专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US07276526B2 Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands 有权
标题翻译：取代的噻唑和恶唑作为促肾上腺皮质激素释放激素配体
公开(公告)号：US07276526B2
公开(公告)日：2007-10-02
申请号：US10192055
申请日：2002-07-10
申请人： Andreas Termin , Peter Grootenhuis , Dean Wilson , Valentina Molteni , Long Mao
发明人： Andreas Termin , Peter Grootenhuis , Dean Wilson , Valentina Molteni , Long Mao
IPC分类号： C07D417/08 , A61K31/427
CPC分类号： C07D277/22 , C07D263/32 , C07D277/24 , C07D277/26 , C07D277/28 , C07D277/30 , C07D417/04 , C07D417/08 , C07D417/10
摘要： Provided herein are novel substituted thiazoles and oxazoles of the Formula (I): as well as compositions, including pharmaceutical compositions, containing the same, and the use thereof in the treatment of various neurological and psychological disorders, e.g., affective disorder, anxiety and depression, treatable by antagonizing CRF receptors.
摘要翻译：本文提供式（I）的新型取代的噻唑和恶唑：以及包含其的药物组合物的组合物及其在治疗各种神经和心理障碍（例如情感障碍，焦虑和抑郁症）中的用途可通过拮抗CRF受体治疗。

12. 发明授权

US07153491B2 Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging 有权
标题翻译：使用小分子放射性配体发现淀粉样蛋白β肽生产抑制剂和诊断成像
公开(公告)号：US07153491B2
公开(公告)日：2006-12-26
申请号：US10734031
申请日：2003-12-11
申请人： Robert Zaczek , Richard E. Olson , Dietmar A. Seiffert , Lorin Andrew Thompson
发明人： Robert Zaczek , Richard E. Olson , Dietmar A. Seiffert , Lorin Andrew Thompson
IPC分类号： A61K49/00
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2500/02 , G01N2500/20 , G01N2800/2821
摘要： This invention relates to a novel method of screening for inhibitors of beta-amyloid production, and thereby identifying such inhibitors as therapeutics for neurological and other disorders involving APP processing and beta-amyloid production. This invention also relates to identifying macromolecules involved in APP processing and beta-amyloid production. Furthermore, inhibitors identified by the screening method of the present invention are useful in the treatment of neurological disorders, such as Alzheimer's disease, which involve elevated levels of Aβ peptides.
摘要翻译：本发明涉及一种筛选β-淀粉样蛋白生成抑制剂的新方法，从而鉴定了诸如涉及APP加工和β-淀粉样蛋白生成的神经学和其它病症治疗剂的抑制剂。本发明还涉及鉴定参与APP处理和β-淀粉样蛋白生成的大分子。此外，通过本发明的筛选方法鉴定的抑制剂可用于治疗神经障碍，例如阿尔茨海默氏病，其涉及升高的Aβ肽水平。

13. 发明申请

US20060252756A1 Azolo triazines and pyrimidines 失效
公开(公告)号：US20060252756A1
公开(公告)日：2006-11-09
申请号：US11477680
申请日：2006-06-29
申请人： Liqi He , Paul Gilligan , Robert Chorvat , Argyrios Arvanitis
发明人： Liqi He , Paul Gilligan , Robert Chorvat , Argyrios Arvanitis
IPC分类号： A61K31/53
CPC分类号： A61K31/53 , C07D487/04
摘要： Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

14. 发明授权

US07126010B2 Benzylcycloalkyl amines as modulators of chemokine receptor activity 有权
标题翻译：苄基环烷基胺作为趋化因子受体活性的调节剂
公开(公告)号：US07126010B2
公开(公告)日：2006-10-24
申请号：US11040585
申请日：2005-01-21
申请人： Dean A Wacker , John V Duncia , Joseph B Santella, III. , Daniel S Gardner
发明人： Dean A Wacker , John V Duncia , Joseph B Santella, III. , Daniel S Gardner
IPC分类号： C07D207/04 , C07D211/06 , A61K31/40 , A61K31/445 , C07D307/04
CPC分类号： A61K31/16 , A61K31/15 , A61K31/433 , C07C275/38 , C07C275/42 , C07D207/14 , C07D209/40 , C07D211/58 , C07D213/75 , C07D231/40 , C07D231/56 , C07D233/88 , C07D235/30 , C07D257/06 , C07D263/58 , C07D277/46 , C07D277/82 , C07D307/22 , C07D307/66 , C07D333/66 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of inflammatory diseases such as asthma and other allergic diseases.
摘要翻译：本申请描述了可用于预防炎症性疾病如哮喘和其他过敏性疾病的式（I）的CCR3或其药学上可接受的盐形式的调节剂。

15. 发明授权

US07018611B2 Vitronectin receptor antagonist pharmaceuticals 失效
标题翻译： Vitronectin受体拮抗剂药物
公开(公告)号：US07018611B2
公开(公告)日：2006-03-28
申请号：US10281015
申请日：2002-10-26
申请人： Thomas D. Harris , John A. Barrett , Alan P. Carpenter, Jr. , Milind Rajopadhye
发明人： Thomas D. Harris , John A. Barrett , Alan P. Carpenter, Jr. , Milind Rajopadhye
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K49/0002 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/223 , A61K51/0455 , A61K51/0459 , A61K51/0497 , C07D401/12 , C07D401/14
摘要： The present invention describes novel compounds of the formula: (Q)d—Ln—Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful for monitoring therapeutic angiogenesis treatment and destruction of new angiogenic vasculature. The present invention further provides novel compounds useful for imaging atherosclerosis, restenosis, cardiac ischemia, and myocardial reperfusion injury. The present invention still further provides novel compounds useful for the treatment of rheumatoid arthritis. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety. The imageable moiety is a gamma ray or positron emitting radioisotope, a magnetic resonance imaging contrast agent, an X-ray contrast agent, or an ultrasound contrast agent.
摘要翻译：本发明描述了新的下式化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？>（Q）对于癌症的诊断和治疗有用的<？in-line-formula description =“在线公式”end =“tail”？>，肿瘤成像方法患者，以及在患者中治疗癌症的方法。本发明还提供了可用于监测治疗性血管生成治疗和破坏新的血管生成脉管系统的新型化合物。本发明还提供可用于成像动脉粥样硬化，再狭窄，心脏缺血和心肌再灌注损伤的新型化合物。本发明还提供了可用于治疗类风湿性关节炎的新化合物。药物由与血管发生期间上调的受体结合的靶向部分，任选的连接基团和治疗有效的放射性同位素或诊断上有效的可成像部分组成。可成像部分是伽马射线或正电子发射放射性同位素，磁共振成像造影剂，X射线造影剂或超声造影剂。

16. 发明授权

US07015214B2 Cyanamide, alkoxyamino, and urea derivatives of 1,3-benzodiazepine as HIV reverse transcriptase inhibitors 有权
标题翻译：作为HIV逆转录酶抑制剂的1,3-苯二氮卓的氰胺，烷氧基氨基和脲衍生物
公开(公告)号：US07015214B2
公开(公告)日：2006-03-21
申请号：US10108842
申请日：2002-03-27
申请人： Donna M Bilder
发明人： Donna M Bilder
IPC分类号： A61K31/55 , A61P31/18 , C07D243/00
CPC分类号： C07D401/06 , C07D243/10 , C07D405/06 , C07D409/06 , C07D491/04
摘要： The present invention relates to 1,3-benzodiazepin-2-ones and 1,3-benzoxazepin-2-ones of formula I: or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
摘要翻译：本发明涉及式I的1,3-苯并二氮杂-2-酮和1,3-苯并氧氮杂-2-酮或其立体异构形式，立体异构体混合物或其药学上可接受的盐形式，其可用作HIV逆转抑制剂转录酶，以及包含其的药物组合物和诊断试剂盒，及其用于治疗病毒感染的方法或作为测定标准品或试剂。

17. 发明授权

US06994852B1 Inhibition of angiogenesis by antibodies against high molecular weight kininogen domain 5 失效
标题翻译：通过针对高分子量激肽原结构域的抗体抑制血管生成5
公开(公告)号：US06994852B1
公开(公告)日：2006-02-07
申请号：US10129946
申请日：2000-11-10
申请人： Robert W. Colman , Shaker A. Mousa
发明人： Robert W. Colman , Shaker A. Mousa
IPC分类号： A61K39/395
CPC分类号： C07K16/36 , A61K2039/505 , C07K2317/73 , C07K2317/76
摘要： Antibodies directed against an antigenic determinant of high molecular weight kininogen domain 5, particularly a determinant located in the region formed by light chain amino acids Gly(440) to Lys(502), inhibit angiogenesis.
摘要翻译：针对高分子量激肽原结构域5（特别是位于由轻链氨基酸Gly（440）至Lys（502）形成的区域中的决定簇）的抗原决定簇的抗体抑制血管发生。

18. 发明申请

US20050287074A1 Matrix metalloproteinase inhibitors 审中-公开
标题翻译：基质金属蛋白酶抑制剂
公开(公告)号：US20050287074A1
公开(公告)日：2005-12-29
申请号：US11194845
申请日：2005-08-01
申请人： Alan Carpenter , Milind Rajopadhye
发明人： Alan Carpenter , Milind Rajopadhye
IPC分类号： A61K38/00 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/08 , A61K51/00 , A61K51/04 , C07F5/00 , C07F9/6527 , C07K5/06 , C07K5/065
CPC分类号： A61K49/00 , A61K38/00 , A61K49/0002 , A61K49/085 , A61K49/10 , A61K49/223 , A61K51/0497 , C07F9/6527 , C07K5/06026 , C07K5/06078 , C07K5/06191
摘要： Thus the present invention describes diagnostic agents comprising a diagnostic metal and a compound, wherein the compound comprises: 1-10 targeting moieties; a chelator; and 0-1 linking groups between the targeting moiety and chelator; wherein the targeting moiety is a matrix metalloproteinase inhibitor; and wherein the chelator is capable of conjugating to the diagnostic metal. The present invention also provides novel compositions of the compounds of the invention, kits, and their uses in diagnosis of diseases associated with MMPs.
摘要翻译：因此，本发明描述了包含诊断金属和化合物的诊断剂，其中所述化合物包含：1-10个靶向部分; 螯合剂和靶向部分和螯合剂之间的0-1个连接基团; 其中靶向部分是基质金属蛋白酶抑制剂; 并且其中螯合剂能够与诊断金属共轭。本发明还提供本发明化合物，试剂盒及其在诊断与MMP相关的疾病中的用途的新组合物。

19. 发明授权

US06967208B2 Lactam-containing compounds and derivatives thereof as factor Xa inhibitors 有权
标题翻译：含有内酰胺的化合物及其衍生物作为因子Xa抑制剂
公开(公告)号：US06967208B2
公开(公告)日：2005-11-22
申请号：US10245122
申请日：2002-09-17
申请人： Donald J. P. Pinto , Mimi L. Quan , Michael J. Orwat , Yun-Long Li , Wei Han , Jennifer X. Qiao , Patrick Y. S. Lam , Stephanie L. Koch
发明人： Donald J. P. Pinto , Mimi L. Quan , Michael J. Orwat , Yun-Long Li , Wei Han , Jennifer X. Qiao , Patrick Y. S. Lam , Stephanie L. Koch
IPC分类号： A61K31/4439 , A61K31/4709 , A61K31/4745 , A61K31/502 , A61K31/513 , A61K31/538 , C07D211/40 , C07D213/75 , C07D213/81 , C07D213/82 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D413/02 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/16 , A61K31/437 , A61P7/02
CPC分类号： C07D413/14 , A61K31/4365 , A61K31/616 , A61K45/06 , C07D211/40 , C07D211/76 , C07D213/64 , C07D213/75 , C07D213/81 , C07D213/82 , C07D239/10 , C07D241/08 , C07D265/10 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14 , C07D471/04 , C07D495/04 , A61K2300/00
摘要： The present application describes lactam-containing compounds and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
摘要翻译：本申请描述了含有式I的化合物及其衍生物或其药学上可接受的盐形式，其中环P（如果存在）为5-7元碳环或杂环，且环M为5-7元碳环或杂环。本发明的化合物可用作胰蛋白酶样丝氨酸蛋白酶的抑制剂，特别是因子Xa。

20. 发明授权

US06958341B2 Pyrazolopyrimidines as CRF antagonists 有权
标题翻译：吡唑并嘧啶类作为CRF拮抗剂
公开(公告)号：US06958341B2
公开(公告)日：2005-10-25
申请号：US10125623
申请日：2002-04-18
申请人： Richard G. Wilde , Paul J. Gilligan
发明人： Richard G. Wilde , Paul J. Gilligan
IPC分类号： A61P25/00 , C07D487/04 , A61K31/519
CPC分类号： C07D487/04
摘要： The present invention relates to pyrazolopyrimidines according to formula (I) and stereoisomers, isomers and salts thereof wherein R1-R5 are selected from certain alkyl, aryl and heteroaryl species as defined in the specification wherein all of the compounds are useful as CRF antagonists and are thus useful in the treatment of neurological disorders as well as a multitude of other CRF associated diseases or conditions.
摘要翻译：本发明涉及式（I）的吡唑并嘧啶及其立体异构体，异构体和盐，其中R 1至Z 5选自某些烷基，芳基和杂芳基，如在本说明书中定义，其中所有化合物可用作CRF拮抗剂，因此可用于治疗神经系统疾病以及多种其它CRF相关疾病或病症。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式