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161. 发明授权

US09120096B2 Manipulating the size of liquid droplets in digital microfluidics 有权
标题翻译：在数字微流体中操纵液滴的尺寸
公开(公告)号：US09120096B2
公开(公告)日：2015-09-01
申请号：US14571914
申请日：2014-12-16
申请人： TECAN TRADING AG
发明人： Marc N. Feiglin , Joseph A. Mamone , Michael Franklin , Timothy Francis Lee
IPC分类号： G01N27/447 , B01L3/00 , B01L3/02 , B01F13/00 , B01L7/00 , C12Q1/68 , G01N27/453
CPC分类号： B01L3/502792 , B01F13/0071 , B01F13/0076 , B01F2215/0037 , B01L3/0268 , B01L3/502715 , B01L3/527 , B01L7/525 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2200/16 , B01L2300/0636 , B01L2300/0819 , B01L2300/1822 , B01L2300/1883 , B01L2400/0409 , B01L2400/0415 , B01L2400/0427 , B01L2400/0475 , C12Q1/686 , G01N27/447 , G01N27/44756 , G01N27/453 , C12Q2563/143 , C12Q2563/149 , C12Q2563/159
摘要： A biological sample processing system (1) includes a liquid droplet manipulation instrument (20) with an electrode array (21) for inducing a movement of a liquid droplet (19) by electrowetting; a substrate (22); and a control unit (23). An electrode selector (34) of the control unit (23) is configured to individually select and provide each electrode (35) of the electrode array (21) with a voltage. The control unit (23) includes a central processing unit (36) for individually selecting at least one electrode (35) and for providing the selected electrode(s) (35) with an individual voltage pulse. The biological sample processing system (1) also includes a cartridge (40) with a container (2).
摘要翻译：生物样品处理系统（1）包括具有电极阵列（21）的液滴操作仪器（20），用于通过电润湿来诱导液滴（19）的移动; 衬底（22）; 和控制单元（23）。控制单元（23）的电极选择器（34）被配置为单独地选择并提供电极阵列（21）的每个电极（35）。控制单元（23）包括一个中央处理单元（36），用于分别选择至少一个电极（35），并为所选择的电极（35）提供一个单独的电压脉冲。生物样品处理系统（1）还包括具有容器（2）的盒（40）。

162. 发明授权

US08882982B2 System and instrument for processing biological samples and manipulating liquids having biological samples 有权
标题翻译：用于处理生物样品和操作具有生物样品的液体的系统和仪器
公开(公告)号：US08882982B2
公开(公告)日：2014-11-11
申请号：US13139647
申请日：2009-12-16
申请人： Marc N. Feiglin
发明人： Marc N. Feiglin
IPC分类号： G01N27/453 , B01L3/00 , B01L3/02
CPC分类号： B01L3/502792 , B01F13/0071 , B01F13/0076 , B01F2215/0037 , B01L3/0268 , B01L3/502715 , B01L3/527 , B01L7/525 , B01L2200/027 , B01L2200/0605 , B01L2200/10 , B01L2200/16 , B01L2300/0636 , B01L2300/0819 , B01L2300/1822 , B01L2300/1883 , B01L2400/0409 , B01L2400/0415 , B01L2400/0427 , B01L2400/0475 , C12Q1/686 , G01N27/447 , G01N27/44756 , G01N27/453 , C12Q2563/143 , C12Q2563/149 , C12Q2563/159
摘要： A biological sample processing system comprises a container for large volume processing, a flat polymer film having a lower surface and a hydrophobic upper surface, which is kept at a distance d to the base side of the container by the protrusions. The distance d defines at least one gap when the container is positioned on the film. A liquid droplet manipulation instrument comprises at least one electrode array for inducing liquid droplet movements; a substrate supporting the at least one electrode array; and a control unit is characterized in that the container and the film are reversibly attached to the liquid droplet manipulation instrument. The system thus enables displacement of at least one liquid droplet from the at least one well through the channel of the container onto the hydrophobic upper surface of the flat polymer film and above the at least one electrode array; wherein the liquid droplet manipulation instrument controls a guided movement of the liquid droplet on the hydrophobic upper surface of the flat polymer film by electrowetting and to process there the biological sample.
摘要翻译：生物样品处理系统包括用于大体积加工的容器，具有下表面和疏水性上表面的平坦聚合物膜，其通过突起保持在容器底部的距离d处。当容器位于胶片上时，距离d限定至少一个间隙。液滴操作仪器包括用于引起液滴运动的至少一个电极阵列; 支撑所述至少一个电极阵列的基板; 并且控制单元的特征在于，容器和膜可逆地附接到液滴操纵仪器。因此，该系统使得至少一个液滴从至少一个井通过容器的通道移位到平坦聚合物膜的疏水性上表面上并位于至少一个电极阵列上方; 其特征在于，所述液滴操作装置通过电润湿来控制所述液滴在所述平坦聚合物膜的所述疏水性上表面上的引导移动，并在所述生物样品处理。

163. 发明申请

US20140200683A1 LABORATORY SYSTEM 有权
标题翻译：实验室系统
公开(公告)号：US20140200683A1
公开(公告)日：2014-07-17
申请号：US13739455
申请日：2013-01-11
申请人： TECAN TRADING AG
发明人： Mark MA
IPC分类号： G05B15/02
CPC分类号： G05B15/02 , B01L3/0293 , G01N35/1011 , G01N35/109 , G01N2035/1076 , G05B19/0426 , G05B2219/25482
摘要： A laboratory system and a method for controlling a laboratory system comprises multiple subsystems; each subsystem being configured to receive and carry out a command; and a master control device configured to process command groups and/or command(s) within the same command group simultaneously; to process command groups and/or command(s) of different command groups sequentially; and within a command group, to process command group(s) and/or command(s) grouped into a command group before processing other commands command group(s) and/or command(s).
摘要翻译：实验室系统和控制实验室系统的方法包括多个子系统; 每个子系统被配置为接收和执行命令; 以及主控制装置，被配置为同时处理同一命令组内的命令组和/或命令; 按顺序处理不同命令组的命令组和/或命令; 并在命令组内处理在处理其他命令组和/或命令之前分组到命令组中的命令组和/或命令。

164. 发明授权

US08658042B2 Microplate carrier having magnets 有权
标题翻译：具有磁铁的微孔板载体
公开(公告)号：US08658042B2
公开(公告)日：2014-02-25
申请号：US12198210
申请日：2008-08-26
申请人： Gerhard Fasching , Teresa Hruschka , Lutz Niggl , Patrick Niklaus
发明人： Gerhard Fasching , Teresa Hruschka , Lutz Niggl , Patrick Niklaus
IPC分类号： B01L3/00 , G01N31/20 , B03C1/30
CPC分类号： B03C1/288 , B01L3/5085 , B01L9/523 , B01L2300/0829 , B03C2201/18 , G01N35/0098
摘要： Relates to a microplate carrier (1) for a microplate (2), in whose wells (3) magnetic particles (5), which are suspended in a liquid (4), with or without samples adhering thereto are located, the microplate carrier (1) comprising permanent magnets (6) generating magnetic fields which are implemented to collect and retain the magnetic particles (5) on the floor (14) and/or on the walls (7) of the wells (3) of this microplate (2). The microplate carrier (1) according to the invention is characterized in that it comprises two permanent magnets (6) situated diametrically opposite in relation to the well (3) for each well (3) of the microplate (2), which have the same polarity directed toward the well (3) and whose magnetic axis (25) is at least essentially perpendicular to the footprint of the microplate (2) to be placed. A corresponding method based on the use of the microplate carrier (1) is also disclosed.
摘要翻译：与微孔板（2）的微板载体（1）相关，微板载体（2）位于其中悬挂在液体（4）中的孔（3）中的磁性颗粒（5））中，附着或不附着样品，微板载体 1）包括产生磁场的永磁体（6），其被实施以收集并保持在该微孔板（2）的孔（3）的地板（14）和/或壁（7）上的磁性颗粒（5））。根据本发明的微孔板载体（1）的特征在于它包括相对于微板（2）的每个孔（3）相对于井（3）径向相对的两个永磁体（6），其具有相同的指向井（3）的极性，其磁轴（25）至少基本上垂直于要放置的微板（2）的覆盖区。还公开了基于微板载体（1）的使用的相应方法。

165. 发明申请

US20140036070A1 METHOD AND APPARATUS FOR DETECTING OR CHECKING AN ARRANGEMENT OF LABORATORY ARTICLES ON A WORK AREA OF A LABORATORY WORK STATION 有权
标题翻译：用于检测或检查实验室文件在实验室工作站工作区域的方法和装置
公开(公告)号：US20140036070A1
公开(公告)日：2014-02-06
申请号：US13954158
申请日：2013-07-30
申请人： Tecan Trading AG
发明人： Simon M. Eckard , Nikolaus Ingenhoven
IPC分类号： G06K9/00
CPC分类号： G06K9/00624 , G06T7/74 , G06T2207/20104
摘要： A method of detecting an original arrangement of laboratory articles of a laboratory work station records reference digital images with a digital camera. An image is displayed and visible regions with characteristic features are selected by a user within an input device. Reference image sections and corresponding reference image parameter files are produced and stored. A current arrangement of laboratory articles is compared with a previously recorded original arrangement. Detection of the current arrangement occurred by recording current digital images with a digital camera and creating current image sections defined by X/Y parameters of the reference image parameter files from the current digital images. A computer-based comparison of the processed current image sections with the processed reference image sections occurred and an analysis of this comparison and the display of agreements, deviations and errors is found.
摘要翻译：检测实验室工作站的实验室物品的原始布置的方法用数字照相机记录参考数字图像。显示图像，并且用户在输入设备内选择具有特征特征的可见区域。生成并存储参考图像部分和对应的参考图像参数文件。将现有的实验室物品安排与以前记录的原始安排进行比较。通过使用数字照相机记录当前数字图像并且从当前数字图像创建由参考图像参数文件的X / Y参数定义的当前图像部分来发生当前布置的检测。发生了处理过的当前图像部分与经处理的参考图像部分的基于计算机的比较，并且发现了该比较的分析以及协议，偏差和错误的显示。

166. 发明授权

US08602470B2 Gripper claw with replaceable gripper fingers 有权
标题翻译：夹爪用可更换夹爪的手指
公开(公告)号：US08602470B2
公开(公告)日：2013-12-10
申请号：US13549970
申请日：2012-07-16
申请人： Tino Bieler
发明人： Tino Bieler
IPC分类号： B66C1/42
CPC分类号： B25J15/026 , B25J15/0475
摘要： A gripper claw has replaceable gripper fingers and two gripper jaws each with a first jaw flange. The jaws are fastened to respective jaw flanges and are movable on linear guides, toward and away from one another. Each jaw has a holding mandrel, with holding cone. Each finger is reversibly insertable into one gripper jaw and has a finger base with depression complementary to a respective cone. The cone has a length that is at least one-third of its largest diameter, and its smallest diameter is at most 90% of the largest cone diameter. The jaws and the bases form a holding mechanism which holds the fingers in a stop position on a respective gripper jaw and they form a stabilizing mechanism that, with the holding cone, prevent tilting of the fingers.
摘要翻译：夹爪具有可更换的夹爪和两个夹爪，每个具有第一夹爪。钳口被紧固到相应的钳口凸缘上，并且可以在线性引导件上彼此朝向和远离地移动。每个钳口具有保持心轴，具有保持锥。每个手指可逆地插入到一个夹爪中，并具有带有与相应锥体互补的凹陷的手指基部。锥体的长度至少为其最大直径的三分之一，其最小直径为最大圆锥直径的至多90％。夹爪和基座形成保持机构，该保持机构将手指保持在相应夹持爪上的停止位置，并且它们形成稳定机构，与保持锥一起防止手指倾斜。

167. 发明申请

US20130126552A1 METHOD FOR SELECTING PIPETTING PARAMETERS FOR A LIQUID 有权
标题翻译：选择液体配管参数的方法
公开(公告)号：US20130126552A1
公开(公告)日：2013-05-23
申请号：US13736658
申请日：2013-01-08
申请人： Tecan Trading AG
发明人： Nikolaus INGENHOVEN , Robert LIEBHARD , Adi ZUPPIGER , Werner HALG
IPC分类号： G01N1/14
CPC分类号： G01N1/14 , B01L3/021 , B01L2200/143 , B01L2200/146 , B01L2400/0487 , G01N35/1016 , G01N2035/1025 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/2575
摘要： A method of selecting pipetting parameters of a pipetting device for dispensing or pipetting a specific volume of a liquid sample, includes a fluid column of a fluid chamber of the pipetting device set into oscillation at the beginning of the aspiration, the pressure is monitored with the pressure transducer in the fluid chamber, and the pressure changes generated during aspiration into measuring signals are recorded. These measuring signals are processed by a computer or micro-processor and reproduced as a pressure curve, which is characteristic for the fluid column with the aspirated liquid sample, and which is compared with known pressure curves. Based on this comparison, pipetting parameters of the pipetting device are selected for the dispense or for pipetting a specific volume of the liquid sample. Selectable pipetting parameters include a speed of a movement of a pump piston of the pipetting device.
摘要翻译：选择用于分配或吸移特定体积的液体样品的移液装置的移液参数的方法包括在抽吸开始时设置成振荡的移液装置的流体室的流体柱，压力由记录在流体室中的压力传感器，并且记录在抽吸期间产生的测量信号中的压力变化。这些测量信号由计算机或微处理器处理并作为压力曲线再现，该压力曲线是具有吸入液体样品的流体柱的特征，并且与已知的压力曲线进行比较。基于该比较，选择移液装置的移液参数用于分配或吸移特定体积的液体样品。可选择的移液参数包括移液装置的泵活塞的移动速度。

168. 发明授权

US08357544B2 Method for selecting pipetting parameters for a liquid 有权
标题翻译：选择液体移液参数的方法
公开(公告)号：US08357544B2
公开(公告)日：2013-01-22
申请号：US11488473
申请日：2006-07-18
申请人： Nikolaus Ingenhoven , Robert Liebhard , Adi Zuppiger , Werner Hälg
发明人： Nikolaus Ingenhoven , Robert Liebhard , Adi Zuppiger , Werner Hälg
IPC分类号： G01N1/10
CPC分类号： G01N1/14 , B01L3/021 , B01L2200/143 , B01L2200/146 , B01L2400/0487 , G01N35/1016 , G01N2035/1025 , Y10T436/11 , Y10T436/113332 , Y10T436/115831 , Y10T436/2575
摘要： The present invention relates to a method for classifying a liquid (1) in a known pipetting system for this liquid (1), the method being characterized in that the changes of a selected, measurable, and physically founded virtual parameter are detected as a data set typical for this liquid (1); this typical data set of the selected virtual parameter is compared to corresponding data sets of known liquids, and the liquid (1) is classified on the basis of this comparison. An especially preferred method and a device for classifying a liquid (1) relate to a device which comprises a fluid chamber (2), to which a measuring chamber (3) is connected, whose internal pressure is monitored using a pressure transducer (4). At least a first part (5) of this fluid chamber (2) may be brought into fluid connection with a sample (6) of this liquid (1).
摘要翻译：本发明涉及一种用于对该液体（1）的已知吸移系统中的液体（1）进行分类的方法，其特征在于，将所选择的，可测量的和物理上建立的虚拟参数的变化作为数据被检测为这种液体（1）设定典型; 将所选虚拟参数的典型数据集与已知液体的相应数据集进行比较，并且基于该比较对液体（1）进行分类。用于分类液体（1）的特别优选的方法和装置涉及一种包括流体室（2）的装置，其中连接有测量室（3），其内部压力使用压力传感器（4）监测，。该流体室（2）的至少第一部分（5）可以与该液体（1）的样品（6）流体连接。

169. 发明授权

US08216527B2 Positive displacement pump with pressure sensor 有权
标题翻译：具有压力传感器的正排量泵
公开(公告)号：US08216527B2
公开(公告)日：2012-07-10
申请号：US12985119
申请日：2011-01-05
申请人： Jimmy Dzuong
发明人： Jimmy Dzuong
IPC分类号： B01L3/00
CPC分类号： B01L3/0217 , B01L3/0275 , B01L2200/025 , B01L2200/14 , B01L2300/0627 , B01L2300/0832 , B01L2300/0858 , B01L2300/14 , B01L2400/0478
摘要： A positive displacement pump (1) is equipped with a pump cylinder (2), a pump piston (7), a cylinder space (9), a pressure sensor (10), and a pressure channel (12). A main portion (13) of the pressure channel (12) extends parallel to a longitudinal axis (3) of the pump cylinder (2), for providing fluidic connection between the cylinder space (9) and the pressure sensor (10). In the improved alternative positive displacement pump (1), the cylinder wall (4) comprises a piston sleeve (14) that is located on the inner side of the cylinder wall (4) and that extends over essentially the entire length of the pump cylinder (2) to the cylinder bottom (5). The improved alternative positive displacement pump (1) is further characterized in that, the main portion (13) of the pressure channel (12) is located in the cylinder wall (4) comprising the piston sleeve (14), which is thus preventing the pump piston (7) from touching or compromising the pressure sensor (10) or an inner surface (30) of the cylinder wall (4) when moving past the position of the pressure sensor (10). Also disclosed are a liquid handling robot that comprises a single or multiple arrangement of the positive displacement pump (1) and liquid handling workstation that comprises such a liquid handling robot.
摘要翻译：正排量泵（1）配备有泵缸（2），泵活塞（7），气缸空间（9），压力传感器（10）和压力通道（12）。压力通道（12）的主要部分（13）平行于泵缸（2）的纵向轴线（3）延伸，用于在气缸空间（9）和压力传感器（10）之间提供流体连接。在改进的替代正排量泵（1）中，气缸壁（4）包括位于气缸壁（4）的内侧上的活塞套筒（14），并且基本上在泵缸体的整个长度上延伸（2）连接到气缸底部（5）。改进的替代正排量泵（1）的特征还在于，压力通道（12）的主要部分（13）位于包括活塞套筒（14）的气缸壁（4）中，从而防止泵活塞（7）在移动经过压力传感器（10）的位置时不接触或损害压力传感器（10）或气缸壁（4）的内表面（30）。还公开了一种液体处理机器人，其包括容积式泵（1）的单个或多个排列以及包括这种液体处理机器人的液体处理工作站。

170. 发明授权

US08215826B2 Device and method for moving liquid containers 有权
标题翻译：移液装置的装置及方法
公开(公告)号：US08215826B2
公开(公告)日：2012-07-10
申请号：US11913363
申请日：2006-05-04
申请人： Adi Zuppiger , Roland Fuchs , Urs Knecht
发明人： Adi Zuppiger , Roland Fuchs , Urs Knecht
IPC分类号： B01F11/00 , B01F11/02 , B65H1/00
CPC分类号： B01F11/0014 , B01F11/0022 , B01F11/0034 , B01F2215/0037
摘要： A method according to Claim 25, wherein essentially homogeneous material mixtures are achieved or maintained in these liquid containers.
摘要翻译： 26.根据权利要求25的方法，其中在这些液体容器中实现或维持基本均匀的材料混合物。

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