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11. 发明申请

US20120010702A1 OPHTHALMIC IMPLANT FOR TREATMENT OF GLAUCOMA 审中-公开
标题翻译：用于治疗玻璃体的OPHTHALMIC植入物
公开(公告)号：US20120010702A1
公开(公告)日：2012-01-12
申请号：US13233986
申请日：2011-09-15
申请人： Robert STEGMANN , Stanley R. CONSTON , David J. KUPIECKI , John McKENZIE , Candice D. PINSON , Ronald K. YAMAMOTO
发明人： Robert STEGMANN , Stanley R. CONSTON , David J. KUPIECKI , John McKENZIE , Candice D. PINSON , Ronald K. YAMAMOTO
IPC分类号： A61F2/14
CPC分类号： A61F9/00781
摘要： An implant is placed within Schlemm's canal of the eye and provides tension to the trabecular meshwork. The tension is continuous and increases the aqueous outflow without the necessity of administering cholinergic drugs to treat glaucoma.
摘要翻译：将植入物放置在眼睛的施莱姆的运河内，并向小梁网提供张力。张力是连续的，并且增加水流出物，而不需要施用胆碱能药物治疗青光眼。

12. 发明授权

US08034105B2 Ophthalmic implant for treatment of glaucoma 失效
标题翻译：用于治疗青光眼的眼科植入物
公开(公告)号：US08034105B2
公开(公告)日：2011-10-11
申请号：US11305306
申请日：2005-12-16
申请人： Robert Stegmann , Stanley R. Conston , David J. Kupiecki , John McKenzie , Candice D. Pinson , Ronald K. Yamamoto
发明人： Robert Stegmann , Stanley R. Conston , David J. Kupiecki , John McKenzie , Candice D. Pinson , Ronald K. Yamamoto
IPC分类号： A61F2/14 , A61M5/00
CPC分类号： A61F9/00781
摘要： A method is provided for increasing the outflow of fluid through Schlemm's canal that is useful for treatment of glaucoma. The implant is placed in Schlemm's canal by use of a flexible delivery instrument attached to the implant. The instrument and implant are positioned within the canal, the implant is released and the distal and proximal ends of the implant are connected to apply sufficient axial tensioning force on the inner wall of the canal to increase fluid permeability. In another embodiment a delivery instrument attached to the implant is positioned in the canal securing one of the distal or proximal ends of the implant within the canal. The implant provides sufficient axial tensioning force on the inner wall of the canal to increase fluid permeability of the inner wall of the canal. The other of the distal or proximal ends may be secured to maintain the tensioning force on the inner wall of the canal.
摘要翻译：提供了一种增加流体穿过施莱姆氏管的流出方法，可用于治疗青光眼。通过使用附着在植入物上的柔性递送器械将植入物置于施莱姆氏管中。仪器和植入物定位在管内，植入物被释放，并且植入物的远端和近端被连接以在管的内壁上施加足够的轴向张力以增加流体渗透性。在另一个实施例中，附接到植入物的递送器械定位在将移植物的远端或近端中的一端固定在管内的运河中。植入物在管道的内壁上提供足够的轴向张力，以增加管道内壁的流体渗透性。远端或近端中的另一个可以被固定以保持在管的内壁上的张紧力。

13. 发明申请

US20100173866A1 APPARATUS AND METHOD FOR OCULAR TREATMENT 审中-公开
标题翻译：用于眼科治疗的装置和方法
公开(公告)号：US20100173866A1
公开(公告)日：2010-07-08
申请号：US12609345
申请日：2009-10-30
申请人： MICHAEL HEE , Stanley R. Conston , David J. Kupiecki , John R. McKenzie , Ronald Yamamoto , Michael Nash
发明人： MICHAEL HEE , Stanley R. Conston , David J. Kupiecki , John R. McKenzie , Ronald Yamamoto , Michael Nash
IPC分类号： A61K31/728 , A61M37/00 , A61F9/00 , A61F9/011 , A61B3/14 , A61K31/56 , A61P27/02
CPC分类号： A61F9/0017 , A61B90/39 , A61B2090/3614 , A61B2090/3925 , A61B2090/3945 , A61F9/00736 , A61F9/00781 , A61F9/008 , A61F2009/00851
摘要： The invention provides tools, materials and related methods to surgically access the suprachoroidal space of an eye for the purpose of performing minimally invasive surgery or to deliver drugs to the eye. The invention provides a flexible microcannula or microcatheter device (11, 13) that may be placed into the suprachoroidal space (12, 14) through a small incision (12A) of the overlying tissues, maneuvered into the appropriate region of the space, and then activated to treat tissues adjacent to the distal tip of the device.
摘要翻译：本发明提供了用于手术进入眼睛的脉管外空间以进行微创手术或将药物递送至眼睛的工具，材料和相关方法。本发明提供了一种柔性微插管或微导管装置（11,13），其可以通过上层组织的小切口（12A）放置在脉管外空间（12,14）中，操纵到空间的适当区域，然后被激活以处理邻近该装置的远端的组织。

14. 发明授权

US07699882B2 Apparatus and method for surgical bypass of aqueous humor 失效
标题翻译：房水手术旁路的装置和方法
公开(公告)号：US07699882B2
公开(公告)日：2010-04-20
申请号：US10528276
申请日：2003-09-17
申请人： Robert Stamper , Stanley R. Conston , Ronald K. Yamamoto
发明人： Robert Stamper , Stanley R. Conston , Ronald K. Yamamoto
IPC分类号： A61F2/06 , A61F9/00
CPC分类号： A61F9/00781
摘要： The invention provides minimally invasive microsurgical tools and methods to form an aqueous humor shunt or bypass for the treatment of glaucoma. The invention enables surgical creation of a tissue tract (7) within the tissues of the eye to directly connect a source of aqueous humor such as the anterior chamber (1), to an ocular vein (4). The tissue tract (7) from the vein (4) may be connected to any source of aqueous humor, including the anterior chamber (1), an aqueous collector channel, Schlemm's canal (2), or a drainage bleb. Since the aqueous humor passes directly into the venous system, the normal drainage process for aqueous humor is restored. Furthermore, the invention discloses devices and materials that can be implanted in the tissue tract to maintain the tissue space and fluid flow.
摘要翻译：本发明提供微创显微手术工具和方法以形成用于治疗青光眼的房水分流或旁路。本发明使得能够在眼睛的组织内手术创建组织道（7），以直接将前房（1）的房水源直接连接到眼静脉（4）。来自静脉（4）的组织道（7）可以连接到房水的任何来源，包括前房（1），含水收集器通道，施莱姆管（2）或排水泡。由于房水直接通入静脉系统，房水正常引流过程恢复正常。此外，本发明公开了可以植入组织道中以保持组织空间和流体流动的装置和材料。

15. 发明申请

US20090247955A1 MICROLITER INJECTOR 审中-公开
公开(公告)号：US20090247955A1
公开(公告)日：2009-10-01
申请号：US12412586
申请日：2009-03-27
申请人： Ronald K. Yamamoto , Stanley R. Conston
发明人： Ronald K. Yamamoto , Stanley R. Conston
IPC分类号： A61M5/31
CPC分类号： A61M5/2459 , A61M5/286 , A61M5/288 , A61M5/3129 , A61M5/31505 , A61M5/31531 , A61M5/3291 , A61M5/34 , A61M5/347 , A61M2005/3107 , A61M2005/3118 , A61M2005/3121 , A61M2005/3131
摘要： Injectors are provided that may be pre-filled aseptically with an active biological agent into a sterile cavity and sealed in such a manner that the injectate may be readily expelled into the body. The injectors are particularly useful for injecting precisely measured small volumes of sterile agents.
摘要翻译：提供了可以将活性生物试剂无菌预填充到无菌腔中并以这样的方式密封的注射器，使得注射剂可以容易地排入体内。注射器对于注射精确测量的小体积的无菌试剂特别有用。

16. 发明授权

US08123729B2 Treatment of ocular disease 失效
标题翻译：眼病的治疗
公开(公告)号：US08123729B2
公开(公告)日：2012-02-28
申请号：US12587375
申请日：2009-10-05
申请人： Ronald K. Yamamoto , Stanley R. Conston , Michael F. Nash , Paul S. Koch
发明人： Ronald K. Yamamoto , Stanley R. Conston , Michael F. Nash , Paul S. Koch
IPC分类号： A61M35/00
CPC分类号： A61B8/10 , A61B8/0841 , A61F9/00781
摘要： The invention relates to a novel apparatus for the treatment of ocular disease, particularly glaucoma. The apparatus consists of a locating device to locate Schlemm's Canal within the anterior portion of the eye and a surgical tool to access the canal for treatment. The apparatus allows for guided, minimally invasive surgical access to Schlemm's Canal to enable surgical procedures to be performed on the canal and trabecular meshwork to reduce intraocular pressure. The apparatus may also deliver devices or substances to Schlemm's Canal in the treatment of glaucoma.
摘要翻译：本发明涉及用于治疗眼部疾病，特别是青光眼的新型装置。该装置包括一个定位装置，用于在眼前部位置定位Schlemm's运河，另外还有一个外科手术工具可以进入运河进行治疗。该装置允许引导，微创手术进入施莱姆运河，使得能够在运河和小梁网上进行外科手术以降低眼内压。该装置还可以将器械或物质运送到施莱姆运河治疗青光眼。

17. 发明申请

US20120022424A1 DEVICE FOR PLACING CIRCUMFERENTIAL IMPLANT IN SCHLEMM'S CANAL 审中-公开
标题翻译：用于在SCHLEMM's CANAL中放置循环植入物的装置
公开(公告)号：US20120022424A1
公开(公告)日：2012-01-26
申请号：US13115543
申请日：2011-05-25
申请人： Ronald K. YAMAMOTO , Stanley R. Conston
发明人： Ronald K. YAMAMOTO , Stanley R. Conston
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61B2090/306 , A61B2090/3945
摘要： A device is provided to enable placing an implant within the full circumference of Schlemm's canal of an eye. The device comprises a flexible elongated solid element with a proximal end and a distal tip that transmits light such as one or more strands of a fiber optic. The device is characterized by selected mechanical characteristics to allow advancement within Schlemm's canal. The fiber optic element transmits light from a proximal connector to the distal tip to provide a lighted tip that may be viewed transclerally when the device is advanced along Schlemm's canal.
摘要翻译：提供了一种装置，以使植入物能够放置在眼睛的施莱姆运河的整个圆周内。该装置包括具有近端的柔性细长实体元件和透射诸如光纤的一束或多股的光的远端。该装置的特征在于选择的机械特性，以允许在施莱姆运河内前进。光纤元件将光从近端连接器透射到远侧末端，以提供当器件沿着施莱姆氏管前进时可以经视观察的点亮尖端。

18. 发明申请

US20100191177A1 DEVICE FOR ASPIRATING FLUIDS 审中-公开
标题翻译：吸入流体装置
公开(公告)号：US20100191177A1
公开(公告)日：2010-07-29
申请号：US12359169
申请日：2009-01-23
申请人： Tom S. Chang , Friedrich Ho , Stanley R. Conston , Ronald K. Yamamoto
发明人： Tom S. Chang , Friedrich Ho , Stanley R. Conston , Ronald K. Yamamoto
IPC分类号： A61F9/00
CPC分类号： A61F9/00736 , A61F9/00727 , A61M1/0084 , A61M2210/0612
摘要： Surgical devices are provided for aspiration of the subretinal fluid (SRF) of the eye in a retinal detachment that allows re-apposition of the sensory retina to the underlying RPE. The device is connected to a vacuum source, introduced into the posterior chamber through a sclerostomy port and placed against the detached retinal tissue. The device pulls on and captures the surface of the sensory retina, causing a micro needle to pierce through the tissue. As the sensory retina is captured and held in place by the vacuum, a protected pocket is created and the tissue is prevented from folding onto itself and occluding the micro needle tip.
摘要翻译：提供手术装置用于在视网膜脱离中吸引眼睛的视网膜下液体（SRF），其允许感觉视网膜重新附着到下面的RPE。该装置连接到真空源，通过硬皮造口进入后腔，并抵靠分离的视网膜组织放置。该装置拉动并捕获感觉视网膜的表面，导致微针刺穿组织。当感官视网膜通过真空捕获并保持在适当位置时，产生受保护的口袋，并且防止组织折叠到自身上并封闭微针尖端。

19. 发明申请

US20100191103A1 APPARATUS AND METHOD FOR SURGICAL BYPASS OF AQUEOUS HUMOR 审中-公开
标题翻译：装置和方法用于外源性人体外科手术
公开(公告)号：US20100191103A1
公开(公告)日：2010-07-29
申请号：US12720543
申请日：2010-03-09
申请人： ROBERT STAMPER , STANLEY R. CONSTON , RONALD K. YAMAMOTO
发明人： ROBERT STAMPER , STANLEY R. CONSTON , RONALD K. YAMAMOTO
IPC分类号： A61F9/007 , A61B18/20 , A61B18/18 , A61B8/10
CPC分类号： A61F9/00781
摘要： The invention provides minimally invasive microsurgical tools and methods to form an aqueous humor shunt or bypass for the treatment of glaucoma. The invention enables surgical creation of a tissue tract (7) within the tissues of the eye to directly connect a source of aqueous humor such as the anterior chamber (1), to an ocular vein (4). The tissue tract (7) from the vein (4) may be connected to any source of aqueous humor, including the anterior chamber (1) ), an aqueous collector channel, Schlemm's canal (2), or a drainage bleb. Since the aqueous humor passes directly into the venous system, the normal drainage process for aqueous humor is restored. Furthermore, the invention discloses devices and materials that can be implanted in the tissue tract to maintain the tissue space and fluid flow.
摘要翻译：本发明提供微创显微手术工具和方法以形成用于治疗青光眼的房水分流或旁路。本发明使得能够在眼睛的组织内手术创建组织道（7），以直接将前房（1）的房水源直接连接到眼静脉（4）。来自静脉（4）的组织道（7）可以连接到任何房水来源，包括前房（1）），含水收集通道，施莱姆管（2）或排水泡。由于房水直接通入静脉系统，房水正常引流过程恢复正常。此外，本发明公开了可以植入组织道中以保持组织空间和流体流动的装置和材料。

20. 发明申请

US20090043321A1 Apparatus And Method For Surgical Enhancement Of Aqueous Humor Drainage 审中-公开
标题翻译：水性幽默排水手术增强装置及方法
公开(公告)号：US20090043321A1
公开(公告)日：2009-02-12
申请号：US11587785
申请日：2005-04-29
申请人： Stanley R. Conston , Michael Hee , David J. Kupiecki , John R. McKenzie , Ronald Yamamoto
发明人： Stanley R. Conston , Michael Hee , David J. Kupiecki , John R. McKenzie , Ronald Yamamoto
IPC分类号： A61M1/00 , A61F9/04
CPC分类号： A61F9/008 , A61B18/14 , A61F9/00781
摘要： An apparatus is provided for forming a tissue tract (8, 11A, 17A) from within a first passageway of an eye (11, 17) connecting to a second passageway in the eye (12, 16) comprising an elongated tool with a proximal end and distal end. The tool has an outer diameter in the range of about 50 to about 1000 microns. Methods of using the tool are provided for creating a fluid path for aqueous humor of an eye from a first passageway of the eye, such as the Schlemm's Canal, to a second passageway, such as the suprachoroidal space
摘要翻译：提供一种用于从连接到眼睛（12,16）中的第二通道的眼睛（11,17）的第一通道内形成组织管道（8,11A，17A）的装置，包括具有近端的细长工具和远端。该工具的外径在约50至约1000微米的范围内。提供了使用该工具的方法，用于从眼睛的第一通道（例如施莱姆氏管）产生到眼睛的房水的流体路径到第二通道，例如脉管外空间

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