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161. 发明申请

US20080122140A1 Microfluidic systems including three-dimensionally arrayed channel networks 审中-公开
标题翻译：微流体系统包括三维排列的通道网络
公开(公告)号：US20080122140A1
公开(公告)日：2008-05-29
申请号：US11983405
申请日：2007-11-08
申请人： Janelle R. Anderson , Daniel T. Chiu , Rebecca J. Jackman , Oksana Cherniavskaya , J. Cooper McDonald , George M. Whitesides
发明人： Janelle R. Anderson , Daniel T. Chiu , Rebecca J. Jackman , Oksana Cherniavskaya , J. Cooper McDonald , George M. Whitesides
IPC分类号： B29C35/08
CPC分类号： B29C33/3857 , B01D61/18 , B01D67/003 , B01D67/0034 , B01D69/02 , B01D71/70 , B01D2323/24 , B01D2323/34 , B01D2325/028 , B01D2325/08 , B01L3/502707 , B01L2300/0874 , B01L2300/0887 , B29C33/3892 , B29C33/52 , B29C35/0888 , B29C39/021 , B29C39/34 , B29C2035/0827 , B33Y80/00 , B81B2201/058 , B81C1/00119 , B81C2201/019 , Y10T436/11 , Y10T436/2575
摘要： The present invention provides, in certain embodiments, improved microfluidic systems and methods for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The inventive methods can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems provided according to the invention can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks of the invention can be fabricated via replica molding processes, also provided by the invention, utilizing mold masters including surfaces having topological features formed by photolithography. The microfluidic networks of the invention are, in some cases, comprised of a single replica molded layer, and, in other cases, are comprised of two, three, or more replica molded layers that have been assembled to form the overall microfluidic network structure. The present invention also describes various novel applications for using the microfluidic network structures provided by the invention.
摘要翻译：本发明在某些实施方案中提供了改进的微流体系统和用于制造包含一个或多个微流体通道水平的改进的微流体系统的方法。本发明的方法可以提供拓扑复杂和改进的微流体系统的方便的途径。根据本发明提供的微流体系统可以包括其中流体流动路径的三维排列的网络，其中包括跨过网络的其它通道的通道，而在交叉点处没有物理交叉点。本发明的微流体网络可以通过本发明提供的复制模制工艺，利用模具主体，其包括具有通过光刻形成的拓扑特征的表面。在一些情况下，本发明的微流体网络由单个复制模制层组成，并且在其它情况下由两个，三个或更多个复制模制层组成，以形成整个微流体网络结构。本发明还描述了使用本发明提供的微流体网络结构的各种新颖应用。

162. 发明授权

US06858203B2 Method of making phosphate-binding polymers for oral administration 有权
标题翻译：制备磷酸盐结合聚合物用于口服给药的方法
公开(公告)号：US06858203B2
公开(公告)日：2005-02-22
申请号：US10322904
申请日：2002-12-17
申请人： Stephen Randall Holmes-Farley , W. Harry Mandeville, III , George M. Whitesides
发明人： Stephen Randall Holmes-Farley , W. Harry Mandeville, III , George M. Whitesides
IPC分类号： A61K9/14 , A61K31/00 , A61K31/785 , A61K31/795 , A61K45/08 , A61K47/30 , A61P3/00 , C08F8/00 , C08F20/00 , C08F20/02 , C08F20/52 , C08F22/38 , C08F26/00 , C08F26/02 , C08G59/40 , C08G73/00 , C08G73/02 , C08K5/02 , C08K5/09 , C08K5/11 , C08K5/1515 , C08K5/29 , C08L39/02 , C08L79/02
CPC分类号： A61K31/662 , A61K31/785 , A61K31/795
摘要： Phosphate-binding polymers are provided for removing phosphate from the gastrointestinal tract. The polymers are orally administered, and are useful for the treatment of hyperphosphatemia.
摘要翻译：提供磷酸盐结合聚合物用于从胃肠道除去磷酸盐。口服聚合物，可用于治疗高磷血症。

163. 发明授权

US06843262B2 Fluidic switches and methods for controlling flow in fluidic systems 有权
标题翻译：用于控制流体系统流量的流体开关和方法
公开(公告)号：US06843262B2
公开(公告)日：2005-01-18
申请号：US10131610
申请日：2002-04-24
申请人： Rustem F. Ismagilov , Paul J. A. Kenis , George M. Whitesides , David Rosmarin
发明人： Rustem F. Ismagilov , Paul J. A. Kenis , George M. Whitesides , David Rosmarin
IPC分类号： F15C1/14 , F15C5/00 , F16K99/00 , F17D1/16
CPC分类号： F15C1/146 , F15C5/00 , F16K99/0001 , F16K99/0028 , F16K99/0042 , F16K2099/0078 , F16K2099/0084 , F16K2099/0094 , Y10T137/0396 , Y10T137/2164 , Y10T137/2191 , Y10T137/2224 , Y10T137/2808
摘要： The present invention relates to fluidic systems, including switches for fluidic systems. The switches of the present invention may be particularly applicable to microfluidic systems. The switches of the invention may include a switching region having more than one position corresponding to more than one aspect ratio. Alternatively, the switches of the invention may include multiple inlets and a system for the selective supply of carrier fluid. The present invention also relates to a method of controlling a fluid in a microfluidic system and may be performed using the switches of the present invention.
摘要翻译：本发明涉及流体系统，包括用于流体系统的开关。本发明的开关可以特别适用于微流体系统。本发明的开关可以包括具有多于一个对应于多于一个宽高比的位置的开关区域。或者，本发明的开关可以包括多个入口和用于选择性地供应载体流体的系统。本发明还涉及一种控制微流体系统中的流体的方法，并且可以使用本发明的开关来执行。

164. 发明授权

US06767194B2 Valves and pumps for microfluidic systems and method for making microfluidic systems 有权
公开(公告)号：US06767194B2
公开(公告)日：2004-07-27
申请号：US10041718
申请日：2002-01-08
申请人： Noo Li Jeon , Daniel T. Chiu , Christopher J. Wargo , Insung S. Choi , Hongkai Wu , Janelle R. Anderson , George M. Whitesides , Justin C. McDonald , Steven J. Metallo , Howard A. Stone
发明人： Noo Li Jeon , Daniel T. Chiu , Christopher J. Wargo , Insung S. Choi , Hongkai Wu , Janelle R. Anderson , George M. Whitesides , Justin C. McDonald , Steven J. Metallo , Howard A. Stone
IPC分类号： F04B5310
CPC分类号： B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/16 , B01L2300/0816 , B01L2300/0887 , B01L2400/0487 , B01L2400/0611 , B01L2400/0638 , B01L2400/0677 , F04B43/043 , F16K99/0001 , F16K99/0007 , F16K99/0015 , F16K99/003 , F16K99/0034 , F16K99/0048 , F16K99/0057 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , F16K2099/0086 , F16K2099/0094 , Y10T137/0497 , Y10T137/7891 , Y10T137/7895 , Y10T137/791 , Y10T137/87917
摘要： The present invention relates to microfluidic systems, including valves and pumps for microfluidic systems. The valves of the invention include check valves such as diaphragm valves and flap valves. Other valves of the invention include one-use valves. The pumps of the present invention include a reservoir and at least two check valves. The reservoir may be of variable volume. The present invention also relates to a flexible microfluidic system. The present invention additionally relates to a method of making microfluidic systems including those of the present invention. The method includes forming a microfluidic system on a master, connecting a support to the microfluidic system and removing the microfluidic system from the master. The support may remain connected to the microfluidic system or the microfluidic system may be transferred to another substrate. The present invention further relates to a method of manipulating a flow of a fluid in a microfluidic system. This method includes initiating fluid flow in a first direction and inhibiting fluid flow in a second direction and may be practiced with the valves of the present invention.

165. 发明授权

US06753131B1 Transparent elastomeric, contact-mode photolithography mask, sensor, and wavefront engineering element 有权
标题翻译：透明弹性体，接触模式光刻掩模，传感器和波前工程元件
公开(公告)号：US06753131B1
公开(公告)日：2004-06-22
申请号：US09422611
申请日：1999-10-21
申请人： John A. Rogers , Rebecca J. Jackman , Kateri E. Paul , Olivier J. A. Schueller , Tricia Lynn Breen , George M. Whitesides
发明人： John A. Rogers , Rebecca J. Jackman , Kateri E. Paul , Olivier J. A. Schueller , Tricia Lynn Breen , George M. Whitesides
IPC分类号： G03C500
CPC分类号： B82Y40/00 , B82Y10/00 , G03F1/34 , G03F1/50 , G03F1/60 , G03F7/0002
摘要： A contact-mode photolithography phase mask includes a diffracting surface having a plurality of indentations and protrusions. The protrusions are brought into contact with a surface of positive photoresist, and the surface exposed to electromagnetic radiation through the phase mask. The phase shift due to radiation passing through the indentations as opposed to the protrusions is essentially complete. Minima in intensity of electromagnetic radiation are thereby produced at boundaries between the indentations and protrusions. The elastomeric mask conforms well to the surface of photoresist and, following development, features smaller than 100 nm can be obtained. Patterns including curved portions are obtained, as well as curved and/or linear patterns on non-planar surfaces. An elastomeric transparent diffraction grating serves also as a spatial light modulator photothermal detector, strain gauge, and display device. A technique for simplified photolithography is also described. A photoreactive, contoured surface is exposed to electricmagnetic radiation and contours in the surface alters the electromagnetic radiation to promote selective surface photoreaction. The contours can act as lenses, gratings, or the like, such that the photoreactive surface itself can selectively direct uniform radiation to promote selective photoreaction within itself. A photoresist layer having a contoured surface thus can be exposed to uniform radiation, without a mask, followed by development and lift-off to create a photoresist pattern that can be used in any of a variety of ways. The invention provides methods of making contoured, photoreactive surfaces, and contoured photoreactive surfaces themselves.
摘要翻译：接触模式光刻相位掩模包括具有多个凹陷和突起的衍射表面。突起与正性光致抗蚀剂的表面接触，并且表面暴露于通过相位掩模的电磁辐射。与突起相反的通过压痕的辐射的相移基本上完成。因此，在凹陷和突起之间的边界处产生电磁辐射强度的微小。弹性体掩模与光致抗蚀剂的表面相适应，并且在显影之后，可以获得小于100nm的特征。获得包括弯曲部分的图案，以及在非平面表面上的曲线和/或线性图案。弹性透明衍射光栅还用作空间光调制器光热检测器，应变计和显示装置。还描述了用于简化光刻的技术。光反应的轮廓表面暴露于电磁辐射，并且表面中的轮廓改变电磁辐射以促进选择性表面光反应。轮廓可以用作透镜，光栅等，使得光反应表面本身可以选择性地引导均匀的辐射以促进其本身内的选择性光反应。因此，具有轮廓表面的光致抗蚀剂层可以暴露于均匀的辐射，而不需要掩模，然后显影和剥离以产生可以以各种方式中的任何一种使用的光致抗蚀剂图案。本发明提供了制造轮廓，光反应表面和轮廓光反应表面本身的方法。

166. 发明授权

US06686184B1 Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks 有权
标题翻译：使用包括三维排列的通道网络的微流体标记的表面图案化
公开(公告)号：US06686184B1
公开(公告)日：2004-02-03
申请号：US09578562
申请日：2000-05-25
申请人： Janelle R. Anderson , Daniel T. Chiu , Noo-Li Jeon , Sui Huang , Ravi Kane , Insung S. Choi , Donald E. Ingber , George M. Whitesides
发明人： Janelle R. Anderson , Daniel T. Chiu , Noo-Li Jeon , Sui Huang , Ravi Kane , Insung S. Choi , Donald E. Ingber , George M. Whitesides
IPC分类号： C12N1100
CPC分类号： C12N11/00 , B01F13/0059 , B01J2219/00382 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01J2219/00725 , B01J2219/00743 , B01L3/0258 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/424 , B29C39/10 , B33Y80/00 , B81B1/00 , B81C99/009 , B82Y5/00 , B82Y30/00 , C40B40/10 , C40B60/14 , G01N33/5005 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/815
摘要： Microfluidic systems and methods are provided for fabricating complex patterns of materials, such as proteins, inorganic materials or cells, on surfaces. Complex, discontinuous patterns on surfaces can be formed incorporating or depositing multiple materials. A stamp structure has a flow path containing a series of interconnected channels. The channels include a first channel within an interior of the stamp structure, a second channel within a stamping surface of the structure defining a pattern, and a channel fluidically interconnecting the first and second channels. After contacting the stamp with a surface, a fluid is introduced into the flow path so that the fluid contacts the surface to form a pattern. In another embodiment, the stamp structure has two non-fluidically interconnected first and second flow paths defining first and second patterns of channels to produce non-continuous first and second patterns on a surface.
摘要翻译：提供微流体系统和方法用于在表面上制造复杂的材料图案，例如蛋白质，无机材料或细胞。可以形成结合或沉积多种材料的表面上的复杂的不连续图案。邮票结构具有包含一系列互连通道的流路。通道包括印模结构内部的第一通道，限定图案的结构的冲压表面内的第二通道以及流体地互连第一和第二通道的通道。在将印模与表面接触之后，将流体引入流动路径中，使得流体接触表面以形成图案。在另一个实施例中，印模结构具有限定第一和第二图案通道的两个非流体互连的第一和第二流动路径，以在表面上产生不连续的第一和第二图案。

167. 发明授权

US06509013B1 Method of making phosphate-binding polymers for oral administration 失效
标题翻译：制备磷酸盐结合聚合物用于口服给药的方法
公开(公告)号：US06509013B1
公开(公告)日：2003-01-21
申请号：US09542329
申请日：2000-04-04
申请人： Stephen Randall Holmes-Farley , W. Harry Mandeville, III , George M. Whitesides
发明人： Stephen Randall Holmes-Farley , W. Harry Mandeville, III , George M. Whitesides
IPC分类号： A61K31785
CPC分类号： A61K31/662 , A61K31/785 , A61K31/795
摘要： Phosphate-binding polymers are provided for removing phosphate from the gastrointestinal tract. The polymers are orally administered, and are useful for the treatment of hyperphosphatemia.
摘要翻译：提供磷酸盐结合聚合物用于从胃肠道除去磷酸盐。口服聚合物，可用于治疗高磷血症。

168. 发明授权

US06304364B1 Elastomeric light valves 失效
标题翻译：弹性光阀
公开(公告)号：US06304364B1
公开(公告)日：2001-10-16
申请号：US08873191
申请日：1997-06-11
申请人： Dong Qin , Younan Xia , George M. Whitesides
发明人： Dong Qin , Younan Xia , George M. Whitesides
IPC分类号： G02B2600
CPC分类号： B82Y30/00 , B82Y10/00 , G02B5/122 , G02B5/201 , G02B5/206 , G02B5/24
摘要： Electromagnetic radiation valves are provided. In one system, a transparent, elastomeric article is provided having a contoured surface including protrusions and intervening indentations. The contoured surface is placed adjacent a transparent plate and a void pattern defined by indentations of the contoured surface is filled with an opaque fluid. The protrusions decrease in cross-sectional area in the direction in which they extend away from the bulk of the elastomeric article, thus compression of the elastomeric protrusions against the transparent plate results in an increase in surface area in elastomeric protrusions against the transparent plate due to deformation of the protrusions, and the opaque fluid is displaced from the voids. Increased transmission of the electromagnetic radiation results. In another system, a similar elastomeric article includes an array of corner cubes that are totally internally reflective of the electromagnetic radiation. Increased deformation of the protrusions of the transparent plate results in decreased total internal reflection of light, due to the progressive destruction of the corner-cube geometry, and the passage of light is increased with compression.
摘要翻译：提供电磁辐射阀。在一个系统中，提供透明的弹性制品，其具有包括突起和中间凹口的轮廓表面。轮廓表面放置在透明板附近，并且由不规则表面的凹痕限定的空隙图案填充有不透明流体。突出部分在其远离弹性体制品的本体延伸的方向上的横截面积减小，因此弹性体突起抵靠透明板的压缩导致弹性体突出物相对于透明板的表面积增加，由于突起的变形，不透明的液体从空隙中移位。增加电磁辐射的传播结果。在另一系统中，类似的弹性体制品包括完全内反射电磁辐射的角立方体阵列。由于角立方几何形状的逐渐破坏，透明板的突起的增加变形导致光的全内反射减少，并且光的通过随着压缩而增加。

169. 发明授权

US6048623A Method of contact printing on gold coated films 失效
标题翻译：镀金膜上接触印刷的方法
公开(公告)号：US6048623A
公开(公告)日：2000-04-11
申请号：US769594
申请日：1996-12-18
申请人： Dennis S. Everhart , George M. Whitesides
发明人： Dennis S. Everhart , George M. Whitesides
IPC分类号： B05D1/28 , B41M3/00 , G03F7/00 , G03F7/16 , B32B15/10
CPC分类号： B82Y30/00 , B05D1/283 , B41M3/003 , B82Y10/00 , B82Y40/00 , G03F7/0002 , G03F7/161 , G03F7/165 , Y10T428/2804
摘要： The present invention comprises methods of contact printing of patterned, self-assembling monolayers of alkanethiolates, carboxylic acids, hydroxamic acids, and phosphonic acids on metallized thermoplastic films, the compositions produced thereby, and the use of these compositions. Patterned self-assembling monolayers allow for the controlled placement of fluids thereon which contain a chemically reactive, indicator functionality. The optical sensing devices produced thereby when the film is exposed to an analyte and light, can produce optical diffraction patterns which differ depending on the reaction of the self-assembling monolayer with the analyte of interest. The light can be in the visible spectrum, and be either reflected from the film, or transmitted through it, and the analyte can be any compound reacting with the fluid on the self-assembling monolayer. The present invention also provides a flexible support for a self-assembling monolayer on gold or another suitable metal.
摘要翻译：本发明包括在金属化热塑性薄膜上接触印刷图案化的自组装单烷基硫醇盐，羧酸，异羟肟酸和膦酸的单元，由此制备的组合物以及这些组合物的用途。图案化的自组装单层允许在其上控制放置含有化学反应性指示剂功能的流体。当膜暴露于分析物和光时，由此产生的光学感测装置可以产生根据自组装单层与感兴趣的分析物的反应而不同的光学衍射图。光可以在可见光谱中，并且可以从膜反射或透过它，并且分析物可以是与自组装单层上的流体反应的任何化合物。本发明还提供了一种对金或其它合适金属上的自组装单层的柔性支撑。

170. 发明授权

US5951881A Fabrication of small-scale cylindrical articles 失效
标题翻译：小型圆柱形制品的制造
公开(公告)号：US5951881A
公开(公告)日：1999-09-14
申请号：US681235
申请日：1996-07-22
申请人： John A. Rogers , Rebecca J. Jackman , George M. Whitesides
发明人： John A. Rogers , Rebecca J. Jackman , George M. Whitesides
IPC分类号： B05D1/28 , G03F7/00 , G03F7/16 , G03F7/18 , G03F7/24 , H01F41/04 , H01L22/027
CPC分类号： G02B6/02142 , B05D1/283 , B82Y30/00 , B82Y40/00 , G02B6/02138 , G03F7/00 , G03F7/161 , G03F7/18 , G03F7/24 , H01F41/042 , G02B6/02152
摘要： Techniques for fabrication of small-scale metallic structures such as microinductors, microtransformers and stents are described. A chemically active agent such as a catalyst is applied from an applicator in a pattern to an exterior surface of an article, metal is deposited according to the pattern and optionally, removed from the substrate. Where the substrate is cylindrical, the pattern can serve as a stent. Alternatively, a pattern of a self-assembled monolayer can be printed on a surface, which pattern can dictate metal plating or etching resulting in a patterned metal structure that can be cylindrical. In another embodiment, a structure is patterned on a surface that serves as a phase-modulating pattern or amplitude-modulating pattern. The article subsequently is exposed to radiation that can induce a change in refractive index within the article, and the phase-modulating or amplitude-modulating pattern results in different indices of refraction being created in different portions of the article. By this technique, a grating can be written into a core of an optical fiber.
摘要翻译：描述了微型电感器，微型变压器和支架等小型金属结构的制造技术。将化学活性剂如催化剂从涂布器以图案施加到制品的外表面，根据图案沉积金属，并任选地从基材上除去金属。在基底为圆柱形的情况下，图案可用作支架。或者，自组装单层的图案可以印刷在表面上，该图案可以规定金属电镀或蚀刻，导致可以是圆柱形的图案化金属结构。在另一个实施例中，在用作相位调制图案或幅度调制图案的表面上图案化结构。该物品随后暴露于可引起制品内的折射率变化的辐射，并且相位调制或幅度调制图案导致在制品的不同部分产生不同的折射率。通过这种技术，可以将光栅写入光纤的核心。

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