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11. 发明授权

US10392149B2 Label applicator 有权
公开(公告)号：US10392149B2
公开(公告)日：2019-08-27
申请号：US16000270
申请日：2018-06-05
申请人： bioMerieux, Inc.
发明人： Dejan Zeljic , James Killala-Ringwood , Daniel Joseph Pingel , Daniel Oliver Luebbert
IPC分类号： B65C9/26 , B65C9/36 , B65C3/00 , B65C9/00
摘要： A label applicator, system, and method for applying labels to curved sides of objects, such as cell culture dishes, is provided. In an aspect, the label applicator includes a body having a first side and a second side, the second side comprising a curved surface; a base; at least one first resilient member having a defined length between a first end and a second end; and at least one second resilient member engaging the body and the base, wherein the second end of the at least one first resilient member is configured to removably attach to a label and, when the label is in contact with the second end and an object, to apply a pressure to the label that increases as the at least one first resilient member and at least one second resilient member are compressed. The system may also include a label verifier and/or label verification system.

12. 发明授权

US10047387B2 System and method for automatically venting and sampling a culture specimen container 有权
公开(公告)号：US10047387B2
公开(公告)日：2018-08-14
申请号：US14078609
申请日：2013-11-13
申请人： BIOMERIEUX, INC.
发明人： Christopher S. Ronsick , Mark S. Wilson , Ronnie J. Robinson
IPC分类号： C12Q1/24 , G01N35/00 , G01N35/10
CPC分类号： C12Q1/24 , G01N35/0099 , G01N35/1079 , Y10S901/30
摘要： Apparatus for automated venting and/or sampling of a specimen container having a closure sealing the interior of the specimen container from the environment is disclosed. The apparatus includes a rack holding the specimen container; a venting and/or sampling device having a needle, a chamber in fluid communication with the needle and a port in fluid communication with the chamber; a robotic transfer mechanism moveable relative to the rack; a sample removal apparatus attached to the robotic transfer mechanism having gripping features for gripping the venting device. The sample removal apparatus and robotic transfer mechanism are moveable relative to the specimen container so as to automatically insert the needle of the venting device through the closure of the specimen container to thereby vent the interior of the specimen container and obtain equilibrium between the interior of the specimen container and the atmosphere and withdraw a portion of the sample from the specimen container into the venting and/or sampling device.

13. 发明授权

US10011385B2 Label applicator 有权
公开(公告)号：US10011385B2
公开(公告)日：2018-07-03
申请号：US14978246
申请日：2015-12-22
申请人： bioMerieux, Inc.
发明人： Dejan Zeljic , James Killala-Ringwood , Daniel Joseph Pingel , Daniel Oliver Luebbert
IPC分类号： B65C9/26 , B65C9/36 , B65C3/00 , B65C9/00
CPC分类号： B65C9/26 , B65C3/00 , B65C9/0006 , B65C9/36 , B65C2210/0008
摘要： A label applicator, system, and method for applying labels to curved sides of objects, such as cell culture dishes, is provided. In an aspect, the label applicator includes a body having a first side and a second side, the second side comprising a curved surface; a base; at least one first resilient member having a defined length between a first end and a second end; and at least one second resilient member engaging the body and the base, wherein the second end of the at least one first resilient member is configured to removably attach to a label and, when the label is in contact with the second end and an object, to apply a pressure to the label that increases as the at least one first resilient member and at least one second resilient member are compressed. The system may also include a label verifier and/or label verification system.

14. 发明授权

US09874568B2 Method of detecting at least one mechanism of resistance to carbapenems by mass spectrometry 有权
公开(公告)号：US09874568B2
公开(公告)日：2018-01-23
申请号：US15370128
申请日：2016-12-06
申请人： BIOMERIEUX, INC.
发明人： Yannick Charretier , Jean-Philippe Charrier , Christine Franceschi , Gilles Zambardi , Tiphaine Cecchini , Elodie Degout-Charmette
IPC分类号： A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , G01N33/68 , C12Q1/04 , C12Q1/37
CPC分类号： G01N33/6848 , C12Q1/04 , C12Q1/37 , G01N2333/948 , G01N2333/976 , G01N2333/986
摘要： The present invention pertains to a method of detection, by mass spectrometry, of at least one marker of at least one mechanism of resistance to at least one antimicrobial, resistance of at least one microorganism contained in a sample, characterized in that the antimicrobial is a carbapenem, and said resistance markers are proteins or peptides. Preferably, said proteins or peptides are proteins from said microorganism.

15. 发明授权

US09856503B2 Combined detection instrument for culture specimen containers and instrument for identification and/or characterization of a microbial agent in a sample 有权
公开(公告)号：US09856503B2
公开(公告)日：2018-01-02
申请号：US14453830
申请日：2014-08-07
申请人： BIOMERIEUX, INC.
发明人： Ronnie J. Robinson , Mark S. Wilson , Christopher S. Ronsick , John D. Walsh , Jones M. Hyman , Thurman C. Thorpe , Bradford G. Clay
IPC分类号： G01N35/00 , C12M1/00 , B01L3/00 , C12Q1/04 , C12M1/34 , C12Q1/02 , G01N35/04
CPC分类号： C12Q1/04 , C12M41/36 , C12Q1/02 , G01N35/00603 , G01N35/0099 , G01N35/026 , G01N2035/00148 , G01N2035/0406 , G01N2035/0453 , G01N2035/0465
摘要： A detection instrument determines whether a specimen container (e.g., blood culture bottle) is positive for presence of microbial agent growth therein. When the container is deemed positive it is made available (e.g, transferred or exposed to) to an automated instrument performing identification and/or characterization of the microbial agent. The identification and/or characterization instrument removes a portion of the sample from the specimen container and places it into a disposable separation and concentration device. The microbial agent is concentrated via optional selective lysis of non-microbial agent cellular material which may be present and centrifugation. A reading module reads the concentrated microbial agent using spectroscopic methods, e.g., measurements of intrinsic fluorescence. Such interrogation may occur while the microbial agent remains concentrated in the disposable device.

16. 发明授权

US09790534B2 Methods for separation, characterization and/or identification of microorganisms using spectroscopy 有权
公开(公告)号：US09790534B2
公开(公告)日：2017-10-17
申请号：US14146367
申请日：2014-01-02
申请人： John Walsh , Jones Hyman , Thurman Thorpe , Bradford Clay , Christopher Ronsick
发明人： John Walsh , Jones Hyman , Thurman Thorpe , Bradford Clay , Christopher Ronsick
IPC分类号： C12Q1/04 , G01N33/68 , H01J49/00
CPC分类号： C12Q1/04 , G01N33/6848 , H01J49/00
摘要： The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The invention further provides for spectroscopic interrogation of the separated microorganism sample to produce measurements of the microorganism and characterizing and/or identifying the microorganism in the sample using said spectroscopic measurements.

17. 发明授权

US09574219B2 Device for sampling a specimen container 有权
标题翻译：用于取样样品容器的装置
公开(公告)号：US09574219B2
公开(公告)日：2017-02-21
申请号：US12800392
申请日：2010-05-14
申请人： Christopher S. Ronsick , Mark S. Wilson , Ronnie J. Robinson , John Walsh , Jones M. Hyman
发明人： Christopher S. Ronsick , Mark S. Wilson , Ronnie J. Robinson , John Walsh , Jones M. Hyman
IPC分类号： G01N1/12 , C12Q1/24 , G01N35/00 , G01N35/10
CPC分类号： C12Q1/24 , G01N35/0099 , G01N35/1079 , Y10S901/30
摘要： A sampling device for a specimen container having a closure sealing the interior of the specimen container from the environment includes a needle, a body coupled to the needle and defining a chamber in fluid communication with the needle, the body further comprising a port forming an opening in the body, the port in fluid communication with the chamber. A multitude of the sampling devices may be stored in a cassette. The sampling devices may include a second chamber for separation and concentration of a microbial agent present in a sample. In this configuration second chamber is connected to the first chamber via a valve or the like.
摘要翻译：用于样本容器的采样装置具有将样本容器的内部与环境密封的封闭件，其包括：针头，与所述针头相连并且限定与所述针流体连通的室，所述主体还包括形成开口在身体中，与腔室流体连通的端口。多个采样装置可以存储在盒中。采样装置可以包括用于分离和浓缩样品中存在的微生物剂的第二室。在该构造中，第二室通过阀等连接到第一室。

18. 发明授权

US09562260B2 Nucleic acid amplification reaction station for disposable test devices 有权
标题翻译：一次性试验装置的核酸扩增反应站
公开(公告)号：US09562260B2
公开(公告)日：2017-02-07
申请号：US12924351
申请日：2010-09-24
申请人： Bryan W. Kluttz , Geoff A. McKinley , Fabio Gennari , Michel Guy , Christopher Cotter , Luigi Catazariti , Louis Graziano , Bruno Colin , Cecile Paris , Jacque Dachaud
发明人： Bryan W. Kluttz , Geoff A. McKinley , Fabio Gennari , Michel Guy , Christopher Cotter , Luigi Catazariti , Louis Graziano , Bruno Colin , Cecile Paris , Jacque Dachaud
IPC分类号： B01L3/00 , A01B1/00 , C12Q1/68 , B01L7/00 , G01N35/02 , G01N35/04
CPC分类号： C12Q1/6848 , B01L3/502 , B01L7/52 , B01L7/525 , B01L2200/026 , B01L2200/16 , B01L2300/044 , B01L2300/0809 , B01L2300/0825 , B01L2300/0861 , B01L2300/087 , B01L2300/1822 , B01L2400/0487 , B01L2400/049 , B01L2400/0633 , B01L2400/0644 , B01L2400/0655 , G01N35/026 , G01N2035/0436
摘要： An instrument for conducting nucleic acid amplification reactions in a disposable test device. The test device includes a first reaction chamber containing a first nucleic acid amplification reagent (e.g., primers and nucleotides) and a second reaction chamber either containing, or in fluid communication, with a second nucleic acid amplification reagent (e.g., an amplification enzyme such as RT). The instrument includes a support structure receiving the test device. A temperature control system maintains the first reaction chamber at a first elevated temperature but simultaneously maintains the second nucleic acid amplification reagent at a second temperature lower than the first temperature so as to preserve the second nucleic acid amplification reagent. An actuator operates on a fluid conduit in the test device to place the first and second reaction chambers in fluid communication with each other after a reaction has occurred in the first reaction chamber at the first temperature. A pneumatic system is also provided that assists in fluid transfer of a reaction solution from the first chamber to the second chamber.
摘要翻译：用于在一次性测试装置中进行核酸扩增反应的仪器。测试装置包括含有第一核酸扩增试剂（例如引物和核苷酸）的第一反应室和含有或与第二核酸扩增试剂（例如，扩增酶如 RT）。仪器包括接收测试装置的支撑结构。温度控制系统将第一反应室保持在第一升高温度，同时将第二核酸扩增试剂保持在低于第一温度的第二温度，以便保留第二核酸扩增试剂。致动器在测试装置中的流体导管上操作，以在第一温度下在第一反应室中发生反应之后使第一和第二反应室彼此流体连通。还提供了一种有助于将反应溶液从第一室流体转移到第二室的气动系统。

19. 发明申请

US20140343864A1 METHOD FOR IDENTIFYING MICROORGANISMS VIA MASS SPECTROMETRY AND SCORE NORMALIZATION 审中-公开
标题翻译：通过质谱分析和分辨率正常化识别微生物的方法
公开(公告)号：US20140343864A1
公开(公告)日：2014-11-20
申请号：US14361885
申请日：2012-11-30
申请人： bioMerieux, Inc.
发明人： Grégory Strubel , Maud Arsac , Denis Desseree , Pierre-Jean Cotte-Pattat , Pierre Mahe
IPC分类号： H01J49/00 , G01N33/483
CPC分类号： H01J49/0036 , C12Q1/04 , G01N33/483 , G01N33/6848 , G06K9/00147 , G06K9/6269 , G06K9/627 , G06K9/6278 , H01J49/26
摘要： An identification by mass spectrometry of a microorganism from among reference microorganisms represented by reference data sets includes: determining a set of data of the microorganism according to a spectrum; for each reference microorganism, calculating a distance between the determined and reference sets; and calculating a probability f(m) according to relation f  ( m ) = pN  ( m  μ , σ ) pN  ( m  μ , σ ) + ( 1 - p )  N  ( m  μ _ , σ _ ) where: m is the distance calculated for the reference microorganism; N(m|μ,σ) is the value, for m, of a random variable modeling the distance between a reference microorganism to be identified and the reference microorganism, when the microorganism is the reference microorganism; N(m| μ, σ) is the value, for m, of a random variable modeling the distance between a microorganism to be identified and the reference microorganism, when the microorganism is not the reference microorganism; and p is a scalar in the range from 0 to 1.
摘要翻译：通过参考数据组所表示的参考微生物中的微生物的质谱鉴定包括：根据光谱确定微生物的一组数据; 对于每个参考微生物，计算所确定的和参考组之间的距离; 并且根据关系式（m）= pN（mμ，＆sgr;）pN（mμ，＆sgr）+（1-p）N（mμ）计算概率f（m） _，＆sgr; _）其中：m是参考微生物计算的距离; 当微生物是参照微生物时，N（m |μ，＆sgr;）是m的值，用于建立待鉴定的参考微生物与参照微生物之间的距离的随机变量; N（m |μ，＆sgr;）是当微生物不是参照微生物时，随机变量建模待鉴定微生物与参照微生物之间的距离的m值; p是0到1范围内的标量。

20. 发明申请

US20140234889A1 METHOD FOR NEUTRALIZATION OF ANTIBIOTICS IN A CULTURE MEDIUM 有权
标题翻译：培养基中抗生素中和的方法
公开(公告)号：US20140234889A1
公开(公告)日：2014-08-21
申请号：US14069576
申请日：2013-11-01
申请人： Douglas Lovern
发明人： Douglas Lovern
IPC分类号： C12Q1/02
CPC分类号： C12Q1/025 , C12N1/20 , C12N1/38 , C12Q1/04
摘要： The present invention is directed to a method and means for the neutralization, binding, and/or inactivation of antimicrobials in a test sample. The invention is also directed to a method of detecting the presence of one or more microorganisms in a test sample by culturing the test sample in a culture media comprising one or more primary amine-containing compounds.
摘要翻译：本发明涉及在测试样品中中和，结合和/或灭活抗微生物剂的方法和手段。本发明还涉及通过在包含一种或多种含伯胺化合物的培养基中培养测试样品来检测测试样品中一种或多种微生物的存在的方法。

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