专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

151. 发明申请

US20140249158A1 Therapeutic Nanoparticles Comprising a Therapeutic Agent and Methods of Making and Using Same 审中-公开
公开(公告)号：US20140249158A1
公开(公告)日：2014-09-04
申请号：US14276490
申请日：2014-05-13
申请人： BIND Therapeutics, Inc.
发明人： Maria Figueiredo , Erick Peeke , David Dewitt , Christina Van Geen Hoven , Greg Troiano , James Wright , Young-Ho Song , Hong Wang
IPC分类号： A61K9/51 , A61K31/506 , A61K31/404
CPC分类号： A61K9/1617 , A61K9/0019 , A61K9/1647 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K9/5192 , A61K31/404 , A61K31/506 , A61K47/10 , A61K47/12 , A61K47/34 , A61K47/541 , A61P35/00
摘要： The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable nitrogen, and a polymer. Other aspects include methods of making and using such nanoparticles.

152. 发明申请

US20140213641A1 POLYMERIC NANOPARTICLES FOR DRUG DELIVERY 审中-公开
标题翻译：用于药物递送的聚合物纳米颗粒
公开(公告)号：US20140213641A1
公开(公告)日：2014-07-31
申请号：US14115991
申请日：2012-05-09
申请人： Salvador Borros Gomez , Primiano Pio Di Mauro
发明人： Salvador Borros Gomez , Primiano Pio Di Mauro
IPC分类号： A61K9/51 , A61K31/337
CPC分类号： A61K9/5153 , A61K9/0019 , A61K31/337
摘要： Disclosed are nanoparticles comprising a block copolymer and optionally one or more active agent(s), compositions comprising said nanoparticles and methods of preparing said nanoparticles. The block copolymer comprises blocks (i) a first polymer that is a polyester or polyamide and (ii) a second polymer comprising a hydrocarbon chain containing ester or ether bonds with hydroxyl number ≧10. The active agent(s) may be present within the nanoparticles or on the surfaces of the nanoparticles. The nanoparticles may optionally be associated with a surface-modifying moiety such that they are useful as drug delivery and molecular imaging devices. The surface-modifying moiety may target the nanoparticles to a desired target, cell, tissue or biomarker.
摘要翻译：公开了包含嵌段共聚物和任选的一种或多种活性剂的纳米颗粒，包含所述纳米颗粒的组合物和制备所述纳米颗粒的方法。嵌段共聚物包含嵌段（i）第一聚合物，其为聚酯或聚酰胺，和（ii）第二聚合物，其包含含羟基≥10的含烃链或酯键的烃链。活性剂可以存在于纳米颗粒内或纳米颗粒的表面上。纳米颗粒可以任选地与表面改性部分相关联，使得它们可用作药物递送和分子成像装置。表面改性部分可以将纳米颗粒靶向所需的靶，细胞，组织或生物标志物。

153. 发明申请

US20140205671A1 SYNTHESIS AND USE OF POLYHYDROXYALKANOATE (PHA) NANOCAPSULES AS A PROTEIN CARRIER 审中-公开
标题翻译：作为蛋白质载体的聚羟基烷酸（PHA）纳米催化剂的合成与利用
公开(公告)号：US20140205671A1
公开(公告)日：2014-07-24
申请号：US14158053
申请日：2014-01-17
申请人： NANO AND ADVANCED MATERIALS INSTITUTE LIMITED
发明人： Peter Hoi Fu YU , Alex Ho Yin CHAN , Kwok Ping HO
IPC分类号： A61K9/51 , A61K38/28
CPC分类号： A61K9/5153 , A61K38/22 , A61K38/28
摘要： A method of synthesizing PHA nanocapsules as a protein carrier, particularly, the synthesis of PHA nanocapsules synthesized by a modified precipitation/solvent evaporation technique with neutralization. Specifically, the method comprises the steps of sonicating a first solution comprising a triblock PHA copolymer, stirring the first solution into a second solution to give a third solution, the second solution containing a protein, and the second solution being acidic. Further, the method comprises adding the third solution with a neutralizing agent to give a neutralized solution, and sonicating the neutralized solution to form a final solution, wherein the synthesized PHA nanocapsules containing the protein are formed in the final solution. Further, PHA nanocapsules encapsulated with the protein is used by administering the synthesized PHA nanocapsule to an animal in need thereof via the oral cavity.
摘要翻译：合成PHA纳米胶囊作为蛋白质载体的方法，特别是通过改性沉淀/溶剂蒸发技术中和合成的PHA纳米胶囊的合成方法。具体地说，该方法包括以下步骤：超声处理包含三嵌段PHA共聚物的第一溶液，将第一溶液搅拌成第二溶液以产生第三溶液，第二溶液含有蛋白质，第二溶液为酸性。此外，该方法包括用中和剂加入第三溶液以得到中和的溶液，并且将中和的溶液超声处理以形成最终溶液，其中在最终溶液中形成含有蛋白质的合成的PHA纳米胶囊。此外，通过将合成的PHA纳米胶囊经由口腔给予有需要的动物来使用用蛋白质包封的PHA纳米胶囊。

154. 发明申请

US20140186453A1 Therapeutic Polymeric Nanoparticles with mTOR Inhibitors and Methods of Making and Using Same 有权
标题翻译：具有mTOR抑制剂的治疗性聚合物纳米颗粒及其制备和使用方法
公开(公告)号：US20140186453A1
公开(公告)日：2014-07-03
申请号：US14091343
申请日：2013-11-27
申请人： BIND Therapeutics, Inc.
发明人： Stephen E. Zale , Greg Troiano , Mir Mukkaram Ali , Jeff Hrkach , James Wright
IPC分类号： A61K9/14 , A61K31/436
CPC分类号： A61K9/14 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/00 , A61K31/435 , A61K31/436 , C07C59/08 , Y10S977/773
摘要： The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 1 to about 20 weight percent of a mTOR inhibitor; and about 70 to about 99 weight percent biocompatible polymer.
摘要翻译：本公开一般涉及治疗性纳米颗粒。本文公开的示例性纳米颗粒可包括约1至约20重量％的mTOR抑制剂; 和约70至约99重量％的生物相容性聚合物。

155. 发明授权

US08758826B2 Cannabinoid receptor binding agents, compositions, and methods 有权
标题翻译：大麻素受体结合剂，组合物和方法
公开(公告)号：US08758826B2
公开(公告)日：2014-06-24
申请号：US13541400
申请日：2012-07-03
申请人： Jonathan Austin Bevier
发明人： Jonathan Austin Bevier
IPC分类号： A61K9/00 , A61K9/14 , A61K31/05 , A61K31/352 , A61K31/343 , A61P17/00 , A61K31/353 , A61K9/70 , A61K9/51 , A61K47/10 , A61K47/48
CPC分类号： A61K9/14 , A61K9/0014 , A61K9/127 , A61K9/5153 , A61K9/5161 , A61K9/7015 , A61K9/7061 , A61K31/05 , A61K31/085 , A61K31/192 , A61K31/352 , A61K31/353 , A61K47/10 , A61K47/38 , A61K47/6923 , A61K47/6929 , A61K47/6939 , Y10T428/2982
摘要： A composition comprising a cannabinoid receptor binding agent attached to a particle for the treatment of skin conditions. The particle may be a nanoparticle, such as nanocrystalline cellulose. The particle may further be modified with functional moieties. Drug delivery properties may be modified by coating the particles or using vesicles to deliver the cannabinoid receptor binding agent and particle. A substrate may be used to deliver the composition to the skin.
摘要翻译：一种组合物，其包含与粒子连接以用于治疗皮肤病症的大麻素受体结合剂。颗粒可以是纳米颗粒，例如纳米晶体纤维素。颗粒可以进一步用功能部分修饰。可以通过涂覆颗粒或使用囊泡来递送大麻素受体结合剂和颗粒来改变药物递送性质。可以使用底物将组合物递送至皮肤。

156. 发明申请

US20140161893A1 POLYMER BLEND PARTICLES FOR INTRACELLULAR DELIVERY OF AGENTS 审中-公开
标题翻译：用于细胞递送代理的聚合物混合颗粒
公开(公告)号：US20140161893A1
公开(公告)日：2014-06-12
申请号：US14152876
申请日：2014-01-10
申请人： University of Washington through its Center for Commercialization
发明人： Hong Shen , Patrick S. Stayton , Anthony Convertine , Kenny K. Tran
IPC分类号： A61K9/14 , A61K39/00
CPC分类号： A61K39/00 , A61K9/5026 , A61K9/5138 , A61K9/5153 , A61K9/5192 , A61K38/00 , A61K39/385 , A61K2039/55555 , A61K2039/55561
摘要： Core-shell polymer blend particles are described. The particles include a pH-responsive polymeric shell and a pH-irresponsive polymeric core. The core can include a biodegradable hydrolysable polymer and the shell can include a pH-responsive copolymer that can include constitutional units that are cationic and/or anionic at physiological pH. The core-shell polymer blend particles can allow the controlled delivery of agents into a plurality of distinct intracellular compartments.
摘要翻译：描述了核 - 壳聚合物共混物颗粒。颗粒包括pH响应聚合物壳和不含pH的聚合物核心。核心可以包括可生物降解的可水解聚合物，并且壳可以包括pH响应性共聚物，其可以包括在生理pH下为阳离子和/或阴离子的结构单元。核 - 壳聚合物共混物颗粒可以允许将药剂控制递送到多个不同的细胞内区室中。

157. 发明申请

US20140161891A1 COMPOSITION OF PI3K INHIBITOR AND USE THEREOF 审中-公开
标题翻译： PI3K抑制剂的组成及其用途
公开(公告)号：US20140161891A1
公开(公告)日：2014-06-12
申请号：US13710026
申请日：2012-12-10
申请人： WU-CHOU SU , DAR-BIN SHIEH , CHEN-SHENG YEH , CHIA-CHENG HOU
发明人： WU-CHOU SU , DAR-BIN SHIEH , CHEN-SHENG YEH , CHIA-CHENG HOU
IPC分类号： A61K9/50 , A61K31/5377
CPC分类号： A61K31/5377 , A61K9/146 , A61K9/5153
摘要： The present invention is related to a composition of PI3K inhibitor, comprising: 0.01˜10 mg of PI3K inhibitor; 10˜500 mg of poly(lactic-co-glycolic acid) (PLGA) which is encapsulated onto the surface of the PI3K inhibitor and the surface is non-modified by a modifier; and the composition has a size of 10˜1000 nm. Thereby, an excellent effect on suppressing the growth of tumor cells will be achieved by the encapsulation of PI3K inhibitor into PLGA nanomaterials without any modifier on its surface, the optimization of a ratio of PI3K inhibitor to PLGA, and the accordingly slow release of the composition.
摘要翻译：本发明涉及PI3K抑制剂的组合物，其包含：0.01〜10mg PI3K抑制剂; 将10〜500mg封装在PI3K抑制剂表面上的聚（乳酸 - 共 - 乙醇酸）（PLGA）和表面未被改性剂修饰; 该组合物的尺寸为10〜1000nm。因此，通过将PI3K抑制剂包被在PLGA纳米材料中，在其表面上没有任何改性剂，优化PI3K抑制剂与PLGA的比例以及相应的组合物缓慢释放，可以实现抑制肿瘤细胞生长的良好效果。

158. 发明申请

US20140141067A1 MODIFIED POLYNUCLEOTIDES ENCODING SEPTIN-4 有权
标题翻译：修饰的多核苷酸编码SEPTIN-4
公开(公告)号：US20140141067A1
公开(公告)日：2014-05-22
申请号：US14107079
申请日：2013-12-16
申请人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Susan Whoriskey , Ron Weiss
发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Susan Whoriskey , Ron Weiss
IPC分类号： C07K14/47
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
摘要翻译：本发明涉及用于制备，制造和治疗使用肿瘤学相关多核苷酸，肿瘤学相关的初级转录物和肿瘤相关的mmRNA分子的组合物和方法。

159. 发明申请

US20140107189A1 MODIFIED POLYNUCLEOTIDES ENCODING APOPTOSIS INDUCING FACTOR 1 有权
标题翻译：修饰的多核苷酸编码病毒诱导因子1
公开(公告)号：US20140107189A1
公开(公告)日：2014-04-17
申请号：US14106988
申请日：2013-12-16
申请人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Susan Whoriskey , Ron Weiss
发明人： Stephane Bancel , Tirtha Chakraborty , Antonin de Fougerolles , Susan Whoriskey , Ron Weiss
IPC分类号： C07K14/535 , C07K14/505
CPC分类号： A61K48/0066 , A61K9/1271 , A61K9/145 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K31/7115 , A61K38/00 , A61K38/17 , A61K38/177 , A61K38/1816 , A61K38/1891 , A61K38/191 , A61K38/193 , A61K38/212 , A61K38/45 , A61K38/4846 , A61K47/543 , A61K48/0033 , A61K48/005 , A61K48/0075 , C07H21/02 , C07K14/005 , C07K14/435 , C07K14/43595 , C07K14/47 , C07K14/4705 , C07K14/4713 , C07K14/4723 , C07K14/4746 , C07K14/475 , C07K14/485 , C07K14/495 , C07K14/505 , C07K14/515 , C07K14/525 , C07K14/535 , C07K14/5418 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/745 , C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/40 , C12N9/0069 , C12N9/0091 , C12N9/1051 , C12N9/1241 , C12N9/16 , C12N9/2402 , C12N9/2445 , C12N9/6435 , C12N9/6437 , C12N9/644 , C12N9/6443 , C12N9/6451 , C12N9/88 , C12N9/93 , C12N15/11 , C12N15/52 , C12N15/85 , C12N15/87 , C12P13/04 , C12P21/00 , C12P21/005 , C12Y113/12007 , C12Y116/03001 , C12Y207/07012 , C12Y304/21007 , C12Y304/21022 , C12Y304/21027 , C12Y403/02001 , C12Y603/02019 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/423 , Y02A50/463 , Y02A50/491
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related primary transcripts and oncology-related mmRNA molecules.
摘要翻译：本发明涉及用于制备，制造和治疗使用肿瘤学相关多核苷酸，肿瘤学相关的初级转录物和肿瘤相关的mmRNA分子的组合物和方法。

160. 发明申请

US20140072632A1 METHODS FOR FABRICATING ISOLATED MICRO- OR NANO-STRUCTURES USING SOFT OR IMPRINT LITHOGRAPHY 有权
标题翻译：使用软件或印刷图形制作分离的微米或纳米结构的方法
公开(公告)号：US20140072632A1
公开(公告)日：2014-03-13
申请号：US13852683
申请日：2013-03-28
申请人： The University of North Carolina at Chapel Hill
发明人： Joseph M. DeSimone , Jason P. Rolland , Benjamin W. Maynor , Larken E. Euliss , Ginger Denison Rothrock , Ansley E. Dennis , Edward T. Samulski , R. Jude Samulski
IPC分类号： A61K9/14
CPC分类号： A61K9/14 , A61K9/0097 , A61K9/5138 , A61K9/5153 , A61K9/5192 , A61K47/34 , B81C99/0085 , B82Y10/00 , B82Y40/00 , G03F7/0002 , H01L51/0004 , H01L51/0021 , Y10T428/24273 , Y10T428/24479 , Y10T428/3154
摘要： The presently disclosed subject matter describes the use of fluorinated elastomer-based materials, in particular perfluoropolyether (PFPE)-based materials, in high-resolution soft or imprint lithographic applications, such as micro- and nanoscale replica molding, and the first nano-contact molding of organic materials to generate high fidelity features using an elastomeric mold. Accordingly, the presently disclosed subject matter describes a method for producing free-standing, isolated nanostructures of any shape using soft or imprint lithography technique.
摘要翻译：目前公开的主题描述了基于氟化弹性体的材料，特别是基于全氟聚醚（PFPE）的材料在高分辨率软或压印光刻应用中的应用，例如微米和纳米级复制成型，以及第一纳米接触使用弹性体模具成型有机材料以产生高保真特征。因此，目前公开的主题描述了使用软或压印光刻技术生产任何形状的独立的，分离的纳米结构的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式