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161. 发明授权

US09070543B2 Ion mobility separator with variable effective length 有权
标题翻译：具有可变有效长度的离子迁移分离器
公开(公告)号：US09070543B2
公开(公告)日：2015-06-30
申请号：US14479805
申请日：2014-09-08
申请人： Micromass UK Limited
发明人： Martin Raymond Green , David J. Langridge , Jason Lee Wildgoose
IPC分类号： B01D59/44 , B01D59/46 , B01D59/50 , H01J49/26 , H01J49/36 , G01N27/62 , H01J49/42 , H01J49/06
CPC分类号： H01J49/36 , G01N27/624 , H01J49/06 , H01J49/42 , H01J49/426
摘要： An ion mobility separator or spectrometer is disclosed comprising an inner cylinder and an outer cylinder defining an annular volume through which ions are transmitted. Spiral electrodes a-f are arranged on a surface of the inner cylinder and/or on a surface of the outer cylinder. A first device is arranged and adapted to maintain a DC electric field and/or a pseudo-potential force which acts to urge ions from a first end of the ion mobility separator or spectrometer to a second end of the ion mobility separator or spectrometer. A second device is arranged and adapted to apply transient DC voltages to the one or more spiral electrodes in order to urge ions towards the first end of the ion mobility separator or spectrometer. The net effect is to extend the effective path length of the ion mobility separator.
摘要翻译：公开了一种离子迁移率分离器或光谱仪，其包括限定通过离子传播的环形体积的内圆筒和外圆筒。螺旋电极a-f布置在内筒的表面上和/或外筒的表面上。第一装置被布置和适于维持DC电场和/或伪电势力，其用于将离子从离子迁移率分离器或光谱仪的第一端推动到离子迁移率分离器或光谱仪的第二端。第二装置被布置并适于将瞬态DC电压施加到一个或多个螺旋电极，以便促使离子朝向离子迁移率分离器或光谱仪的第一端。净效应是延长离子迁移率分离器的有效路径长度。

162. 发明申请

US20150144778A1 Data Independent Acquisition of Product Ion Spectra and Reference Spectra Library Matching 有权
标题翻译：数据独立采集产品离子谱和参考光谱库匹配
公开(公告)号：US20150144778A1
公开(公告)日：2015-05-28
申请号：US14329645
申请日：2014-07-11
申请人： Ronald F. Bonner , Stephen A. Tate , Rudolf Aebersold , Pedro Jose Navarro Alvarez , Oliver Rinner , Lukas Reiter , Ludovic Gillet
发明人： Ronald F. Bonner , Stephen A. Tate , Rudolf Aebersold , Pedro Jose Navarro Alvarez , Oliver Rinner , Lukas Reiter , Ludovic Gillet
IPC分类号： H01J49/00
CPC分类号： H01J49/0036 , G01N30/7233 , G06F19/703 , G06F19/709 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/42
摘要： Systems and methods are used to store an electronic record of all product ion spectra of all detectable compounds of a sample. A plurality of product ion scans are performed on a tandem mass spectrometer one or more times in a single sample analysis across a mass range using a plurality of mass selection windows. All sample product ion spectra of all detectable compounds for each mass selection window are produced. All sample product ion spectra for each mass selection window are received from the tandem mass spectrometer using a processor. All sample product ion spectra for each mass selection window are stored as an electronic record of all detectable compounds of the sample using the processor. The electronic record is used to characterize compounds known at the time the electronic record is stored or to characterize compounds that became known after the electronic record was stored.
摘要翻译：系统和方法用于存储所有可检测的样品化合物的所有产物离子光谱的电子记录。在使用多个质量选择窗口的质量范围内的单个样品分析中，在串联质谱仪上进行多次产品离子扫描。产生用于每个质量选择窗口的所有可检测化合物的所有样品产物离子光谱。使用处理器从串联质谱仪接收每个质量选择窗口的所有样品产物离子光谱。每个质量选择窗口的所有样品产品离子光谱都使用处理器作为样品的所有可检测化合物的电子记录进行存储。电子记录用于表征在电子记录存储时已知的化合物或表征在电子记录存储之后已知的化合物。

163. 发明授权

US08884219B2 Differential mobility spectrometer with asymmetrically oscillating driving electrical field 有权
标题翻译：差动迁移谱仪具有不对称振荡的驱动电场
公开(公告)号：US08884219B2
公开(公告)日：2014-11-11
申请号：US12988768
申请日：2009-04-17
申请人： Alexei Boulbitch
发明人： Alexei Boulbitch
IPC分类号： H01J49/42 , G01N27/62
CPC分类号： H01J49/42 , G01N27/622 , G01N27/624
摘要： A method of operating a differential mobility spectrometer includes an ionization chamber, a filter channel and a detection region. In the ionization chamber, analyte ions are produced from a sample, the so-obtained ions are then subjected in the filter channel to a time-varying electric field. The time-varying electric field has a longitudinal field component drawing the analyte ions from the ionization chamber through the filter channel into the detection region and a transversal field component, which is the superposition of an asymmetrically oscillating transversal field causing the analyte ions to move to and fro in transversal direction and a compensation field for selecting a species of analyte ions by substantially canceling the average transversal velocity of the selected species. Analyte ions of the selected species having passed through the filter channel are collected in the detection region and a detection signal responsive to the number of analyte ions collected is generated as a function of the compensating field. The longitudinal field component oscillates in longitudinal direction in such a way that it imparts to the analyte ions on average a non-zero longitudinal velocity in direction of the detection region while it causes them, on a shorter time scale, to move to and fro in longitudinal direction in the filter channel.
摘要翻译：操作差动迁移谱仪的方法包括电离室，滤波器通道和检测区域。在电离室中，从样品产生分析物离子，然后将如此获得的离子在滤波器通道中经受时变电场。时变电场具有纵向场分量，其将从离子化室通过滤波器通道的分析物离子画成检测区域和横向场分量，其是不对称振荡横向场的叠加，使得分析物离子移动到并且通过基本上抵消所选择的物种的平均横向速度来选择一种分析物离子的补偿场。已经通过过滤通道的所选物质的分析离子被收集在检测区域中，并且响应于所收集的分析物离子数量而产生响应于补偿场的函数的检测信号。纵向场分量在纵向方向上振荡，使得其在分析物离子平均上在检测区域的方向上赋予分析离子平均非零的纵向速度，同时它们在较短的时间尺度上来回移动滤波器通道的纵向。

164. 发明授权

US08841605B2 Method of ion abundance augmentation in a mass spectrometer 有权
标题翻译：质谱仪中离子丰度增加的方法
公开(公告)号：US08841605B2
公开(公告)日：2014-09-23
申请号：US12296746
申请日：2007-04-13
申请人： Alexander A. Makarov
发明人： Alexander A. Makarov
IPC分类号： H01J49/00 , H01J49/42
CPC分类号： H01J49/42 , H01J49/0031 , H01J49/0045
摘要： A method of improving the detection limits of a mass spectrometer by: generating sample ions from an ion source; storing the sample ions in a first ion storage device; ejecting the stored ions into an ion selection device; selecting and ejecting ions of a chosen mass to charge ratio out of the ion selection device; storing the ions ejected from the ion selection device in a second ion storage device without passing them back through the ion selection device; repeating the preceding steps so as to augment the ions of the said chosen mass to charge ratio stored in the second ion storage device; and transferring the augmented ions of the said chosen mass to charge ratio back to the first ion storage device for subsequent analysis.
摘要翻译：一种通过以下步骤改进质谱仪的检测限的方法：从离子源产生样品离子; 将样品离子存储在第一离子存储装置中; 将所储存的离子喷射到离子选择装置中; 从所述离子选择装置中选择和排出所选择的质荷比的离子; 将从所述离子选择装置喷出的离子存储在第二离子存储装置中，而不将其返回通过所述离子选择装置; 重复前述步骤，以便增加存储在第二离子存储装置中的所选择的质荷比的离子; 以及将所述选择的质量与充电比例的增强离子转移回到第一离子存储装置，用于随后的分析。

165. 发明授权

US08829433B2 Ion mobility separator with variable effective length 有权
标题翻译：具有可变有效长度的离子迁移分离器
公开(公告)号：US08829433B2
公开(公告)日：2014-09-09
申请号：US14004486
申请日：2012-03-13
申请人： Martin Raymond Green , David J. Langridge , Jason Lee Wildgoose
发明人： Martin Raymond Green , David J. Langridge , Jason Lee Wildgoose
IPC分类号： B01D59/44 , H01J49/36
CPC分类号： H01J49/36 , G01N27/624 , H01J49/06 , H01J49/42 , H01J49/426
摘要： An ion mobility separator or spectrometer is disclosed comprising an inner cylinder and an outer cylinder defining an annular volume through which ions are transmitted. Spiral electrodes a-f are arranged on a surface of the inner cylinder and/or on a surface of the outer cylinder. A first device is arranged and adapted to maintain a DC electric field or a pseudo-potential force which acts to urge ions from a first end of the ion mobility separator or spectrometer to a second end of the ion mobility separator or spectrometer. A second device is arranged and adapted to apply one or more transient DC voltages to the spiral electrodes in order to urge ions towards the first end of the ion mobility separator or spectrometer. The net effect is to extend the effective path length of the ion mobility separator.
摘要翻译：公开了一种离子迁移率分离器或光谱仪，其包括限定通过离子传播的环形体积的内圆筒和外圆筒。螺旋电极a-f布置在内筒的表面上和/或外筒的表面上。第一装置被布置并适于维持DC电场或伪电势力，其作用是将离子从离子迁移率分离器或光谱仪的第一端推到离子迁移率分离器或光谱仪的第二端。第二装置被布置并适于将一个或多个瞬态DC电压施加到螺旋电极，以促使离子朝向离子迁移分离器或光谱仪的第一端。净效应是延长离子迁移率分离器的有效路径长度。

166. 发明授权

US08809770B2 Data independent acquisition of product ion spectra and reference spectra library matching 有权
标题翻译：数据独立采集产品离子谱和参考光谱库匹配
公开(公告)号：US08809770B2
公开(公告)日：2014-08-19
申请号：US13819769
申请日：2011-09-14
申请人： Ronald F. Bonner , Stephen A. Tate , Rudolf Aebersold , Pedro Jose Navarro Alvarez , Oliver Rinner , Lukas Reiter , Ludovic Gillet
发明人： Ronald F. Bonner , Stephen A. Tate , Rudolf Aebersold , Pedro Jose Navarro Alvarez , Oliver Rinner , Lukas Reiter , Ludovic Gillet
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/0036 , G01N30/7233 , G06F19/703 , G06F19/709 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/42
摘要： Systems and methods are used to store an electronic record of all product ion spectra of all detectable compounds of a sample. A plurality of product ion scans are performed on a tandem mass spectrometer one or more times in a single sample analysis across a mass range using a plurality of mass selection windows. All sample product ion spectra of all detectable compounds for each mass selection window are produced. All sample product ion spectra for each mass selection window are received from the tandem mass spectrometer using a processor. All sample product ion spectra for each mass selection window are stored as an electronic record of all detectable compounds of the sample using the processor. The electronic record is used to characterize compounds known at the time the electronic record is stored or to characterize compounds that became known after the electronic record was stored.
摘要翻译：系统和方法用于存储所有可检测的样品化合物的所有产物离子光谱的电子记录。在使用多个质量选择窗口的质量范围内的单个样品分析中，在串联质谱仪上进行多次产品离子扫描。产生用于每个质量选择窗口的所有可检测化合物的所有样品产物离子光谱。使用处理器从串联质谱仪接收每个质量选择窗口的所有样品产物离子光谱。每个质量选择窗口的所有样品产品离子光谱都使用处理器作为样品的所有可检测化合物的电子记录进行存储。电子记录用于表征在电子记录存储时已知的化合物或表征在电子记录存储之后已知的化合物。

167. 发明申请

US20140224978A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20140224978A1
公开(公告)日：2014-08-14
申请号：US14256301
申请日：2014-04-18
申请人： Micromass UK Limited
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： G01N27/62 , H01J49/02
CPC分类号： G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/02 , H01J49/062 , H01J49/065 , H01J49/066 , H01J49/40 , H01J49/401 , H01J49/42
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator. The potential wells are translated along the length of the ion guide.
摘要翻译：公开了一种质谱仪，其包括离子迁移谱仪或分离器，以及布置在离子迁移谱仪或分离器下游的离子导向器。在离子导向器中产生多个轴向势阱，使得从离子迁移谱仪或分离器接收的离子变得限制在单独的轴向势阱中。潜在的孔保持从离子迁移谱仪或分离器接收的离子的保真度和/或组成。势阱沿离子导向器的长度平移。

168. 发明授权

US08637810B2 Atmospheric pressure ionization mass spectrometer 有权
标题翻译：大气压电离质谱仪
公开(公告)号：US08637810B2
公开(公告)日：2014-01-28
申请号：US13806680
申请日：2010-06-24
申请人： Kazuo Mukaibatake , Daisuke Okumura
发明人： Kazuo Mukaibatake , Daisuke Okumura
IPC分类号： H01J49/42
CPC分类号： H01J49/42 , H01J49/044 , H01J49/067 , H01J49/34
摘要： In a first-stage intermediate vacuum chamber, cluster ions causing a background noise are dominantly formed in area (A), while fragment ions are dominantly generated in area (B). Taking this fact into account, in an in-source CID analysis mode, a DC voltage higher than that applied to a skimmer is applied to a first ion guide so as to create an accelerating electric field in area (B), whereby the ions are sufficiently energized to promote the fragmentation. When the in-source CID is not performed, a DC voltage higher than that applied to the first ion guide is applied to the exit end of a desolvation tube so as to create an accelerating electric field only in area (A) without creating such a field in area (B), whereby both the formation of the cluster ions and the generation of the fragment ions are suppressed, so that a high-quality chromatogram can be obtained.
摘要翻译：在第一级中间真空室中，在区域（A）中主要形成引起背景噪声的簇离子，而在区域（B）中主要产生碎片离子。考虑到这个事实，在源内CID分析模式中，将高于施加到分离器的DC电压施加到第一离子引导件，以在区域（B）中产生加速电场，由此离子充分活力来促进分裂。当不执行源内CID时，将高于施加到第一离子导向器的DC电压施加到去溶剂化管的出口端，以便仅在区域（A）中产生加速电场，而不产生这样的场中的区域（B），从而抑制了簇离子的形成和碎片离子的产生，从而可以获得高质量的色谱图。

169. 发明申请

US20130344610A1 SYSTEMS AND METHODS FOR SAMPLE ANALYSIS 有权
公开(公告)号：US20130344610A1
公开(公告)日：2013-12-26
申请号：US13977758
申请日：2011-12-29
申请人： Robert Graham Cooks , Guangtao Li , Xin Li , Zheng Ouyang
发明人： Robert Graham Cooks , Guangtao Li , Xin Li , Zheng Ouyang
IPC分类号： H01J49/42
CPC分类号： H01J49/0459 , G01N33/28 , H01J49/0031 , H01J49/0431 , H01J49/06 , H01J49/42 , Y10T436/214 , Y10T436/24 , Y10T436/25875
摘要： The invention generally relates to systems and methods for sample analysis. In certain embodiments, the invention provides a system for analyzing a sample that includes a probe including a material connected to a high voltage source, a device for generating a heated gas, and a mass analyzer.

170. 发明授权

US08513594B2 Mass spectrometer with ion storage device 有权
标题翻译：离子存储装置的质谱仪
公开(公告)号：US08513594B2
公开(公告)日：2013-08-20
申请号：US12296724
申请日：2007-04-13
申请人： Alexander Makarov
发明人： Alexander Makarov
IPC分类号： H01J49/00
CPC分类号： H01J49/42 , H01J49/0031 , H01J49/0045
摘要： A method of mass spectrometry having steps of, in a first cycle: storing sample ions in a first ion storage device, the first ion storage device having an exit aperture and a spatially separate ion transport aperture; ejecting the stored ions out of the exit aperture; transporting the ejected ions into an ion selection device which is spatially separated from the said first ion storage device; carrying out ion selection within the spatially separated ion selection device; returning at least some of the ions ejected from the first ion storage device, or their derivatives, back from the spatially separate ion selection device to the first ion storage device, following the step of ion selection; receiving the said returned ions through the ion transport aperture of the first ion storage device; and storing the received ions in the first ion storage device.
摘要翻译：一种质谱法，其具有以下步骤：在第一循环中：将样品离子存储在第一离子存储装置中，所述第一离子存储装置具有出口孔和空间上分离的离子传输孔; 将存储的离子排出出口孔; 将排出的离子输送到与所述第一离子存储装置空间分离的离子选择装置中; 在空间分离的离子选择装置内进行离子选择; 在离子选择步骤之后，将从第一离子存储装置或其衍生物排出的至少一些离子从空间分离的离子选择装置返回到第一离子存储装置; 通过第一离子存储装置的离子传送孔接收所述返回的离子; 以及将接收到的离子存储在第一离子存储装置中。

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