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141. 发明申请

US20130164732A1 INORGANIC PYROPHOSPHATE AND USES THEREOF 有权
标题翻译：无机磷酸盐及其用途
公开(公告)号：US20130164732A1
公开(公告)日：2013-06-27
申请号：US13708728
申请日：2012-12-07
申请人： The Curators of the University of Missouri
发明人： Peter Sutovsky , Young-Joo Yi
IPC分类号： A01N1/02 , C12N5/075 , A61D19/02 , C12N5/02
CPC分类号： A61B17/43 , A01N1/0226 , A61D19/02 , C12N5/0604 , C12N5/0609 , C12N5/061 , C12N5/0612 , C12N2500/05 , C12N2517/10 , G01N33/5005
摘要： The present invention provides a new and improved sperm stimulating additive comprising a certain amount of inorganic pyrophosphate (PPi). Addition of PPi in the media for human/animal in vitro fertilization (IVF) improves fertilization rate; addition of PPi in the semen extender for farm animal artificial insemination (AI) may improve pregnancy rates; furthermore, mammalian oocytes matured in vitro in a medium including PPi attain improved fertilization and developmental potential, while embryos cultured in medium supplemented with PPi have improved development to blastocyst.
摘要翻译：本发明提供了一种新的和改进的精子刺激性添加剂，其包含一定量的无机焦磷酸盐（PPi）。用于人/动物体外受精（IVF）的培养基中添加PPi可提高受精率; 用于农场动物人工授精（AI）的精液延长剂中添加PPi可能会提高怀孕率; 此外，在包括PPi的培养基中体外成熟的哺乳动物卵母细胞获得改善的受精和发育潜力，而在补充有PPi的培养基中培养的胚胎已经改善了囊胚发育。

142. 发明申请

US20130133871A1 Multiple Thermal Circuit Heat Spreader 审中-公开
标题翻译：多热回路散热器
公开(公告)号：US20130133871A1
公开(公告)日：2013-05-30
申请号：US13640758
申请日：2011-04-12
申请人： Hongbin Ma , Peng Cheng , Joseph A. Boswell
发明人： Hongbin Ma , Peng Cheng , Joseph A. Boswell
IPC分类号： F28D15/00
CPC分类号： F28D15/00 , F28D15/0266 , H01L23/427 , H01L2924/0002 , H01L2924/00
摘要： A heat spreader has more than one thermal circuit to give better performance over a wider range of heat input regimes. Different working fluids may be used in the different thermal circuits. The thermal circuits may extend in three dimensions to improve the density of the channels in limited space.
摘要翻译：散热器具有多个热回路，以在更宽范围的热输入方式下提供更好的性能。不同的工作流体可用于不同的热回路。热电路可以在三维中延伸以在有限的空间内改善通道的密度。

143. 发明申请

US20130129618A1 EGCG STABILIZED GOLD NANOPARTICLES AND METHOD FOR MAKING SAME 有权
标题翻译： EGCG稳定的金纳米颗粒及其制备方法
公开(公告)号：US20130129618A1
公开(公告)日：2013-05-23
申请号：US13668916
申请日：2012-11-05
申请人： THE CURATORS OF THE UNIVERSITY OF MISS
发明人： Kattesh V. Katti , Raghuraman Kannan , Kativa K. Katti , Satish Kumar Nune , Cathy S. Cutler , Charles Caldwell , Ravi Shukla , Nripen Chanda , Ajit Zambre
IPC分类号： A61K9/14 , A61P35/00 , A61K49/00 , A61K51/12 , A61K33/24 , B82Y5/00
CPC分类号： A61K51/1244 , A61K9/148 , A61K31/353 , A61K33/24 , A61K41/00 , A61K51/1251
摘要： The invention provides stabilized, biocompatible gold nanoparticles that are stabilized with material from epigallocatechin Gallate (EGCg), which is a polyphenols- or flavanoids-rich plant material that can be obtained from green tea. The EGCg is an an antioxidant reducing agent derived from green tea. The gold nanoparticles of the invention can be radioactive or non radioactive and are formed via a simple room temperature fabrication method. In preferred embodiment method of making, an aqueous solution containing gold salts is provided. The aqueous solution is mixed with EGCg in a buffer, such as deionized water. The gold salts react to form biocompatible gold nanoparticles that are stabilized with a coating of EGCg. The thermodynamically feasible redox couple of AuCl4-EGCg leading to the reduction of AuCl4- by EGCg to form gold nanoparticles. In another embodiment, pre-cooled gold salt and EGCg solutions form multi-layered EGCg coated particles.
摘要翻译：本发明提供了稳定的生物相容性金纳米颗粒，其由来自表儿茶酸乙酸酯（EGCg）的材料稳定，其是可以从绿茶中获得的富含多酚或类黄酮的植物材料。 EGCg是一种来自绿茶的抗氧化剂还原剂。本发明的金纳米颗粒可以是放射性的或非放射性的，并且通过简单的室温制造方法形成。在优选的实施方案中，提供含有金盐的水溶液。将水溶液与EGCg混合在缓冲液中，例如去离子水。金盐反应形成用EGCg涂层稳定的生物相容性金纳米颗粒。 AuCl4-EGCg的热力学可行的氧化还原对导致由EGCg还原AuCl4以形成金纳米颗粒。在另一个实施方案中，预冷金盐和EGCg溶液形成多层EGCg涂覆的颗粒。

144. 发明申请

US20130115328A1 MICROENCAPSULATED PROBIOTICS FOR REDUCING FECAL SHEDDING OF PATHOGENIC MICROBES IN ANIMALS 审中-公开
标题翻译：用于减少动物中病原微生物的角质层沉积的微型沉积技术
公开(公告)号：US20130115328A1
公开(公告)日：2013-05-09
申请号：US13559361
申请日：2012-07-26
申请人： Azlin Mustapha , Monty Kerley , Juhee Ahn
发明人： Azlin Mustapha , Monty Kerley , Juhee Ahn
IPC分类号： A23K1/16
CPC分类号： A23K40/35 , A23K10/18 , A23K20/00 , A23K20/163 , A23K50/10
摘要： Disclosed are methods and compositions for reducing E. coli O157:H7 colonization and shedding in ruminant animals. In certain aspects, methods are provided comprising delivering microencapsulated probiotic bacteria to the gastrointestinal tract of a ruminant animal. Microencapsulated probiotics for delivery to the gastrointestinal tract of a ruminant animal in order to reduce E. coli O157:H7 shedding are also provided.
摘要翻译：公开了用于减少反刍动物中大肠杆菌O157：H7定居和脱落的方法和组合物。在某些方面，提供了将微胶囊化的益生菌递送到反刍动物的胃肠道的方法。也提供用于递送至反刍动物胃肠道的微胶囊化益生菌以减少大肠杆菌O157：H7脱落。

145. 发明申请

US20130104262A1 Drought Responsive Genes In Plants And Methods of Their Use 审中-公开
标题翻译：植物中的抗旱基因及其使用方法
公开(公告)号：US20130104262A1
公开(公告)日：2013-04-25
申请号：US13727180
申请日：2012-12-26
申请人： The Curators Of The University Of Missouri
发明人： Henry T. Nguyen , Babu Valliyodan
IPC分类号： C12N15/82
CPC分类号： C12N15/8273 , C07K14/415
摘要： Microarrays are employed to analyze soybean transcriptions under water stress conditions in both root and leaf tissues at vegetative stage. Novel drought responsive genes may be thus identified and may be used for enhancing drought tolerance in soybean or other plants through genetic/metabolic engineering. This disclosure pertains to nucleic acid molecules isolated from Soybean that encode polypeptides that may be important for drought tolerance. The disclosure also relates to methods of using these genes from soybean in transgenic plants to confer the desired agronomic traits, and to use such genes or regulatory elements thereof to assist germplasm enhancement by molecular breeding or to identify other factors or chemicals that may enhance a plant's capability to grow under drought conditions.
摘要翻译：微阵列用于在营养阶段的根和叶组织的水胁迫条件下分析大豆转录。因此，可以鉴定出新的干旱反应性基因，并且可以通过遗传/代谢工程用于增强大豆或其他植物的耐旱性。本公开涉及从大豆分离的编码可能对耐旱性重要的多肽的核酸分子。本公开还涉及在转基因植物中使用来自大豆的这些基因用于赋予所需农学性状的方法，并且使用这些基因或其调控元件来帮助通过分子育种增强种质，或鉴定其它因素或化学物质，其可以增强植物的在干旱条件下生长的能力。

146. 发明授权

US08337875B2 Controlling vessel growth and directionality in mammals and implantable material 有权
标题翻译：控制哺乳动物和可植入材料中的血管生长和方向性
公开(公告)号：US08337875B2
公开(公告)日：2012-12-25
申请号：US12683211
申请日：2010-01-06
申请人： Steven B. Jung , Delbert E. Day
发明人： Steven B. Jung , Delbert E. Day
IPC分类号： A61F2/00
CPC分类号： C03C13/00 , A61L27/10 , A61L27/58 , C03C4/0007 , C03C4/0035 , C03C2213/02
摘要： A method for directing vessel growth toward a blood-deficient site in a mammal comprising implanting into the mammal an assembly of at glass fibers to form a vascular bridge with a first end of the vascular bridge in contact with the blood-deficient site and a second end of the vascular bridge remote from the blood-deficient site. Over time the bridge biodegrades and promotes vascularity in the direction of the bridge.
摘要翻译：一种用于将血管生长导向哺乳动物的血液缺乏部位的方法，包括向玻璃纤维植入哺乳动物组件以形成与血液缺陷部位接触的血管桥的第一端的血管桥，第二远离血液缺乏部位的血管桥端。随着时间的推移，桥梁在桥梁的方向上生物降解和促进血管分布。

147. 发明授权

US08303522B2 Device for transfecting cells using shock waves generated by the ignition of nanoenergetic materials 失效
标题翻译：使用由纳米能量材料的点燃产生的冲击波来转染细胞的装置
公开(公告)号：US08303522B2
公开(公告)日：2012-11-06
申请号：US12253706
申请日：2008-10-17
申请人： Steve Apperson , Shubhra Gangopadhyay , Luis Polo-Parada , Andrey Bezmelnitsyn , Keshab Gangopadhyay
发明人： Steve Apperson , Shubhra Gangopadhyay , Luis Polo-Parada , Andrey Bezmelnitsyn , Keshab Gangopadhyay
IPC分类号： A61H1/00
CPC分类号： A61B17/2202 , A61B17/22004 , A61B2017/22025
摘要： A miniature device for generating shock waves using the energy of combustion of a nanoenergetic material and directing the shock waves into biological tissues is described.
摘要翻译：描述了使用纳米能量材料的燃烧能量并将冲击波引导到生物组织中产生冲击波的微型装置。

148. 发明授权

US08260637B2 System and method for linking a web-based resource with an electronic medical record 有权
标题翻译：将基于网络的资源与电子医疗记录相关联的系统和方法
公开(公告)号：US08260637B2
公开(公告)日：2012-09-04
申请号：US12572412
申请日：2009-10-02
申请人： Karl M. Kochendorfer , Jared S. Coberly
发明人： Karl M. Kochendorfer , Jared S. Coberly
IPC分类号： G06Q50/00
CPC分类号： G06Q10/10 , G06F19/00 , G06Q10/06 , G06Q50/22 , G06Q50/24 , G16H10/60
摘要： A data processing system and method that, in some cases, include an EMR system and a web server. In some cases, the EMR system includes a plurality of electronic medical records for a plurality of patients. One or more of the electronic medical records may include a URL or HTTP Post message that defines a path to a web-based resource, such as a treatment algorithm or medical calculator. In some embodiments, the URL and/or HTTP Post message is constructed based on information in a patient's medical record.
摘要翻译：在某些情况下，包括EMR系统和Web服务器的数据处理系统和方法。在一些情况下，EMR系统包括用于多个患者的多个电子医疗记录。一个或多个电子医疗记录可以包括定义到诸如治疗算法或医疗计算器的基于网络的资源的路径的URL或HTTP Post消息。在一些实施例中，URL和/或HTTP Post消息是基于患者医疗记录中的信息构建的。

149. 发明申请

US20120221573A1 Methods and systems for biclustering algorithm 有权
标题翻译：双簇算法的方法和系统
公开(公告)号：US20120221573A1
公开(公告)日：2012-08-30
申请号：US13385042
申请日：2012-01-30
申请人： Donald Coolidge Wunsch, II , Rui Xu , Sejun Kim
发明人： Donald Coolidge Wunsch, II , Rui Xu , Sejun Kim
IPC分类号： G06F17/30
CPC分类号： G06F17/30539 , G06F19/24
摘要： Methods and systems for improved unsupervised learning are described. The unsupervised learning can consist of biclustering a data set, e.g., by biclustering subsets of the entire data set. In an example, the biclustering does not include feeding know and proven results into the biclustering methodology or system. A hierarchical approach can be used that feeds proven clusters back into the biclustering methodology or system as the input. Data that does not cluster may be discarded. Thus, a very large unknown data set can be acted on to learn about the data. The system is also amenable to parallelization.
摘要翻译：描述了改进的无监督学习的方法和系统。无监督学习可以包括例如通过对整个数据集进行二聚簇的二聚簇数据集的二聚簇。在一个例子中，双组分不包括将知道和证明的结果提供给双组分方法或系统。可以使用分级方法，将验证的群集作为输入返回到双重聚类方法或系统。不会聚集的数据可能被丢弃。因此，可以采用非常大的未知数据集来了解数据。该系统也适用于并行化。

150. 发明申请

US20120205011A1 Protective Conversion Coating on Mixed-Metal Subtrates and Methods Thereof 有权
标题翻译：混合金属基体上的保护性转化涂层及其方法
公开(公告)号：US20120205011A1
公开(公告)日：2012-08-16
申请号：US13450667
申请日：2012-04-19
申请人： Matthew J. O'Keefe , Surender Maddela
发明人： Matthew J. O'Keefe , Surender Maddela
IPC分类号： C23C22/03 , C23C22/05 , B32B15/04 , C23C22/78
CPC分类号： C23G3/00 , C23C22/68 , C23G1/00 , C25D13/20 , C25D13/22
摘要： Mixed-metal automotive vehicle bodies-in-white comprising ferrous metal surfaces, zinc surfaces, aluminum alloy surfaces, and magnesium alloy surfaces are cleaned and immersed in an aqueous bath comprising an adhesion promoter and an aqueous electrocoat bath (the adhesion promoter may be in the electrocoat bath. The adhesion promoter, which may be a cerium salt, is selected to react with each metal in the body surfaces to form an oxide layer that provides corrosion resistance for the surface and adherence for the deposited polymeric paint coating. The body is cathodic in the electrocoat deposition.
摘要翻译：将包含黑色金属表面，锌表面，铝合金表面和镁合金表面的混合金属机车车身清洁并浸入包含粘合促进剂和水性电泳浴的水浴中（粘合促进剂可以在选择可以是铈盐的粘合促进剂与身体表面中的每种金属反应以形成氧化物层，其为表面提供耐腐蚀性并且对于沉积的聚合物涂料涂层的粘附性。身体是在电泳沉积中阴极。

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