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181. 发明申请

US20110044911A1 Use of Functionalized Magnetic Nanoparticles in Cancer Detection and Treatment 有权
标题翻译：功能磁性纳米粒子在癌症检测和治疗中的应用
公开(公告)号：US20110044911A1
公开(公告)日：2011-02-24
申请号：US12934048
申请日：2009-04-01
申请人： Massoud Akhtari , Jerome Engel
发明人： Massoud Akhtari , Jerome Engel
IPC分类号： A61K49/06 , A61K49/14 , A61K49/10 , A61K49/04 , A61K31/175 , A61K36/18 , A61K31/56 , A61P35/00 , B82Y5/00
CPC分类号： A61K49/1866 , A61K41/0052 , A61K47/62 , A61K47/6923 , A61K49/1845 , A61K49/1863 , B82Y5/00
摘要： The present invention provides methods of detecting a cancer cell in an individual, methods of grading a cancer, and methods of treating a cancer. The methods involve use of functionalized magnetic nanoparticles that comprise a moiety that provides for selective association with, and/or metabolic uptake into, a cancer cell.
摘要翻译：本发明提供了检测个体中的癌细胞的方法，癌症分级方法和治疗癌症的方法。所述方法包括使用包含提供与癌细胞选择性结合和/或代谢摄入的部分的官能化磁性纳米粒子。

182. 发明授权

US07871597B2 Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents 有权
标题翻译：多元醇和聚醚氧化铁络合物作为药理学和/或MRI造影剂
公开(公告)号：US07871597B2
公开(公告)日：2011-01-18
申请号：US10410527
申请日：2003-04-09
申请人： Ernest V. Groman , Kenneth G. Paul , Timothy B. Frigo , Howard Bengele , Jerome M. Lewis
发明人： Ernest V. Groman , Kenneth G. Paul , Timothy B. Frigo , Howard Bengele , Jerome M. Lewis
IPC分类号： A61B5/055 , A01N43/04 , A61K31/715
CPC分类号： A61K49/126 , A61K9/14 , A61K31/721 , A61K33/26 , A61K47/36 , A61K47/6923 , A61K47/6929 , A61K49/186 , A61K49/1863 , B82Y5/00
摘要： Pharmacological compositions, and methods for administration, of the type employing an iron oxide complex with a polyol or polyether. The methods of administration may comprise parenteral administration of an effective dose of the complex formulated in a biocompatible liquid delivered at a rate of from about 1 mL/sec to less than 1 mL/min and wherein upon administration the complex provides minimal detectable free iron in a subject, and minimal incidence of anaphylaxis. The pharmacological compositions are of the type employing a polyol or polyether iron oxide complex, which, upon parenteral administration to a subject, are substantially immunosilent, provide minimal anaphylaxis and minimal free iron, and undergo minimal dissolution in vivo.
摘要翻译：使用氧化铁配合物与多元醇或聚醚的类型的药物组合物和给药方法。给药方法可以包括肠胃外给药配制在以约1mL / sec至小于1mL / min的速率递送的生物相容性液体中的复合物，并且其中在给药时，复合物提供了最小可检测的游离铁一个主题和最小的过敏反应发生率。药物组合物是使用多元醇或聚醚氧化铁络合物的类型，其在对受试者的肠胃外给药时基本上是免疫安全的，提供最小的过敏反应和最小的游离铁，并且在体内经历最小的溶解。

183. 发明申请

US20100330045A1 Mesenchymal precursor cell 有权
标题翻译：间充质前体细胞
公开(公告)号：US20100330045A1
公开(公告)日：2010-12-30
申请号：US12660003
申请日：2010-02-17
申请人： Stan Gronthos , Andrew Zannettino , Paul Simmons
发明人： Stan Gronthos , Andrew Zannettino , Paul Simmons
IPC分类号： A61K35/12 , A61P19/02
CPC分类号： A61K35/28 , A61K47/48861 , A61K47/6923 , A61K48/00 , A61K2035/124 , C12N5/0663 , C12N2500/42 , C12N2501/39
摘要： A method of enriching mesenchymal precursor cells including the step of enriching for cells based on at least two markers. The markers may be either i) the presence of markers specific for mesenchymal precursor cells, ii) the absence of markers specific for differentiated mesenchymal cells, or iii) expression levels of markers specific for mesenchymal precursor cells. The method may include a first solid phase sorting step utilising MACS recognising expression of the antigen to the STRO-1 Mab, followed by a second sorting step utilising two colour FACS to screen for the presence of high level STRO-1 antigen expression as well as the expression of VCAM-1.
摘要翻译：一种富含间充质前体细胞的方法，包括基于至少两种标记物富集细胞的步骤。标记可能是i）对间质前体细胞特异性标志物的存在，ii）不存在对分化的间充质细胞特异性的标记，或iii）对间充质前体细胞特异的标志物的表达水平。该方法可以包括利用识别STRO-1 Mab抗原表达的MACS的第一固相分选步骤，随后使用两色FACS来筛选高水平STRO-1抗原表达的存在的第二分选步骤，以及 VCAM-1的表达。

184. 发明申请

US20100266695A1 MULTIVALENT CLUSTERING TARGETING STRATEGY FOR DRUG CARRIERS 有权
标题翻译：针对药物传播者的多元化集群目标战略
公开(公告)号：US20100266695A1
公开(公告)日：2010-10-21
申请号：US12708520
申请日：2010-02-18
申请人： Tatiana Segura , Quinn Ng
发明人： Tatiana Segura , Quinn Ng
IPC分类号： A61K9/14 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61P35/00
CPC分类号： A61K47/6923 , A61K47/59 , A61K47/62
摘要： The present invention provides clustered ligand vehicles for the delivery of a nucleic acid therapeutic agent to a target expressing a receptor. The invention further provides methods for treating a disease state by targeting a nucleic acid therapeutic agent to a target expressing a receptor using clustered ligand vehicles.
摘要翻译：本发明提供了用于将核酸治疗剂递送到表达受体的靶的簇配体载体。本发明还提供了通过使用聚簇配体载体将核酸治疗剂靶向表达受体的靶来治疗疾病状态的方法。

185. 发明申请

US20100260677A1 METHODS AND SYSTEMS FOR TREATMENT AND/OR DIAGNOSIS 审中-公开
标题翻译：用于治疗和/或诊断的方法和系统
公开(公告)号：US20100260677A1
公开(公告)日：2010-10-14
申请号：US12716217
申请日：2010-03-02
申请人： Sangeeta N. Bhatia , Geoffrey A. von Maltzahn
发明人： Sangeeta N. Bhatia , Geoffrey A. von Maltzahn
IPC分类号： A61K9/14 , A61K49/00
CPC分类号： C07K7/02 , A61K41/0052 , A61K47/62 , A61K47/6923 , C07K7/08
摘要： The invention relates to methods and systems that can be used for treatment and/or diagnosis. In one aspect, the present invention involves systems and methods for activating a biological cascade in a subject, and administering, to the subject, a composition or a component comprising an agent able to bind a product of a biological cascade or otherwise interact with the biological cascade. The biological cascade may be, for example, a coagulation cascade, a complement cascade, an inflammation cascade, or the like. In some cases, the concentration of a protein, the metabolic demand for a substrate, or the like may be increased as a result of activation of the biological cascade. As a specific non-limiting example, in one set of embodiments, the biological cascade may be a coagulation cascade and the composition administered to the subject may include a fibrin-binding peptide and an antitumor species. By activating the biological cascade, e.g., with an activation composition or by applying energy, coagulation may be induced in a tumor, which the antitumor species may associate with due to an increase in fibrin caused by the coagulation cascade. In addition, in certain aspects, the present invention involves systems and methods for changing tissue from a first state to a second state, for instance, with a first composition comprising nanoparticles. The second composition may be more responsive to the tissue in the second state than in the first state in some cases. In still other aspects, the present invention is generally directed to systems and methods for making such compositions, systems and methods for promoting such compositions, kits involving such compositions, or the like.
摘要翻译：本发明涉及可用于治疗和/或诊断的方法和系统。在一个方面，本发明涉及用于激活受试者中的生物级联的系统和方法，以及向受试者施用组合物或组分，所述组合物或组分包含能够结合生物级联产物或以其它方式与生物级联相互作用的试剂级联。生物级联可以是例如凝血级联，补体级联，炎症级联等。在某些情况下，由于生物级联的活化，蛋白质的浓度，对底物的代谢需求等可能会增加。作为具体的非限制性实例，在一组实施方案中，生物级联可以是凝血级联，并且施用于受试者的组合物可以包括纤维蛋白结合肽和抗肿瘤物质。通过活化生物级联，例如通过活化组合物或通过施加能量，可以在肿瘤中诱导凝血，抗肿瘤物质可能由于凝血级联引起的纤维蛋白增加而与之结合。此外，在某些方面，本发明涉及用于将组织从第一状态改变到第二状态的系统和方法，例如，包含纳米颗粒的第一组合物。在某些情况下，第二组合物可能对第二状态中的组织比对第一状态更有反应。在其它方面，本发明一般涉及用于制备这种组合物的系统和方法，用于促进这种组合物的系统和方法，涉及这种组合物的试剂盒等。

186. 发明申请

US20100260676A1 PRECISION-GUIDED NANOPARTICLE SYSTEMS FOR DRUG DELIVERY 有权
标题翻译：用于药物递送的精确指导的纳米系统
公开(公告)号：US20100260676A1
公开(公告)日：2010-10-14
申请号：US12526297
申请日：2008-02-11
申请人： Robert N. Hanson , Mansoor Amiji , Volkmar Weissig
发明人： Robert N. Hanson , Mansoor Amiji , Volkmar Weissig
IPC分类号： A61K49/00 , A61K9/14 , A61K39/395 , A61K31/28 , A61K31/295 , A61K31/565 , A61K31/198 , A61K38/19 , A61K31/195
CPC分类号： A61K49/0002 , A61K9/51 , A61K47/6923 , A61K47/6929 , A61K51/1244 , B82Y5/00
摘要： A method of preparing multifunctionalized nanoparticles involves using a modular system of half-linkers to attach functional moieties that serve to deliver the nanoparticles to a desired target, exert an effect at the target, or track the nanoparticles within a cell or an animal. The modular chemistry of the half-linker system permits the custom design and synthesis of functionalized nanoparticles bearing multiple groups and therefore results in precise delivery to desired cell types and intracellular locations. The functionalized nanoparticles can be used to treat or diagnose a variety of medical conditions, including neoplastic diseases, infectious diseases, and chronic diseases.
摘要翻译：制备多功能纳米颗粒的方法包括使用半连接体的模块化系统来附着功能部分，其用于将纳米颗粒递送到期望的靶，在靶上发挥作用，或跟踪细胞或动物内的纳米颗粒。半连接器系统的模块化化学允许定制设计和合成具有多个组的官能化纳米颗粒，因此导致精确递送到期望的细胞类型和细胞内位置。功能化纳米颗粒可用于治疗或诊断各种医疗状况，包括肿瘤疾病，传染病和慢性疾病。

187. 发明申请

US20100247611A1 TITANIUM DIOXIDE NANOTUBES FOR PRODUCTION AND DELIVERY OF NITRIC OXIDE AND METHODS FOR PRODUCTION THEREOF 有权
标题翻译：用于生产和输送氧化氮的二氧化钛纳米管及其生产方法
公开(公告)号：US20100247611A1
公开(公告)日：2010-09-30
申请号：US12750403
申请日：2010-03-30
申请人： Kenneth J. Balkus, JR. , Chalita Ratanatawanate
发明人： Kenneth J. Balkus, JR. , Chalita Ratanatawanate
IPC分类号： A61K9/70 , B05D1/36 , A61K33/24 , A61K33/34 , A61K33/26
CPC分类号： A61K33/24 , A61K33/00 , A61K41/0042 , A61K47/6923 , B82Y5/00 , B82Y30/00 , C01G21/21 , C01G23/047 , C01P2002/82 , C01P2004/04 , C01P2004/13
摘要： The present disclosure describes compositions operable for releasing nitric oxide under photochemical conditions. The compositions include a titanium dioxide nanomaterial and a nitric oxide-releasing compound deposited on the titanium dioxide nanomaterial that is operable to release nitric oxide under photochemical conditions. Titanium dioxide nanomaterials include, for example, titanium dioxide nanotubes. To facilitate the photochemical release of nitric oxide, some embodiments of the compositions further include a semiconductor that is deposited on the titanium dioxide nanotubes. Both the semiconductor and the nitric oxide-releasing compound may be deposited on the interior surface, exterior surface, or both of the titanium dioxide nanotubes. A polymer may wrap the titanium dioxide nanotubes to protect the nitric oxide-releasing compounds from moisture. Also disclosed herein are methods for producing such compositions and medical devices obtained therefrom.
摘要翻译：本公开描述了可用于在光化学条件下释放一氧化氮的组合物。组合物包括沉积在二氧化钛纳米材料上的二氧化钛纳米材料和一氧化氮释放化合物，其可操作以在光化学条件下释放一氧化氮。二氧化钛纳米材料包括例如二氧化钛纳米管。为了促进一氧化氮的光化学释放，组合物的一些实施方案还包括沉积在二氧化钛纳米管上的半导体。半导体和一氧化氮释放化合物都可以沉积在二氧化钛纳米管的内表面，外表面或两者上。聚合物可以包裹二氧化钛纳米管以保护释放一氧化氮的化合物免受湿气侵害。本文还公开了用于制备由此获得的组合物和医疗装置的方法。

188. 发明申请

US20100183504A1 MULTIMODAL IMAGING PROBES FOR IN VIVO TARGETED AND NON-TARGETED IMAGING AND THERAPEUTICS 审中-公开
标题翻译：多目标成像和非目标成像和治疗方法的多模式成像探针
公开(公告)号：US20100183504A1
公开(公告)日：2010-07-22
申请号：US12663225
申请日：2008-06-13
申请人： Fanqing Frank Chen
发明人： Fanqing Frank Chen
IPC分类号： A61K51/12 , A61K49/18 , C12N5/071 , A61P35/00
CPC分类号： G01N21/6428 , A61K41/0071 , A61K47/6923 , A61K47/6929 , A61K49/0002 , A61K49/0065 , A61K49/0067 , A61K49/085 , A61K49/106 , A61K49/1881 , A61K51/1244 , B82Y5/00
摘要： In certain embodiments this invention provides a nanoparticle-based technology platform for multimodal in vivo imaging and therapy. The nanoparticle-based probes detects diseased cells by MRI, PET or deep tissue Near Infrared (NIR) imaging, and are capable of detecting diseased cells with greater sensitivity than is possible with existing technologies. The probes also target molecules that localize to normal or diseased cells, and initiates apoptosis of diseased cells.
摘要翻译：在某些实施方案中，本发明提供了一种用于多峰体内成像和治疗的基于纳米颗粒的技术平台。基于纳米颗粒的探针通过MRI，PET或深部组织近红外（NIR）成像来检测患病细胞，并且能够以比现有技术可能更高的灵敏度检测患病细胞。探针还靶向定位于正常或患病细胞的分子，并引发患病细胞的凋亡。

189. 发明申请

US20100136115A1 Pharmaceutical Titanium Dioxide Composite Allowing Disappearance of Drug Efficacy By Light Irradiation 审中-公开
标题翻译：药物二氧化钛复合物允许通过光照射消除药物功效
公开(公告)号：US20100136115A1
公开(公告)日：2010-06-03
申请号：US11990040
申请日：2006-08-04
申请人： Shuji Sonezaki , Koki Kanehira , Yumi Ogami , Toshiaki Banzai , Yoshinobu Kubota
发明人： Shuji Sonezaki , Koki Kanehira , Yumi Ogami , Toshiaki Banzai , Yoshinobu Kubota
IPC分类号： A61K9/14 , A61K31/704 , A61K38/14 , A61P35/00
CPC分类号： A61K41/0028 , A61K9/0019 , A61K31/704 , A61K47/58 , A61K47/6923 , A61K47/6929 , B82Y5/00
摘要： Disclosed is a titanium dioxide composite material which can be dispersed in an aqueous solvent stably and can be administered to a living body in a simple manner and in which the pharmacological effect of a therapeutic compound carried on the composite material can be eliminated by irradiation with light. Also disclosed is a dispersion product of the composite material. The composite material comprises titanium dioxide which has a photocatalytic activity and a therapeutic compound attached to the titanium dioxide through a hydrophilic polymer. The composite material is stable in an aqueous solvent and can be administered to a living body in a simple manner. After the composite material is administered to a living body, a site on the living body where the pharmacological effect of the therapeutic compound is not needed to be developed can be irradiated with light to induce the light excitation of titanium dioxide at the site, thereby decomposing the therapeutic compound to reduce any adverse side effect of the therapeutic compound.
摘要翻译：公开了一种二氧化钛复合材料，其可以稳定地分散在水性溶剂中，并且可以简单的方式施用于生物体，并且通过照射光可以消除携带在复合材料上的治疗化合物的药理作用。还公开了复合材料的分散体。复合材料包括具有光催化活性的二氧化钛和通过亲水性聚合物连接到二氧化钛上的治疗化合物。复合材料在水性溶剂中稳定，可以以简单的方式施用于生物体。在将复合材料施用于生物体后，可以用光照射生物体上不需要开发治疗化合物的药理作用的部位，从而在该部位诱导二氧化钛的光激发，从而分解该治疗化合物用于减少治疗化合物的任何副作用。

190. 发明申请

US20100087522A1 NOVEL MUSCLE RELAXANT USING NEGATIVE CHARGE GOLD NANOPARTICLE WITH CHOLINE 有权
标题翻译：使用负离子充电金纳米颗粒的新型肌肉松弛剂
公开(公告)号：US20100087522A1
公开(公告)日：2010-04-08
申请号：US12531875
申请日：2007-11-22
申请人： Chur Chin
发明人： Chur Chin
IPC分类号： A61K31/28 , C12Q1/02 , A61P21/00
CPC分类号： A61K33/24 , A61K9/0019 , A61K31/14 , A61K47/6923
摘要： A drug having a muscle relaxing effect can be prepared by binding negatively charged gold nanoparticles having a size of 1.4 nm fitted to synaptic clefts to choline through ionic bonds, thereby inducing gold-sulfur bonds in the Cys loop of an acetylcholine receptor in neuromuscular junction, and thus blocking the electric current induced in signal transduction from a nerve to a muscle, thereby blocking neuromuscular transmission chemically and physically. When the reverse is administered after surgery, the gold-sulfur bonds are broken due to the re-flow of the electric current, and thus the gold nanoparticles are again released and metabolized into neuromuscular junction. Further, such muscle relaxing effect can be applied as an anticonvulsant.
摘要翻译：具有肌肉松弛作用的药物可以通过将具有1.4nm大小的带负电荷的金纳米颗粒与突触裂缝配合以通过离子键胆碱来制备，从而在神经肌肉接头中的乙酰胆碱受体的Cys环中诱导金 - 硫键，从而阻断从神经到肌肉的信号转导中诱发的电流，从而阻断神经肌肉的化学和物理传递。手术后反复给药时，由于电流的再流动，金 - 硫键断裂，金纳米颗粒再次释放并代谢成神经肌肉接头。此外，这种肌肉松弛效果可以用作抗惊厥药。

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