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11. 发明申请

US20080269190A1 Quaternary ammonium compounds useful as muscarinic receptor antagonists 有权
标题翻译：可用作毒蕈碱受体拮抗剂的季铵化合物
公开(公告)号：US20080269190A1
公开(公告)日：2008-10-30
申请号：US12148887
申请日：2008-04-23
申请人： Craig Husfeld , YuHua Ji , Rick Lee , Li Li , YongQi Mu , Cameron Smith , Johnny Uy
发明人： Craig Husfeld , YuHua Ji , Rick Lee , Li Li , YongQi Mu , Cameron Smith , Johnny Uy
IPC分类号： A61K31/397 , C07D211/58 , A61K31/4468 , C07D405/06 , A61P11/00 , A61K31/453 , C07D205/04
CPC分类号： C07D409/14 , C07D205/04 , C07D211/26 , C07D211/58 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12
摘要： The invention provides compounds of the formula: in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R1-6, a, Z and Q are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
摘要翻译：本发明提供下式的化合物：盐或两性离子形式或其药学上可接受的盐，其中R 1-6，a，Z和Q如说明书中所定义。这些化合物是毒蕈碱受体拮抗剂。本发明还提供含有这些化合物的药物组合物，制备这些化合物的方法和使用这些化合物例如治疗慢性阻塞性肺疾病和哮喘等肺疾病的方法。

12. 发明授权

US07249191B1 Transparent bridge that terminates TCP connections 有权
标题翻译：透明网桥，终止TCP连接
公开(公告)号：US07249191B1
公开(公告)日：2007-07-24
申请号：US10251101
申请日：2002-09-20
申请人： Paul Hutchison , Cameron Smith , Vilis Ositis
发明人： Paul Hutchison , Cameron Smith , Vilis Ositis
IPC分类号： G06F15/16
CPC分类号： H04L29/1249 , H04L29/12028 , H04L61/103 , H04L61/256 , H04L67/06 , H04L69/16 , H04L69/163
摘要： A multi-application transparent platform intercepts an incoming application file communicated from a source across a first TCP connection by terminating the first TCP connection on the multi-application transparent platform and supplying the application file to an application program. The application file is received onto the platform in the form of multiple incoming Ethernet frames. The application layer program analyzes the application file and identifies characteristics of the application file, such as virus content, that are not apparent in the individual Ethernet frames that carried the application file over the first TCP connection. The platform resends the application file over a second TCP connection in outgoing frames having the same IP addresses and Ethernet MAC addresses as the incoming frames. The platform can be inserted into a running network without reconfiguring devices on the network.
摘要翻译：多应用透明平台通过终止多应用透明平台上的第一TCP连接并将应用文件提供给应用程序来拦截通过第一TCP连接从源传送的传入应用文件。应用文件以多个传入的以太网帧的形式被接收到平台上。应用层程序分析应用程序文件，并识别通过第一个TCP连接承载应用程序文件的各个以太网帧中不明显的应用程序文件（如病毒内容）的特征。该平台通过第二个TCP连接在具有与传入帧相同的IP地址和以太网MAC地址的输出帧中重新发送应用程序文件。该平台可以插入到正在运行的网络中，而无需重新配置网络上的设备。

13. 发明申请

US20060040999A1 CETP inhibitors 有权
标题翻译： CETP抑制剂
公开(公告)号：US20060040999A1
公开(公告)日：2006-02-23
申请号：US11173295
申请日：2005-07-01
申请人： Amjad Ali , Joann Napolitano , Qiaolin Deng , Zhijian Lu , Peter Sinclair , Gayle Taylor , Christopher Thompson , Nazia Quraishi , Cameron Smith , Julianne Hunt , Adrian Dowst , Yi-Heng Chen , Hong Li
发明人： Amjad Ali , Joann Napolitano , Qiaolin Deng , Zhijian Lu , Peter Sinclair , Gayle Taylor , Christopher Thompson , Nazia Quraishi , Cameron Smith , Julianne Hunt , Adrian Dowst , Yi-Heng Chen , Hong Li
IPC分类号： A61K31/421 , C07D263/16
CPC分类号： C07F7/10 , A61K31/4015 , A61K31/4166 , A61K31/4168 , A61K31/421 , A61K31/422 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07D207/26 , C07D207/27 , C07D233/32 , C07D233/38 , C07D233/50 , C07D233/52 , C07D263/04 , C07D263/20 , C07D263/22 , C07D263/24 , C07D263/26 , C07D285/06 , C07D285/10 , C07D401/04 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/04 , C07D417/10
摘要： Compounds having the structures of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis: In the compounds of Formula I, B or R2 is a phenyl group which has an ortho aryl, heterocyclic, benzoheterocyclic or benzocycloalkyl substituent, and one other position on the 5-membered ring has an aromatic, heterocyclic, cycloalkyl, benzoheterocyclic or benzocycloalkyl substituent connected directly to the ring or attached to the ring through a —CH2—.
摘要翻译：具有式I结构的化合物，包括化合物的药学上可接受的盐，是CETP抑制剂，可用于升高HDL-胆固醇，降低LDL-胆固醇，以及用于治疗或预防动脉粥样硬化。在式I化合物中，B或 R 2是具有邻芳基，杂环，苯并杂环或苯并环烷基取代基的苯基，并且在5元环上的另一个位置具有直接连接的芳族，杂环，环烷基，苯并杂环或苯并环烷基取代基通过-CH 2 - 2连接到环上或连接到环上。

14. 发明申请

US20050231391A1 Flight timer 失效
标题翻译：飞行计时器
公开(公告)号：US20050231391A1
公开(公告)日：2005-10-20
申请号：US10816972
申请日：2004-04-01
申请人： Frederick Boyns , Craig Kllcourse , Cameron Smith , Blake Stancik , Scott Thielman
发明人： Frederick Boyns , Craig Kllcourse , Cameron Smith , Blake Stancik , Scott Thielman
IPC分类号： G01C23/00 , G08B21/00
CPC分类号： G01C23/00
摘要： A timer usable in navigating and piloting an aircraft, the timer having a plurality of application modes for management of time and numeric data, including an approach mode, a fuel mode, a chronograph mode and a clock mode. Each application mode can drive independent but simultaneous time count sequences for use in flight management and navigation such as counting down approach times, fuel-tank switching intervals and other time sensitive events, as well as providing military time, standard time and UTC time.
摘要翻译：一种可用于导航和驾驶飞行器的定时器，定时器具有用于管理时间和数字数据的多种应用模式，包括进场模式，燃料模式，计时模式和时钟模式。每个应用模式都可以驱动独立但同时的时间计数序列，用于飞行管理和导航，例如倒数接近时间，燃料箱切换间隔和其他时间敏感事件，以及提供军事时间，标准时间和UTC时间。

15. 发明授权

US06908674B2 Jadeite and its production 失效
标题翻译：翡翠及其生产
公开(公告)号：US06908674B2
公开(公告)日：2005-06-21
申请号：US09799192
申请日：2001-03-05
申请人： Suresh Shankarappa Vagarali , Thomas Richard Anthony , John Casey , Robert Charles DeVries , Stephen Lee Dole , John William Lucek , Alan Cameron Smith , Biju Varghese , Steven William Webb
发明人： Suresh Shankarappa Vagarali , Thomas Richard Anthony , John Casey , Robert Charles DeVries , Stephen Lee Dole , John William Lucek , Alan Cameron Smith , Biju Varghese , Steven William Webb
IPC分类号： B01J3/06 , C01B33/20 , C01B33/26 , B32B5/16
CPC分类号： C01B33/26 , B01J3/062 , B01J2203/068 , C01B33/20 , Y10T428/2982 , Y10T428/2996
摘要： A jadeite material has a thickness in excess of about 1.0 mm and CIELAB indices of L*>42, a* +6. The grain size of the jadeite material is less than about 30 microns and is an equiaxed grain structure. The jadeite material has an optical transmission peak between 500 and 565 nm with an I/IO optical transmission ratio of over 40%. The first step in making the jadeite material is to wrap a glass block, convertible by HP/HT into jadeite and having a nominal composition of NaAlSi2O6, with a graphite or refractive metal sheet. The wrapped glass block is placed in an HP/HT apparatus, rapidly heated, and subjected therein to a pressure in excess of about 3 GPa and a temperature in excess of about 1000° C. for a time adequate to convert the glass block into jadeite. The jadeite material then is cooled and the pressure subsequently released.
摘要翻译：翡翠材料的厚度超过约1.0mm，CIELAB指数L *> 42，a * <-6和b *> + 6。翡翠材料的晶粒尺寸小于约30微米，是等轴晶粒结构。翡翠材料具有在500和565nm之间的光传输峰值，其中I / I / O光透射率超过40％。制造翡翠材料的第一步是将玻璃块包裹，由HP / HT转化为翡翠，并具有标称组成的NaAlSi 2 O 6 6，与石墨或折射金属片。将包裹的玻璃块放置在HP / HT装置中，快速加热，并在其中进行超过约3GPa的压力和超过约1000℃的温度，足以将玻璃块转化成翡翠。然后将翡翠材料冷却并随后释放压力。

16. 发明申请

US20050107367A1 Thiopyrane-4-ones as dna protein kinase inhibitors 失效
标题翻译：硫代吡喃-4-酮作为dna蛋白激酶抑制剂
公开(公告)号：US20050107367A1
公开(公告)日：2005-05-19
申请号：US10486811
申请日：2002-08-14
申请人： Niall Martin , Graeme Cameron Smith , Roger Griffin , Bernard Golding , Ian Hardcastle , Laurent Rigoreau , David Newell , Hilary Calvert , Nicola Curtin , Paul Workman , Florence Raynaud , Bernard Nutley
发明人： Niall Martin , Graeme Cameron Smith , Roger Griffin , Bernard Golding , Ian Hardcastle , Laurent Rigoreau , David Newell , Hilary Calvert , Nicola Curtin , Paul Workman , Florence Raynaud , Bernard Nutley
IPC分类号： C12N9/99 , A61K31/5377 , A61P31/12 , A61P35/00 , A61P43/00 , C07D335/02 , C07D409/10 , A61K31/541 , A61K31/496 , C07D413/04 , C07D417/04 , C07D49/04
CPC分类号： C07D335/02
摘要： The present invention provides compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein R1 and R2 are independently hydrogen, an option ally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and R3 is an optionally substituted C3-20 heterocyclyl or C5-20 aryl group, and their use as pharmaceuticals, particularly in treating diseases which are retroviral mediated or ameliorated by the inhibition of DNA-PK,
摘要翻译：本发明提供式（I）化合物及其异构体，盐，溶剂化物，化学保护形式及其前药，其中R 1和R 2独立地为氢，选择性地取代C 1-7烷基，C 3-20杂环基或C 5-20-20芳基，或可一起形成与它们所连接的氮原子一起形成具有4-8个环原子的任选取代的杂环; 并且R 3是任选取代的C 3-20杂环基或C 5-20芳基，并且它们作为药物的用途，特别是在治疗通过抑制DNA-PK介导或改善的逆转录病毒的疾病，

17. 外观设计

USD480641S1 Push lid 失效
标题翻译：推盖
公开(公告)号：USD480641S1
公开(公告)日：2003-10-14
申请号：US29162318
申请日：2002-06-11
申请人： Gary A. Hurlbut , Tami L. Fujii , Sara E. Hill , B. Cameron Smith , Scott C. Thielman
设计人： Gary A. Hurlbut , Tami L. Fujii , Sara E. Hill , B. Cameron Smith , Scott C. Thielman

18. 发明授权

US5687977A Steerable toboggan 失效
标题翻译：方向滑雪板
公开(公告)号：US5687977A
公开(公告)日：1997-11-18
申请号：US597465
申请日：1996-02-02
申请人： Bruce Cameron Smith
发明人： Bruce Cameron Smith
IPC分类号： B62B13/12 , B62B13/02
CPC分类号： B62B13/12
摘要： A steerable toboggan for sledding on snow is disclosed which includes a support having a bottom gliding surface which slides directly on the snow, and a pair of runner arms carrying guide ribs which extend forwardly beyond the gliding surface. Each of the guide ribs includes a curved portion which is vertically movable relative to the other between a raised position, with the curved portion raised above the snow, and a lowered position where the curved portion of the guide rib is brought against the snow. The toboggan is steered by selectively lowering the curved portion of one of the guide ribs onto the snow as the toboggan moves. The bulk of the user's weight is supported by the underlying snow, enabling the support to be formed from thinner less expensive materials, without requiring complex manufacturing processes.
摘要翻译：公开了一种用于在雪地上雪橇的可操纵的雪橇，其包括具有在雪上直接滑动的底部滑翔表面的支撑件，以及一对承载引导肋的向前延伸到滑行表面之上的导向肋。每个引导肋包括弯曲部分，该弯曲部分可相对于彼此垂直移动，该凸起部分在凸起位置与弯曲部分在雪上方升高之间，以及下降位置，其中引导肋的弯曲部分抵靠着雪。通过选择性地将滑板中的一个的弯曲部分降低到雪上，从而使雪橇滑行转向。用户体重的大部分由底层的雪支撑，使得支撑由更薄的更便宜的材料形成，而不需要复杂的制造工艺。

19. 外观设计

USD981581S1 Arched massage head 有权
公开(公告)号：USD981581S1
公开(公告)日：2023-03-21
申请号：US29772188
申请日：2021-02-26
申请人： William Smith , Cameron Smith , Dominic Rainville
设计人： William Smith , Cameron Smith , Dominic Rainville

20. 发明申请

US20220008284A1 SELF-MASSAGE DEVICE HAVING INTERCHANGEABLE MASSAGE HEADS AND BOARD 有权
公开(公告)号：US20220008284A1
公开(公告)日：2022-01-13
申请号：US17180654
申请日：2021-02-19
申请人： William Smith , Cameron Smith , Dominic Rainville
发明人： William Smith , Cameron Smith , Dominic Rainville
IPC分类号： A61H23/02
摘要： Described is a self-massage device including a massage board with multiple connected indentations formed along the length of the massage board. The self-massage device also includes one or more massage heads having a top portion formed to contact a portion of a user's body, and a bottom portion having a protrusion formed to be removably inserted into one or more of the connected indentations in the massage board via a pressure mechanism.

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