. This movement produces a first gap between the second body member and the first body member as well as a second gap. A first motor drives a first spur gear until it abuts the first body member and thereby closes the second gap. The voltage is allowed to drop to zero causing the electrorestrictive device to contract again, thereby causing the first gap to close and a third gap to open up between a second gear ring and a distal surface of the second body member. A second motor moves the second gear ring proximally of an elongate tubular member and to cause it to close the third gap.
    • 自动扩展装置具有电子收缩装置。 当向电气限制装置施加电压时,使线性轴承引导件与第二主体构件相对于第一主体构件向远侧移动。 该运动在第二主体构件和第一主体构件之间产生第一间隙以及第二间隙。 第一马达驱动第一正齿轮,直到它抵靠第一主体部件并由此封闭第二间隙。 允许电压降至零,导致电致伸缩装置再次收缩,从而使第一间隙闭合,第三间隙在第二齿圈与第二主体构件的远侧表面之间打开。 第二马达将第二齿圈移动到细长管状构件的近侧并使其闭合第三间隙。