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11. 发明授权

US09645548B2 System, apparatus and method for extracting image cross-sections of an object from received electromagnetic radiation 有权
公开(公告)号：US09645548B2
公开(公告)日：2017-05-09
申请号：US14331720
申请日：2014-07-15
申请人： CellOptic, Inc.
发明人： Joseph Rosen
IPC分类号： G03H1/26 , G03H1/02 , G03H1/04 , G03H1/08 , G03H1/00 , G03H1/06
CPC分类号： G03H1/26 , G03H1/0005 , G03H1/041 , G03H1/0443 , G03H1/06 , G03H1/08 , G03H5/00 , G03H2001/0033 , G03H2001/0452 , G03H2210/33 , G03H2223/23 , G03H2226/11
摘要： An apparatus and method to produce a hologram of a cross-section of an object includes an electromagnetic radiation assembly configured to receive a received electromagnetic radiation, such as light, from the object. The electromagnetic radiation assembly is further configured to diffract the received electromagnetic radiation and transmit a diffracted electromagnetic radiation. An image capture assembly is configured to capture an image of the diffracted electromagnetic radiation and produce the hologram of the cross-section of the object from the captured image. The hologram of the cross-section includes information regarding a single cross-section of the object.

12. 发明申请

US20090303559A1 SYSTEM, APPARATUS AND METHOD FOR EXTRACTING THREE-DIMENSIONAL INFORMATION OF AN OBJECT FROM RECEIVED ELECTROMAGNETIC RADIATION 有权
标题翻译：从接收电磁辐射提取物体的三维信息的系统，装置和方法
公开(公告)号：US20090303559A1
公开(公告)日：2009-12-10
申请号：US12374139
申请日：2006-07-18
申请人： Joseph Rosen , Gary Brooker
发明人： Joseph Rosen , Gary Brooker
IPC分类号： G03H1/06 , G03H1/04 , G03H1/08 , G03H1/26 , G03H5/00
CPC分类号： G03H1/06 , G02B5/32 , G03H1/0005 , G03H1/0244 , G03H1/0443 , G03H1/08 , G03H5/00 , G03H2001/0033 , G03H2001/0066 , G03H2001/0447 , G03H2001/0458 , G03H2222/24 , G03H2223/12 , G03H2223/13 , G03H2225/33 , G03H2240/13 , G03H2240/24
摘要： An apparatus and method to produce a hologram of an object includes an electromagnetic radiation assembly configured to receive a received electromagnetic radiation, such as light, from the object. The electromagnetic radiation assembly is further configured to diffract the received electromagnetic radiation and transmit a diffracted electromagnetic radiation. An image capture assembly is configured to capture an image of the diffracted electromagnetic radiation and produce the hologram of the object from the captured image.
摘要翻译：用于产生物体的全息图的装置和方法包括：电磁辐射组件，被配置为从物体接收接收的电磁辐射，例如光。电磁辐射组件还被配置为衍射接收的电磁辐射并传输衍射的电磁辐射。图像捕获组件被配置为捕获衍射电磁辐射的图像并从捕获的图像产生对象的全息图。

13. 发明申请

US20070091307A1 METHOD AND SYSTEM FOR WIDE-FIELD MULTI-PHOTON MICROSCOPY HAVING A CONFOCAL EXCITATION PLANE 有权
标题翻译：具有共焦激发平面的宽域多光子显微镜的方法与系统
公开(公告)号：US20070091307A1
公开(公告)日：2007-04-26
申请号：US11612159
申请日：2006-12-18
申请人： Gary Brooker
发明人： Gary Brooker
IPC分类号： G01J3/30
CPC分类号： G02B21/0076
摘要： According to one aspect of the invention, a wide-field microscope includes a stage configured to hold a specimen having a fluorescent material therein, and a multi-photon excitation light source configured to produce a substantially parallel beam of excitation light having a single photon energy less than an absorption energy required for single photon excitation of the fluorescent material. An infinity corrected objective is optically coupled to the multi-photon excitation light source and configured to focus the substantially parallel beam of excitation light onto the specimen such that multi-photon excitation of the fluorescent material simultaneously occurs over a predetermined area of the specimen. A focus lens is configured to focus emission light emitted from the predetermined area of the specimen onto at least two pixels of an image detector simultaneously. A focus lens is configured to focus emission light emitted from the predetermined area of the specimen onto an image plane, such that the image plane can be viewed through a binocular eyepiece or an imaging array detector.
摘要翻译：根据本发明的一个方面，一种宽视场显微镜包括一个被配置为将具有荧光材料的样本保持在其中的台，以及多光子激发光源，被配置为产生基本上平行的具有单个光子能量的激发光束小于荧光材料的单光子激发所需的吸收能量。无穷远校正的物镜与多光子激发光源光学耦合，并被配置为将基本上平行的激发光束聚焦到样本上，使得荧光材料的多光子激发同时发生在样本的预定区域上。聚焦透镜被配置为将从样本的预定区域发射的发射光同时聚焦到图像检测器的至少两个像素。聚焦透镜被配置为将从样本的预定区域发射的发射光聚焦到图像平面上，使得可以通过双目目镜或成像阵列检测器观察图像平面。

14. 发明授权

US07170675B2 Method and system for wide-field multi-photon microscopy having a confocal excitation plane 有权
标题翻译：具有共焦激发平面的宽场多光子显微镜的方法和系统
公开(公告)号：US07170675B2
公开(公告)日：2007-01-30
申请号：US10847862
申请日：2004-05-19
申请人： Gary Brooker
发明人： Gary Brooker
IPC分类号： G02B21/00 , G02B21/06
CPC分类号： G02B21/0076
摘要： According to one aspect of the invention, a wide-field microscope includes a stage configured to hold a specimen having a fluorescent material therein, and a multi-photon excitation light source configured to produce a substantially parallel beam of excitation light having a single photon energy less than an absorption energy required for single photon excitation of the fluorescent material. An infinity corrected objective is optically coupled to the multi-photon excitation light source and configured to focus the substantially parallel beam of excitation light onto the specimen such that multi-photon excitation of the fluorescent material simultaneously occurs over a predetermined area of the specimen. A focus lens is configured to focus emission light emitted from the predetermined area of the specimen onto at least two pixels of an image detector simultaneously. A focus lens is configured to focus emission light emitted from the predetermined area of the specimen onto an image plane, such that the image plane can be viewed through a binocular eyepiece or an imaging array detector.
摘要翻译：根据本发明的一个方面，一种宽视场显微镜包括一个被配置为将具有荧光材料的样本保持在其中的台，以及多光子激发光源，被配置为产生基本上平行的具有单个光子能量的激发光束小于荧光材料的单光子激发所需的吸收能量。无穷远校正的物镜与多光子激发光源光学耦合，并被配置为将基本上平行的激发光束聚焦到样本上，使得荧光材料的多光子激发同时发生在样本的预定区域上。聚焦透镜被配置为将从样本的预定区域发射的发射光同时聚焦到图像检测器的至少两个像素。聚焦透镜被配置为将从样本的预定区域发射的发射光聚焦到图像平面上，使得可以通过双目目镜或成像阵列检测器观察图像平面。

15. 发明授权

US11698606B2 System, apparatus and method for extracting three-dimensional information of an object from received electromagnetic radiation 有权
公开(公告)号：US11698606B2
公开(公告)日：2023-07-11
申请号：US14680777
申请日：2015-04-07
申请人： CellOptic, Inc.
发明人： Joseph Rosen , Gary Brooker
IPC分类号： G03H1/08 , G03H1/06 , G03H1/00 , G03H1/04 , G03H5/00 , G03H1/02 , G02B5/32
CPC分类号： G03H1/06 , G03H1/0005 , G03H1/0443 , G03H1/08 , G03H5/00 , G02B5/32 , G03H1/0244 , G03H2001/0033 , G03H2001/0066 , G03H2001/0447 , G03H2001/0458 , G03H2222/24 , G03H2223/12 , G03H2223/13 , G03H2225/33 , G03H2240/13 , G03H2240/24
摘要： An apparatus and method to produce a hologram of an object includes an electromagnetic radiation assembly configured to receive a received electromagnetic radiation, such as light, from the object. The electromagnetic radiation assembly is further configured to diffract the received electromagnetic radiation and transmit a diffracted electromagnetic radiation. An image capture assembly is configured to capture an image of the diffracted electromagnetic radiation and produce the hologram of the object from the captured image.

16. 发明申请

US20220020116A1 HOLOGRAPHIC ULTRA RESOLUTION IMAGING 有权
公开(公告)号：US20220020116A1
公开(公告)日：2022-01-20
申请号：US17379672
申请日：2021-07-19
申请人： CELLOPTIC, INC.
发明人： Nisan SIEGEL , Gary Brooker
IPC分类号： G06T3/40 , G06T5/50 , G06T7/00 , G03H1/26
摘要： An advance in ultra-high-resolution optical imaging has been achieved by the introduction of iterative high-resolution image-building algorithms to incoherent holography. A recorded FINCH hologram is used as the basis of a method in which a high resolution image is built using detailed knowledge of the point spread functions of the FINCH hologram or reconstructed image, and then iteratively improved by successive algorithm generations of comparison to the recorded FINCH hologram and alteration of the high resolution image.

17. 发明授权

US11209776B2 Birefringent lens interferometer for use in microscopy and other applications 有权
公开(公告)号：US11209776B2
公开(公告)日：2021-12-28
申请号：US16816949
申请日：2020-03-12
申请人： CellOptic, Inc.
发明人： Gary Brooker , Nisan Siegel
IPC分类号： G03H1/04 , G02B5/30 , G03H1/06 , G02B3/08 , G03H1/00 , A61B3/13 , G02B1/02 , G02B21/00 , G03H1/08
摘要： Techniques to improve image quality in holography utilizing lenses made from materials with non-quantized anisotropic electromagnetic properties, such as birefringent materials, to advantageously split an incoming beam of light into two coincident beams with different focal lengths that interfere with one another and thus create holograms free of electro-optical or pixelated devices are disclosed for microscopy and other applications. The use of thin birefringent lenses and single crystal alpha-BBO lenses are introduced. Corresponding systems, methods and apparatuses are described.

18. 发明授权

US09891585B2 Incoherent fluorescence digital holographic microscopy using transmission liquid crystal lens 有权
公开(公告)号：US09891585B2
公开(公告)日：2018-02-13
申请号：US15026785
申请日：2014-09-29
申请人： Gary Brooker
发明人： Gary Brooker , Nisan Siegel , Joseph Rosen
IPC分类号： G03H1/04 , G03H1/06 , G02B21/00 , G02B21/16 , G03H5/00 , G03H1/00
CPC分类号： G03H1/0443 , G02B21/0068 , G02B21/16 , G03H1/041 , G03H1/06 , G03H5/00 , G03H2001/005 , G03H2001/0447 , G03H2001/0452 , G03H2222/24 , G03H2222/31 , G03H2223/22 , G03H2225/22
摘要： A new optical arrangement that creates high efficiency, high quality Fresnel Incoherent Correlation Holography (FINCH) holograms using transmission liquid crystal GRIN (TLCGRIN) diffractive lenses has been invented. This is in contrast to the universal practice in the field of using a reflective spatial light modulator (SLM) to separate sample and reference beams. Polarization sensitive TLCGRIN lenses enable a straight optical path, have 95% transmission efficiency, are analog devices without pixels and are free of many limitations of reflective SLM devices. An additional advantage is that they create an incoherent holographic system that is achromatic over a wide bandwidth. Two spherical beams created by the combination of a glass and a polarization sensitive TLCGRIN lenses interfere and a hologram is recorded by a digital camera. FINCH configurations which increase signal to noise ratios and imaging speed are also described.

19. 发明授权

US09678473B2 Apparatus for producing a hologram 有权
公开(公告)号：US09678473B2
公开(公告)日：2017-06-13
申请号：US14363380
申请日：2012-12-07
申请人： CELLOPTIC, INC.
发明人： Joseph Rosen , Gary Brooker , Nisan Siegel
IPC分类号： G03H1/00 , G03H1/04 , G03H1/06 , G03H1/02
CPC分类号： G03H1/0005 , G03H1/041 , G03H1/0443 , G03H1/06 , G03H2001/005 , G03H2001/0224 , G03H2001/0447 , G03H2001/0452 , G03H2223/23
摘要： An apparatus for producing a hologram includes a collimation lens configured to receive incoherent light emitted from an object; a spatial light modulator (SLM) that includes at least one diffractive lens which is configured to receive the incoherent light from the collimation lens and split the incoherent light into two beams that interfere with each other; and a camera configured to record the interference pattern of the two beams to create a hologram, wherein a ratio between a distance from the SLM to the camera and a focal length of the diffractive lens is greater than 1.

20. 发明申请

US20160154377A1 SYSTEM, APPARATUS AND METHOD FOR EXTRACTING THREE-DIMENSIONAL INFORMATION OF AN OBJECT FROM RECEIVED ELECTROMAGNETIC RADIATION 审中-公开
公开(公告)号：US20160154377A1
公开(公告)日：2016-06-02
申请号：US15014742
申请日：2016-02-03
申请人： CELLOPTIC, INC.
发明人： Joseph ROSEN , Gary BROOKER
IPC分类号： G03H1/08 , G03H1/04
CPC分类号： G03H1/0841 , G03B35/02 , G03H1/0402 , G03H1/041 , G03H1/0443 , G03H1/06 , G03H1/08 , G03H2001/0224 , G03H2001/0436 , G03H2001/0452 , G03H2001/0458 , G03H2001/085 , G03H2223/23 , G03H2225/33 , G03H2240/13 , G03H2240/21 , G03H2240/23 , G03H2240/24 , H04N1/00827
摘要： An apparatus and method to produce a hologram of an object includes an electromagnetic radiation assembly configured to receive a received electromagnetic radiation, such as light, from the object. The electromagnetic radiation assembly is further configured to diffract the received electromagnetic radiation and transmit a diffracted electromagnetic radiation. An image capture assembly is configured to capture an image of the diffracted electromagnetic radiation and produce the hologram of the object from the captured image.

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