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11. 发明申请

US20040081970A1 Calcium-sensing receptor 2 (CaR2) and methods for using 审中-公开
标题翻译：钙感受体2（CaR2）和使用方法
公开(公告)号：US20040081970A1
公开(公告)日：2004-04-29
申请号：US10283842
申请日：2002-10-29
申请人： Athersys, Inc.
发明人： George Mbella Ekema , Pieter W. Faber , Benjamin Philip Faga , Gregory B. Foust , John J. Harrington , Paul David Jackson , Robert W. Mays
IPC分类号： C12Q001/68 , G01N033/53 , C07H021/04 , C07K014/705 , C07K016/28
CPC分类号： G01N33/5044 , A61K38/00 , C07H21/04 , C07K14/705 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/6872 , G01N2500/10
摘要： The current disclosure provide a novel human calcium sensing receptor named CaR2 and the nucleotide sequence that encodes the receptor. The disclosure further provides antibodies specific for CaR2. Also disclosed are methods of identifying modulators of the receptor and methods of using the identified modulators to treat calcium receptor mediated conditions.
摘要翻译：目前的公开提供了一种名为CaR2的新型人体钙感觉受体和编码该受体的核苷酸序列。本公开进一步提供对CaR2特异性的抗体。还公开了鉴定受体调节剂的方法和使用鉴定的调节剂治疗钙受体介导的病症的方法。

12. 发明申请

US20180318346A1 IMMUNOMODULATORY PROPERTIES OF MAPCS AND USES THEREOF 审中-公开
公开(公告)号：US20180318346A1
公开(公告)日：2018-11-08
申请号：US15970385
申请日：2018-05-03
申请人： ATHERSYS, INC. , OREGON HEALTH & SCIENCE UNIVERISTY
发明人： Robert DEANS , Richard MAZIARZ , Magdalena KOVACSOVICS , Philip STREETER , Wouter VAN'T HOF
IPC分类号： A61K35/12 , A61K35/28 , A61N5/10 , C12N5/074 , A61K35/14 , A61K45/06 , A61K39/00
CPC分类号： A61K35/12 , A61K35/14 , A61K35/28 , A61K39/001 , A61K45/06 , A61K2035/122 , A61K2035/124 , A61N5/10 , C12N5/0607
摘要： Isolated cells are described that are not embryonic stem cells, not embryonic germ cells, and not germ cells. The cells can differentiate into at least one cell type of each of at least two of the endodermal, ectodermal, and mesodermal lineages. The cells do not provoke a harmful immune response. The cells can modulate immune responses. As an example, the cells can suppress an immune response in a host engendered by allogeneic cells, tissues, and organs. Methods are described for using the cells, by themselves or adjunctively, to treat subjects. For instance, the cells can be used adjunctively for immunosuppression in transplant therapy. Methods for obtaining the cells and compositions for using them also are described.

13. 发明申请

US20040253590A1 COMPOSITIONS AND METHODS FOR MAKING MUTATIONS IN CELL LINES AND ANIMALS 审中-公开
公开(公告)号：US20040253590A1
公开(公告)日：2004-12-16
申请号：US10342923
申请日：2003-01-15
申请人： Athersys, Inc.
发明人： John Joseph Harrington , Paul David Jackson , Li Jiang
IPC分类号： C12Q001/68 , C12N015/85
CPC分类号： C12N15/102 , C12N15/01 , C12Q1/6897
摘要： Abstract of DisclosureThe present invention is directed generally to reduction or inactivation of gene function or gene expression in cells in vitro and in multiorganisms. The invention encompasses methods for mutating cells using a combination of mutagens, particularly wherein at least one mutagen is an insertional mutagen, to achieve homozygous gene mutation or mutation of multiple genes required cumulatively to achieve a phenotype to create knock-outs, knock-downs, and other modifications in the same cell. The invention is also directed to cells (and libraries thereof) and organisms created by the methods of the invention, including those in which at least one of the genes created by insertional mutagenesis is tagged by means of the insertion sequences thereby allowing identification of the mutated gene(s). The invention is also directed to libraries of mutated cells and their uses. The invention is also directed to methods of identifying mutations with methods of the invention, in cells (and libraries thereof) and organisms, by means of the insertional tag.

14. 发明申请

US20040224378A1 Methods for using ADAMTS-12, an integrin and metalloprotease with thrombspondin motifs 审中-公开
标题翻译：使用ADAMTS-12，整合素和金属蛋白酶与血小板反应蛋白基序的方法
公开(公告)号：US20040224378A1
公开(公告)日：2004-11-11
申请号：US10164893
申请日：2002-06-07
申请人： Athersys, Inc.
发明人： Paul David Jackson , Anthony Eugene Ting , Pieter W. Faber
IPC分类号： C12Q001/37
CPC分类号： G01N33/5011 , C12N9/6489 , C12Q1/37 , G01N33/5088 , G01N2333/8146 , G01N2500/00
摘要： The present invention relates to methods for using a human A Disintegrin And Metalloprotease containing ThromboSpondin repeats (ADAM-TS). The invention also relates to methods for using polynucleotides encoding the metalloprotease. The invention relates to methods using the ADAM-TS polypeptides and polynucleotides as a target for diagnosis and treatment in metalloprotease-mediated or -related disorders. The invention further relates to drug-screening methods using the ADAM-TS polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the ADAM-TS polypeptides and polynucleotides. The invention further relates to agonists and antagonists identified by drug screening methods with the ADAM-TS polypeptides and polynucleotides as a target. The invention further related to methods of treating a subject suffering from a ADAM-TS associated disorder.
摘要翻译：本发明涉及使用含有血小板反应蛋白重复序列（ADAM-TS）的人A解体素和金属蛋白酶的方法。本发明还涉及使用编码金属蛋白酶的多核苷酸的方法。本发明涉及使用ADAM-TS多肽和多核苷酸作为金属蛋白酶介导的或相关疾病中的诊断和治疗靶标的方法。本发明还涉及使用ADAM-TS多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。本发明还包括基于ADAM-TS多肽和多核苷酸的激动剂和拮抗剂。本发明还涉及用ADAM-TS多肽和多核苷酸作为靶标的药物筛选方法鉴定的激动剂和拮抗剂。本发明还涉及治疗患有ADAM-TS相关病症的受试者的方法。

15. 发明申请

US20030224519A1 Compositions and methods for making mutations in cell lines and animals 有权
标题翻译：用于在细胞系和动物中进行突变的组合物和方法
公开(公告)号：US20030224519A1
公开(公告)日：2003-12-04
申请号：US10345115
申请日：2003-01-15
申请人： Athersys, Inc.
发明人： John Joseph Harrington , Paul David Jackson , Li Jiang
IPC分类号： C12Q001/68 , C12N015/01
CPC分类号： C12N15/01 , C12N15/102 , C12Q1/6897
摘要： The present invention is directed generally to reduction or inactivation of gene function or gene expression in cells in vitro and in multicellular organisms. The invention encompasses methods for mutating cells using a combination of mutagens, particularly wherein at least one mutagen is an insertional mutagen, to achieve homozygous gene mutation or mutation of multiple genes required cumulatively to achieve a phenotype to create knock-outs, knock-downs, and other modifications in the same cell. The invention is also directed to cells (and libraries thereof) and organisms created by the methods of the invention, including those in which at least one of the genes created by insertional mutagenesis is tagged by means of the insertion sequences thereby allowing identification of the mutated gene(s). The invention is also directed to libraries of mutated cells and their uses. The invention is also directed to methods of identifying mutations with methods of the invention, in cells (and libraries thereof) and organisms, by means of the insertional tag.
摘要翻译：本发明一般涉及体外和多细胞生物体中细胞中基因功能或基因表达的还原或失活。本发明包括使用诱变剂的组合突变细胞的方法，特别是其中至少一种诱变剂是插入型诱变剂，以实现纯合基因突变或累积需要多个基因的突变以实现表型以产生敲除，敲低，和在同一个单元格中的其他修改。本发明还涉及通过本发明的方法产生的细胞（及其文库）和生物体，包括其中通过插入突变产生的至少一个基因通过插入序列进行标记，从而允许识别突变的基因。本发明还涉及突变细胞的文库及其用途。本发明还涉及借助于插入标签在本发明的方法，细胞（和其文库）和生物体中鉴定突变的方法。

16. 发明申请

US20030134421A1 Methods for mutating genes in cells and animals using insertional mutagenesis 有权
标题翻译：使用插入突变在细胞和动物中突变基因的方法
公开(公告)号：US20030134421A1
公开(公告)日：2003-07-17
申请号：US10288555
申请日：2002-11-04
申请人： Athersys, Inc.
发明人： John Joseph Harrington , Paul David Jackson , Li Jiang
IPC分类号： C12N015/85 , C12N005/06
CPC分类号： C12N15/86 , A01K2217/075 , A01K2267/03 , C12N2740/10043 , C12N2800/60 , C12N2800/90 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/445
摘要： The present invention is in the fields of molecular biology, cell biology, and genetics. The invention is directed generally to mutating genes in cells in vitro and in multi-cellular organisms. The invention encompasses methods for mutating genes in cells using polynucleotides that act as insertional mutagens. Such methods are used to achieve mutation of a single gene to achieve a desired phenotype as well as mutation of multiple genes, required cumulatively to achieve a desired phenotype, in a cell or in a multi-cellular organism. The invention is also directed to methods of identifying one or more mutated genes, made by the methods of the invention, in cells and in multi-cellular organisms, by means of a tagging property provided by the insertional mutagen(s). The insertional mutagen thus allows identification of one or more genes that are mutated by insertion of an insertional mutagen. The invention is also directed to methods for correlating a phenotype with a gene by screening or selecting cells that have been mutated by an insertional mutagen incorporated into one or more genes in a cell and identifying the gene or genes causing the phenotype by means of a tagging property in one or more of the insertional mutagens. The invention is also directed to cells and multi-cellular organisms created by the methods of the invention and uses of the cells and multicellular organisms. The invention is also directed to libraries of cells created by the methods of the invention and uses of the libraries.
摘要翻译：本发明涉及分子生物学，细胞生物学和遗传学领域。本发明一般涉及体外和多细胞生物体中细胞中的突变基因。本发明包括使用充当插入诱变剂的多核苷酸突变细胞中的基因的方法。这样的方法用于实现单个基因的突变，以实现期望的表型以及在细胞或多细胞生物体中累积需要累积所需表型的多个基因的突变。本发明还涉及通过本发明的方法在细胞和多细胞生物体中通过插入诱变剂提供的标记特性鉴定一种或多种突变基因的方法。因此，插入型诱变剂允许鉴定通过插入插入型突变体而突变的一种或多种基因。本发明还涉及通过筛选或选择已经通过掺入细胞中的一个或多个基因的插入突变体突变的细胞并通过标记鉴定引起表型的基因或基因来将表型与基因相关联的方法属性在一个或多个插入诱变剂。本发明还涉及由本发明的方法和细胞和多细胞生物体的用途产生的细胞和多细胞生物体。本发明还涉及通过本发明的方法和图书馆的使用而创建的细胞库。

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