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    • 15. 发明申请
    • PROCESS FOR PREPARING A CYCLIC TERTIARY AMINE
    • 制备循环胺的方法
    • US20120095221A1
    • 2012-04-19
    • US13273784
    • 2011-10-14
    • Christof Wilhelm WigbersJohann-Peter MelderBernd SteinHarald Meißner
    • Christof Wilhelm WigbersJohann-Peter MelderBernd SteinHarald Meißner
    • C07D295/03
    • C07D295/03C07D295/023
    • A process for preparing a cyclic tertiary amine of the formula I where A is a C4-alkylene group, a C5-alkylene group or a —(CH2)2—B—(CH2)2— group, where B is oxygen (O) or an N—R1 radical and R1 is C1-C5-alkyl, aryl or C5-C7-cycloalkyl, and the radical R2 is a linear or branched C2-C16-alkyl, C5-C7-cycloalkyl or C7-C20-aralkyl, in which (i) an amino alcohol II from the group consisting of 1,4-aminobutanol, 1,5-aminopentanol, aminodiglycol (ADG) and aminoethylethanolamine of the formula IIa where R1 is as defined above or hydrogen (H), in which case R1═R2 in the amine I, is reacted with a primary or secondary alcohol R2OH (III) at a temperature in the range from 150 to 270° C. in the liquid phase in the presence of a copper-comprising heterogeneous catalyst in a reactor.
    • 其中A是C 4 - 亚烷基,C 5 - 亚烷基或 - (CH 2)2 -B-(CH 2)2 - 基团,其中B是氧(O))的式I的环状叔胺的方法, 或N-R 1基团,并且R 1是C 1 -C 5 - 烷基,芳基或C 5 -C 7 - 环烷基,并且基团R 2是直链或支链C 2 -C 16 - 烷基,C 5 -C 7 - 环烷基或C 7 -C 20 - 芳烷基, 其中(i)由式IIa的其中R1如上所定义的氢原子(H)的1,4-氨基丁醇,1,5-氨基戊醇,氨基二甘醇(ADG)和氨基乙基乙醇胺组成的组中的氨基醇II,其中 在胺I中的情况R1 = R2在初级醇或仲醇R 2 OH(III)中,在含有铜的非均相催化剂的存在下,在液相中在150-270℃的温度下反应 反应堆。